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Helikobakter Pylori Pozitif Ülser ve Gastritli Hastalarda SVCAM-1 Düzeyleri

Year 2011, Volume: 12 Issue: 3, 123 - 128, 01.12.2011

Şafak Şahin Cihat Şarkış M. Zahir Bakıcı Hatice Özer

Abstract

Keywords

-

References

  • Lee EL, Feldman M. Gastritis and Gastropathies. In: Feldman M, Friedman LS, Brandt LJ. Sleisenger and Fordran’s Gastrointestinal and Liver Disease. Pathophysiology / Diagnosis /Management. Saunders Elsevier. 2006; Vol 1: 1067-88.
  • Stolte M, Meining A: The updated Sydney system: Classification and grading of gastritis as the basis of diagnosis and treatment. Can J Gastroenterol 2001;15: 591.
  • Cave DR. Transmission and epidemiology of Helicobacter pylori.Am J Med 1996;100:12-7.
  • Moran AD. Pathogenic properties of Helicobacter pylori. Scand J Gastroenterol 1996;31: 22-31.
  • Shimizu T, Kusugami K, Ina K, et al. Helicobacter pylori-associated gastric ulcer exhibits enhanced mucosal chemokine activity at the ulcer site. Digestion 2000; 62: 87-94.
  • Abbas K.A., Lichtman A.H. Cellelar and Molecular İmmunolagy. 2003; 5th Ed. Califorinia Chapter: 6. p.:105-127, Chapter: 11. p.:243-275; Chapter: 12. p.:275-298;
  • Kelly K.A., Natarajan S., Ruther P., Wisse A., et al. Chlamydia trachomatis infection induces mucosal adressin cell adhesion molecule-1 and vascular cell adhesion molecule-1, providing an immunologic link between the fallopian tube and other mucosal tissues. J. İnfect. Dis. 2001; 184:885-91.
  • Zheng, P. Y., J. Hua, K. G. Yeoh, and B. Ho. Association of peptic ulcerwith increased expression of Lewis antigens but not cagA, iceA, and vacA in Helicobacter pylori isolates in an Asian population. Gut 2000; 47: 18–22.
  • Carpenter HA, Talley NJ. Gastroscopy is incomplete without biopsy: clinical relevance of distinguishing
  • Gastroenterology 1995;108:917-24. from
  • gastritis. 10. Fauci A, Braunwald E, Isselbacher KJ, et al. Gastritis. Harrison’s Principle of Internal Medicine. Companion Handbook. 14th ed. McGraw-Hill; 1998; 1610-6.
  • Thoreson, C.A. Hamlet, J. Celik, M. Bystrom, et al. Differences in surface-exposed antigen expression between Helicobacter pylori strains isolated from duodenal ulcer patients and from asymptomatic subjects. J. Clin. Microbiol. 2000; 38: 3436–41.
  • Blaser, M. J.. The role of Helicobacter pylori in gastritis and its progression to peptic ulcer disease. Aliment. Pharmacol. Ther. 1995; 9: 27–30.
  • Garza-Gonzales E, Boskues-Padilla FJ, Mendoza- Iberra SI, Flores-Gutierrez JP, Maldonado-Garza HJ, Perez-Perez GI. Assessment of the toll-like receptor 4Asp299Gly,
  • polymorphisms in the risk for the development of distal gastric cancer. BMC Cancer 2007;7: 70-5.
  • Noffsinger AE, Stemmermann GN, Kim OJ, Fenoglio-Preiser CM. Gastric cancer pathology. In: Kelsen DP, Daly JM, Kern SE, Levin B, Teper JE, Eds.
  • Lippincott Williams and Wilkins Co. 2002; 355-69. Oncology,
  • Philadelphia: 15. Kim JS, Jung HC, Kim JM, Song IS, Kim CY. Interleukin-8 expression by human neutrophils activated by Helicobacter pylori soluble proteins. Scand J Gastroenterol 1998; 33: 1249-55
  • Salehi Z, Jelodar M H, Rassa M, Aheki M. Helicobacter pylori cagA status and peptic ulcer disease in Iran. Dig Dis Sci 2008; PMID: 18612816 17. Hatz, R. A., G. Rieder, M. Stolte, E. Bayerdorffer, et al. Pattern of adhesion molecule expression on vascular
  • associated antral gastritis. Gastroenterology 1997; 112:1908–19 in Helicobacter
  • pylori- 18. Galamb O, Gyorffy B, Sipos F, Dinya E, et al. Helicobacter pylori and antrum erosion-specific gene expression patterns: the discriminative role of CXCL13 and VCAM1 transcripts. Helicobacter. 2008;13(2):112-26.
  • Innocenti M, Thoreson AC, Ferrero RL, Stromberg E, et al. Helicobacter pylori induced activation of human endothelial cells. Infect Immun 2002; 70: 4581-90
  • Byrne MF, Corcoran PA, Atherton JC, Sheehan KM, et al. Stimulation of adhesion molecule expression by Helicobacter pylori and increased neutrophil adhesion to human umbilical vein endothelial cells. FEBS Lett 2002; 532: 411-4
  • Oshima T, Ozono R, Yano Y, Oishi Y, et al. Association of Helicobacter pylori infection with systemic inflammation and endothelial dysfunction in healthy male subjects. J Am Coll Cardiol. 2005 19;45:1219-22.
  • Seth R, Raymond FD, Makgoba MW. Circulating ICAM-1 isoforms: diagnostic prospects for infl ammatory and immune disorders. Lancet 1991; 338: 83-4
  • Ding YB, Chen GY, Xia JG, Zang XW, Yang HY, Yang L. Association of VCAM-1 overexpression with oncogenesis, tumor angiogenesis and metastasis of gastric carcinoma. World J Gastroenterol. 2003 Jul;9:1409-14.
  • Muller AM, Weichert A, Muller KM. E-cadherin, E-selectin and vascular cell adhesion molecule: immunohistochemical markers for differentiation betweenmesothelioma and metastatic pulmonary adenocarcinoma? Virchows Arch 2002; 441: 41-6
  • Maciorkowska E, Kaczmarski M, Panasiuk A, Kondej-Muszynska K, Kemona A. Soluble adhesion molecules ICAM-1, VCAM-1, P-selectin in children with
  • Gastroenterol 2005; 11: 745-6750 infection. World J

