Trietanolamin Esaslı Tuzların In Vitro Antiproliferatif, Antibakteriyel ve Anti-Anjiyojenik Çalışmaları

Year 2024, Volume: 14 Issue: 3, 1192 - 1203, 15.09.2024

Hüseyin Akbaş , Seçil Erden Tayhan , Sema Bilgin

https://doi.org/10.31466/kfbd.1446890

Abstract

Siklopropankarboksilat, merkaptoasetat, trikloroasetat ve 4-dodesilbenzensülfonat anyonları ile trietanolamonyum (TEA) katyonu TEA esaslı tuzların oluşumuna yol açtı. TEA tuzlarının antibakteriyel aktivitesi bazı bakterilere karşı incelendi ve elde edilen sonuçlar minimum inhibitör konsantrasyon (MİK) değerlerinin hesaplanmasında kullanıldı. Ek olarak, TEA tuzlarının antiproliferatif aktiviteleri meme kanseri hücre hattı üzerinde in vitro olarak incelendi. Ayrıca, bu tuzların anti-anjiyogenik etkisini değerlendirmek için HUVEC'ler (insan vasküler endotelyal hücre hattı) tarafından in vitro çizik analizi yapılmıştır. Bu bileşikler, kanser hücrelerinin hücre canlılığını kayda değer düzeyde değiştirmdi. Öte yandan TEA tuzlarının insan endotel hücre göçünü bir miktar engellediği gösterildi. Dolayısıyla, bu bileşiklerin anjiyogenezi engelleme konusunda sınırlı yeteneğe sahip olduğu belirlendi.

Keywords

Anti-anjiyojenik etki, Antiproliferatif etki, Antibakteriyel etki, Trietanolamonyum tuzları

In Vitro Antiproliferative, Antibacterial, and Anti-Angiogenic Studies of Triethanolamine-Based Salts

Abstract

The triethanolammonium (TEA) cation associated with the anion cyclopropanecarboxylate, mercaptoacetate, trichloroacetate, and 4-dodecylbenzenesulfonate led to the formation of TEA-based salts. The antibacterial activity of the TEA salts was examined against some bacteria and the obtained results were used to calculate minimal inhibitory concentrations (MICs) values. Additionally, the antiproliferative activities of TEA salts were examined in vitro on breast cancer cell line. Furthermore, in vitro scratch assay was performed by HUVECs (human vascular endothelial cell line) to assess the anti-angiogenic effect of these salts. These compounds did not dramatically differentiate the cell viability of cancer cells. On the other hand, it was demonstrated that TEA salts blocked human endothelial cell migration slightly. Therefore, these compounds were determined to have a limited ability to inhibit angiogenesis.

Keywords

Anti-angiogenic effect, Antiproliferative effect, Antibacterial effect, Triethanolammonium salts

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