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Anafilaksi

Year 2015, Volume: 16 Issue: 1, 77 - 82, 08.05.2015
https://doi.org/10.18229/ktd.87939

Abstract

Anaphylaxis is a severe, multisystemic reaction that occurs suddenly after contact with an allergen. Especially cutaneous, respiratory, cardiovasculer and gastrointestinal systems, all the organs and systems are affected. The most common findings of anaphylaxis are urticaria and angioedema in adults, while respiratory symptoms in children. Immediate diagnosis and treatment is vital. Initial management of the pediatric patient with suspected anaphylaxis should include a rapid, thorough assessment of the airway, breathing and circulation, with administration of IM adrenaline immediately and appropriate dose

References

  • 1- Tupper J, Visser S. Anaphylaxis. A review and update. Canadian Family Physician 2010;56(10):1009-11.
  • 2- Lane RD, Bolte RG. Pediatric anaphylaxis. Pediatr Emerg Care 2007;23(1):49-56.
  • 3- Dean D, Richard D, Peavy M, Gilfillan A. Mechanisms of mast cell signaling in anaphylaxis. J Allergy Clin Immunol 2009;124(4):639-48.
  • 4- Ogawa Y, Grant JA. Mediators of anaphylaxis. Immunol Allergy Clin North Am 2007;27(2):249-60.
  • 5- Finkelman FD. Anaphylaxis: Lessons from mouse models. J Allergy Clin Immunol 2007;120(3):506-15.
  • 6- Kraft S, Kinet JP. New developments in FcƐRI regulation, function and inhibition. Nat Rev Immunol 2007;7(5):365-78.
  • 7- Nagata H, Worobec AS, Oh CK, et al. Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associate hematologic disorder. Proc Natl Acad Sci USA 1995;92(23):10560-4.
  • 8- Akin C, Scott LM, Kocabas CN, et al. Demonstration of an aberrant mast-cell population with clonal markers in a subset of patients with ‘idiopathic’ anaphylaxis. Blood 2007;110(7):2331-3.
  • 9- Dinakar C. Anaphylaxis in Children: Current Understanding and key Issues in diagnosis and treatment. Curr Allergy Asthma Rep 2012;12(6):641-9.
  • 10- Serbes M, Can D, Atlıhan F. Common features of anaphylaxis in children. Allergol Immunopathol 2013;41(4):255-60.
  • 11- De Silva IL, Mehr SS, Tey D, Tang ML. Pediatric anaphylaxis: A 5 year retrospective review. Allergy 2008;63(8):1071-6.
  • 12- Orhan F, Canitez Y, Bakirtas A, et al. Anaphylaxis in Turkish children: a multi-centre, retrospective, case study. Clinical Ɛt Experimental Allergy 2011;41(12):1767-76
  • 13- Lee JM, Greenes DS. Biphasic anaphylactic reactions in pediatrics. Pediatrics 2000;106(4):762-6.
  • 14- Sampson HA, Munoz- Furlong A, Campbell RL, et al. Second symposium on the definition and management of anaphylaxis: Summary report-Second National Institute of Allergy and Infectious Desease/Food Allergy Anaphylaxis Network Symposium. J Allergy Clin Immunol 2006;117(2):391-7.
  • 15- Cheng A. Emergency treatment of anaphylaxis in infants and children. Canadian Pediatricεε Society, Acute Care Committee. Pediatr Child Health 2011;16(1):35-40.
  • 16- Joint Task Force on Practice Parameters; American Academy of Allergy, Asthma and Immunology; American College of Allergy, Asthma and Immunology. The diagnosis and management of anaphylaxis: an updated practice parameter. J Allergy Clin Immunol 2005;115(3 Suppl 2):483-523.
  • 17- Settipane GA. The restaurant syndromes. Arch Intern Med 1986;146(11):2129-30.
  • 18- Davis JE, Norris RL. Allergic emergencies in children: The pivotal role of epinephrine. Pediatric Emergency Medicine Practice 2007;4(2):1-28.
  • 19- Simons FE, Gu X, Simons KJ. Epinephrine absorption in adults: Intramusculer versus subcutaneous injections. J Allergy Clin Immunol 2001;108(5):871-3.
  • 20- Simons FE, Roberts JR, Gu X, Simons KJ. Epinephrine absorption in children with a history of anaphylaxis. J Allergy Clin Immunol 1998;101(1 Pt 1):33-7.
  • 21- Topal E, Bakırtaş A, Yilmaz O, et al. Epidemiological and Clinical Features of Anaphylaxis: Single Center Experience with 109 Childeren 2013;26(2):88-92
  • 22- Topal E, Bakırtaş A, Yilmaz O, et al. Anaphylaxis in infancy compared with older children. Allergy Asthma Proc 2013;34(3):233-8
  • 23- Sheikh A, Ten Broek V, Brown SG, Simons FE. H1- antihistamines for the treatment of anaphylaxis: Cochrane systemic review. Allergy 2007;62(8):830-7.
  • 24- Andreae DA, Andreae MA. Should antihistamines be used to treat anaphylaxis? BMJ 2009;339:b2489.
  • 25- Knight R, Lin RY, Curry A, et al. Clinical effects of combined antiH1 and antiH2 treatment in patients presenting with acute allergic sydromes: A randomized controlled trial. Ann Emerg Med 1999;34(4):18-9.
  • 26- Lin RY, Curry A, Pesola GR, et al. Improved outcomes in patients with acute allergic syndromes who are treated with combined H1 and H2 antagonists. Ann Emergy Med 2000;36(5):462-8.
  • 27- Arga M, Bakirtas A. The past, the present and the future of epinephrine autoinjectors. Asthma Allergy Immunol 2011;9(3)115-122

