Abstract
Objective: The purpose was to investigate the AMH level and other ovarian reserve markers in the different ovarian response groups. Material and Methods: 80 patients treated with intrauterine insemination were evaluated who were admitted to the Infertility Clinic, Department of Obstetrics and Gynecology of Ege University between September 2009 and May 2011. According to ovarian response each of the groups were divided as less, normal, more ovarian response subgroups and these subgroups were compared for basal AMH, LH, FSH, E2, PRL, age, number of antral follicles and pregnancy. Results: There was found only statistical difference between duration of infertility when Clomiphene citrate and gonadotropin-given groups were According to low, normal and more ovarian response, there was AMH, FSH, LH, antral folliclecount, age, E2 values. The AMH was correlated with antral follicle count (p <0.01) and the age (p <0.05). Conclusion: The serum AMH concentration was only slightly - and not statistically significant different for the IUI patients with a low, a normal or a high ovarian response
References
- Doğan DG, Berker B. Over rezervinin değerlendiril- mesi (Evaluation of ovarian reserve). Turkiye Klinikleri J Gynecol Obst 2008;18(4):254-65.
- Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril 1997;67(5):817–21.
- Freiesleben NC, Rosendahl M, Johannsen TH, et al. Prospective investigation of serum anti-Mullerian hormone concentration in ovulatory intrauterine insemination
- Reproductive BioMedicine 2010;20(5):582–7. a preliminary
- study. 4. Lekamge DN, Barry M, Kolo M, et al. Anti-müllerian hormone as a predictor of IVF outcome. Reprod Biomed 2007;14(5):602–10.
- Broer SL, Mol BWJ, Hendriks D, et al. The role of antimullerian hormone in prediction of outcome after IVF: comparison with the antral follicle count. Fertil Steril 2009;91(3):705–14.
- Nardo LG, Yates AP, Roberts SA, et al. The relationships between AMH, androgens, insulin resistance and basal ovarian follicular status in non- obese subfertile women with and without polycystic ovary 2009;24(11):2917–23. Human
- Reproduction 7. Van Rooij IA, Tonkelaar I, Broekmans FJ, et al. Anti- mullerian hormone is a promising predictor for the occurrence of the menopausal transition. Menopause 2004;11(6):601-6.
- Elgindy EA, El-Haieg DO, El-Sabaey A. Anti- müllerian hormone: correlation of early follicular, ovulatory and midluteal levels with ovarian response and cycle outcome in intracytoplasmic sperm injection patients. Fertil Steril 2008;89(6):1670–6.
- Hall JE, Welt CK, and Cramer DW. İnhibin A and İnhibin B reflect ovarian fuction in assisted reproduction but are less useful predicting outcome. Hum Reprod 1999;14(2):409-15.
- Bancsi LF, Huijs AM, Den Quden CT, et al. Basal follicle stimulating hormone levels are of limited value in predicting ongoing pregnancy rates after in vitro fertilization. Fertil Steril 2000;73(3):552-7.
- Broer SL, Mol BW, Hendriks D, et al. The role of
- antimullerian hormone in prediction of outcome after
- IVF: comparison with the antral follicle count. Fertil
- Steril 2009;91(3):705-12.
- Hazout A, Bouchard P, Seifer DB, et al. Serum anti
- mullerian hormone/mullerian-inhibiting substance
- appears to be a more discriminatory marker of
- assisted reproductive technology outcome than
- follicle-stimulating hormone, inhibin B, or estradiol.
- Fertil Steril 2004;82(5):1323–9.
- Eldar-Geva T, Ben-Chetrit A, Spitz IM, et al.
- Dynamic assays of inhibin B, anti-Mullerian hormone
- and estradiol following FSH stimulation and ovarian
- ultrasonography as predictors of IVF outcome. Hum
- Reprod 2005;20(11):3178–83.
- Smeenk JM, Sweep FC, Zielhuis GA, et al. Antimüllerian
- responsiveness, but not embryo quality or pregnancy, after in vitro fertilization or intracyoplasmic sperm injection. Fertil Steril 2007;87(1):223–6.
- ovarian 15. Li HW, Yeung WS, Lau EY, et al. Evaluating the performance of serum antimullerian hormone concentration in predicting the live birth rate of controlled ovarian stimulation and intrauterine insemination Fertil Steril 2010;94(6):2177-81.
- Scheffer GJ, Broekmans FJ, Bancsi LF, et al. Quantitative transvaginal two and three dimensional sonography of the ovaries: reproducibility of antral follicle counts. Ultrasound in Obstetrics and Gynecology 2002;20(3):270–5.
