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Acute Myeloid Leukemia (M4)/Myeloid Sarcoma Presenting with Hyperleukocytosis, 47,XX + mar Case

Year 2023, Volume: 13 Issue: 1, 87 - 90, 26.04.2023

Abstract

Hyperleukocytosis is defined as a blood blast count >100.000/ mm3 and may occur most commonly in monocytic (M4) acute myeloid leukemia (AML). Hyperleukocytosis is a medical emergency associated with lung and central nervous system leukostasis. An 18-month-old female patient was brought to our clinic with anemia, thrombocytopenia, and leukocytosis with bilateral palpebral swelling/proptosis, a palpable mass in the midline, and lymphadenopathy in the neck. Myeloid sarcoma was suspected. The patient had AML M4 morphological features, and 47,XX + mar was detected in bone marrow karyotype analysis. She had complications such as hyperleukocytosis, leukostasis (blurring of consciousness, tachypnea/tachycardia), tumor lysis syndrome, and disseminated intravascular coagulation. In addition to low-dose cytoreduction chemotherapy, leukocyte apheresis was performed. All symptoms and complaints of the patient disappeared. Therefore, myeloid sarcoma should be considered in young children with orbital swelling/ proptosis, an abdominal mass, high leukocyte count at diagnosis, AML M4 morphological features, and diffuse intravascular coagulation.

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There are 12 citations in total.

Details

Primary Language English
Subjects Clinical Sciences
Journal Section Case Report
Authors

Mustafa Özay This is me

Publication Date April 26, 2023
Published in Issue Year 2023 Volume: 13 Issue: 1

Cite

APA Özay, M. (2023). Acute Myeloid Leukemia (M4)/Myeloid Sarcoma Presenting with Hyperleukocytosis, 47,XX + mar Case. Kafkas Journal of Medical Sciences, 13(1), 87-90.
AMA Özay M. Acute Myeloid Leukemia (M4)/Myeloid Sarcoma Presenting with Hyperleukocytosis, 47,XX + mar Case. KAFKAS TIP BİL DERG. April 2023;13(1):87-90.
Chicago Özay, Mustafa. “Acute Myeloid Leukemia (M4)/Myeloid Sarcoma Presenting With Hyperleukocytosis, 47,XX + Mar Case”. Kafkas Journal of Medical Sciences 13, no. 1 (April 2023): 87-90.
EndNote Özay M (April 1, 2023) Acute Myeloid Leukemia (M4)/Myeloid Sarcoma Presenting with Hyperleukocytosis, 47,XX + mar Case. Kafkas Journal of Medical Sciences 13 1 87–90.
IEEE M. Özay, “Acute Myeloid Leukemia (M4)/Myeloid Sarcoma Presenting with Hyperleukocytosis, 47,XX + mar Case”, KAFKAS TIP BİL DERG, vol. 13, no. 1, pp. 87–90, 2023.
ISNAD Özay, Mustafa. “Acute Myeloid Leukemia (M4)/Myeloid Sarcoma Presenting With Hyperleukocytosis, 47,XX + Mar Case”. Kafkas Journal of Medical Sciences 13/1 (April 2023), 87-90.
JAMA Özay M. Acute Myeloid Leukemia (M4)/Myeloid Sarcoma Presenting with Hyperleukocytosis, 47,XX + mar Case. KAFKAS TIP BİL DERG. 2023;13:87–90.
MLA Özay, Mustafa. “Acute Myeloid Leukemia (M4)/Myeloid Sarcoma Presenting With Hyperleukocytosis, 47,XX + Mar Case”. Kafkas Journal of Medical Sciences, vol. 13, no. 1, 2023, pp. 87-90.
Vancouver Özay M. Acute Myeloid Leukemia (M4)/Myeloid Sarcoma Presenting with Hyperleukocytosis, 47,XX + mar Case. KAFKAS TIP BİL DERG. 2023;13(1):87-90.