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EVALUATING THE EFFECTS OF PERIODONTAL HEALTH ON IN VITRO FERTILIZATION OUTCOMES

Year 2020, Volume: 21 Issue: 4, 289 - 294, 14.10.2020
https://doi.org/10.18229/kocatepetip.806963

Abstract

OBJECTIVE: This study aims to evaluate the effect of periodontal status, which has been proven to have effects on systemic health, on the outcomes of in vitro fertilization (IVF) treatment which is applied to infertile women.
MATERIAL AND METHODS: Sociodemographic data have been collected from female patients diagnosed with infertility through a questionnaire. On the day of the blood test, plaque index, gingival index, probing depth and bleeding index on probing were measured. Recruited patients were classified into the healthy, gingivitis, and periodontitis groups according to the aforementioned criteria. These groups were compared with respect to human chorionic gonadotropin (hCG) dosage, estradiol and progesterone levels, the number of oocyte and embryos transferred, and pregnancy outcomes. One-way ANOVA, Tukey HDS, Tampane’s T2, Kruskal-Wallis, Mann-Whitney U, and chi-square tests were used in this study.
RESULTS: The three groups were statistically similar in the aspect of retrieved oocytes, transferred embryos and pregnancy outcomes. Although three groups had statistically similar in terms of estradiol levels on the day of hCG administration, progesterone levels were significantly higher in the periodontitis group compared to healthy and gingivitis groups.
CONCLUSIONS: This elevation in progesterone levels observed in the periodontitis group is below the threshold level which could affect the IVF outcomes. Large scale and long-term studies are needed to clarify the effects of periodontal status on IVF outcomes.

References

  • 1. Mariotti A. Dental plaque-induced gingival disease. Ann Periodontol 1999; 4:7-19.
  • 2. Klokkevold PR, Mealey BL. In: Newman MG, Takei HH, Klokkevold PR, Carranza FA, ed. Carranza’s Clinical Periodontology. 11th ed. Elsevier-Saunders; St. Louis, Missouiri: 2012: 304-19.
  • 3. Collins JG, Windley HW, Arnold RR, Offenbacher S. Effects of a Porphyromonas gingivalis infection on inflammatory mediator response and pregnancy outcome in hamsters. Infect Immun 1994; 62(10): 4356-61.
  • 4. Temoin S, Chakaki A, Askari A, et al. Identification of oral bacterial DNA in synovial fluid of patients with arthritis with native and failed prosthetic joints. J Clin Rheumatol 2012; 18: 117–21.
  • 5. Han YW, Ikegami A, Bissada NF, Herbst M, Redline RW, Ashmead GG. Transmission of an uncultivated Bergeyella strain from the oral cavity to amniotic fluid in a case of preterm birth. J Clin Microbiol 2006; 44: 1475–83.294.
  • 6. Goepfert AR, Jeffcoat MK, Andrews WW, et al. Periodontal disease and upper genital tract inflammation in early spontaneous preterm birth. Obstet Gynecol 2004; 104(4): 777-83.
  • 7. Han YW, Fardini Y, Chen C, et al. Term stillbirth caused by oral Fusobacterium nucleatum. Obstet Gynecol 2010; 115: 442–5.
  • 8. Hajishengallis G. Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol 2015; 15(1): 30-44.
  • 9. Kumar A, Basra M, Begum N, et al. Association of maternal periodontal health with adverse pregnancy outcome. J Obstet Gynaecol Res 2013; 39(1): 40-5.
  • 10. Forner L, Larsen T, Kilian M, Holmstrup P. Incidence of bacteremia after chewing, tooth brushing and scaling in individuals with periodontal inflammation. J Clin Periodontol 2006; 33: 401–7.
  • 11. Practice Committee of the American Society for Reproductive Medicine, Definitions of infertility and recurrent pregnancy loss. Fertil Steril 2008; 90(3): 60.
  • 12. Talbert LM, Hammond MG, Shabanowitz R, Bailey LE. Assisted reproductive technologies at the UNC Hospitals. An update. NC Med J 1990; 51: 201.
  • 13. Pavlatou A, Tsami A, Vlahos N, Mantzavinos T, Vrotsos I. The effect of in vitro fertilization on gingival inflammation according to women's periodontal status: clinical data. J Int Acad Periodontol 2013; 15(2): 36-42.
  • 14. Silness J, Löe H. Periodontal disease in pregnancy. II. correletion between oral hygiene and periodontal condition. Acta Odontol Scand 1964; 22: 121-35.
  • 15. Löe H, Silness J. Periodontal disease in pregnancy I.prevelance and severity. Acta Odontol Scand 1963; 21: 531-51.
  • 16. Ainamo J, Bay I. Problems and proposals for recording gingivitis and plaque. Int Dent J 1975; 25(4): 229-35.
  • 17. Gibbons RV, Germs DR. Billings, and the theory of focal infection. Clin Infect Dis 1998;27(3):627-633.
  • 18. Billings F. Focal Infection as the Cause of General Disease. Bull N Y Acad Med 1930;6(12):759-773.
  • 19. Schelegel PN, Girardi SK. In Vitro Fertilization for Male Factor Infertility. J Clin Endocrinol Metab. 1997;82(3): 709-716.
  • 20. Kondapalli LA, Molinaro TA, Sammel MD, Dokras A. A decrease in serum estradiol levels after human chorionic gonadotrophin administration predicts significantly lower clinical pregnancy and live birth rates in in vitro fertilization cycles. Hum Reprod 2012;27(9):2690-2697.
  • 21. Sharma V, Allgar V, Rajkhowa M. Factors influencing the cumulative conception rate and discontinuation of in vitro fertilization treatment for infertility. Fertil Steril 2002;78(1):40-46.
  • 22. Nelson SM, Lawlor DA. Predicting live birth, preterm delivery, and low birth weight in infants born from in vitro fertilisation: a prospective study of 144,018 treatment cycles. PLoS Med 2011;8(1): e1000386.
  • 23. Bu Z, Zhao F, Wang K, et al. Serum progesterone elevation adversely affects cumulative live birth rate in different ovarian responders during in vitro fertilization and embryo transfer: a large retrospective study. PLoS One 2014;9(6):e100011.
  • 24. Li R, Qiao J, Wang L, Zhen X, Lu Y. Serum progesterone concentration on day of HCG administration and IVF outcome. Reprod Biomed Online 2008;16(5): 627-631.
  • 25. Kobayashi T, Okada M, Ito S, et al. Assessment of interleukin-6 receptor inhibition therapy on periodontal condition in patients with rheumatoid arthritis and chronic periodontitis. J Periodontol 2014;85(1):57-67.
  • 26. Zhu Y, Wu M, Wu CY, Xia GQ. Role of progesterone in TLR4-MyD88-dependent signaling pathway in pre-eclampsia. J Huazhong Univ Sci Technolog Med Sci 2013;33(5):730-734.