Helikobakter Pylori Pozitif Ülser ve Gastritli Hastalarda SVCAM-1 Düzeyleri

Year 2011, Volume: 12 Issue: 3, 123 - 128, 01.12.2011

Şafak Şahin Cihat Şarkış M. Zahir Bakıcı Hatice Özer

Abstract

Gastrit tüm dünyada çok yaygın olarak rastlanılan bir hastalıktır. Hastalığın etyolojisinde çok çeşitli etkenler mevcuttur (toksik, viral bakteriyel, immün vb.). Farklı klinik formlarda ortaya çıkabilmektedir. Hastalığın patogenezi tam olarak anlaşılamamıştır. Bu açıdan bakıldığında özellikle en sık rastlanılan etkenlerden H. pylori tipiktir, çünkü çok değişik klinik seyir gösterebilmekte aynı zamanda lenfoma ve mide kanserine yol açabilmektedir. Adhezyon moleküllerinin inflamasyon oluşumunda önemli rol oynadıkları bilinmektedir, dolayısıyla gastrit patogenezinde de rol oynamaktadırlar. Bu çalışmada amacımız; H. pylori pozitif hastalarda SVCAM-1 düzeyinin arttığını göstermek ve inflamas-yonda diğer gastritlere göre bu yolağın daha yoğun bir şekilde kullanıldığını ortaya koymaktır. Çalışmaya önceden belirlediğimiz kriterlere uygun 49 (E:26, K:23)’u H. pylori pozitif ve 29 (E:10, K:19)’u H. pylori negatif iki grup olmak üzere toplam 78 hasta alındı. Çalışmaya katılan tüm hastalarda SVCAM-1 düzeyi ve patolojik özellikleri çalışıldı ve istatiksel olarak iki grup karşılaştırıldı; H. pylori pozitif grupta SVCAM-1 düzeyi istatiksel olarak anlamlı düzeyde yüksek bulundu. Sonuç olarak bu çalışma SVCAM-1 düzeyinin H. pylori enfeksiyonuna bağlı olarak gastrit hastalarında immunoenflamatuvar tepkide diğer etkenlerin yol açtığı gastritlere göre daha ağırlıklı bir rol oynadığını göstermektedir

