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Bilişsel rehabilitasyonun Alzheimer hastalığı ve hafif bilişsel bozukluk üzerindeki etkisine yönelik gözden geçirme

Year 2025, Volume: 9 Issue: 1, 106 - 115, 25.04.2025
https://doi.org/10.57127/kpd.26024438.1262396

Abstract

Günümüzde Alzheimer hastalığı (AH) ve hafif bilişsel bozukluk (HBB) dünya üzerinde sayısız bireyi etkileyerek en yaygın nörodejeneratif hastalıklar arasında yerini almaktadır. Alzheimer hastalığı bellek işlevlerinden dil işlevlerine kadar geniş bir yelpazede bilişsel işlevleri etkilemektedir ve hastalığın ilerlemesi ile bireyler üçüncü şahısların yardımına ihtiyaç duyabilmektedir. Hafif bilişsel bozulma, bireylerin bilişsel işlevlerinde gözlemlenen bozulmanın en erken evresi olarak tanımlanabilir. HBB’de birden fazla bilişsel alanda bozulmalar gözlemlenebilirken bireylerin günlük yaşamlarında bir miktar işlevsellik gösterebildikleri görülmektedir. Ayrıca Alzheimer hastalığı ve HBB beynin bazı bölgelerinde (parietal lob, frontal lob, temporal lob) dejenerasyona neden olur ve hastalık ilerledikçe, bazı beyin bölgelerinde büzülmeler meydana gelebilir. Bu nedenle, Alzheimer hastalığı ve HBB tanısı almış bireylerin günlük aktivitelerini geliştirmek adına bir dizi müdahale tekniği ortaya çıkmıştır. Bilişsel rehabilitasyon, günlük yaşam aktivitelerini iyileştirmeye odaklanan bireyselleştirilmiş bir süreçtir. Ayrıca bilişsel rehabilitasyonun etkinliği, Alzheimer hastalığı ve HBB’nin etkilediği bilişsel alanlarda çeşitli araştırmacılar tarafından ortaya konmuştur. Farklı araştırmacılar, farklı bilişsel rehabilitasyon programlarının bireylerin hayatlarının bilişsel, sosyal ve psikolojik alanlarını etkili bir şekilde geliştirdiğini ortaya koymuştur. Bu nedenle bu alanyazın taraması, 2015 yılından sonra Alzheimer hastası olan ve HBB'li bireylere uygulanan bilişsel rehabilitasyon programlarının etkinliğini incelemeyi ve incelenen bulguları derlemeyi amaçlamaktadır.

Ethical Statement

DECLARATIONS Ethics Committee Approval N/A Conflict of Interest All authors of this article declare that there is no conflict of interest related to the article. Informed Consent N/A Project/Funding Information This study was not conducted as part of any project, and no funding or grants were used. Data Sharing/Availability N/A Authors’ Contributions PUC and CA contributed to the conceptualization and design of the study. PUC and CA performed literature review and writing of the article. PUC suggested corrections for and supervised the article. All authors reviewed and approved the final version of the article.

