Non Alkolik Yağlı Karaciğer Hastalığında Güncel Medikal Tedavi

Year 2015, Volume: 16 Issue: 1, 67 - 76, 08.05.2015

Akif Acay

https://doi.org/10.18229/ktd.66765

Cited By: 1

Abstract

Non Alkolik Yağlı Karaciğer Hastalığı, en yaygın karaciğer hastalıklarından biridir. NAYKH, obezitenin dünya epidemisiyle paralel olarak artmaktadır. NAYKH, basit yağlanmadan steatohepatite, ileri fibroz ve siroza ilerleyebilir. Kanıtlar; insülin direnci, oksidatif stres ve genetik faktörlerlerin interaksiyonunu içeren çoklu mekanizmaların NAYKH’nın gelişimini başlattığını göstermektedir. Halen onaylanmış bir ilaç tedavisi olmamasına rağmen pek çok yaklaşımın faydalı olabileceği göz önünde bulundurulmalıdır. İnsülin duyarlaştırıcılar, antioksidanlar, antilipidemik ilaçlar ve antiinflamatuar ilaçların faydalı etkileri gösterilmiştir. Bu yazıda NAYKH’ nın mevcut tedavisi ve potansiyel yeni tedaviler üzerine odaklanılmıştır

Keywords

naykh, güncel, tedavi

Non Alkolik Yağlı Karaciğer Hastalığında Güncel Medikal Tedavi

Abstract

Nonalcoholic fatty liver disease is one of the most prevalent liver disease. NAFLD is increasing in parallel with the worldwide epidemic of obesity. NAFLD may progress from simple steatosis to steatohepatitis, advanced fibrosis and cirrhosis. Several evidences suggest that multiple mechanisms including insulin resistance, oxidative stress, inflammation, and genetic factors interact to initiate the development of NAFLD. Despite that there is currently no approved drug therapy for NAFLD, many approaches consider to be beneficial. Insulin sensitizers, antioxidants, antilipidemic drugs and antiinflammatory agents showed promising effects. This paper is focused on the currently treatments for NAFLD

Keywords

nafld, current, treatment

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