Year 2020, Volume 21 , Issue 2, Pages 211 - 216 2020-05-11

ACINETOBACTER CALCOACETICUS- ACINETOBACTER BAUMANNII COMPLEX (ABC) VE YENİ TÜRLERİ
ACINETOBACTER CALCOACETICUS- ACINETOBACTER BAUMANNII (ABC) AND NEW SPECIES

Berrin ESEN [1] , Ayşegül GÖZALAN [2]


Acinetobacter cinsi’nin sınıflandırılmasında 12 farklı genomik tür bulunduğu gösterilmiş, taksonomisinde son 30 yılda DNA-temelli metotların yaygın kullanımı sayesinde değişiklikler kaydedilmiştir. Bugün için Acinetobacter cinsi içerisinde 49 tür bulunmaktadır. A. calcoaceticus- A.baumannii complex içinde (ABC) klinik olarak önemli türler olan A. baumannii (genomik tür 2), Acinetobacter nosocomialis (genomik tür 13TU), Acinetobacter pittii (genomik tür 3) ve Acinetobacter calcoaceticus (genomik tür 1) türleri biyokimyasal olarak ayırd edilemezler. DNA-DNA hibridizasyon, rpoB gen sekans analizi ve multilocus sequence typing (MLST) ile A. calcoaceticus- A. baumannii complex’e son yıllarda iki yeni patojenik tür olan Acinetobacter seifertii ve Acinetobacter djikshoorniae eklenmiştir. Ayrıca non-A.baumannii türleri arasında plazmide lokalize blaNDM-1 geni taşıyan ve A. djikshoorniae’nın model suşu olan JVAP01T suşunun taslak genom dizilimi de yayınlanmıştır. Bugün için; Acinetobacter cinsinin tür düzeyinde ayrımı için; RNA polimeraz β-subunit (rpoB) geni, DNA giraz B (gyrB) geni sekans analizi ve/veya multilocus sequence analysis (MLSA) altın standard moleküler metotlar olarak kabul edilmektedir. Diğer yöntemler; amplified ribosomal DNA restriction analysis (ARDRA), Fourier transform infrared spectroscopy (FTIR) , ve Matriks assisted lazer desorption ionization time of flight mass spectrometry (MALDI-TOF MS)’dur. Acinetobacter türlerine karşı antimikrobiyal direnç gelişimini önlemek için izolatların tür düzeyinde güvenilir yöntemler kullanılarak tanımlanmaları, uygun antibiyotiklerin kullanılması ve kesintisiz enfeksiyon kontrol önlemlerinin uygulanması önemlidir.

The Acinetobacter genus had 12 genomic species. In the last 30 years based on DNA-DNA hybridization the taxonomic differences has been reported. Currently 49 species are recognized. The biochemically indistinguishable strains, A. baumannii (genomik species 2), Acinetobacter nosocomialis (genomik species 13TU), Acinetobacter pittii (genomik species 3) and Acinetobacter calcoaceticus (genomik species 1) are the clinical important species in the A.calcoaceticus- A.baumannii complex (ABC). Two nowel pathogenic species, Acinetobacter seifertii and Acinetobacter djikshoorniae has been included to A. calcoaceticus- A.baumannii complex by DNA-DNA hybridizaition method, rpoB gene sequence analysis and multilocus sequence typing (MLST) methods. Draft genome sequence of a pathogenic strain JVAP01T, model strain of A. djikshoorniae, which a conjugative plasmid with blaNDM-1 gene has been reported. RNA polimerase β-subunit (rpoB)gene, DNA gyrase B (gyrB) gene sequence analysıs and /or multilocus sequence analysis (MLSA) are known as gold standard molecular methods for the idenitfication at species level. Others are amplified ribosomal DNA restriction analysis (ARDRA), Fourier transform infrared spectroscopy (FTIR) and Matriks assisted lazer desorption ionization time of flight mass spectrometry (MALDI-TOF MS). There is critical importance in keeping the development of antimicrobial resistance of Acinetobacter species at lowest levels such as using relaible laboratory methods, continous infection control measures and rationale antibiotic strategies.