References

  • American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). American Psychiatric Press.
  • Amieva, H., Robert, P. H., Grandoulier, A. S., Meillon, C., De Rotrou, J., Andrieu, S., Berr, C., Desgranges, B., Dubois, B., Girtanner, C., Joël, M. E., Lavallart, B., Nourhashemi, F., Pasquier, F., Rainfray, M., Touchon, J., Chêne, G., & Dartigues, J. F. (2016). Group and individual cognitive therapies in Alzheimer's disease: The ETNA3 randomized trial. International Psychogeriatrics, 28(5), 707–717.
  • Anderson, J., Arens, K., Johnson, R., & Coppens, P. (2001). Spaced retrieval vs. memory tape therapy in memory rehabilitation for dementia of the Alzheimer's type. Clinical Gerontologist: The Journal of Aging and Mental Health, 24(1-2), 123–140.
  • Atri, A. (2019). Current and future treatments in Alzheimer’s disease. Seminars in Neurology, 39(2), 227–240.
  • Bäckman, L. (1996). Utilizing compensatory task conditions for episodic memory in Alzheimer’s disease. Acta Neurologica Scandinavica, Supplementum, 165, 109–113.
  • Bäckman, L., Jones, S., Berger, A. K., Laukka, E. J., & Small, B. J. (2004). Multiple cognitive deficits during the transition to Alzheimer’s disease. Journal of Internal Medicine, 256(3), 195–204.
  • Barekatain, M., Alavirad, M., Tavakoli, M., Emsaki, G., & Maracy, M. R. (2016). Cognitive rehabilitation in patients with nonamnestic mild cognitive impairment. Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences, 21, 101.
  • Bekris, L. M., Yu, C. E., Bird, T. D., & Tsuang, D. W. (2010). Genetics of Alzheimer disease. Journal of Geriatric Psychiatry and Neurology, 23(4), 213–227.
  • Bleathman, C. (1988). Validation therapy with the demented elderly. Journal of Advanced Nursing, 13(4), 511–514.
  • Breijyeh, Z., & Karaman, R. (2020). Comprehensive review on Alzheimer’s disease: Causes and treatment. Molecules, 25(24), 5789.
  • Burns, A., & Iliffe, S. (2009). Alzheimer’s disease. BMJ, 338(feb05 1), b158–b158.
  • Büyükturan Ö. (2014). Alzheimer demans hastalarında egzersiz eğitiminin fonksiyonellik üzerine etkilerinin incelenmesi (Unpublished doctoral dissertation). Hacettepe University, Ankara.
  • Cappon, D., Jahanshahi, M., & Bisiacchi, P. (2016). Value and efficacy of transcranial direct current stimulation in the cognitive rehabilitation: A critical review since 2000. Frontiers in Neuroscience, 10, 157.
  • Cicerone, K. D., Dahlberg, C., Malec, J. F., Langenbahn, D. M., Felicetti, T., Kneipp, S., Ellmo, W., Kalmar, K., Giacino, J. T., Harley, J. P., Laatsch, L., Morse, P. A., & Catanese, J. (2005). Evidence-based cognitive rehabilitation: Updated review of the literature from 1998 through 2002. Archives of Physical Medicine and Rehabilitation, 86(8), 1681–1692.
  • Cicerone, K. D., Goldin, Y., Ganci, K., Rosenbaum, A., Wethe, J. V., Langenbahn, D. M., Malec, J. F., Bergquist, T. F., Kingsley, K., Nagele, D., Trexler, L., Fraas, M., Bogdanova, Y., & Harley, J. P. (2019). Evidence-based cognitive rehabilitation: Systematic review of the literature from 2009 through 2014. Archives of Physical Medicine and Rehabilitation, 100(8), 1515–1533.
  • Clare, L., Wilson, B. A., Carter, G., Breen, K., Gosses, A., & Hodges, J. R. (2000). Intervening with everyday memory problems in dementia of Alzheimer type: An errorless learning approach. Journal of Clinical and Experimental Neuropsychology, 22(1), 132–146.
  • Cotelli, M., Manenti, R., Brambilla, M., Gobbi, E., Ferrari, C., Binetti, G., & Cappa, S. F. (2019). Cognitive telerehabilitation in mild cognitive impairment, Alzheimer’s disease and frontotemporal dementia: A systematic review. Journal of Telemedicine and Telecare, 25(2), 67–79.
  • Davis, R. N., Massman, P. J., & Doody, R. S. (2001). Cognitive intervention in Alzheimer disease: A randomized placebo-controlled study. Alzheimer Disease and Associated Disorders, 15(1), 1–9.
