Cellular Pathways In Endoplasmic Reticulum Stress And The Role Of Beta Cell Apoptosis Induced By Endoplasmic Reticulum Stress In The Pathogenesis Of Type II Diabetes

Year 2015, Volume: 16 Issue: 3, 227 - 237, 27.08.2015

Sefa Çelik Serkan Şen , Ömer Hazman

https://doi.org/10.18229/ktd.19744

Abstract

It was assumed that apoptosis is the main factor in beta cell deaths in type II diabetes. Apoptosis is important owing to eradicate the damaged or harmful cells without inflammation
in various biological facts. This process is also important for homeostasis of organism. B cells are often exposed to ER stress due to excess insulin secretion. In recent years, it was showed
that endoplasmic reticulum was an important organelle in apoptotic signal conduction. Investigations including apoptosis induced ER stress will supply new approaches in to clarify the new mechanisms in diabetic pathogenesis and new treatment strategies in diabetes.

Keywords

Tip 2 Diabetes, Endoplasmic reticulum stress, Apoptosis

Endoplasmik Retikulum Stresine Cevap Yolakları ve Tip 2 Diyabet Patogenezinde Endoplasmik Retikulum Stres Aracılı Beta Hücre Apoptosisinin Rolü

Abstract

Tip 2 Diabetes Mellitus (T2DM) hastalarındaki beta hücre kayıplarının temel nedeninin apoptosis olduğu düşünülmektedir. Apoptosisin önemi; çeşitli biyolojik olaylarda gereksiz, hasarlı ya da zararlı hücrelerin inflamatuvar yanıt olmaksızın yok edilişini sağlamasından ve organizmanın iç dengesinin devamlılığına katkıda bulunmasından ileri gelmektedir. β hücreleri yoğun olarak insülin sentezlemesi ve salgılaması nedeniyle sıklıkla ER stresine maruz kalmaktadır. Son yıllardaki çalışmalarda β hücrelerinde Endoplazmik Retikulum (ER)’un apoptotik ölüm sinyallerinin iletilmesinde önemli bir organel olduğu gösterilmiştir. β-hücrelerinde ER stresi aracılı apoptosis üzerine yapılacak çalışmalar diyabet patogenezinde yeni mekanizmaların aydınlatılmasına ve tedavi hedeflerinin iyi belirlenmesine ışık tutacaktır.

Keywords

Tip 2 Diyabet, Endoplastik retikulum stresi, Apoptosis

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