PERİODONTAL SAĞLIĞIN İN VİTRO FERTİLİZASYON SONUÇLARI ÜZERİNE ETKİSİNİN DEĞERLENDİRİLMESİ

Year 2020, Volume: 21 Issue: 4, 289 - 294, 14.10.2020
https://doi.org/10.18229/kocatepetip.806963

Abstract

AMAÇ: Bu çalışmanın amacı sistemik sağlık üzerinde etkisi kanıtlanmış olan periodontal durumun infertil kadınlarda uygulanan in vitro fertilizasyon tedavisi sonuçları üzerindeki etkisini değerlendirmektir.
GEREÇ VE YÖNTEM: İnfertilite tanısı konmuş kadın hastalardan sosyodemografik veriler bir anket yardımıyla toplanmıştır. Kan testi gününde plak indeksi, gingival indeks, cep derinliği, sondalamada kanama indeksi ölçümleri yapılmıştır. Buna göre; sağlıklı, gingivitisli ve periodontitisli olarak sınıflandırılan hastalar ile kullanılan human chorionic hormon gonadotropin (hCG) dozu, östradiol ve progesteron seviyeleri, transfer edilen embriyo sayıları, oosit sayıları ve gebelik sonuçları karşılaştırılmıştır. Çalışmada, tek yönlü ANOVA, Tukey HDS, Tampane’s T2, Kruskal-Wallis, Mann-Whitney U ve ki-kare testleri kullanılmıştır.
BULGULAR: Gruplar arasında oosit sayıları, transfer edilen embriyo sayıları ve gebelik sonuçları açısından bir farklılık gözlenmemiştir. Gruplar arasında hCG günü östradiol seviyesi açısından bir farklılık gözlenmemesine karşın hCG günü progesteron seviyesi periodontitis grubunda sağlıklı ve gingivitisli gruba göre anlamlı şekilde yüksek bulunmuştur.
SONUÇ: Periodontitis grubunda gözlenen progesteron seviyesindeki yükselme IVF sonucunu etkileyebilecek olan eşik değerin altındadır. Periodontal durumun infertilite tedavisi üzerindeki etki mekanizmasının belirlenmesi için geniş ölçekli ve uzun vadeli çalışmalara ihtiyaç duyulmaktadır.