Keywords

H.pylori SVCAM-1 gastrit inflamasyon

References

  • Lee EL, Feldman M. Gastritis and Gastropathies. In: Feldman M, Friedman LS, Brandt LJ. Sleisenger and Fordran’s Gastrointestinal and Liver Disease. Pathophysiology / Diagnosis /Management. Saunders Elsevier. 2006; Vol 1: 1067-88.
  • Stolte M, Meining A: The updated Sydney system: Classification and grading of gastritis as the basis of diagnosis and treatment. Can J Gastroenterol 2001;15: 591.
  • Cave DR. Transmission and epidemiology of Helicobacter pylori.Am J Med 1996;100:12-7.
  • Moran AD. Pathogenic properties of Helicobacter pylori. Scand J Gastroenterol 1996;31: 22-31.
  • Shimizu T, Kusugami K, Ina K, et al. Helicobacter pylori-associated gastric ulcer exhibits enhanced mucosal chemokine activity at the ulcer site. Digestion 2000; 62: 87-94.
  • Abbas K.A., Lichtman A.H. Cellelar and Molecular İmmunolagy. 2003; 5th Ed. Califorinia Chapter: 6. p.:105-127, Chapter: 11. p.:243-275; Chapter: 12. p.:275-298;
  • Kelly K.A., Natarajan S., Ruther P., Wisse A., et al. Chlamydia trachomatis infection induces mucosal adressin cell adhesion molecule-1 and vascular cell adhesion molecule-1, providing an immunologic link between the fallopian tube and other mucosal tissues. J. İnfect. Dis. 2001; 184:885-91.
  • Zheng, P. Y., J. Hua, K. G. Yeoh, and B. Ho. Association of peptic ulcerwith increased expression of Lewis antigens but not cagA, iceA, and vacA in Helicobacter pylori isolates in an Asian population. Gut 2000; 47: 18–22.
  • Carpenter HA, Talley NJ. Gastroscopy is incomplete without biopsy: clinical relevance of distinguishing
  • Gastroenterology 1995;108:917-24. from
  • gastritis. 10. Fauci A, Braunwald E, Isselbacher KJ, et al. Gastritis. Harrison’s Principle of Internal Medicine. Companion Handbook. 14th ed. McGraw-Hill; 1998; 1610-6.
  • Thoreson, C.A. Hamlet, J. Celik, M. Bystrom, et al. Differences in surface-exposed antigen expression between Helicobacter pylori strains isolated from duodenal ulcer patients and from asymptomatic subjects. J. Clin. Microbiol. 2000; 38: 3436–41.
  • Blaser, M. J.. The role of Helicobacter pylori in gastritis and its progression to peptic ulcer disease. Aliment. Pharmacol. Ther. 1995; 9: 27–30.
  • Garza-Gonzales E, Boskues-Padilla FJ, Mendoza- Iberra SI, Flores-Gutierrez JP, Maldonado-Garza HJ, Perez-Perez GI. Assessment of the toll-like receptor 4Asp299Gly,
  • polymorphisms in the risk for the development of distal gastric cancer. BMC Cancer 2007;7: 70-5.
  • Noffsinger AE, Stemmermann GN, Kim OJ, Fenoglio-Preiser CM. Gastric cancer pathology. In: Kelsen DP, Daly JM, Kern SE, Levin B, Teper JE, Eds.
  • Lippincott Williams and Wilkins Co. 2002; 355-69. Oncology,
  • Philadelphia: 15. Kim JS, Jung HC, Kim JM, Song IS, Kim CY. Interleukin-8 expression by human neutrophils activated by Helicobacter pylori soluble proteins. Scand J Gastroenterol 1998; 33: 1249-55
  • Salehi Z, Jelodar M H, Rassa M, Aheki M. Helicobacter pylori cagA status and peptic ulcer disease in Iran. Dig Dis Sci 2008; PMID: 18612816 17. Hatz, R. A., G. Rieder, M. Stolte, E. Bayerdorffer, et al. Pattern of adhesion molecule expression on vascular
  • associated antral gastritis. Gastroenterology 1997; 112:1908–19 in Helicobacter
  • pylori- 18. Galamb O, Gyorffy B, Sipos F, Dinya E, et al. Helicobacter pylori and antrum erosion-specific gene expression patterns: the discriminative role of CXCL13 and VCAM1 transcripts. Helicobacter. 2008;13(2):112-26.
  • Innocenti M, Thoreson AC, Ferrero RL, Stromberg E, et al. Helicobacter pylori induced activation of human endothelial cells. Infect Immun 2002; 70: 4581-90
  • Byrne MF, Corcoran PA, Atherton JC, Sheehan KM, et al. Stimulation of adhesion molecule expression by Helicobacter pylori and increased neutrophil adhesion to human umbilical vein endothelial cells. FEBS Lett 2002; 532: 411-4
  • Oshima T, Ozono R, Yano Y, Oishi Y, et al. Association of Helicobacter pylori infection with systemic inflammation and endothelial dysfunction in healthy male subjects. J Am Coll Cardiol. 2005 19;45:1219-22.
  • Seth R, Raymond FD, Makgoba MW. Circulating ICAM-1 isoforms: diagnostic prospects for infl ammatory and immune disorders. Lancet 1991; 338: 83-4
  • Ding YB, Chen GY, Xia JG, Zang XW, Yang HY, Yang L. Association of VCAM-1 overexpression with oncogenesis, tumor angiogenesis and metastasis of gastric carcinoma. World J Gastroenterol. 2003 Jul;9:1409-14.
  • Muller AM, Weichert A, Muller KM. E-cadherin, E-selectin and vascular cell adhesion molecule: immunohistochemical markers for differentiation betweenmesothelioma and metastatic pulmonary adenocarcinoma? Virchows Arch 2002; 441: 41-6
  • Maciorkowska E, Kaczmarski M, Panasiuk A, Kondej-Muszynska K, Kemona A. Soluble adhesion molecules ICAM-1, VCAM-1, P-selectin in children with
  • Gastroenterol 2005; 11: 745-6750 infection. World J
There are 29 citations in total.

