Research Article
BibTex RIS Cite

ELF-EMF'in Beyin, Karaciğer ve Kalp Dokularında Oksidatif Parametreler Üzerine Etkilerinin Değerlendirilmesi

Year 2019, Volume: 9 Issue: 2, 264 - 274, 15.12.2019
https://doi.org/10.31466/kfbd.594986

Abstract

Bu çalışmanın
amacı, sürekli ve kesikli aşırı düşük frekanslı manyetik alanların (ELF-EMF)
beyin, karaciğer ve kalp dokularında; malondialdehit (MDA), nitrik oksit (NO)
ve glutatyon (GSH) seviyeleri üzerindeki muhtemel etkilerini araştırmaktır. 18
gine domuzu üzerinde yapılan deneyler için hayvanlar üç gruba ayrılmıştır (her
grup için n = 6). Deney grupları sürekli (4 saat / gün) veya kesikli olarak (2
saat açık / 2 saat kapalı / 2 saat açık) 7 gün boyunca 1.5 Hz frekansında ve 50
mT şiddetinde EMF’ye maruz bırakılmıştır. Dokulardaki MDA, NO ve GSH düzeyleri
spektrofotometrik yöntemlerle belirlenmiştir. Kesikli maruziyet; kontrol ve
sürekli maruziyet gruplarına kıyasla beyinde GSH seviyelerini arttırırken, MDA seviyelerini
düşürmüştür. Her iki maruziyet grubunun GSH konsantrasyonlarının karaciğerde
yükseldiği bulunmuştur. Karaciğerde ve kalpte, her iki uygulama grubunda da
sürekli maruz kalma ile NO seviyeleri artmış, ancak kesikli maruziyet her iki
deney grubunda da NO düzeylerini azaltmıştır. Bu çalışmanın sonuçları, çeşitli
dokuların manyetik alan maruziyetlerine tepkilerinin, manyetik alanların
yoğunluğuna ve maruz kalma süresine göre değiştiğini göstermiştir.

References

  • Sirmatel O, Sert C, Tümer C, et al. (2007) Change of nitric oxide concentration in men exposed to a 1.5 T constant magnetic field. Bioelectromagnetics 28(2):152-154.
  • Urtasun R, Conde de la Rosa L, Nieto N. (2008) Oxidative and nitrosative stress and fibrogenic response. Clinical Liver Disease 12(4):769-790.
  • Yin C, Luo X, Duan Y, et al. (2016) Neuroprotective effects of lotus seedpod procyanidins on extremely low frequency electromagnetic field-induced neurotoxicity in primary cultured hippocampal neurons. Biomedicine & Pharmacotherapy 82:628-639.
  • Luo X, Chen M, Duan Y, et al. (2016) Chemoprotective action of lotus seedpod procyanidins on oxidative stress in mice induced by extremely low-frequency electromagnetic field exposure. Biomedicine & Pharmacotherapy 82:640-648. Martínez-Sámano J, Torres-Durán PV, Juárez-Oropeza MA, et al. (2010) Effects of acute electromagnetic field exposure and movement restraint on antioxidant system in liver, heart, kidney and plasma of Wistar rats: a preliminary report. International Journal of Radiation Biology 86(12):1088-1094.

Evaluation of The Effects of ELF-EMF on Oxidative Parameters in Brain, Liver and Heart Tissues

Year 2019, Volume: 9 Issue: 2, 264 - 274, 15.12.2019
https://doi.org/10.31466/kfbd.594986

Abstract

The aim of the present study was to investigate the prospective effects of continuous and intermittent extremely low-frequency magnetic fields (ELF-EMFs) on the levels of malondialdehyde (MDA), nitric oxide (NO) and glutathione (GSH) in brain, heart, and liver tissues. The experiments performed on 18 guinea pigs were divided into three groups (n= 6 for each group). 50 Hz of 1.5 mT a magnetic field was used for exposure. Experimental groups were exposed for 4 h/day either continuously or intermittently (2h on/ 2h off/ 2h on) EMF for a period of 7 days. MDA, NO and GSH levels were determined by spectrophotometric methods. The intermittent exposure was increased GSH levels whereas that was reduced MDA levels in the brain when compared to control and continuous exposure groups. GSH concentrations of both experimental groups were found to be elevated in the liver. In the liver and heart, NO levels were increased by the continuous exposure in both administration groups, however, intermittent exposure has reduced NO levels in the both of the experimental groups.  Results of this study indicated that the responses of various tissues to magnetic field exposures differed according to intensity and exposure duration of magnetic fields.

References

  • Sirmatel O, Sert C, Tümer C, et al. (2007) Change of nitric oxide concentration in men exposed to a 1.5 T constant magnetic field. Bioelectromagnetics 28(2):152-154.
  • Urtasun R, Conde de la Rosa L, Nieto N. (2008) Oxidative and nitrosative stress and fibrogenic response. Clinical Liver Disease 12(4):769-790.
  • Yin C, Luo X, Duan Y, et al. (2016) Neuroprotective effects of lotus seedpod procyanidins on extremely low frequency electromagnetic field-induced neurotoxicity in primary cultured hippocampal neurons. Biomedicine & Pharmacotherapy 82:628-639.
  • Luo X, Chen M, Duan Y, et al. (2016) Chemoprotective action of lotus seedpod procyanidins on oxidative stress in mice induced by extremely low-frequency electromagnetic field exposure. Biomedicine & Pharmacotherapy 82:640-648. Martínez-Sámano J, Torres-Durán PV, Juárez-Oropeza MA, et al. (2010) Effects of acute electromagnetic field exposure and movement restraint on antioxidant system in liver, heart, kidney and plasma of Wistar rats: a preliminary report. International Journal of Radiation Biology 86(12):1088-1094.
There are 4 citations in total.

Details

Primary Language English
Journal Section Articles
Authors

Emine Gülçeri Güleç Peker 0000-0001-7244-0281

K. Barbaros Balabanlı

Arın Tomruk This is me

A. Gülnihal Canseven Kurşun This is me

Şule Coşkun Cevher

Publication Date December 15, 2019
Published in Issue Year 2019 Volume: 9 Issue: 2

Cite

APA Güleç Peker, E. G., Balabanlı, K. B., Tomruk, A., Canseven Kurşun, A. G., et al. (2019). Evaluation of The Effects of ELF-EMF on Oxidative Parameters in Brain, Liver and Heart Tissues. Karadeniz Fen Bilimleri Dergisi, 9(2), 264-274. https://doi.org/10.31466/kfbd.594986