  • Desikan, R. S., Cabral, H. J., Hess, C. P., Dillon, W. P., Glastonbury, C. M., Weiner, M. W., Schmansky, N. J., Greve, D. N., Salat, D. H., Buckner, R. L., Fischl, B., & Alzheimer's Disease Neuroimaging Initiative. (2009). Automated MRI measures identify individuals with mild cognitive impairment and Alzheimer’s disease. Brain: A Journal of Neurology, 132(8), 2048–2057.
  • Douglas, S., James, I., & Ballard, C. (2004). Non-pharmacological interventions in dementia. Advances in Psychiatric Treatment, 10(3), 171–177.
  • Farina, E., Fioravanti, R., Chiavari, L., Imbornone, E., Alberoni, M., Pomati, S., Pinardi, G., Pignatti, R., & Mariani, C. (2002). Comparing two programs of cognitive training in Alzheimer’s disease: A pilot study. Acta Neurologica Scandinavica, 105(5), 365–371.
  • Feil, N. (1992). Validation therapy with late-onset dementia populations. In G. M. M. Jones & B. M. L. Miesen (Eds.), Care-giving in dementia: Research and applications (pp. 199–218). Routledge.
  • Forbes, D., Forbes, S. C., Blake, C. M., Thiessen, E. J., & Forbes, S. (2015). Exercise programs for people with dementia. The Cochrane Database of Systematic Reviews, 2015(4), CD006489.
  • Fratiglioni, L., De Ronchi, D., & Agüero-Torres, H. (1999). Worldwide prevalence and incidence of dementia. Drugs & Aging, 15(5), 365–375.
  • Ge, S., Zhu, Z., Wu, B., & McConnell, E. S. (2018). Technology-based cognitive training and rehabilitation interventions for individuals with mild cognitive impairment: A systematic review. BMC Geriatrics, 18(1), 213.
  • Germain, S., Wojtasik, V., Lekeu, F., Quittre, A., Olivier, C., Godichard, V., & Salmon, E. (2018). Efficacy of cognitive rehabilitation in Alzheimer disease: A 1-year follow-up study. Journal of Geriatric Psychiatry and Neurology, 32(1), 16–23.
  • Hill, N. T., Mowszowski, L., Naismith, S. L., Chadwick, V. L., Valenzuela, M., & Lampit, A. (2017). Computerized cognitive training in older adults with mild cognitive impairment or dementia: A systematic review and meta-analysis. The American Journal of Psychiatry, 174(4), 329–340.
  • Hsu, D., & Marshall, G. A. (2017). Primary and secondary prevention trials in Alzheimer disease: Looking back, moving forward. Current Alzheimer Research, 14(4), 426–440.
  • Hu, M., Wu, X., Shu, X., Hu, H., Chen, Q., Peng, L., & Feng, H. (2021). Effects of computerised cognitive training on cognitive impairment: A meta-analysis. Journal of Neurology, 268(5), 1680–1688.
  • Hwang, J. H., Cha, H. G., Cho, Y. S., Kim, T. S., & Cho, H. S. (2015). The effects of computer-assisted cognitive rehabilitation on Alzheimer’s dementia patients memories. Journal of Physical Therapy Science, 27(9), 2921–2923.
  • Irazoki, E., Contreras-Somoza, L. M., Toribio-Guzmán, J. M., Jenaro-Río, C., van der Roest, H., & Franco-Martín, M. A. (2020). Technologies for cognitive training and cognitive rehabilitation for people with mild cognitive impairment and dementia. A systematic review. Frontiers in Psychology, 11, 648.
  • Jiang, T., Yu, J. T., Tian, Y., & Tan, L. (2013). Epidemiology and etiology of Alzheimer's disease: From genetic to non-genetic factors. Current Alzheimer Research, 10(8), 852–867.
  • Kasper, E, Ochmann, S., Hoffmann, W., Scneider, W., Cavedo, E., Hampel, H., & Teipel, S. (2015). Cognitive rehabilitation in Alzheimer's disease- A conceptual and methodological review. The Journal of Prevention of Alzheimer's Disease, 2(2),142–152.
  • Keleş, E., & Özalevli, S. (2018). Alzheimer hastalığı ve tedavi yaklaşımları. İzmir Kâtip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi, 3(2), 39–42.
  • Kim, S. (2015). Cognitive rehabilitation for elderly people with early-stage Alzheimer’s disease. Journal of Physical Therapy Science, 27(2), 543–546.
