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Rat Modelinde Tubal Sterilizasyonun Tuba, Yumurtalıklar ve Endometrium Üzerine Etkileri

Year 2019, Volume: 9 Issue: 3, 185 - 190, 01.12.2019

Rulin Deniz Yakup Baykuş Yasemen Adalı Muhammet Bora Uzuner Ömür Öztürk

Abstract

Amaç: Tubal sterilizasyonunun (TS) overyan fonksiyonları üzerindeki olası etkileri, etiyolojisi ve fizyopatolojisi henüz bilinmemekle birlikte hala tartışmalıdır. TS sonrası overyan ve endometriyal histopatoloji sınırlı çalışmalarda analiz edildi. Bu çalışmada, ratlarda Pomeroy tekniği ile tubal sterilizasyonun tubalar, overyan ve endometrial dokulardaki histopatolojik ve biyokimyasal değişimlerinin değerlendirmesi amaçlandı. Materyal ve Metot: Yirmi adet dişi Wistar albino rat, laparotomi (Grup 1) ve laparotomi + TS (Grup 2) olarak rastgele belirlenerek iki gruba ayrıldı. Hematoksilen-Eosin boyamasından sonra histopatolojik değerlendirme yapıldı. Folikül uyarıcı hormon (FSH), estradiol (E2) ve laktat dehidrojenaz (LDH) seviyeleri biyokimyasal olarak ölçüldü. Bulgular: Grup 2’de Grup 1’e göre overler, tubalar ve endometriyal dokularda inflamasyon, hyalinizasyon ve konjesyon vardı. Grup 2’de Grup 1’e göre E2 (p<0.05) değerlerindeki istatistiksel anlamlı düşüş tespit edildi. Grup 2’de Grup 1’e göre ortalama FSH ve LDH (p>0.05) değerlerinde ise istatistiksel olarak anlamlı olmasa da artış tespit edildi. Sonuç: Tubal sterilizasyonunun rat overlerinde enflamatuar hücre infiltrasyonu gibi zararlı etkilere neden olduğu söylenebilir. Tubal sterilizasyondan sonra azalan yumurtalık rezervlerinin muhtemel mekanizmalarını açıklamak için daha ileri çalışmalara ihtiyaç vardır.