References

  • 1. Mariotti A. Dental plaque-induced gingival disease. Ann Periodontol 1999; 4:7-19.
  • 2. Klokkevold PR, Mealey BL. In: Newman MG, Takei HH, Klokkevold PR, Carranza FA, ed. Carranza’s Clinical Periodontology. 11th ed. Elsevier-Saunders; St. Louis, Missouiri: 2012: 304-19.
  • 3. Collins JG, Windley HW, Arnold RR, Offenbacher S. Effects of a Porphyromonas gingivalis infection on inflammatory mediator response and pregnancy outcome in hamsters. Infect Immun 1994; 62(10): 4356-61.
  • 4. Temoin S, Chakaki A, Askari A, et al. Identification of oral bacterial DNA in synovial fluid of patients with arthritis with native and failed prosthetic joints. J Clin Rheumatol 2012; 18: 117–21.
  • 5. Han YW, Ikegami A, Bissada NF, Herbst M, Redline RW, Ashmead GG. Transmission of an uncultivated Bergeyella strain from the oral cavity to amniotic fluid in a case of preterm birth. J Clin Microbiol 2006; 44: 1475–83.294.
  • 6. Goepfert AR, Jeffcoat MK, Andrews WW, et al. Periodontal disease and upper genital tract inflammation in early spontaneous preterm birth. Obstet Gynecol 2004; 104(4): 777-83.
  • 7. Han YW, Fardini Y, Chen C, et al. Term stillbirth caused by oral Fusobacterium nucleatum. Obstet Gynecol 2010; 115: 442–5.
  • 8. Hajishengallis G. Periodontitis: from microbial immune subversion to systemic inflammation. Nat Rev Immunol 2015; 15(1): 30-44.
  • 9. Kumar A, Basra M, Begum N, et al. Association of maternal periodontal health with adverse pregnancy outcome. J Obstet Gynaecol Res 2013; 39(1): 40-5.
  • 10. Forner L, Larsen T, Kilian M, Holmstrup P. Incidence of bacteremia after chewing, tooth brushing and scaling in individuals with periodontal inflammation. J Clin Periodontol 2006; 33: 401–7.
  • 11. Practice Committee of the American Society for Reproductive Medicine, Definitions of infertility and recurrent pregnancy loss. Fertil Steril 2008; 90(3): 60.
  • 12. Talbert LM, Hammond MG, Shabanowitz R, Bailey LE. Assisted reproductive technologies at the UNC Hospitals. An update. NC Med J 1990; 51: 201.
  • 13. Pavlatou A, Tsami A, Vlahos N, Mantzavinos T, Vrotsos I. The effect of in vitro fertilization on gingival inflammation according to women's periodontal status: clinical data. J Int Acad Periodontol 2013; 15(2): 36-42.
  • 14. Silness J, Löe H. Periodontal disease in pregnancy. II. correletion between oral hygiene and periodontal condition. Acta Odontol Scand 1964; 22: 121-35.
  • 15. Löe H, Silness J. Periodontal disease in pregnancy I.prevelance and severity. Acta Odontol Scand 1963; 21: 531-51.
  • 16. Ainamo J, Bay I. Problems and proposals for recording gingivitis and plaque. Int Dent J 1975; 25(4): 229-35.
  • 17. Gibbons RV, Germs DR. Billings, and the theory of focal infection. Clin Infect Dis 1998;27(3):627-633.
  • 18. Billings F. Focal Infection as the Cause of General Disease. Bull N Y Acad Med 1930;6(12):759-773.
  • 19. Schelegel PN, Girardi SK. In Vitro Fertilization for Male Factor Infertility. J Clin Endocrinol Metab. 1997;82(3): 709-716.
  • 20. Kondapalli LA, Molinaro TA, Sammel MD, Dokras A. A decrease in serum estradiol levels after human chorionic gonadotrophin administration predicts significantly lower clinical pregnancy and live birth rates in in vitro fertilization cycles. Hum Reprod 2012;27(9):2690-2697.
  • 21. Sharma V, Allgar V, Rajkhowa M. Factors influencing the cumulative conception rate and discontinuation of in vitro fertilization treatment for infertility. Fertil Steril 2002;78(1):40-46.
  • 22. Nelson SM, Lawlor DA. Predicting live birth, preterm delivery, and low birth weight in infants born from in vitro fertilisation: a prospective study of 144,018 treatment cycles. PLoS Med 2011;8(1): e1000386.
  • 23. Bu Z, Zhao F, Wang K, et al. Serum progesterone elevation adversely affects cumulative live birth rate in different ovarian responders during in vitro fertilization and embryo transfer: a large retrospective study. PLoS One 2014;9(6):e100011.
  • 24. Li R, Qiao J, Wang L, Zhen X, Lu Y. Serum progesterone concentration on day of HCG administration and IVF outcome. Reprod Biomed Online 2008;16(5): 627-631.
  • 25. Kobayashi T, Okada M, Ito S, et al. Assessment of interleukin-6 receptor inhibition therapy on periodontal condition in patients with rheumatoid arthritis and chronic periodontitis. J Periodontol 2014;85(1):57-67.
  • 26. Zhu Y, Wu M, Wu CY, Xia GQ. Role of progesterone in TLR4-MyD88-dependent signaling pathway in pre-eclampsia. J Huazhong Univ Sci Technolog Med Sci 2013;33(5):730-734.
There are 26 citations in total.