  • Knopman, D. S., Amieva, H., Petersen, R. C. Chételat, G., Holtzman, D. M., Hyman, B. T., Nixon, R. A., & Jones, D. T. (2021). Alzheimer disease. Nature Reviews Disease Primers, 7(1), 33.
  • Knopman, D. S., & Petersen, R. C. (2014). Mild cognitive impairment and mild dementia: A clinical perspective. Mayo Clinic Proceedings, 89(10), 1452–1459.
  • Kurth, S., Wojtasik, V., Lekeu, F., Quittre, A., Olivier, C., Godichard, V., Bastin, C., & Salmon, E. (2021). Efficacy of cognitive rehabilitation versus usual treatment at home in patients with early stages of Alzheimer disease. Journal of Geriatric Psychiatry and Neurology, 34(3), 209–215.
  • Li, H., Li, J., Li, N., Li, B., Wang, P., & Zhou, T. (2011). Cognitive intervention for persons with mild cognitive impairment: A meta-analysis. Ageing Research Reviews, 10(2), 285–296.
  • Lök, N., & Buldukoğlu, K. (2014). Psychosocial practices that enhance cognitive activity in dementia. Current Approaches in Psychiatry, 6(3), 210–216.
  • Neal, M., & Barton Wright, P. (2003). Validation therapy for dementia. The Cochrane Database of Systematic Reviews, (3), CD001394.
  • O’Sullivan, M., Coen, R., O’Hora, D., & Shiel, A. (2015). Cognitive rehabilitation for mild cognitive impairment: Developing and piloting an intervention. Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology, and Cognition, 22(3), 280–300.
  • Pardo-Moreno, T., González-Acedo, A., Rivas-Domínguez, A., García-Morales, V., García-Cozar, F. J., Ramos-Rodríguez, J. J., & Melguizo-Rodríguez, L. (2022). Therapeutic approach to Alzheimer’s disease: Current treatments and new perspectives. Pharmaceutics, 14(6), 1117.
  • Petersen, R. C. (2016). Mild cognitive impairment. CONTINUUM: Lifelong Learning in Neurology, 22(2), 404–418.
  • Regan, B., Wells, Y., Farrow, M., O’Halloran, P., & Workman, B. (2017). MAXCOG—Maximizing cognition: A randomized controlled trial of the efficacy of goal-oriented cognitive rehabilitation for people with mild cognitive impairment and early Alzheimer disease. The American Journal of Geriatric Psychiatry, 25(3), 258–269.
  • Santos, G. D., Nunes, P. V., Stella, F., Brum, P. S., Yassuda, M. S., Ueno, L. M., Gattaz, W. F., & Forlenza, O. V. (2015). Multidisciplinary rehabilitation program: Effects of a multimodal intervention for patients with Alzheimer’s disease and cognitive impairment without dementia. Archives of Clinical Psychiatry (São Paulo), 42(6), 153–156.
  • Scanland, S. G., & Emershaw, L. E. (1993). Reality orientation and validation therapy: Dementia, depression, and functional status. Journal of Gerontological Nursing, 19(6), 7–11.
  • Sherman, E. (1993). Mental health and successful adaptation in later life. Generations: Journal of the American Society on Aging, 17(1), 43–46.
  • Viña, J., & Sanz-Ros, J. (2018). Alzheimer’s disease: Only prevention makes sense. European Journal of Clinical Investigation, 48(10), e13005.
  • Vitiello, M. V., & Borson, S. (2001). Sleep disturbances in patients with Alzheimer's disease: Epidemiology, pathophysiology and treatment. CNS Drugs, 15(10), 777–796.
  • Wenk, G. L. (2003). Neuropathologic changes in Alzheimer's disease. The Journal of Clinical Psychiatry, 64(Suppl 9), 7–10.
  • Wilson, B. A. (2002). Towards a comprehensive model of cognitive rehabilitation. Neuropsychological Rehabilitation, 12(2), 97–110.
  • Woods, D. L., Craven, R. F., & Whitney, J. (2005). The effect of therapeutic touch on behavioral symptoms of person with dementia. Alternative Therapies in Health and Medicine, 11(1), 66–74.
  • Zhang, H., Huntley, J., Bhome, R., Holmes, B., Cahill, J., Gould, R. L., Wang, H., Yu, X., & Howard, R. (2019). Effect of computerised cognitive training on cognitive outcomes in mild cognitive impairment: A systematic review and meta-analysis. BMJ Open, 9(8), e027062.

