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Prognostik Nutrisyonel İndeksin ve Sistemik İmmün-İnflamasyon İndeksin Ülseratif Kolit Hastalık Şiddetinin Belirlenmesindeki Rolü

Year 2022, Volume: 12 Issue: 1, 31 - 36, 01.04.2022

Abstract

Amaç: Ülseratif kolit (ÜK) gastrointestinal sistemin kronik, idiyopatik, tekrarlayan inflamatuar bir hastalığıdır. Son yıllarda ÜK’in hastalık aktivitesini belirlemek için biyokimyasal parametreler yaygın olarak kullanılmaktadır. Bu çalışmada, prognostik nutrisyonel indeksi (PNİ) ve sistemik immün-inflamasyon indeksi (SII) ile hastalık aktivitesi arasındaki ilişkinin belirlenmesi amaçlanmıştır.
Materyal ve Metot: Bu retrospektif çalışmaya Ankara Şehir Hastanesi Gastroenteroloji Bölümü İBH ünitesinde 1 Mart 2019 ile 31 Mart 2021 tarihleri arasında takip edilen tüm erişkin hastalar dahil edildi. PNİ ve SII ile ÜK’in endoskopik aktivite şiddeti arasındaki ilişki analiz edildi. Ek olarak PNİ ve SII aktif ve remisyondaki hasta grupları arasında karşılaştırıldı. Hastalık aktivitesinin belirlenmesinde Rachmilewitz endoskopik aktivite indeksi (EAİ) kullanıldı.
Bulgular: Çalışma grubu 402 hastadan oluşuyordu. Bu hastaların 165’i endoskopik olarak remisyon grubunda, 237’si endoskopik olarak aktif gruptaydı. Aktif ÜK grubunda, SII, NLR ve PLR değerleri, inaktif ÜK hastalarına kıyasla anlamlı olarak daha yüksekti ve PNI değerleri daha düşük saptandı (p<0,05 tüm parametreler için). Ek olarak, NLR, PLR, SII pozitif olarak ve PNİ negatif olarak endoskopik aktivite indeksi ile korele saptandı (sırasıyla, R=0,29, R=0,24, R=0,38, R=-0,32; ve tüm parametreler için p<0,001).
Sonuç: PNİ ve SII, ÜK aktivitesi ile önemli ölçüde ilişkiliydi. PNİ ve SII, ÜK’de hastalık aktivitesinin değerlendirilmesi için faydalı bir araç olabilir.