Details

Primary Language Turkish
Subjects Clinical Sciences
Journal Section Articles
Authors

Nurcan Altaş This is me 0000-0001-7439-5015

Hilal Uslu Toygar This is me 0000-0001-7409-1484

Ülkem Cilasun This is me 0000-0002-0131-2933

Banu Kumbak Aygün This is me 0000-0002-3428-7359

Becen Demir This is me 0000-0001-7771-2602

Publication Date October 14, 2020
Acceptance Date December 5, 2019
Published in Issue Year 2020 Volume: 21 Issue: 4

Cite

APA Altaş, N., Uslu Toygar, H., Cilasun, Ü., Kumbak Aygün, B., et al. (2020). PERİODONTAL SAĞLIĞIN İN VİTRO FERTİLİZASYON SONUÇLARI ÜZERİNE ETKİSİNİN DEĞERLENDİRİLMESİ. Kocatepe Tıp Dergisi, 21(4), 289-294. https://doi.org/10.18229/kocatepetip.806963
AMA Altaş N, Uslu Toygar H, Cilasun Ü, Kumbak Aygün B, Demir B. PERİODONTAL SAĞLIĞIN İN VİTRO FERTİLİZASYON SONUÇLARI ÜZERİNE ETKİSİNİN DEĞERLENDİRİLMESİ. KTD. October 2020;21(4):289-294. doi:10.18229/kocatepetip.806963
Chicago Altaş, Nurcan, Hilal Uslu Toygar, Ülkem Cilasun, Banu Kumbak Aygün, and Becen Demir. “PERİODONTAL SAĞLIĞIN İN VİTRO FERTİLİZASYON SONUÇLARI ÜZERİNE ETKİSİNİN DEĞERLENDİRİLMESİ”. Kocatepe Tıp Dergisi 21, no. 4 (October 2020): 289-94. https://doi.org/10.18229/kocatepetip.806963.
EndNote Altaş N, Uslu Toygar H, Cilasun Ü, Kumbak Aygün B, Demir B (October 1, 2020) PERİODONTAL SAĞLIĞIN İN VİTRO FERTİLİZASYON SONUÇLARI ÜZERİNE ETKİSİNİN DEĞERLENDİRİLMESİ. Kocatepe Tıp Dergisi 21 4 289–294.
IEEE N. Altaş, H. Uslu Toygar, Ü. Cilasun, B. Kumbak Aygün, and B. Demir, “PERİODONTAL SAĞLIĞIN İN VİTRO FERTİLİZASYON SONUÇLARI ÜZERİNE ETKİSİNİN DEĞERLENDİRİLMESİ”, KTD, vol. 21, no. 4, pp. 289–294, 2020, doi: 10.18229/kocatepetip.806963.
ISNAD Altaş, Nurcan et al. “PERİODONTAL SAĞLIĞIN İN VİTRO FERTİLİZASYON SONUÇLARI ÜZERİNE ETKİSİNİN DEĞERLENDİRİLMESİ”. Kocatepe Tıp Dergisi 21/4 (October 2020), 289-294. https://doi.org/10.18229/kocatepetip.806963.
JAMA Altaş N, Uslu Toygar H, Cilasun Ü, Kumbak Aygün B, Demir B. PERİODONTAL SAĞLIĞIN İN VİTRO FERTİLİZASYON SONUÇLARI ÜZERİNE ETKİSİNİN DEĞERLENDİRİLMESİ. KTD. 2020;21:289–294.
MLA Altaş, Nurcan et al. “PERİODONTAL SAĞLIĞIN İN VİTRO FERTİLİZASYON SONUÇLARI ÜZERİNE ETKİSİNİN DEĞERLENDİRİLMESİ”. Kocatepe Tıp Dergisi, vol. 21, no. 4, 2020, pp. 289-94, doi:10.18229/kocatepetip.806963.
Vancouver Altaş N, Uslu Toygar H, Cilasun Ü, Kumbak Aygün B, Demir B. PERİODONTAL SAĞLIĞIN İN VİTRO FERTİLİZASYON SONUÇLARI ÜZERİNE ETKİSİNİN DEĞERLENDİRİLMESİ. KTD. 2020;21(4):289-94.

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