Review of literature on effectiveness of cognitive rehabilitation on Alzheimer’s disease and mild cognitive impairment

Year 2025, Volume: 9 Issue: 1, 106 - 115, 25.04.2025
https://doi.org/10.57127/kpd.26024438.1262396

Abstract

Alzheimer's disease (AD) and mild cognitive impairment (MCI) have taken their place among the most common neurodegenerative diseases by affecting countless people around the world. Mild cognitive impairment can be defined as the earliest stage of deterioration in cognitive functions. While impairment in more than one cognitive domain can be seen in MCI, it is seen that individuals can show some level of functionality in daily life. Also, Alzheimer's and MCI cause degeneration in some parts of the brain (parietal lobe, frontal lobe, temporal lobe), and disease progresses, and shrinkage may occur in some brain regions. Thus, a series of intervention techniques have been introduced to improve the daily living activities of individuals diagnosed with Alzheimer's and MCI. Cognitive rehabilitation is an individualized process that focuses on improving daily living activities. Furthermore, the effectiveness of cognitive rehabilitation on Alzheimer's disease and MCI in numerous cognitive domains is proven by different researchers. Different researchers prove that different cognitive rehabilitation programs effectively improve the cognitive, social, and psychological domains of individuals' lives. Therefore, this literature review aims to examine the effectiveness of cognitive rehabilitation programs applied after 2015 to individuals with Alzheimer's and MCI and to compile the examined findings.

Ethical Statement

DECLARATIONS Ethics Committee Approval N/A Conflict of Interest All authors of this article declare that there is no conflict of interest related to the article. Informed Consent N/A Project/Funding Information This study was not conducted as part of any project, and no funding or grants were used. Data Sharing/Availability N/A Authors’ Contributions PUC and CA contributed to the conceptualization and design of the study. PUC and CA performed literature review and writing of the article. PUC suggested corrections for and supervised the article. All authors reviewed and approved the final version of the article.

