The Hypothesis of a New Extrachromosomal Approach to Cancer Treatment

Year 2023, Volume: 13 Issue: 1, 91 - 99, 26.04.2023

Abdullah Doğan

Abstract

There are important unexplained points in cancer formation and its treatment with drugs. Some of the cancer drugs used in the treatment affect the genetic material of cancer cells. These types of drugs have a high toxicity. Despite important drugs used in cancer treatment have been developed today, there are serious problems in developing a drug with high specificity. This is because the pharmacological action points where drugs can affect cancerous cells and which are different from normal cells have not been fully determined. The current article reveals hypotheses about some extrachromosomal action points that may be beneficial in cancer treatment. Depending on the proposed hypothesis, information about the chemicals to be investigated is given.

Keywords

antineoplastic drugs, Warburg hypothesis, aromatic amino acid, aromatic alpha-keto acid; Coenzyme Q10

References

• 1. Doğan A. Veteriner Farmakoloji. Eser Basım Yayın Dağıtım Matbaacılık, Erzurum, 2017.
• 2. Doğan A. Veteriner Toksikoloji. Eser Basım Yayın Dağıtım Matbaacılık, Erzurum, 2016.
• 3. Hahn WC, Bader JS, Braun TP, Califano A, Clemons PA, Druker BJ, Ewald AJ, Fu H, Jagu S, Kemp CJ, Kim W, Kuo CJ, McManus M, Mills GB, Mo X, Sahni N, Schreiber SI, Talamas JA, Tamayo P, Tyner JW, Wagner BK, Weiss WA, Gerhard DS. An expanded universe of cancer targets. Cell. 2021;184(4):1142–1155.
• 4. Protoonkogen onkogen tümör supresör genler, Ankara. [cited 2021 Sept 20]; Available from: https://acikders.ankara.edu.tr
• 5. Antón JFR. Warburg Effect: Metabolism in cancer cells. [cited 2021 Apr 2]; Available from: https:// josefelixrodriguezantonweb.com/2016/09/10/warburg-effectmetabolism-in-cancer-cells/
• 6. Devic S. Warburg Effect-A consequence or the cause of carcinogenesis? J Cancer. 2016;7(7):817–822.
• 7. Mathews M, White S, Xue Y. The effects of coenzyme Q10 on women with breast cancer: Systematic review protocol. JBI Database Syst Rev Implement Rep. 2014;12(8):127–144.
• 8. Warburg effect (oncology). [cited 2021 Jun 12]; Available from: https://en.wikipedia.org
• 9. Fung J. The paradox of cancer’s Warburg Effect. [cited 2021 Apr 8]; Available from: https://medium.com/@drjasonfung/theparadox-of-cancers-warburg-effect- 7fb572364b81.
• 10. Kiriş HT. Warburg etkisi ve kanserde meydana gelen metabolik değişimler. [cited 2021 Apr 6]; Available from: https://evrimagaci. org/warburg-etkisi-ve-kanserde-meydana-gelen-metabolikdegisimler-7901Yayınlanma Tarihi 30/08/2019 12:48. 24.
• 11. Mathew G, Vander Heiden Lewis C and Craig BT. Understanding the Warbung effect: The metabolic requirements of cell proliferation. Sci. 2009;324(5930):1029–1033.
• 12. Warburg O. On the Orgine of Cancer Cells. Sci. 1956;123(3191):309–14.
• 13. Şahin Ş. Ubikinol mü? Ubikinon mu? [cited 2021 Jun 12]; Available from: http://eczacininsesi. com/?yon=haber&id=10429.
• 14. Altınışık M. Protein ve aminoasit metabolizması. [cited 2021 May 11]; Available from: https://www.mustafaaltinisik.org. uk/89-1-19.pdf 15. Aromatic aminoacide. [cited 2021 May 16]; Available from: https://en.wikipedia.org 16. Erdem Ş. Fenilalanin hidroksilaz geninde görülen yaygın mutasyonların taranması. Yüksek Lisans Tezi. Erciyes Üniversitesi Sağlık Bilimleri Enstitüsü Tıbbi Genetik Anabilim Dalı. Kayseri, 2013.
• 17. Fernandez-Lafuente R, Rodriguez V, Guisan JM. The coimmobilization of D-amino acid oxidase and catalase enables the quantitative transformation of D-amino acids (D-phenylalanine) into a-keto acids (phenylpyruvic acid). Enzyme Microb Technol. 1998;23(1):28–33.