References

  • 1. Magro F, Gionchetti P, Eliakim R, et al., Third European evidence-based consensus on diagnosis and management of ulcerative colitis. Part 1: definitions, diagnosis, extra-intestinal manifestations, pregnancy, cancer surveillance, surgery, and ileo-anal pouch disorders. Journal of Crohn’s & Colitis. 2017;11(6):649–70.
  • 2. Langholz E, Munkholm P, Nielsen OH, Kreiner S, Binder V. Incidence and prevalence of ulcerative colitis in Copenhagen county from 1962 to 1987. Scand J Gastroenterol. 1991;26:1247–56.
  • 3. DeRoche TC, Xiao SY, Liu X. Histological evaluation in ulcerative colitis. Gastroenterol Rep (Oxf )2014;2(3):178–92.
  • 4. Travis SP. Review article: the management of mild to severe acute ulcerative colitis. Aliment Pharmacol Ther. 2004;20(Suppl. 4):88–92.
  • 5. Cima RR, Pemberton JH. Medical and surgical management of chronic ulcerative colitis. Arch Surg. 2005;140:300–10.
  • 6. Leighton JA, Shen B, Baron TH, Adler DG, Davila R, Egan JV, et al. Standards of Practice Committee, American Society for Gastrointestinal Endoscopy: endo scopy in the diagnosis and treatment of inflammatory bowel disease. Gastrointest Endosc. 2006;63:558–65.
  • 7. Vermeire S, Van Assche G, Rutgeerts P. Laboratory markers in IBD. Useful, magic, or unnecessary toys? Gut. 2006;55:426–431.
  • 8. Posul E, Yilmaz B, Aktas G, Kurt M. Does neutrophil-tolymphocyte ratio predict active ulcerative colitis? Wien Klin Wochenschr. 2015;127(7–8):262–5.
  • 9. Seo M, Yamada T, Morita T, Furukawa Y, Tamaki S, Iwasaki Y, et al. Prognostic value of systemic immune-inflammation index in patients with chronic heart failure (P589). Eur. Heart J. 2018;39:70–10. Jeong Y, Jeon SR, Kim HG, Moon JR, Lee TH, Jang JY, Cho JH, Park JS, Park H, Lee KH, Kim JO, Lee JS, Ko BM, Park S. The role of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in ulcerative colitis. Intest Res. 2021;19(1):62–70.
  • 11. Chohno T, Uchino M, Sasaki H, Bando T, Takesue Y, Ikeuchi H. Associations Between the Prognostic Nutritional Index and Morbidity/Mortality During Intestinal Resection in Patients with Ulcerative Colitis. World J Surg. 2018;42(7):1949–1959.
  • 12. Naber AH, de Jong DJ. Assessment of disease activity in inflammatory bowel disease; relevance for clinical trials. Neth J Med. 2003;61:105–10.
  • 13. Bohl JL, Sobba K. Indications and Options for Surgery in Ulcerative Colitis. Surg Clin North Am. 2015;95(6):1211–32.
  • 14. Conrad K, Roggenbuck D, Laass MW. Diagnosis and classification of ulcerative colitis. Autoimmun Rev. 2014;13(4–5):463–6.
  • 15. Ungaro R, Mehandru S, Allen PB, Peyrin-Biroulet L, Colombel JF. Ulcerative colitis. Lancet. 2017;389(10080):1756–1770.
  • 16. Yoon JY, Park SJ, Hong SP, Kim TI, Kim WH, Cheon JH. Cor relations of C-reactive protein levels and erythrocyte sedimentation rates with endoscopic activity indices in patients with ulcerative colitis. Dig Dis Sci. 2014;59(4):829–37.
  • 17. Zittan E, Kelly OB, Kirsch R, Milgrom R, Burns J, Nguyen GC, Croitoru K, Van Assche G, Silverberg MS, Steinhart AH. Low Fecal Calprotectin Correlates with Histological Remission and Mucosal Healing in Ulcerative Colitis and Colonic Crohn’s Disease. Inflamm Bowel Dis. 2016;22(3):623–30.
  • 18. Osada T, Ohkusa T, Okayasu I, Yoshida T, Hirai S, Beppu K, Shibuya T, Sakamoto N, Kobayashi O, Nagahara A, Terai T, Watanabe S. Correlations among total colonoscopic findings, clinical symptoms, and laboratory markers in ulcerative colitis. J Gastroenterol Hepatol. 2008;23 Suppl 2:262–7.
  • 19. Chang S, Malter L, Hudesman D. Disease monitoring in inflammatory bowel disease. World J Gastroenterol. 2015;21(40):11246–59.
  • 20. Demir AK, Demirtas A, Kaya SU, Tastan I, Butun I, Sagcan M, Sahin S, Tasliyurt T, Yilmaz A. The relationship between the neutrophil-lymphocyte ratio and disease activity in patients with ulcerative colitis. Kaohsiung J Med Sci. 2015;31(11):585–90.
  • 21. Hu B, Yang XR, Xu Y, et al. Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res. 2014;20:6212–22. Yang R, Chang Q, Meng X, Gao N, Wang W. Prognostic value of Systemic immune-inflammation index in cancer: A metaanalysis. J Cancer. 2018;9:3295–302.
  • 23. Ahn SS, Jung SM, Song JJ, Park YB, Lee SW. Prognostic nutritional index is correlated with disease activity in patients with systemic lupus erythematosus. Lupus. 2018;27:1697–7.
  • 24. Peters Jr T. Metabolism: Albumin in the body. In: All About Albumin: Biochemistry, Genetics and Medical Applications. Amsterdam: Elsevier; 1996. p. 188–250.
  • 25. Nicholson JP, Wolmarans MR, Park GR. The role of albumin in critical illness. Br J Anaesth. 2000;85:599–610.
  • 26. Moshage HJ, Janssen JA, Franssen JH, Hafkenscheid JC, Yap SH. Study of the molecular mechanism of decreased liver synthesis of albumin in inflammation. J Clin Invest. 1987;79:1635–41.
  • 27. Correa-Rodríguez M, Pocovi-Gerardino G, Callejas-Rubio JL, Fernández RR, Martín-Amada M, Cruz-Caparros MG, OrtegoCenteno N, Rueda-Medina B. The Prognostic Nutritional Index and Nutritional Risk Index Are Associated with Disease Activity in Patients with Systemic Lupus Erythematosus. Nutrients. 2019;11(3):638.
  • 28. Ataş N, Babaoğlu H, Demirel E, Çelik B, Bilici Salman R, Satış H, Karadeniz H, Güler AA, Haznedaroğlu S, Göker B, Tufan A, Öztürk MA. Use of prognostic nutritional index in the evaluation of disease activity in patients with Behçet’s disease. Eur J Rheumatol. 2020;7(3):99–104.