Keywords

tubal sterilizasyon; Pomeroy tekniği; over; endometriyum; rat

References

  • 1. Rojansky N, Halbreich U. Prevalence and severity of premenstrual changes after tubal sterilization. J Reprod Med 1991;36(8):551–5.
  • 2. Wilcox LS, Martinez-Schnell B, Peterson HB, Ware JH, Hughes JM. Menstrual function after tubal sterilization. Am J Epidemiol 1992;135(12):1368–81.
  • 3. Huber AW, Mueller MD, Ghezzi F, Cromi A, Dreher E, Raio L. Tubal sterilization: complications of laparoscopy and minilaparotomy. Eur J Obstet Gynecol Reprod Biol 2007;134(1):105–9.
  • 4. Kelekci S, Yilmaz B, Yakut Y, Yasar L, Savan K, Sonmez S. Hormonal and ovarian stromal blood supply changes after laparoscopic tubal sterilization: a prospective controlled study. Contraception 2006;73(3):279–83.
  • 5. Kelekci S, Yorgancioglu Z, Yilmaz B, Yasar L, Savan K, Sonmez S, et al. Effect of tubal ligation on ovarian reserve and the ovarian stromal blood supply. Aust N Z J Obstet Gynaecol 2004;44(5):449–51.
  • 6. Aygen EM, Ozdamar S, Serin S, Babug M. Ovarian morphology of rats after fallopian tube sterilization. Contraception 2002;66(3):211–4.
  • 7. Cevrioglu AS, Degirmenci B, Acar M, Yilmazer M, Erol D, Kahraman A, et al. Examination of changes caused by tubal sterilization in ovarian hormone secretion and uterine and ovarian artery blood flow rates. Contraception 2004;70(6):467– 73.
  • 8. Kaya C, Turgut H, Cengiz H, Turan A, Ekin M, Yasar L. The effect of tubal sterilization with the Pomeroy technique and bipolar electrocauterization on the ovarian reserve and serum anti-Mullerian hormone levels in a rat model. Eur J Obstet Gynecol Reprod Biol 2015;185:108–13.
  • 9. Kjer JJ, Mogensen AM. The arterial blood supply of the parametrium. Eur J Obstet Gynecol Reprod Biol 1989;30(3):275–8.
  • 10. Wu E, Xiao B, Yan W, Li H, Wu B. Hormonal profile of the menstrual cycle in Chinese women after tubal sterilization. Contraception 1992;45(6):583–93.
  • 11. Bulent Tiras M, Noyan V, Ozdemir H, Guner H, Yildiz A, Yildirim M. The changes in ovarian hormone levels and ovarian artery blood flow rate after laparoscopic tubal sterilization. Eur J Obstet Gynecol Reprod Biol 2001;99(2):219–21.
  • 12. Kuscu E, Duran HE, Zeyneloglu HB, Demirhan B, Bagis T, Saygili E. The effect of surgical sterilization on ovarian function: a rat model. Eur J Obstet Gynecol Reprod Biol 2002;100(2):204–7.
  • 13. Chen Y, Jefferson WN, Newbold RR, Padilla-Banks E, Pepling ME. Estradiol, progesterone, and genistein inhibit oocyte nest breakdown and primordial follicle assembly in the neonatal mouse ovary in vitro and in vivo. Endocrinology 2007;148(8):3580–90.
  • 14. Simaga S, Osmak M, Babic D, Sprem M, Vukelic B, Abramic M. Quantitative biochemical analysis of lactate dehydrogenase in human ovarian tissues: correlation with tumor grade. Int J Gynecol Cancer 2005;15(3):438–44.
  • 15. Committee for the Update of the Guide for the Care and Use of Laboratory Animals. Guide for the Care and Use of Laboratory Animals 2011.
  • 16. Moher D, Schulz KF, Altman D, Group C. The CONSORT Statement: revised recommendations for improving the quality of reports of parallel-group randomized trials 2001. Explore (NY) 2005;1(1):40–5.
  • 17. Taner CE, Aban M, Yilmaz N, Senturk N, Toy E. Pomeroy tubal ligation by laparoscopy and minilaparotomy. Adv Contracept 1994;10(2):151–5.
  • 18. Krissi H, Orvieto R, Dicker D, Dekel A, Ben Rafael Z. Torsion of a fallopian tube following Pomeroy tubal ligation: a rare case report and review of the literature. Eur J Obstet Gynecol Reprod Biol 1997;72(1):107–9.
  • 19. Revel A, Abramov Y, Yagel S, Nadjari M. Utero-ovarian morphology and blood flow after tubal ligation by the Pomeroy technique. Contraception 2004;69(2):151–6.
  • 20. Kelekci S, Yilmaz B, Yasar L, Savan K, Sonmez S, Kart C. Ovarian reserve and ovarian stromal blood supply after tubal ligation by the Pomeroy technique: comparison with controls. Gynecol Endocrinol 2005;20(5):279–83.
  • 21. Carmona F, Cristobal P, Casamitjana R, Balasch J. Effect of tubal sterilization on ovarian follicular reserve and function. Am J Obstet Gynecol 2003;189(2):447–52.
  • 22. Hakverdi AU, Taner CE, Erden AC, Satici O. Changes in ovarian function after tubal sterilization. Adv Contracept 1994;10(1):51–6.
  • 23. Alvarez F, Faundes A, Brache V, Tejada AS, Segal S. Prospective study of the pituitary-ovarian function after tubal sterilization by the Pomeroy or Uchida techniques. Fertil Steril 1989;51(4):604–8.
  • 24. de Cristofaro D, Zancanari C, Fiaccavento S, Pezzoli C. Endometrial pathological changes after Fallopian ring tubal ligation. Endoscopy 1982;14(4):139–40.
  • 25. Duran B, Demirkoprulu N, Guvenal T, Arici S, Tuncer E, Cetin M, et al. Histopathological changes in ovary and endometrium after tubal ligation: a rat model. Acta Obstet Gynecol Scand 2003;82(3):220–4.
  • 26. Riedel HH, Ahrens H, Semm K. Late complications of sterilization according to method. J Reprod Med 1981;26(7):353–8.
  • 27. Souza AZ, Fonseca AM, Izzo VM, Clauzet RM, Salvatore CA. Ovarian histology and function after total abdominal hysterectomy. Obstet Gynecol. 1986;68(6):847–9.

