Year 2020, Volume 21 , Issue 2, Pages 191 - 194 2020-05-11

HEMATOKRİTE GÖRE DÜZELTİLMİŞ ERİTROSİT SEDİMENTASYON HIZI, C-REAKTİF PROTEİN İLE DAHA İYİ BİR KORELASYONA SAHİPTİR
HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN

Seda ÇELİK [1] , Duygu Mine YAVUZ [2] , Ergin TAŞKIN [3] , Fatih BOY [4] , Fatih KARA [5]


AMAÇ: Eritrosit sedimentasyon hızı (ESR) klinik uygulamada yaygın olarak kullanılan bir laboratuvar belirtecidir. ESR, temel olarak iki faktörden etkilenir: fibrinojen gibi plazma proteinleri ve hematokrit gibi eritrositler ile ilişkili bazı durumlar. Hematokritin ESR üzerindeki etkisini ortadan kaldırarak ESR'yi yorumlayabilmek için bazı formüller geliştirilmiştir. Bu çalışmanın amacı, hematokrite göre düzeltilmiş ESR formüllerinin C-reaktif protein (CRP) ile daha iyi bir korelasyonunun olup olmadığını belirlemekti.
GEREÇ VE YÖNTEM: Hastanemiz veri tabanından Şubat 2018'e ait veriler alındı. Aynı anda elde edilen kan örneklerinde ölçülen ESR, CRP ve hematokrit değerlerine ait toplam 1206 hastanın sonuçları, bu parametreler arasında bir korelasyon olup olmadığı açısından analiz edildi. Hematokrite göre düzeltilmiş ESR değerleri, aşağıdaki formüllerle hesaplandı: (a) Hematokrite göre düzeltilmiş sedimentasyon-1 (HA-ESR-1) = [(15)/(55-hematokrit)]X sedimentasyon, (b) Hematokrite göre düzeltilmiş sedimentasyon- 2 (HA-ESR-2) = (hematokrit/45)X sedimentasyon.
BULGULAR: HA-ESR-2 standart ESR ölçümlerine kıyasla CRP ile daha iyi bir korelasyona sahipti, ancak HA-ESR-1, CRP ve ESR arasındaki ilişkiyi iyileştiremedi.
SONUÇ: HA-ESR-2'nin CRP ile standart ESR'den anlamlı olarak daha iyi bir korelasyon gösterdiğini bulduk. Bu nedenle, söz konusu formül klinik uygulamada yararlı olabilir.

OBJECTIVE: Erythrocyte sedimentation rate (ESR) is a laboratory marker widely used in clinical practice. It is affected primarily by two factors following: plasma proteins such as fibrinogen and some conditions associated with the erythrocytes such as hematocrit. Some formulas have been developed so as to interpret the ESR by eliminating the effect on the ESR of the hematocrit. The purpose of our research was to determine whether the formulas for ESR adjusted with hematocrit levels have a better correlation with C-reactive protein (CRP).
MATERIAL AND METHODS: The data belong to February 2018 were obtained from database of our hospital. A total of 1206 patients’ results including ESR, CRP, and hematocrit, which had been measured in blood samples simultaneously obtained, were analyzed in terms of whether there is a correlation between these parameters. Hematocrit-adjusted ESR values were calculated by formulas following: (a) Hematocrit-adjusted sedimentation-1 (HA-ESR-1) = [(15)/(55-hematocrit)]X sedimentation, (b) Hematocrit-adjusted sedimentation-2 (HA-ESR-2) = (hematocrit/45)X sedimentation.
RESULTS: While HA-ESR-2 had a better correlation with CRP compared to standard ESR measurements, HA-ESR-1 didn't make good the association between CRP and ESR.
CONCLUSIONS: We found that HA-ESR-2 has significantly a better correlation with CRP than that of standard ESR. Therefore, this formula may be useful in clinical practice.