Details

Primary Language Turkish
Journal Section Articles
Authors

Şafak Şahin This is me

Cihat Şarkış This is me

M. Zahir Bakıcı This is me

Hatice Özer This is me

Publication Date December 1, 2011
Published in Issue Year 2011 Volume: 12 Issue: 3

Cite

APA Şahin, Ş., Şarkış, C., Bakıcı, M. Z., Özer, H. (2011). Helikobakter Pylori Pozitif Ülser ve Gastritli Hastalarda SVCAM-1 Düzeyleri. Kocatepe Tıp Dergisi, 12(3), 123-128. https://doi.org/10.18229/ktd.14097
AMA Şahin Ş, Şarkış C, Bakıcı MZ, Özer H. Helikobakter Pylori Pozitif Ülser ve Gastritli Hastalarda SVCAM-1 Düzeyleri. KTD. December 2011;12(3):123-128. doi:10.18229/ktd.14097
Chicago Şahin, Şafak, Cihat Şarkış, M. Zahir Bakıcı, and Hatice Özer. “Helikobakter Pylori Pozitif Ülser Ve Gastritli Hastalarda SVCAM-1 Düzeyleri”. Kocatepe Tıp Dergisi 12, no. 3 (December 2011): 123-28. https://doi.org/10.18229/ktd.14097.
EndNote Şahin Ş, Şarkış C, Bakıcı MZ, Özer H (December 1, 2011) Helikobakter Pylori Pozitif Ülser ve Gastritli Hastalarda SVCAM-1 Düzeyleri. Kocatepe Tıp Dergisi 12 3 123–128.
IEEE Ş. Şahin, C. Şarkış, M. Z. Bakıcı, and H. Özer, “Helikobakter Pylori Pozitif Ülser ve Gastritli Hastalarda SVCAM-1 Düzeyleri”, KTD, vol. 12, no. 3, pp. 123–128, 2011, doi: 10.18229/ktd.14097.
ISNAD Şahin, Şafak et al. “Helikobakter Pylori Pozitif Ülser Ve Gastritli Hastalarda SVCAM-1 Düzeyleri”. Kocatepe Tıp Dergisi 12/3 (December 2011), 123-128. https://doi.org/10.18229/ktd.14097.
JAMA Şahin Ş, Şarkış C, Bakıcı MZ, Özer H. Helikobakter Pylori Pozitif Ülser ve Gastritli Hastalarda SVCAM-1 Düzeyleri. KTD. 2011;12:123–128.
MLA Şahin, Şafak et al. “Helikobakter Pylori Pozitif Ülser Ve Gastritli Hastalarda SVCAM-1 Düzeyleri”. Kocatepe Tıp Dergisi, vol. 12, no. 3, 2011, pp. 123-8, doi:10.18229/ktd.14097.
Vancouver Şahin Ş, Şarkış C, Bakıcı MZ, Özer H. Helikobakter Pylori Pozitif Ülser ve Gastritli Hastalarda SVCAM-1 Düzeyleri. KTD. 2011;12(3):123-8.

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