Examining Prediabetes Risks in COVID-19 Cases: What Insights Does the COVID Follow-up Clinic Provide?

Year 2025, Volume: 15 Issue: EK-1, 78 - 83, 20.10.2025

Burak Altındağ

Abstract

Aim: Given the potential metabolic impacts of COVID-19, understanding the relationship between post-COVID-19 health and prediabetes can provide insights into the long-term consequences of the disease. This study aims to evaluate the risk factors associated with the development of prediabetes in patients following COVID-19 infection.
Materials and Methods: This descriptive case series study included five patients diagnosed with new-onset prediabetes after COVID-19, who visited the COVID-19 Follow-up Clinic. Demographic data, medical history, and laboratory findings were collected retrospectively from the Health Management System. Risk factors such as physical activity levels, smoking, body mass index, and the use of corticosteroids were assessed concerning prediabetes development.
Results: Prediabetes was diagnosed in 4.2% of patients after COVID-19 disease. The findings revealed that 80% of the patients were male, with an average age of over 65 years. Several risk factors, including age, gender, low physical activity levels, and corticosteroid use during COVID-19 treatment, were associated with an increased likelihood of prediabetes. One patient was found to have high clinical frailty, which may further predispose them to metabolic imbalances.
Conclusion: COVID-19 may contribute not only to acute health issues but also to long-term metabolic risks such as prediabetes. Post-COVID-19 patients with prediabetes require close monitoring and lifestyle interventions to mitigate the risk of progression to diabetes mellitus. This study underscores the importance of assessing metabolic health in COVID-19 survivors and calls for further research with larger sample sizes to deepen our understanding of COVID-19’s long-term effects on metabolic health.

Keywords

prediabetic state , COVID-19 , preventive health services , assessment of healthcare needs

References

• 1. Chan JFW, Yuan S, Kok KH, To KKW, Chu H, Yang J, et al. A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster. Lancet. 2020;395(10223):514–23.
• 2. Li Q, Guan X, Wu P, Wang X, Zhou L, Tong Y, et al. Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia. N Engl J Med. 2020;382(13):1199–207.
• 3. Coronavirus disease 2019(COVID-19)Situation Report - 52. [Internet]. WHO [cited 2025 Mar 16]. Available from: https:// www.who.int/publications/m/item/situation-report---52
• 4. Rovere-Querini P, De Lorenzo R, Conte C, Brioni E, Lanzani C, Yacoub MR, et al. Post-COVID-19 follow-up clinic: Depicting chronicity of a new disease. Acta Biomed. 2020;91:22–8.
• 5. Akpek M. Does COVID-19 Cause Hypertension? Angiology. 2022;73(7):682–7.
• 6. Bornstein SR, Rubino F, Khunti K, Mingrone G, Hopkins D, Birkenfeld AL, et al. Practical recommendations for the management of diabetes in patients with COVID-19. Lancet Diabetes Endocrinol. 2020;8(6):546–50.
• 7. Gentile S, Strollo F, Mambro A, Ceriello A. COVID-19, ketoacidosis and new-onset diabetes: Are there possible cause and effect relationships among them? Diabetes, Obesity and Metabolism. 2020;22:2507–8.
• 8. Smith SM, Boppana A, Traupman JA, Unson E, Maddock DA, Chao K, et al. Impaired glucose metabolism in patients with diabetes, prediabetes, and obesity is associated with severe COVID-19. J Med Virol. 2021;93(1):409–15.
• 9. Tabák AG, Herder C, Rathmann W, Brunner EJ, Kivimäki M. Prediabetes: a high-risk state for diabetes development. Lancet. 2012;379(9833):2279–90.
• 10. Siddiqui S, Zainal H, Harun SN, Sheikh Ghadzi SM, Ghafoor S. Gender differences in the modifiable risk factors associated with the presence of prediabetes: A systematic review. Diabetes and Metabolic Syndrome: Clinical Research and Reviews. 2020;14:1243–52.
• 11. American Thoracic Society. ATS Statement: Guidelines for the Six-Minute Walk Test. Am J Respir Crit Care Med. 2002;166:111–7.
• 12. Marinos Elia P. The “MUST” Report Nutritional screening of adults: a multidisciplinary responsibility. 2003.
• 13. Kaiser MJ, Bauer J., Ramsch C, Uter W, Guigoz Y, Cederholm T, et al. Validation of the Mini Nutritional Assessment short-form (MNA®-SF): A practical tool for identification of nutritional status. J Nutr Heal aging. 2009;13(9):782–8.
• 14. Güngen C, Ertan T, Eker E, Yaşar R, Engin F. Reliability and validity of the standardized Mini Mental State Examination in the diagnosis of mild dementia in Turkish population. Turkish J Psychiatry. 2002;13(4):273–81.
• 15. Rabin R, De Charro F. EQ-5D. A measure of health status from the EuroQol Group. Ann Med. 2001;33(5):337–43.
• 16. Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 1982;5(6):649–55.
• 17. Rockwood K, Theou O. Using the clinical frailty scale in allocating scarce health care resources. Can Geriatr J. 2020;23(3):254–9.
• 18. Ismail L, Materwala H, Al Kaabi J. Association of risk factors with type 2 diabetes: A systematic review. Computational and Structural Biotechnology Journal. 2021;19:1759–85.
• 19. Ekici E. Care Management of Elderly People During Covid 19 Pandemic. Halic Uni J Health Sci. 2020:3.
• 20. Upadhyay J, Trivedi N, Lal A. Risk of Future Type 2 Diabetes Mellitus in Patients Developing Steroid-Induced Hyperglycemia During Hospitalization for Chronic Obstructive Pulmonary Disease Exacerbation. Lung. 2020;198(3):525–33.
• 21. Ormiston CK, Świątkiewicz I, Taub PR. Postural orthostatic tachycardia syndrome as a sequela of COVID-19. Hear Rhythm. 2022;19(11):1880–9.
• 22. Anker MS, Landmesser U, von Haehling S, Butler J, Coats AJS, Anker SD. Weight loss, malnutrition, and cachexia in COVID-19: facts and numbers. Journal of Cachexia, Sarcopenia and Muscle. 2021;12:9–13.
• 23. Kizilirmak D, Fidan U, Sari S, Havlucu Y. Functional parameters and affecting factors in post-COVID period. Tuberk Toraks. 2023;71(2):123–30.
• 24. Clegg A, Hassan-Smith Z. Frailty and the endocrine system. T he Lancet Diabetes and Endocrinology. 2018;6:743–52