The Role of Prognostic Nutritional Index and Systemic Immune-Inflammation Index in Determining Ulcerative Colitis Severity

Year 2022, Volume: 12 Issue: 1, 31 - 36, 01.04.2022

Abstract

Aim: Ulcerative colitis (UC) is a chronic, idiopathic, relapsing inflammatory disease of the gastrointestinal tract. In recent years, biochemical parameters have been widely used to determine the disease activity of UC. The present study aimed to determine the relationship between the prognostic nutritional index (PNI), systemic immune-inflammation index (SII), and disease activity.
Material and Method: All adult patients followed in the IBD unit of the Ankara City Hospital Gastroenterology Department between March 1st, 2019, and March 31st, 2021, were included in this retrospective study. We analyzed the relationship between the SII, PNI, and the endoscopic severity of UC. In addition, PNI and SII were compared between the active and remission group. Disease activity was described by the Rachmilewitz endoscopic activity index (EAI).
Results: The study group consisted of 402 patients. One hundred sixty-five of these patients were in the endoscopic remission group, and 237 were in the endoscopically active group. SII, NLR, and PLR values were significantly higher in the active UC group, and PNI values exhibited a lower mean than inactive UC patients (p<0.05 for all parameters). In addition, the NLR, PLR, and SII were positively, and PNI was negatively correlated with the endoscopic activity index (respectively, R=0.29, R=0.24, R=0.38, R=-0.32; and for all parameters, p<0.001).
Conclusion: PNI and SII were significantly associated with UC activity. PNI and SII may be useful tools for assessing disease activity in UC.