References

  • American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). American Psychiatric Press.
  • Amieva, H., Robert, P. H., Grandoulier, A. S., Meillon, C., De Rotrou, J., Andrieu, S., Berr, C., Desgranges, B., Dubois, B., Girtanner, C., Joël, M. E., Lavallart, B., Nourhashemi, F., Pasquier, F., Rainfray, M., Touchon, J., Chêne, G., & Dartigues, J. F. (2016). Group and individual cognitive therapies in Alzheimer's disease: The ETNA3 randomized trial. International Psychogeriatrics, 28(5), 707–717.
  • Anderson, J., Arens, K., Johnson, R., & Coppens, P. (2001). Spaced retrieval vs. memory tape therapy in memory rehabilitation for dementia of the Alzheimer's type. Clinical Gerontologist: The Journal of Aging and Mental Health, 24(1-2), 123–140.
  • Atri, A. (2019). Current and future treatments in Alzheimer’s disease. Seminars in Neurology, 39(2), 227–240.
  • Bäckman, L. (1996). Utilizing compensatory task conditions for episodic memory in Alzheimer’s disease. Acta Neurologica Scandinavica, Supplementum, 165, 109–113.
  • Bäckman, L., Jones, S., Berger, A. K., Laukka, E. J., & Small, B. J. (2004). Multiple cognitive deficits during the transition to Alzheimer’s disease. Journal of Internal Medicine, 256(3), 195–204.
  • Barekatain, M., Alavirad, M., Tavakoli, M., Emsaki, G., & Maracy, M. R. (2016). Cognitive rehabilitation in patients with nonamnestic mild cognitive impairment. Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences, 21, 101.
  • Bekris, L. M., Yu, C. E., Bird, T. D., & Tsuang, D. W. (2010). Genetics of Alzheimer disease. Journal of Geriatric Psychiatry and Neurology, 23(4), 213–227.
  • Bleathman, C. (1988). Validation therapy with the demented elderly. Journal of Advanced Nursing, 13(4), 511–514.
  • Breijyeh, Z., & Karaman, R. (2020). Comprehensive review on Alzheimer’s disease: Causes and treatment. Molecules, 25(24), 5789.
  • Burns, A., & Iliffe, S. (2009). Alzheimer’s disease. BMJ, 338(feb05 1), b158–b158.
  • Büyükturan Ö. (2014). Alzheimer demans hastalarında egzersiz eğitiminin fonksiyonellik üzerine etkilerinin incelenmesi (Unpublished doctoral dissertation). Hacettepe University, Ankara.
  • Cappon, D., Jahanshahi, M., & Bisiacchi, P. (2016). Value and efficacy of transcranial direct current stimulation in the cognitive rehabilitation: A critical review since 2000. Frontiers in Neuroscience, 10, 157.
  • Cicerone, K. D., Dahlberg, C., Malec, J. F., Langenbahn, D. M., Felicetti, T., Kneipp, S., Ellmo, W., Kalmar, K., Giacino, J. T., Harley, J. P., Laatsch, L., Morse, P. A., & Catanese, J. (2005). Evidence-based cognitive rehabilitation: Updated review of the literature from 1998 through 2002. Archives of Physical Medicine and Rehabilitation, 86(8), 1681–1692.
  • Cicerone, K. D., Goldin, Y., Ganci, K., Rosenbaum, A., Wethe, J. V., Langenbahn, D. M., Malec, J. F., Bergquist, T. F., Kingsley, K., Nagele, D., Trexler, L., Fraas, M., Bogdanova, Y., & Harley, J. P. (2019). Evidence-based cognitive rehabilitation: Systematic review of the literature from 2009 through 2014. Archives of Physical Medicine and Rehabilitation, 100(8), 1515–1533.
  • Clare, L., Wilson, B. A., Carter, G., Breen, K., Gosses, A., & Hodges, J. R. (2000). Intervening with everyday memory problems in dementia of Alzheimer type: An errorless learning approach. Journal of Clinical and Experimental Neuropsychology, 22(1), 132–146.
  • Cotelli, M., Manenti, R., Brambilla, M., Gobbi, E., Ferrari, C., Binetti, G., & Cappa, S. F. (2019). Cognitive telerehabilitation in mild cognitive impairment, Alzheimer’s disease and frontotemporal dementia: A systematic review. Journal of Telemedicine and Telecare, 25(2), 67–79.
  • Davis, R. N., Massman, P. J., & Doody, R. S. (2001). Cognitive intervention in Alzheimer disease: A randomized placebo-controlled study. Alzheimer Disease and Associated Disorders, 15(1), 1–9.
