INVESTIGATION OF TOXICOLOGICAL PROPERTIES OF SOME AZO DYES BY OECD QSAR METHOD

Year 2023, Volume: 9 Issue: 1, 1 - 22, 30.06.2023

Yasemin Keşkek Karabulut , Yelda Yalçın Gürkan

https://doi.org/10.34186/klujes.1242876

Cited By: 1

Abstract

In this study, the toxicological properties of some of the aromatic amine raw materials commonly used in textile dyes and the dyestuffs produced from these raw materials were examined with the OECD QSAR method and their toxicological effects on human health were investigated. In the literature review conducted with the relevant structures, it was seen that no study set was found in terms of toxicology, considering the comparison of raw materials and products.
Studies have found that some aromatic amine raw materials and azo dyes produced from these raw materials are generally moderately irritating. While the related raw materials generally have eye irritant properties, the products do not have any irritating properties. It can be said that 12 aromatic amine raw materials and 13 azo dyes have skin sensitizing properties. The raw materials are 2,6-dibromo-4-nitro aniline, 6-methoxybenzothiazole-2-ylamine, 2-Bromo-4,6-dinotroaniline, and azo dyes, which are Disperse Brown 27-1, Disperse Brown 19 and Disperse Blue 291, are mutagenic.

Keywords

Toxicity, Aromatic Amines, Azo Dyes, OECD QSAR

Supporting Institution

SETAS Kimya San. A.Ş. R&D Center Ministry Projects

Project Number

BY18-0005

Bazı Azo Boyaların Toksikolojik Özelliklerinin OECD QSAR Yöntemiyle Araştırılması

Abstract

Bu çalışmada tekstil boyalarında yaygın olarak kullanılan bazı aromatik amin hammaddelerin ve bu hammaddelerden üretilen boyarmaddelerin toksikolojik özellikleri OECD QSAR yöntemi ile incelenmiş ve insan sağlığı üzerindeki toksikolojik etkileri araştırılmıştır. İlgili yapılarla yapılan literatür taramasında, hammadde ve ürün karşılaştırmasına bakıldığında toksikolojik açıdan herhangi bir çalışma setine rastlanmadığı görülmüştür.
Yapılan araştırmalarda bazı aromatik amin hammaddelerin ve bu hammaddelerden üretilen azo boyaların genel olarak orta derecede tahriş edici olduğunu bulunmuştur. İlgili hammaddeler genel olarak gözü tahriş edici özelliğe sahipken, ürünlerde herhangi bir tahriş edici özellik bulunmamaktadır. 12 aromatik amin hammaddenin ve 13 azo boyasının cildi hassaslaştırıcı özelliği olduğu söylenebilir. Hammaddeler, 2,6-dibromo-4-nitro anilin, 6-methoxybenzothiazole-2-ylamine, 2-Bromo-4,6-dinotroanilin ve bu hammaddelerden üretilen Dispers Brown 27-1, Dispers Brown 19 ve Dispers Blue 291 azo boyaları mutajeniktir.

Keywords

Toksisite, Aromatik Aminler, Azo Boyalar, OECD QSAR

Project Number

BY18-0005

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