  • Bray C, Bell LN, Liang H, et al. Erythrocyte sedimentation rate and C-reactive protein measurements and their relevance in clinical medicine. WMJ 2016;115:317-21.
  • Erdoğdu Hİ, Atalay E. Relationship between high erythrocyte sedimentation rate and 25-hydroxy vitamin D and C-reactive protein levels. Sakarya Med J 2018;8:798-805.
  • Tunç S, Atagün MI, Neşelioğlu S, Bilgin YY, Başbuğ HS, Erel Ö. Ischemia-modified albumin: a unique marker of global metabolic risk in schizophrenia and mood disorders. Psychiatry and clinical psychopharmacology 2018;1-7.
  • Markanday A. Acute phase reactants in infections: evidence-based review and a guide for clinicians. Open Forum Infect Dis 2015;2:ofv098.
  • Fabry TL. Mechanism of erythrocyte aggregation and sedimentation. Blood 1987;70:1572-6.
  • Choi JW, Fujii T, Fujii N. Corrected neutrophil gelatinase-associated lipocalin (NGAL) level adjusted by the scoring system of an inflammation index for screening renal dysfunction in patients with systemic inflammation. Ann Clin Lab Sci 2015;45:248-55.
  • Castell JV, Gomez-Lechon MJ, David M, et al. Interleukin-6 is the major regulator of acute phase protein synthesis in adult human hepatocytes. FEBS Lett 1989;242:237-9.
  • Kotulska A, Kopec-Mędrek M, Grosicka A, Kubicka M, Kucharz EJ. Correlation between erythrocyte sedimentation rate and C-reactive protein level in patients with rheumatic diseases. Reumatologia 2015;53:243-6.
  • Keenan RT, Swearingen CJ, Yazici Y. Erythrocyte sedimentation rate and C-reactive protein levels are poorly correlated with clinical measures of disease activity in rheumatoid arthritis, systemic lupus erythematosus and osteoarthritis patients. Clin Exp Rheumatol 2008;26:814-9.
  • Fernandes HP, Cesar CL, Barjas-Castro Mde L. Electrical properties of the red blood cell membrane and immunohematological investigation. Rev Bras Hematol Hemoter 2011;33:297-301.
  • Aytekin M. The current use and the evolution of erythrocyte sedimentation rate measurement. MBSJHS 2018;4:17-23.
  • Gram HC. Über die correction der senkungsreaktion für den einfluss des zellvolumenprocentes (haemoglobin) und über die normalen grenzen der senkungsreaktion. Acta Med Scandinav 1928;68:108.
  • Rourke MD, Ernstene AC. A method for correcting the erythrocyte sedimentation rate for variatons in the cell volume percentage of blood. J Clin Invest 1930;8(4):545-59.
  • Wintrobe MM, Landsberg JW. A standardized technique for the blood sedimentation test. Am J Med Sci 1935;189:102–15.
  • Santhanam S, Mani M, Tamilselvam TN, Sankaralingam R. ESR, uric acid and its correlation with disease activity in SLE - Is it myth or reality! Indian Journal of Rheumatology 2015;9:112-3.
  • Borawski J, Mysliwiec M. The hematocrit-corrected erythrocyte sedimentation rate can be useful in diagnosing inflammation in hemodialysis patients. Nephron 2001;89:381-3.
  • Girish K. Practical manual of hematology. 1st ed. New Delhi: Jaypee Brothers Publishers; 2011.
  • Poole JCF, Summers GAC. Correction of ESR in anaemia: experimental study based on interchange of cells and plasma between normal and anaemic subjects. BMJ 1952;1:353-6.
Primary Language en
Subjects Medicine
Published Date NİSAN 2020
Journal Section Articles
Authors

Orcid: 0000-0003-2055-3537
Author: Seda ÇELİK
Institution: Department of Biochemistry, Faculty of Medicine, University of Kafkas
Country: Turkey