  • Desikan, R. S., Cabral, H. J., Hess, C. P., Dillon, W. P., Glastonbury, C. M., Weiner, M. W., Schmansky, N. J., Greve, D. N., Salat, D. H., Buckner, R. L., Fischl, B., & Alzheimer's Disease Neuroimaging Initiative. (2009). Automated MRI measures identify individuals with mild cognitive impairment and Alzheimer’s disease. Brain: A Journal of Neurology, 132(8), 2048–2057.
  • Douglas, S., James, I., & Ballard, C. (2004). Non-pharmacological interventions in dementia. Advances in Psychiatric Treatment, 10(3), 171–177.
  • Farina, E., Fioravanti, R., Chiavari, L., Imbornone, E., Alberoni, M., Pomati, S., Pinardi, G., Pignatti, R., & Mariani, C. (2002). Comparing two programs of cognitive training in Alzheimer’s disease: A pilot study. Acta Neurologica Scandinavica, 105(5), 365–371.
  • Feil, N. (1992). Validation therapy with late-onset dementia populations. In G. M. M. Jones & B. M. L. Miesen (Eds.), Care-giving in dementia: Research and applications (pp. 199–218). Routledge.
  • Forbes, D., Forbes, S. C., Blake, C. M., Thiessen, E. J., & Forbes, S. (2015). Exercise programs for people with dementia. The Cochrane Database of Systematic Reviews, 2015(4), CD006489.
  • Fratiglioni, L., De Ronchi, D., & Agüero-Torres, H. (1999). Worldwide prevalence and incidence of dementia. Drugs & Aging, 15(5), 365–375.
  • Ge, S., Zhu, Z., Wu, B., & McConnell, E. S. (2018). Technology-based cognitive training and rehabilitation interventions for individuals with mild cognitive impairment: A systematic review. BMC Geriatrics, 18(1), 213.
  • Germain, S., Wojtasik, V., Lekeu, F., Quittre, A., Olivier, C., Godichard, V., & Salmon, E. (2018). Efficacy of cognitive rehabilitation in Alzheimer disease: A 1-year follow-up study. Journal of Geriatric Psychiatry and Neurology, 32(1), 16–23.
  • Hill, N. T., Mowszowski, L., Naismith, S. L., Chadwick, V. L., Valenzuela, M., & Lampit, A. (2017). Computerized cognitive training in older adults with mild cognitive impairment or dementia: A systematic review and meta-analysis. The American Journal of Psychiatry, 174(4), 329–340.
  • Hsu, D., & Marshall, G. A. (2017). Primary and secondary prevention trials in Alzheimer disease: Looking back, moving forward. Current Alzheimer Research, 14(4), 426–440.
  • Hu, M., Wu, X., Shu, X., Hu, H., Chen, Q., Peng, L., & Feng, H. (2021). Effects of computerised cognitive training on cognitive impairment: A meta-analysis. Journal of Neurology, 268(5), 1680–1688.
  • Hwang, J. H., Cha, H. G., Cho, Y. S., Kim, T. S., & Cho, H. S. (2015). The effects of computer-assisted cognitive rehabilitation on Alzheimer’s dementia patients memories. Journal of Physical Therapy Science, 27(9), 2921–2923.
  • Irazoki, E., Contreras-Somoza, L. M., Toribio-Guzmán, J. M., Jenaro-Río, C., van der Roest, H., & Franco-Martín, M. A. (2020). Technologies for cognitive training and cognitive rehabilitation for people with mild cognitive impairment and dementia. A systematic review. Frontiers in Psychology, 11, 648.
  • Jiang, T., Yu, J. T., Tian, Y., & Tan, L. (2013). Epidemiology and etiology of Alzheimer's disease: From genetic to non-genetic factors. Current Alzheimer Research, 10(8), 852–867.
  • Kasper, E, Ochmann, S., Hoffmann, W., Scneider, W., Cavedo, E., Hampel, H., & Teipel, S. (2015). Cognitive rehabilitation in Alzheimer's disease- A conceptual and methodological review. The Journal of Prevention of Alzheimer's Disease, 2(2),142–152.
  • Keleş, E., & Özalevli, S. (2018). Alzheimer hastalığı ve tedavi yaklaşımları. İzmir Kâtip Çelebi Üniversitesi Sağlık Bilimleri Fakültesi Dergisi, 3(2), 39–42.
  • Kim, S. (2015). Cognitive rehabilitation for elderly people with early-stage Alzheimer’s disease. Journal of Physical Therapy Science, 27(2), 543–546.
  • Knopman, D. S., Amieva, H., Petersen, R. C. Chételat, G., Holtzman, D. M., Hyman, B. T., Nixon, R. A., & Jones, D. T. (2021). Alzheimer disease. Nature Reviews Disease Primers, 7(1), 33.
  • Knopman, D. S., & Petersen, R. C. (2014). Mild cognitive impairment and mild dementia: A clinical perspective. Mayo Clinic Proceedings, 89(10), 1452–1459.