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Primary Language tr
Subjects Medicine
Published Date NİSAN 2020
Journal Section Review
Authors

Orcid: 0000-0003-1590-7150
Author: Berrin ESEN (Primary Author)
Institution: ANKARA EĞİTİM VE ARAŞTIRMA HASTANESİ
Country: Turkey


Orcid: 0000-0003-2203-3156
Author: Ayşegül GÖZALAN
Institution: İstanbul Dr. Lütfü Kırdar Kartal Eğitim ve Araştırma Hastanesi
Country: Turkey


Dates

Publication Date : May 11, 2020

Bibtex @review { kocatepetip545268, journal = {Kocatepe Tıp Dergisi}, issn = {1302-4612}, eissn = {2149-7869}, address = {}, publisher = {Afyonkarahisar Sağlık Bilimleri Üniversitesi}, year = {2020}, volume = {21}, pages = {211 - 216}, doi = {10.18229/kocatepetip.545268}, title = {ACINETOBACTER CALCOACETICUS- ACINETOBACTER BAUMANNII COMPLEX (ABC) VE YENİ TÜRLERİ}, key = {cite}, author = {Esen, Berrin and Gözalan, Ayşegül} }
APA Esen, B , Gözalan, A . (2020). ACINETOBACTER CALCOACETICUS- ACINETOBACTER BAUMANNII COMPLEX (ABC) VE YENİ TÜRLERİ . Kocatepe Tıp Dergisi , 21 (2) , 211-216 . DOI: 10.18229/kocatepetip.545268
MLA Esen, B , Gözalan, A . "ACINETOBACTER CALCOACETICUS- ACINETOBACTER BAUMANNII COMPLEX (ABC) VE YENİ TÜRLERİ" . Kocatepe Tıp Dergisi 21 (2020 ): 211-216 <https://dergipark.org.tr/en/pub/kocatepetip/issue/54261/545268>
Chicago Esen, B , Gözalan, A . "ACINETOBACTER CALCOACETICUS- ACINETOBACTER BAUMANNII COMPLEX (ABC) VE YENİ TÜRLERİ". Kocatepe Tıp Dergisi 21 (2020 ): 211-216
RIS TY - JOUR T1 - ACINETOBACTER CALCOACETICUS- ACINETOBACTER BAUMANNII COMPLEX (ABC) VE YENİ TÜRLERİ AU - Berrin Esen , Ayşegül Gözalan Y1 - 2020 PY - 2020 N1 - doi: 10.18229/kocatepetip.545268 DO - 10.18229/kocatepetip.545268 T2 - Kocatepe Tıp Dergisi JF - Journal JO - JOR SP - 211 EP - 216 VL - 21 IS - 2 SN - 1302-4612-2149-7869 M3 - doi: 10.18229/kocatepetip.545268 UR - https://doi.org/10.18229/kocatepetip.545268 Y2 - 2019 ER -
EndNote %0 Kocatepe Tıp Dergisi ACINETOBACTER CALCOACETICUS- ACINETOBACTER BAUMANNII COMPLEX (ABC) VE YENİ TÜRLERİ %A Berrin Esen , Ayşegül Gözalan %T ACINETOBACTER CALCOACETICUS- ACINETOBACTER BAUMANNII COMPLEX (ABC) VE YENİ TÜRLERİ %D 2020 %J Kocatepe Tıp Dergisi %P 1302-4612-2149-7869 %V 21 %N 2 %R doi: 10.18229/kocatepetip.545268 %U 10.18229/kocatepetip.545268
ISNAD Esen, Berrin , Gözalan, Ayşegül . "ACINETOBACTER CALCOACETICUS- ACINETOBACTER BAUMANNII COMPLEX (ABC) VE YENİ TÜRLERİ". Kocatepe Tıp Dergisi 21 / 2 (May 2020): 211-216 . https://doi.org/10.18229/kocatepetip.545268
AMA Esen B , Gözalan A . ACINETOBACTER CALCOACETICUS- ACINETOBACTER BAUMANNII COMPLEX (ABC) VE YENİ TÜRLERİ. KTD. 2020; 21(2): 211-216.
Vancouver Esen B , Gözalan A . ACINETOBACTER CALCOACETICUS- ACINETOBACTER BAUMANNII COMPLEX (ABC) VE YENİ TÜRLERİ. Kocatepe Tıp Dergisi. 2020; 21(2): 211-216.