Anafilaksi

Year 2015, Volume: 16 Issue: 1, 77 - 82, 08.05.2015
https://doi.org/10.18229/ktd.87939

Abstract

Anafilaksi allerjen ile temas sonrası ani olarak ortaya çıkan ciddi, multisistemik bir reaksiyondur. Kutanöz, respiratuar, kardiyovasküler ve gastrointestinal sistem başta olmak üzere tüm organ ve sistemler etkilenir. Anafilakside en sık rastlanan bulgular erişkinlerde ürtiker ve anjiyoödem iken çocuklarda respiratuar bulgulardır. Anafilaksinin erken tanınması ve tedavisi hayati önem taşır. Anafilaktik reaksiyon geçirmekte olan çocuk hastanın başlangıç tedavisi hızlı değerlendirme, hava yolu, solunum ve dolaşım desteğinin sağlanması, acil ve doğru dozda intramüsküler adrenalin uygulamasını içermelidir

References

  • 1- Tupper J, Visser S. Anaphylaxis. A review and update. Canadian Family Physician 2010;56(10):1009-11.
  • 2- Lane RD, Bolte RG. Pediatric anaphylaxis. Pediatr Emerg Care 2007;23(1):49-56.
  • 3- Dean D, Richard D, Peavy M, Gilfillan A. Mechanisms of mast cell signaling in anaphylaxis. J Allergy Clin Immunol 2009;124(4):639-48.
  • 4- Ogawa Y, Grant JA. Mediators of anaphylaxis. Immunol Allergy Clin North Am 2007;27(2):249-60.
  • 5- Finkelman FD. Anaphylaxis: Lessons from mouse models. J Allergy Clin Immunol 2007;120(3):506-15.
  • 6- Kraft S, Kinet JP. New developments in FcƐRI regulation, function and inhibition. Nat Rev Immunol 2007;7(5):365-78.
  • 7- Nagata H, Worobec AS, Oh CK, et al. Identification of a point mutation in the catalytic domain of the protooncogene c-kit in peripheral blood mononuclear cells of patients who have mastocytosis with an associate hematologic disorder. Proc Natl Acad Sci USA 1995;92(23):10560-4.
  • 8- Akin C, Scott LM, Kocabas CN, et al. Demonstration of an aberrant mast-cell population with clonal markers in a subset of patients with ‘idiopathic’ anaphylaxis. Blood 2007;110(7):2331-3.
  • 9- Dinakar C. Anaphylaxis in Children: Current Understanding and key Issues in diagnosis and treatment. Curr Allergy Asthma Rep 2012;12(6):641-9.
  • 10- Serbes M, Can D, Atlıhan F. Common features of anaphylaxis in children. Allergol Immunopathol 2013;41(4):255-60.
  • 11- De Silva IL, Mehr SS, Tey D, Tang ML. Pediatric anaphylaxis: A 5 year retrospective review. Allergy 2008;63(8):1071-6.
  • 12- Orhan F, Canitez Y, Bakirtas A, et al. Anaphylaxis in Turkish children: a multi-centre, retrospective, case study. Clinical Ɛt Experimental Allergy 2011;41(12):1767-76
  • 13- Lee JM, Greenes DS. Biphasic anaphylactic reactions in pediatrics. Pediatrics 2000;106(4):762-6.
  • 14- Sampson HA, Munoz- Furlong A, Campbell RL, et al. Second symposium on the definition and management of anaphylaxis: Summary report-Second National Institute of Allergy and Infectious Desease/Food Allergy Anaphylaxis Network Symposium. J Allergy Clin Immunol 2006;117(2):391-7.
  • 15- Cheng A. Emergency treatment of anaphylaxis in infants and children. Canadian Pediatricεε Society, Acute Care Committee. Pediatr Child Health 2011;16(1):35-40.