Year 2019, Volume: 9 Issue: 3, 185 - 190, 01.12.2019

Rulin Deniz Yakup Baykuş Yasemen Adalı Muhammet Bora Uzuner Ömür Öztürk

Abstract

References

  • 1. Rojansky N, Halbreich U. Prevalence and severity of premenstrual changes after tubal sterilization. J Reprod Med 1991;36(8):551–5.
  • 2. Wilcox LS, Martinez-Schnell B, Peterson HB, Ware JH, Hughes JM. Menstrual function after tubal sterilization. Am J Epidemiol 1992;135(12):1368–81.
  • 3. Huber AW, Mueller MD, Ghezzi F, Cromi A, Dreher E, Raio L. Tubal sterilization: complications of laparoscopy and minilaparotomy. Eur J Obstet Gynecol Reprod Biol 2007;134(1):105–9.
  • 4. Kelekci S, Yilmaz B, Yakut Y, Yasar L, Savan K, Sonmez S. Hormonal and ovarian stromal blood supply changes after laparoscopic tubal sterilization: a prospective controlled study. Contraception 2006;73(3):279–83.
  • 5. Kelekci S, Yorgancioglu Z, Yilmaz B, Yasar L, Savan K, Sonmez S, et al. Effect of tubal ligation on ovarian reserve and the ovarian stromal blood supply. Aust N Z J Obstet Gynaecol 2004;44(5):449–51.
  • 6. Aygen EM, Ozdamar S, Serin S, Babug M. Ovarian morphology of rats after fallopian tube sterilization. Contraception 2002;66(3):211–4.
  • 7. Cevrioglu AS, Degirmenci B, Acar M, Yilmazer M, Erol D, Kahraman A, et al. Examination of changes caused by tubal sterilization in ovarian hormone secretion and uterine and ovarian artery blood flow rates. Contraception 2004;70(6):467– 73.
  • 8. Kaya C, Turgut H, Cengiz H, Turan A, Ekin M, Yasar L. The effect of tubal sterilization with the Pomeroy technique and bipolar electrocauterization on the ovarian reserve and serum anti-Mullerian hormone levels in a rat model. Eur J Obstet Gynecol Reprod Biol 2015;185:108–13.
  • 9. Kjer JJ, Mogensen AM. The arterial blood supply of the parametrium. Eur J Obstet Gynecol Reprod Biol 1989;30(3):275–8.
  • 10. Wu E, Xiao B, Yan W, Li H, Wu B. Hormonal profile of the menstrual cycle in Chinese women after tubal sterilization. Contraception 1992;45(6):583–93.
  • 11. Bulent Tiras M, Noyan V, Ozdemir H, Guner H, Yildiz A, Yildirim M. The changes in ovarian hormone levels and ovarian artery blood flow rate after laparoscopic tubal sterilization. Eur J Obstet Gynecol Reprod Biol 2001;99(2):219–21.
  • 12. Kuscu E, Duran HE, Zeyneloglu HB, Demirhan B, Bagis T, Saygili E. The effect of surgical sterilization on ovarian function: a rat model. Eur J Obstet Gynecol Reprod Biol 2002;100(2):204–7.
  • 13. Chen Y, Jefferson WN, Newbold RR, Padilla-Banks E, Pepling ME. Estradiol, progesterone, and genistein inhibit oocyte nest breakdown and primordial follicle assembly in the neonatal mouse ovary in vitro and in vivo. Endocrinology 2007;148(8):3580–90.
  • 14. Simaga S, Osmak M, Babic D, Sprem M, Vukelic B, Abramic M. Quantitative biochemical analysis of lactate dehydrogenase in human ovarian tissues: correlation with tumor grade. Int J Gynecol Cancer 2005;15(3):438–44.
  • 15. Committee for the Update of the Guide for the Care and Use of Laboratory Animals. Guide for the Care and Use of Laboratory Animals 2011.
  • 16. Moher D, Schulz KF, Altman D, Group C. The CONSORT Statement: revised recommendations for improving the quality of reports of parallel-group randomized trials 2001. Explore (NY) 2005;1(1):40–5.
  • 17. Taner CE, Aban M, Yilmaz N, Senturk N, Toy E. Pomeroy tubal ligation by laparoscopy and minilaparotomy. Adv Contracept 1994;10(2):151–5.
  • 18. Krissi H, Orvieto R, Dicker D, Dekel A, Ben Rafael Z. Torsion of a fallopian tube following Pomeroy tubal ligation: a rare case report and review of the literature. Eur J Obstet Gynecol Reprod Biol 1997;72(1):107–9.
  • 19. Revel A, Abramov Y, Yagel S, Nadjari M. Utero-ovarian morphology and blood flow after tubal ligation by the Pomeroy technique. Contraception 2004;69(2):151–6.
  • 20. Kelekci S, Yilmaz B, Yasar L, Savan K, Sonmez S, Kart C. Ovarian reserve and ovarian stromal blood supply after tubal ligation by the Pomeroy technique: comparison with controls. Gynecol Endocrinol 2005;20(5):279–83.
  • 21. Carmona F, Cristobal P, Casamitjana R, Balasch J. Effect of tubal sterilization on ovarian follicular reserve and function. Am J Obstet Gynecol 2003;189(2):447–52.
  • 22. Hakverdi AU, Taner CE, Erden AC, Satici O. Changes in ovarian function after tubal sterilization. Adv Contracept 1994;10(1):51–6.
  • 23. Alvarez F, Faundes A, Brache V, Tejada AS, Segal S. Prospective study of the pituitary-ovarian function after tubal sterilization by the Pomeroy or Uchida techniques. Fertil Steril 1989;51(4):604–8.
  • 24. de Cristofaro D, Zancanari C, Fiaccavento S, Pezzoli C. Endometrial pathological changes after Fallopian ring tubal ligation. Endoscopy 1982;14(4):139–40.
  • 25. Duran B, Demirkoprulu N, Guvenal T, Arici S, Tuncer E, Cetin M, et al. Histopathological changes in ovary and endometrium after tubal ligation: a rat model. Acta Obstet Gynecol Scand 2003;82(3):220–4.
  • 26. Riedel HH, Ahrens H, Semm K. Late complications of sterilization according to method. J Reprod Med 1981;26(7):353–8.
  • 27. Souza AZ, Fonseca AM, Izzo VM, Clauzet RM, Salvatore CA. Ovarian histology and function after total abdominal hysterectomy. Obstet Gynecol. 1986;68(6):847–9.
There are 27 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Research Article
Authors