Orcid: 0000-0002-0425-0766
Author: Duygu Mine YAVUZ
Institution: Department of Biochemistry, Faculty of Medicine, University of Kafkas
Country: Turkey


Orcid: 0000-0002-1883-6055
Author: Ergin TAŞKIN
Institution: Department of Biochemistry, Faculty of Medicine, University of Kafkas
Country: Turkey


Orcid: 0000-0003-0979-0996
Author: Fatih BOY
Institution: Department of Biochemistry, Faculty of Medicine, University of Kafkas
Country: Turkey


Orcid: 0000-0002-9729-5380
Author: Fatih KARA (Primary Author)
Institution: Department of Biochemistry, Faculty of Medicine, University of Kafkas
Country: Turkey


Dates

Publication Date : May 11, 2020

Bibtex @research article { kocatepetip581422, journal = {Kocatepe Tıp Dergisi}, issn = {1302-4612}, eissn = {2149-7869}, address = {}, publisher = {Afyonkarahisar Sağlık Bilimleri Üniversitesi}, year = {2020}, volume = {21}, pages = {191 - 194}, doi = {10.18229/kocatepetip.581422}, title = {HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN}, key = {cite}, author = {Çeli̇k, Seda and Yavuz, Duygu Mine and Taşkın, Ergin and Boy, Fatih and Kara, Fatih} }
APA Çeli̇k, S , Yavuz, D , Taşkın, E , Boy, F , Kara, F . (2020). HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN . Kocatepe Tıp Dergisi , 21 (2) , 191-194 . DOI: 10.18229/kocatepetip.581422
MLA Çeli̇k, S , Yavuz, D , Taşkın, E , Boy, F , Kara, F . "HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN" . Kocatepe Tıp Dergisi 21 (2020 ): 191-194 <https://dergipark.org.tr/en/pub/kocatepetip/issue/54261/581422>
Chicago Çeli̇k, S , Yavuz, D , Taşkın, E , Boy, F , Kara, F . "HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN". Kocatepe Tıp Dergisi 21 (2020 ): 191-194
RIS TY - JOUR T1 - HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN AU - Seda Çeli̇k , Duygu Mine Yavuz , Ergin Taşkın , Fatih Boy , Fatih Kara Y1 - 2020 PY - 2020 N1 - doi: 10.18229/kocatepetip.581422 DO - 10.18229/kocatepetip.581422 T2 - Kocatepe Tıp Dergisi JF - Journal JO - JOR SP - 191 EP - 194 VL - 21 IS - 2 SN - 1302-4612-2149-7869 M3 - doi: 10.18229/kocatepetip.581422 UR - https://doi.org/10.18229/kocatepetip.581422 Y2 - 2019 ER -
EndNote %0 Kocatepe Tıp Dergisi HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN %A Seda Çeli̇k , Duygu Mine Yavuz , Ergin Taşkın , Fatih Boy , Fatih Kara %T HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN %D 2020 %J Kocatepe Tıp Dergisi %P 1302-4612-2149-7869 %V 21 %N 2 %R doi: 10.18229/kocatepetip.581422 %U 10.18229/kocatepetip.581422
ISNAD Çeli̇k, Seda , Yavuz, Duygu Mine , Taşkın, Ergin , Boy, Fatih , Kara, Fatih . "HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN". Kocatepe Tıp Dergisi 21 / 2 (May 2020): 191-194 . https://doi.org/10.18229/kocatepetip.581422
AMA Çeli̇k S , Yavuz D , Taşkın E , Boy F , Kara F . HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN. KTD. 2020; 21(2): 191-194.
Vancouver Çeli̇k S , Yavuz D , Taşkın E , Boy F , Kara F . HEMATOCRIT-ADJUSTED ERYTHROCYTE SEDIMENTATION RATE HAS A BETTER CORRELATION WITH C-REACTIVE PROTEIN. Kocatepe Tıp Dergisi. 2020; 21(2): 191-194.