References

  • 1. Magro F, Gionchetti P, Eliakim R, et al., Third European evidence-based consensus on diagnosis and management of ulcerative colitis. Part 1: definitions, diagnosis, extra-intestinal manifestations, pregnancy, cancer surveillance, surgery, and ileo-anal pouch disorders. Journal of Crohn’s & Colitis. 2017;11(6):649–70.
  • 2. Langholz E, Munkholm P, Nielsen OH, Kreiner S, Binder V. Incidence and prevalence of ulcerative colitis in Copenhagen county from 1962 to 1987. Scand J Gastroenterol. 1991;26:1247–56.
  • 3. DeRoche TC, Xiao SY, Liu X. Histological evaluation in ulcerative colitis. Gastroenterol Rep (Oxf )2014;2(3):178–92.
  • 4. Travis SP. Review article: the management of mild to severe acute ulcerative colitis. Aliment Pharmacol Ther. 2004;20(Suppl. 4):88–92.
  • 5. Cima RR, Pemberton JH. Medical and surgical management of chronic ulcerative colitis. Arch Surg. 2005;140:300–10.
  • 6. Leighton JA, Shen B, Baron TH, Adler DG, Davila R, Egan JV, et al. Standards of Practice Committee, American Society for Gastrointestinal Endoscopy: endo scopy in the diagnosis and treatment of inflammatory bowel disease. Gastrointest Endosc. 2006;63:558–65.
  • 7. Vermeire S, Van Assche G, Rutgeerts P. Laboratory markers in IBD. Useful, magic, or unnecessary toys? Gut. 2006;55:426–431.
  • 8. Posul E, Yilmaz B, Aktas G, Kurt M. Does neutrophil-tolymphocyte ratio predict active ulcerative colitis? Wien Klin Wochenschr. 2015;127(7–8):262–5.
  • 9. Seo M, Yamada T, Morita T, Furukawa Y, Tamaki S, Iwasaki Y, et al. Prognostic value of systemic immune-inflammation index in patients with chronic heart failure (P589). Eur. Heart J. 2018;39:70–10. Jeong Y, Jeon SR, Kim HG, Moon JR, Lee TH, Jang JY, Cho JH, Park JS, Park H, Lee KH, Kim JO, Lee JS, Ko BM, Park S. The role of platelet to lymphocyte ratio and neutrophil to lymphocyte ratio in ulcerative colitis. Intest Res. 2021;19(1):62–70.
  • 11. Chohno T, Uchino M, Sasaki H, Bando T, Takesue Y, Ikeuchi H. Associations Between the Prognostic Nutritional Index and Morbidity/Mortality During Intestinal Resection in Patients with Ulcerative Colitis. World J Surg. 2018;42(7):1949–1959.
  • 12. Naber AH, de Jong DJ. Assessment of disease activity in inflammatory bowel disease; relevance for clinical trials. Neth J Med. 2003;61:105–10.
  • 13. Bohl JL, Sobba K. Indications and Options for Surgery in Ulcerative Colitis. Surg Clin North Am. 2015;95(6):1211–32.
  • 14. Conrad K, Roggenbuck D, Laass MW. Diagnosis and classification of ulcerative colitis. Autoimmun Rev. 2014;13(4–5):463–6.
  • 15. Ungaro R, Mehandru S, Allen PB, Peyrin-Biroulet L, Colombel JF. Ulcerative colitis. Lancet. 2017;389(10080):1756–1770.
  • 16. Yoon JY, Park SJ, Hong SP, Kim TI, Kim WH, Cheon JH. Cor relations of C-reactive protein levels and erythrocyte sedimentation rates with endoscopic activity indices in patients with ulcerative colitis. Dig Dis Sci. 2014;59(4):829–37.
  • 17. Zittan E, Kelly OB, Kirsch R, Milgrom R, Burns J, Nguyen GC, Croitoru K, Van Assche G, Silverberg MS, Steinhart AH. Low Fecal Calprotectin Correlates with Histological Remission and Mucosal Healing in Ulcerative Colitis and Colonic Crohn’s Disease. Inflamm Bowel Dis. 2016;22(3):623–30.
  • 18. Osada T, Ohkusa T, Okayasu I, Yoshida T, Hirai S, Beppu K, Shibuya T, Sakamoto N, Kobayashi O, Nagahara A, Terai T, Watanabe S. Correlations among total colonoscopic findings, clinical symptoms, and laboratory markers in ulcerative colitis. J Gastroenterol Hepatol. 2008;23 Suppl 2:262–7.
  • 19. Chang S, Malter L, Hudesman D. Disease monitoring in inflammatory bowel disease. World J Gastroenterol. 2015;21(40):11246–59.
  • 20. Demir AK, Demirtas A, Kaya SU, Tastan I, Butun I, Sagcan M, Sahin S, Tasliyurt T, Yilmaz A. The relationship between the neutrophil-lymphocyte ratio and disease activity in patients with ulcerative colitis. Kaohsiung J Med Sci. 2015;31(11):585–90.
  • 21. Hu B, Yang XR, Xu Y, et al. Systemic immune-inflammation index predicts prognosis of patients after curative resection for hepatocellular carcinoma. Clin Cancer Res. 2014;20:6212–22. Yang R, Chang Q, Meng X, Gao N, Wang W. Prognostic value of Systemic immune-inflammation index in cancer: A metaanalysis. J Cancer. 2018;9:3295–302.
  • 23. Ahn SS, Jung SM, Song JJ, Park YB, Lee SW. Prognostic nutritional index is correlated with disease activity in patients with systemic lupus erythematosus. Lupus. 2018;27:1697–7.
  • 24. Peters Jr T. Metabolism: Albumin in the body. In: All About Albumin: Biochemistry, Genetics and Medical Applications. Amsterdam: Elsevier; 1996. p. 188–250.
  • 25. Nicholson JP, Wolmarans MR, Park GR. The role of albumin in critical illness. Br J Anaesth. 2000;85:599–610.
  • 26. Moshage HJ, Janssen JA, Franssen JH, Hafkenscheid JC, Yap SH. Study of the molecular mechanism of decreased liver synthesis of albumin in inflammation. J Clin Invest. 1987;79:1635–41.
  • 27. Correa-Rodríguez M, Pocovi-Gerardino G, Callejas-Rubio JL, Fernández RR, Martín-Amada M, Cruz-Caparros MG, OrtegoCenteno N, Rueda-Medina B. The Prognostic Nutritional Index and Nutritional Risk Index Are Associated with Disease Activity in Patients with Systemic Lupus Erythematosus. Nutrients. 2019;11(3):638.
  • 28. Ataş N, Babaoğlu H, Demirel E, Çelik B, Bilici Salman R, Satış H, Karadeniz H, Güler AA, Haznedaroğlu S, Göker B, Tufan A, Öztürk MA. Use of prognostic nutritional index in the evaluation of disease activity in patients with Behçet’s disease. Eur J Rheumatol. 2020;7(3):99–104.
There are 26 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Research Article
Authors