Rulin Deniz This is me

Yakup Baykuş This is me

Yasemen Adalı This is me

Muhammet Bora Uzuner This is me

Ömür Öztürk This is me

Publication Date December 1, 2019
Published in Issue Year 2019 Volume: 9 Issue: 3

Cite

APA Deniz, R., Baykuş, Y., Adalı, Y., Uzuner, M. B., et al. (2019). Rat Modelinde Tubal Sterilizasyonun Tuba, Yumurtalıklar ve Endometrium Üzerine Etkileri. Kafkas Journal of Medical Sciences, 9(3), 185-190.
AMA Deniz R, Baykuş Y, Adalı Y, Uzuner MB, Öztürk Ö. Rat Modelinde Tubal Sterilizasyonun Tuba, Yumurtalıklar ve Endometrium Üzerine Etkileri. KAFKAS TIP BİL DERG. December 2019;9(3):185-190.
Chicago Deniz, Rulin, Yakup Baykuş, Yasemen Adalı, Muhammet Bora Uzuner, and Ömür Öztürk. “Rat Modelinde Tubal Sterilizasyonun Tuba, Yumurtalıklar Ve Endometrium Üzerine Etkileri”. Kafkas Journal of Medical Sciences 9, no. 3 (December 2019): 185-90.
EndNote Deniz R, Baykuş Y, Adalı Y, Uzuner MB, Öztürk Ö (December 1, 2019) Rat Modelinde Tubal Sterilizasyonun Tuba, Yumurtalıklar ve Endometrium Üzerine Etkileri. Kafkas Journal of Medical Sciences 9 3 185–190.
IEEE R. Deniz, Y. Baykuş, Y. Adalı, M. B. Uzuner, and Ö. Öztürk, “Rat Modelinde Tubal Sterilizasyonun Tuba, Yumurtalıklar ve Endometrium Üzerine Etkileri”, KAFKAS TIP BİL DERG, vol. 9, no. 3, pp. 185–190, 2019.
ISNAD Deniz, Rulin et al. “Rat Modelinde Tubal Sterilizasyonun Tuba, Yumurtalıklar Ve Endometrium Üzerine Etkileri”. Kafkas Journal of Medical Sciences 9/3 (December 2019), 185-190.
JAMA Deniz R, Baykuş Y, Adalı Y, Uzuner MB, Öztürk Ö. Rat Modelinde Tubal Sterilizasyonun Tuba, Yumurtalıklar ve Endometrium Üzerine Etkileri. KAFKAS TIP BİL DERG. 2019;9:185–190.
MLA Deniz, Rulin et al. “Rat Modelinde Tubal Sterilizasyonun Tuba, Yumurtalıklar Ve Endometrium Üzerine Etkileri”. Kafkas Journal of Medical Sciences, vol. 9, no. 3, 2019, pp. 185-90.
Vancouver Deniz R, Baykuş Y, Adalı Y, Uzuner MB, Öztürk Ö. Rat Modelinde Tubal Sterilizasyonun Tuba, Yumurtalıklar ve Endometrium Üzerine Etkileri. KAFKAS TIP BİL DERG. 2019;9(3):185-90.