Abstract
Amaç: Çalışmamızın amacı, intrauterin inseminasyon sikluslarında, over rezervini değerlendirmede antimüllerian hormon ile diğer rezerv belirteçlerini karşılaştırarak antimüllerian hormonun güvenilirliğinin araştırılmasıdır. Gereç ve Yöntem: Eylül 2009 ile Mayıs 2011 tarihleri arasında Ege Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Kliniği İnfertilite Bölümü’ne başvuran ve intrauterin inseminasyon yapılan 80 hasta değerlendirilmiştir. Bu hastaların 9’unda polikistik over ve hipotalamohipofizer yetmezlik tanısı konulması üzerine çalışma grubuna dahil edilmediler ve çalışmaya dahil edilen 71 hasta klomifen sitrat ve gonadotropin kullanılan hastalar olarak iki gruba ayrıldı. Her iki grup, over yanıtına göre kendi arasında düşük, normal ve fazla over yanıtı olarak ayrılarak gruplar bazal AMH, LH, FSH, E2, PRL, yaş, antral follikül sayısı, gebelik açısından karşılaştırıldı. Bulgular: Klomifen sitrat ve gonadotropin verilen gruplar karşılaştırıldığında sadece infertilite süreleri arasında istatiksel fark saptandı (p<0,01). Düşük, normal, fazla over yanıtına göre AMH, FSH, LH, antral follikül sayısı, yaş, E2 değerleri karşılaştırıldığında istatiksel olarak anlamlılık saptanmamıştır. AMH’ın antral follikül sayısı (p<0,01) ve yaş (p<0,05) ile korele olduğu saptanmıştır. Klinik gebelik ile over yanıtı arasında istatiksel fark saptanmamıştır. Sonuç: Sonuç olarak, temel bulgu serum AMH konsantrasyonunun rFSH ve klomifen sitrat ile tedavi edilen ovulatuar IUI hastalarında over cevabını tahmin etmede anlamlı olmadığı ancak AMH’ın antral follikül sayısı ve yaş ile korele olduğudur
References
- Doğan DG, Berker B. Over rezervinin değerlendiril- mesi (Evaluation of ovarian reserve). Turkiye Klinikleri J Gynecol Obst 2008;18(4):254-65.
- Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril 1997;67(5):817–21.
- Freiesleben NC, Rosendahl M, Johannsen TH, et al. Prospective investigation of serum anti-Mullerian hormone concentration in ovulatory intrauterine insemination
- Reproductive BioMedicine 2010;20(5):582–7. a preliminary
- study. 4. Lekamge DN, Barry M, Kolo M, et al. Anti-müllerian hormone as a predictor of IVF outcome. Reprod Biomed 2007;14(5):602–10.
- Broer SL, Mol BWJ, Hendriks D, et al. The role of antimullerian hormone in prediction of outcome after IVF: comparison with the antral follicle count. Fertil Steril 2009;91(3):705–14.
- Nardo LG, Yates AP, Roberts SA, et al. The relationships between AMH, androgens, insulin resistance and basal ovarian follicular status in non- obese subfertile women with and without polycystic ovary 2009;24(11):2917–23. Human
- Reproduction 7. Van Rooij IA, Tonkelaar I, Broekmans FJ, et al. Anti- mullerian hormone is a promising predictor for the occurrence of the menopausal transition. Menopause 2004;11(6):601-6.
- Elgindy EA, El-Haieg DO, El-Sabaey A. Anti- müllerian hormone: correlation of early follicular, ovulatory and midluteal levels with ovarian response and cycle outcome in intracytoplasmic sperm injection patients. Fertil Steril 2008;89(6):1670–6.
- Hall JE, Welt CK, and Cramer DW. İnhibin A and İnhibin B reflect ovarian fuction in assisted reproduction but are less useful predicting outcome. Hum Reprod 1999;14(2):409-15.
- Bancsi LF, Huijs AM, Den Quden CT, et al. Basal follicle stimulating hormone levels are of limited value in predicting ongoing pregnancy rates after in vitro fertilization. Fertil Steril 2000;73(3):552-7.
- Broer SL, Mol BW, Hendriks D, et al. The role of
- antimullerian hormone in prediction of outcome after
- IVF: comparison with the antral follicle count. Fertil
- Steril 2009;91(3):705-12.
- Hazout A, Bouchard P, Seifer DB, et al. Serum anti
- mullerian hormone/mullerian-inhibiting substance
- appears to be a more discriminatory marker of
- assisted reproductive technology outcome than
- follicle-stimulating hormone, inhibin B, or estradiol.
- Fertil Steril 2004;82(5):1323–9.
- Eldar-Geva T, Ben-Chetrit A, Spitz IM, et al.
- Dynamic assays of inhibin B, anti-Mullerian hormone
- and estradiol following FSH stimulation and ovarian
- ultrasonography as predictors of IVF outcome. Hum
- Reprod 2005;20(11):3178–83.
- Smeenk JM, Sweep FC, Zielhuis GA, et al. Antimüllerian
- responsiveness, but not embryo quality or pregnancy, after in vitro fertilization or intracyoplasmic sperm injection. Fertil Steril 2007;87(1):223–6.
- ovarian 15. Li HW, Yeung WS, Lau EY, et al. Evaluating the performance of serum antimullerian hormone concentration in predicting the live birth rate of controlled ovarian stimulation and intrauterine insemination Fertil Steril 2010;94(6):2177-81.
- Scheffer GJ, Broekmans FJ, Bancsi LF, et al. Quantitative transvaginal two and three dimensional sonography of the ovaries: reproducibility of antral follicle counts. Ultrasound in Obstetrics and Gynecology 2002;20(3):270–5.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | August 1, 2014 |
| Published in Issue | Year 2014 Volume: 15 Issue: 2 |
Cite
