ULTRASONIC-PROMOTED SYNTHESIS OF FUNCTIONALIZED TETRAHYDROPYRIDINES USING TRIFLATE

Abstract

An easy, and effective multicomponent synthesis of a highly substituted tetrahydropyridines has been achieved by reaction of different substituted aromatic aldehydes, β-ketoester (methyl acetoacetate), and p-methoxyaniline, in the presence of ytterbium(III) trifluoromethanesulfonate, Yb(OTf)₃,  as an efficient catalyst under ultrasound irradiation. This method has supplied a different approach for the synthesis of highly substituted tetrahydropyridines in moderate to good yields.

Keywords

• Heterocycles,tetrahydropyridine,triflate,ultrasound

ULTRASONIC-PROMOTED SYNTHESIS OF FUNCTIONALIZED TETRAHYDROPYRIDINES USING TRIFLATE

Abstract

Yüksek derecede sübstitüe edilmiş tetrahidropiridinler, iterbiyum(III)triflorometansülfonat Yb(OTf)₃ katalizörlüğünde, farklı sübstitüe aromatik aldehitler, β-ketoester (metil asetoasetat) ve p-metoksianilinin kolay ve etkili reaksiyonuyla ultrason ışıması altında elde edilmiştir. Bu yöntem yüksek derecede sübstitüe edilmiş tetrahidropiridinlerin iyi verimlerle sentezi için farklı bir yaklaşım sağlamıştır.

Keywords

• Heterosiklikler,tetrahidropiridin,triflat,ultrason

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