  • 16- Joint Task Force on Practice Parameters; American Academy of Allergy, Asthma and Immunology; American College of Allergy, Asthma and Immunology. The diagnosis and management of anaphylaxis: an updated practice parameter. J Allergy Clin Immunol 2005;115(3 Suppl 2):483-523.
  • 17- Settipane GA. The restaurant syndromes. Arch Intern Med 1986;146(11):2129-30.
  • 18- Davis JE, Norris RL. Allergic emergencies in children: The pivotal role of epinephrine. Pediatric Emergency Medicine Practice 2007;4(2):1-28.
  • 19- Simons FE, Gu X, Simons KJ. Epinephrine absorption in adults: Intramusculer versus subcutaneous injections. J Allergy Clin Immunol 2001;108(5):871-3.
  • 20- Simons FE, Roberts JR, Gu X, Simons KJ. Epinephrine absorption in children with a history of anaphylaxis. J Allergy Clin Immunol 1998;101(1 Pt 1):33-7.
  • 21- Topal E, Bakırtaş A, Yilmaz O, et al. Epidemiological and Clinical Features of Anaphylaxis: Single Center Experience with 109 Childeren 2013;26(2):88-92
  • 22- Topal E, Bakırtaş A, Yilmaz O, et al. Anaphylaxis in infancy compared with older children. Allergy Asthma Proc 2013;34(3):233-8
  • 23- Sheikh A, Ten Broek V, Brown SG, Simons FE. H1- antihistamines for the treatment of anaphylaxis: Cochrane systemic review. Allergy 2007;62(8):830-7.
  • 24- Andreae DA, Andreae MA. Should antihistamines be used to treat anaphylaxis? BMJ 2009;339:b2489.
  • 25- Knight R, Lin RY, Curry A, et al. Clinical effects of combined antiH1 and antiH2 treatment in patients presenting with acute allergic sydromes: A randomized controlled trial. Ann Emerg Med 1999;34(4):18-9.
  • 26- Lin RY, Curry A, Pesola GR, et al. Improved outcomes in patients with acute allergic syndromes who are treated with combined H1 and H2 antagonists. Ann Emergy Med 2000;36(5):462-8.
  • 27- Arga M, Bakirtas A. The past, the present and the future of epinephrine autoinjectors. Asthma Allergy Immunol 2011;9(3)115-122
There are 27 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Ayşe Tolunay Oflu This is me

Publication Date May 8, 2015
Published in Issue Year 2015 Volume: 16 Issue: 1

Cite

APA Oflu, A. T. (2015). Anafilaksi. Kocatepe Tıp Dergisi, 16(1), 77-82. https://doi.org/10.18229/ktd.87939
AMA Oflu AT. Anafilaksi. KTD. April 2015;16(1):77-82. doi:10.18229/ktd.87939
Chicago Oflu, Ayşe Tolunay. “Anafilaksi”. Kocatepe Tıp Dergisi 16, no. 1 (April 2015): 77-82. https://doi.org/10.18229/ktd.87939.
EndNote Oflu AT (April 1, 2015) Anafilaksi. Kocatepe Tıp Dergisi 16 1 77–82.
IEEE A. T. Oflu, “Anafilaksi”, KTD, vol. 16, no. 1, pp. 77–82, 2015, doi: 10.18229/ktd.87939.
ISNAD Oflu, Ayşe Tolunay. “Anafilaksi”. Kocatepe Tıp Dergisi 16/1 (April 2015), 77-82. https://doi.org/10.18229/ktd.87939.
JAMA Oflu AT. Anafilaksi. KTD. 2015;16:77–82.
MLA Oflu, Ayşe Tolunay. “Anafilaksi”. Kocatepe Tıp Dergisi, vol. 16, no. 1, 2015, pp. 77-82, doi:10.18229/ktd.87939.
Vancouver Oflu AT. Anafilaksi. KTD. 2015;16(1):77-82.

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