• 18. Chandler JP, Lewıs HB. Comparatıve studıes of the metabolısm of the amino acıds. V. The oxıdatıon of phenylalanıne and phenylpyruvıc acıd in the organism of the rabbit. J Biol Chem. 1932;96(3):619–636.
• 19. Altınışık M. Esansiyel olmayan aminoasitlerin biyosentezi. [cited 2021 May 10]; Available from: https://www.mustafaaltinisik.org.uk
• 20. Aminoasit biyosentezi-Avesis. [cited 2021 May 16]; Available from: https://avesis.yildiz.edu.tr
• 21. Webert WW, Zannonı VG. Reduction of phenylpyruvic acids to phenyllactic acids in mammalian tissues. J Biol Chem. 1966;241(6):1345–1349.
• 22. Doğan A, Doğan ANC. Investigation of the effects of sodium phenylpyruvate on pulmonary adenocarcinoma (A549) and mammary adenocarcinoma (MDA-MB-231) on cell lines. Cauc J Sci. 2022;9(1):20–34.
• 23. Liu M, Brusilow WSA, Needleman R. Activity of the yeast Tat2p tryptophan permease is sensitive to the anti-tumor agent 4-phenylbutyrate. Curr Genet. 2004;46:256–268.
• 24. Ercan P, El SN. Koenzim Q10’un beslenme ve sağlık açısından önemi biyoyararlılığı. Tübav Bilim Derg. 2010;3(2):192–200.
• 25. Etkin bir antioksidan koenzim q10. [cited 2021 Jun 6]; Available from: https://www.centro.com.tr/wp-content/ uploads/2019/05/Centro-Koenzim-Q10-BilimselB%C3%BClten.pdf
• 26. Koenzim Q10. [cited 2021 Jun 6];Available from: https:// www.wikizero.com/tr/ koenzim_q10.
• 27. Fidancı U.R. Kolesterol biyosentezi. 20.04.2009 [cited 2021 Jun 10]; Available from: http://80.251.40.59/veterinary.ankara. edu.tr/fidanci/Ders_Notlari/LM Kolesterol_Biyosentezi.html
• 28. Durmuş M. Ko-enzim Q10 gerçeği ve statinler. [cited 2021 Jun 2]; Available from: https://www.iyibilgi.com/?haber, 90391.
• 29. Palan PR, Mikhail MS, Shaban DW, Romney SL. Plasma concentrations of coenzyme Q10 and tocopherols in cervical intraepithelial neoplasia and cervical cancer. Eur J Cancer Prev. 2003;12(4):321–326.
• 30. Paroha S, Chandel AKS, Dubey RD. Nanosystems for drug delivery of coenzyme Q10. Environ Chem Lett. 2018;16(2018):71–77.
• 31. Sachdanandam P. Antiangiogenic and hypolipidemic activity of coenzyme Q10 supplementation to breast cancer patients undergoing Tamoxifen therapy. BioFactors. 2008;32(2008):151–159.
• 32. Hodges S, Hertz N, Lockwood K and Lister R. CoQ10: could it have a role in cancer management? BioFactors. 1999;9(1999):365–370.
• 33. Roffe L, Schmidt K and Ernst E. Efficacy of Coenzyme Q10 for Improved Tolerability of Cancer Treatments: A systematic review. J Clin Oncol. 2004;22(21):4418–4424.
• 34. Eric Yarnell E and Abascal K. Holistic approaches to prostate cancer. Altern Complemen Ther. 2008;14(4):164–180.
• 35. Quilesa JL. Farquharson AJ, Ramırez-Tortosaa MC, Grant I, Milne L, Huertasa JR, Battinoc M, Mataixa J and Wahleb KWJ. Coenzyme Q differentially modulates phospholipid hydroperoxide glutathione peroxidase gene expression and free radicals production in malignant and non-malignant prostate cells. BioFactors. 2003;18(2003):265–270.
• 36. Bahar M, Khaghani S, Pasalar P, Paknejad M, Khorramizadeh MR, Mirmiranpour H, Nejad SG. Exogenous coenzyme Q10 modulates MMP-2 activity in MCF-7 cell line as a breast cancer cellular model. Nutrition Journal. 2010;9(62):1–9. [cited 2021 Jun 10]; Available from: http://www.nutritionj.com/content/9/1/62.
• 37. Yen H-C, Li S-H, Majıma HJ, Huang Y-H, Chen C-P, Liu, C-C, Tu Y-C, Chen C-W. Up-regulation of antioxidant enzymes and coenzyme Q 10 in a human oral cancer cell line with acquired bleomycin resistance. Free Radic Res 2011;45(6):707–716.