CORYNEBACTERİUM TUBERCULOSTEARİCUM’A BAĞLI GELİŞEN SPONDİLODİSKİTİS OLGUSU

Year 2023, , 375 - 379, 13.07.2023

Duru Mıstanoğlu Pınar Korkmaz , Mehmet Bulent Onal , Şahinde Atlanoğlu

https://doi.org/10.18229/kocatepetip.829062

Abstract

Corynebacterium türleri sıklıkla klinik örneklerden izole edilmekle birlikte, normal cilt florasında yer almaları nedeniyle enfeksiyon ve kolonizasyon ayrımı yapmak zor olabilmektedir. Literatür değerlendirildiğinde C tuberculostearicum enfeksiyonları nadirdir. Altmış bir yaşındaki erkek hasta kliniğimize ateş, bel ve bacaklarda ağrı ve yürümede güçlük şikayeti ile başvurdu. Hastanın kliniği ve radyolojik bulguları spondilodiskitisle uyumluydu. Hastanın operasyonda alınan kültüründe C. tuberculostearicum üredi. Günümüzde Corynebacterium türleri hastanede gelişen enfeksiyonlarda ve/veya immün sistemi baskılanmış olanlarda ortaya çıkan enfeksiyonlarda etken olabilmektedir veya etken olarak karşımıza çıkabilmektedir. Olgumuzda olduğu gibi uzamış hastane yatışı olan ve altta yatan ciddi komorbiditeleri olan hastalarda çoklu ilaç direnci olan suşlar akla gelmeli ve C. tuberculostearicum’un enfeksiyon etkeni olabileceği göz önünde bulundurulmalıdır.

Keywords

Corynebacterium tuberculostearicum, Enfeksiyon, Spondilodiskitis.

A CASE OF SPONDYLODISCITIS DUE TO CORYNEBACTERIUM TUBERCULOSTEARICUM

Abstract

Although Corynebacterium species are often isolated from clinical specimens, it can be difficult to distinguish between infection and colonization due to their presence in normal skin flora. When the literature is evaluated, C tuberculostearicum infections are rare. A 61-year-old male patient was admitted to our clinic with fever, pain in the waist and legs, and difficulty in walking. The patient's clinical and radiological findings were consistent with spondylodiscitis. C. tuberculostearicum grew in the culture of the patient taken during operation. Today, Corynebacterium species can be a causative agent or may appear as a causative agent in infections that develop in hospitals and / or infections that occur in those with a suppressed immune system. Strains with multiple drug resistance should be considered in patients with prolonged hospitalization and severe underlying comorbidities as in our case, and it should be considered that C. tuberculostearicum may be an infectious agent.

Keywords

Corynebacterium tuberculostearicum, Infection, Spondylodiscitis

References

• 1. Mule P, Patil N, Gaikwad S. Corynebacterium tuberculostearicum a potential pathogen in breast abscess- A case report. International Journal of Medical Microbiology and Tropical Diseases. 2018;4:42-4.
• 2. Funke G, von Graevenitz A, Clarridge JE, Bernard KA. Clinical microbiology of coryne form bacteria. Clin Microbiol Rev. 1997;10:125–59.
• 3. McMullen AR, Anderson N, Wallace MA, et al. When good bugs go bad: epidemiology and antimicrobial resistance profiles of Corynebacterium striatum, an emerging multidrug-resistant, opportunistic pathogen. Antimicrob Agents Chemother. 2017;61:01111-17.
• 4. Hinić V, Lang C, Weisser M, et al. Corynebacterium tuberculostearicum: a Potentially Misidentified and Multiresistant Corynebacterium Species Isolated from Clinical Specimens. J Clin Microbiol. 2012;50:2561–7.
• 5. Kalt F, Schulthess B, Sidler F, Herren S, et al. Corynebacterium Species Rarely Cause Orthopedic Infections. J Clin Microbiol. 2018;56:e01200-18.
• 6. Paviour S, Musaad S, Roberts S, et al. Corynebacterium Species Isolated from Patients with Mastitis. Clinical Infectious Diseases. 2002;35:1434–40.
• 7. A Tampakis A, Tampaki EC, Kontzoglou K, et al. Postoperative deep wound dehiscence of thoracotomy with isolation of Corynebacterium tuberculostearicum: surgical site infection or colonization? Eur Rev Med Pharmacol Sci. 2017;21:5264-7.
• 8. Feurer C, Clermont D, Bimet F, et al. Taxonomic characterization of nine strains isolated from clinical and environmental specimens, and proposal of Corynebacterium tuberculostearicum sp. nov. Int J Syst Evol Microbiol. 2004;54:1055–61.
• 9. Omland SH, Ekenberg C, Henrik-Nielsen R, Friis-Møller A. Pancreatic panniculitis complicated by infection with Corynebacterium tuberculostearicum: A case report. IDCases. 2014;1:45-6.
• 10. Rasmussen M, Mohlin AW, Nilson B. From contamination to infective endocarditis-a population-based retrospective study of Corynebacterium isolated from blood cultures. Eur J Clin Microbiol Infect Dis. 2020;39:113-9.
• 11. Mandell GL, Bennett JE, Dolin R (Editor). Mandell, Douglas, and Bennett's principles and practice of infectious diseases. In: Kim R, Reboli AC. Other Coryneform bacteria and Rhodococci. 8th ed, Philadelphia, PA : Churchill Livingstone. 2015:2373-82.
• 12. Courvalin P, Leclercq R, Rice LB (Editor). Corynebacteria. In: Riegel P. Antibiogram. 3th ed, Washington DC: ASM Press, 2010:379–88.