İbrahim Ethem Güven This is me

Batuhan Başpınar This is me

Rasim Eren Cankurtaran This is me

Ertuğrul Kayaçetin This is me

Publication Date April 1, 2022
Published in Issue Year 2022 Volume: 12 Issue: 1

Cite

APA Güven, İ. E., Başpınar, B., Cankurtaran, R. E., Kayaçetin, E. (2022). The Role of Prognostic Nutritional Index and Systemic Immune-Inflammation Index in Determining Ulcerative Colitis Severity. Kafkas Journal of Medical Sciences, 12(1), 31-36.
AMA Güven İE, Başpınar B, Cankurtaran RE, Kayaçetin E. The Role of Prognostic Nutritional Index and Systemic Immune-Inflammation Index in Determining Ulcerative Colitis Severity. KAFKAS TIP BİL DERG. April 2022;12(1):31-36.
Chicago Güven, İbrahim Ethem, Batuhan Başpınar, Rasim Eren Cankurtaran, and Ertuğrul Kayaçetin. “The Role of Prognostic Nutritional Index and Systemic Immune-Inflammation Index in Determining Ulcerative Colitis Severity”. Kafkas Journal of Medical Sciences 12, no. 1 (April 2022): 31-36.
EndNote Güven İE, Başpınar B, Cankurtaran RE, Kayaçetin E (April 1, 2022) The Role of Prognostic Nutritional Index and Systemic Immune-Inflammation Index in Determining Ulcerative Colitis Severity. Kafkas Journal of Medical Sciences 12 1 31–36.
IEEE İ. E. Güven, B. Başpınar, R. E. Cankurtaran, and E. Kayaçetin, “The Role of Prognostic Nutritional Index and Systemic Immune-Inflammation Index in Determining Ulcerative Colitis Severity”, KAFKAS TIP BİL DERG, vol. 12, no. 1, pp. 31–36, 2022.
ISNAD Güven, İbrahim Ethem et al. “The Role of Prognostic Nutritional Index and Systemic Immune-Inflammation Index in Determining Ulcerative Colitis Severity”. Kafkas Journal of Medical Sciences 12/1 (April 2022), 31-36.
JAMA Güven İE, Başpınar B, Cankurtaran RE, Kayaçetin E. The Role of Prognostic Nutritional Index and Systemic Immune-Inflammation Index in Determining Ulcerative Colitis Severity. KAFKAS TIP BİL DERG. 2022;12:31–36.
MLA Güven, İbrahim Ethem et al. “The Role of Prognostic Nutritional Index and Systemic Immune-Inflammation Index in Determining Ulcerative Colitis Severity”. Kafkas Journal of Medical Sciences, vol. 12, no. 1, 2022, pp. 31-36.
Vancouver Güven İE, Başpınar B, Cankurtaran RE, Kayaçetin E. The Role of Prognostic Nutritional Index and Systemic Immune-Inflammation Index in Determining Ulcerative Colitis Severity. KAFKAS TIP BİL DERG. 2022;12(1):31-6.