  • Kurth, S., Wojtasik, V., Lekeu, F., Quittre, A., Olivier, C., Godichard, V., Bastin, C., & Salmon, E. (2021). Efficacy of cognitive rehabilitation versus usual treatment at home in patients with early stages of Alzheimer disease. Journal of Geriatric Psychiatry and Neurology, 34(3), 209–215.
  • Li, H., Li, J., Li, N., Li, B., Wang, P., & Zhou, T. (2011). Cognitive intervention for persons with mild cognitive impairment: A meta-analysis. Ageing Research Reviews, 10(2), 285–296.
  • Lök, N., & Buldukoğlu, K. (2014). Psychosocial practices that enhance cognitive activity in dementia. Current Approaches in Psychiatry, 6(3), 210–216.
  • Neal, M., & Barton Wright, P. (2003). Validation therapy for dementia. The Cochrane Database of Systematic Reviews, (3), CD001394.
  • O’Sullivan, M., Coen, R., O’Hora, D., & Shiel, A. (2015). Cognitive rehabilitation for mild cognitive impairment: Developing and piloting an intervention. Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology, and Cognition, 22(3), 280–300.
  • Pardo-Moreno, T., González-Acedo, A., Rivas-Domínguez, A., García-Morales, V., García-Cozar, F. J., Ramos-Rodríguez, J. J., & Melguizo-Rodríguez, L. (2022). Therapeutic approach to Alzheimer’s disease: Current treatments and new perspectives. Pharmaceutics, 14(6), 1117.
  • Petersen, R. C. (2016). Mild cognitive impairment. CONTINUUM: Lifelong Learning in Neurology, 22(2), 404–418.
  • Regan, B., Wells, Y., Farrow, M., O’Halloran, P., & Workman, B. (2017). MAXCOG—Maximizing cognition: A randomized controlled trial of the efficacy of goal-oriented cognitive rehabilitation for people with mild cognitive impairment and early Alzheimer disease. The American Journal of Geriatric Psychiatry, 25(3), 258–269.
  • Santos, G. D., Nunes, P. V., Stella, F., Brum, P. S., Yassuda, M. S., Ueno, L. M., Gattaz, W. F., & Forlenza, O. V. (2015). Multidisciplinary rehabilitation program: Effects of a multimodal intervention for patients with Alzheimer’s disease and cognitive impairment without dementia. Archives of Clinical Psychiatry (São Paulo), 42(6), 153–156.
  • Scanland, S. G., & Emershaw, L. E. (1993). Reality orientation and validation therapy: Dementia, depression, and functional status. Journal of Gerontological Nursing, 19(6), 7–11.
  • Sherman, E. (1993). Mental health and successful adaptation in later life. Generations: Journal of the American Society on Aging, 17(1), 43–46.
  • Viña, J., & Sanz-Ros, J. (2018). Alzheimer’s disease: Only prevention makes sense. European Journal of Clinical Investigation, 48(10), e13005.
  • Vitiello, M. V., & Borson, S. (2001). Sleep disturbances in patients with Alzheimer's disease: Epidemiology, pathophysiology and treatment. CNS Drugs, 15(10), 777–796.
  • Wenk, G. L. (2003). Neuropathologic changes in Alzheimer's disease. The Journal of Clinical Psychiatry, 64(Suppl 9), 7–10.
  • Wilson, B. A. (2002). Towards a comprehensive model of cognitive rehabilitation. Neuropsychological Rehabilitation, 12(2), 97–110.
  • Woods, D. L., Craven, R. F., & Whitney, J. (2005). The effect of therapeutic touch on behavioral symptoms of person with dementia. Alternative Therapies in Health and Medicine, 11(1), 66–74.
  • Zhang, H., Huntley, J., Bhome, R., Holmes, B., Cahill, J., Gould, R. L., Wang, H., Yu, X., & Howard, R. (2019). Effect of computerised cognitive training on cognitive outcomes in mild cognitive impairment: A systematic review and meta-analysis. BMJ Open, 9(8), e027062.
There are 54 citations in total.

Details

Primary Language English
Subjects Clinical Neuropsychology, Health Psychology, Applied and Developmental Psychology (Other)
Journal Section Reviews
Authors

Pınar Uysal Cantürk 0000-0001-7471-010X

Ceren Akçam 0000-0003-4665-3544

Publication Date April 25, 2025
Submission Date March 9, 2023
Published in Issue Year 2025 Volume: 9 Issue: 1

Cite

APA Uysal Cantürk, P., & Akçam, C. (2025). Review of literature on effectiveness of cognitive rehabilitation on Alzheimer’s disease and mild cognitive impairment. Journal of Clinical Psychology Research, 9(1), 106-115. https://doi.org/10.57127/kpd.26024438.1262396