EVALUATING THE EFFECTS OF PERIODONTAL HEALTH ON IN VITRO FERTILIZATION OUTCOMES

Year 2020, Volume: 21 Issue: 4, 289 - 294, 14.10.2020

Nurcan Altaş Hilal Uslu Toygar Ülkem Cilasun Banu Kumbak Aygün Becen Demir

https://doi.org/10.18229/kocatepetip.806963

Abstract

OBJECTIVE: This study aims to evaluate the effect of periodontal status, which has been proven to have effects on systemic health, on the outcomes of in vitro fertilization (IVF) treatment which is applied to infertile women.
MATERIAL AND METHODS: Sociodemographic data have been collected from female patients diagnosed with infertility through a questionnaire. On the day of the blood test, plaque index, gingival index, probing depth and bleeding index on probing were measured. Recruited patients were classified into the healthy, gingivitis, and periodontitis groups according to the aforementioned criteria. These groups were compared with respect to human chorionic gonadotropin (hCG) dosage, estradiol and progesterone levels, the number of oocyte and embryos transferred, and pregnancy outcomes. One-way ANOVA, Tukey HDS, Tampane’s T2, Kruskal-Wallis, Mann-Whitney U, and chi-square tests were used in this study.
RESULTS: The three groups were statistically similar in the aspect of retrieved oocytes, transferred embryos and pregnancy outcomes. Although three groups had statistically similar in terms of estradiol levels on the day of hCG administration, progesterone levels were significantly higher in the periodontitis group compared to healthy and gingivitis groups.
CONCLUSIONS: This elevation in progesterone levels observed in the periodontitis group is below the threshold level which could affect the IVF outcomes. Large scale and long-term studies are needed to clarify the effects of periodontal status on IVF outcomes.

Keywords

Gingivitis,, Infertility,, In vitro fertilization,

PERİODONTAL SAĞLIĞIN İN VİTRO FERTİLİZASYON SONUÇLARI ÜZERİNE ETKİSİNİN DEĞERLENDİRİLMESİ

Abstract

AMAÇ: Bu çalışmanın amacı sistemik sağlık üzerinde etkisi kanıtlanmış olan periodontal durumun infertil kadınlarda uygulanan in vitro fertilizasyon tedavisi sonuçları üzerindeki etkisini değerlendirmektir.
GEREÇ VE YÖNTEM: İnfertilite tanısı konmuş kadın hastalardan sosyodemografik veriler bir anket yardımıyla toplanmıştır. Kan testi gününde plak indeksi, gingival indeks, cep derinliği, sondalamada kanama indeksi ölçümleri yapılmıştır. Buna göre; sağlıklı, gingivitisli ve periodontitisli olarak sınıflandırılan hastalar ile kullanılan human chorionic hormon gonadotropin (hCG) dozu, östradiol ve progesteron seviyeleri, transfer edilen embriyo sayıları, oosit sayıları ve gebelik sonuçları karşılaştırılmıştır. Çalışmada, tek yönlü ANOVA, Tukey HDS, Tampane’s T2, Kruskal-Wallis, Mann-Whitney U ve ki-kare testleri kullanılmıştır.
BULGULAR: Gruplar arasında oosit sayıları, transfer edilen embriyo sayıları ve gebelik sonuçları açısından bir farklılık gözlenmemiştir. Gruplar arasında hCG günü östradiol seviyesi açısından bir farklılık gözlenmemesine karşın hCG günü progesteron seviyesi periodontitis grubunda sağlıklı ve gingivitisli gruba göre anlamlı şekilde yüksek bulunmuştur.
SONUÇ: Periodontitis grubunda gözlenen progesteron seviyesindeki yükselme IVF sonucunu etkileyebilecek olan eşik değerin altındadır. Periodontal durumun infertilite tedavisi üzerindeki etki mekanizmasının belirlenmesi için geniş ölçekli ve uzun vadeli çalışmalara ihtiyaç duyulmaktadır.

Keywords

Gingivit,İnfertilite, İn vitro fertilizasyon, Periodontit,

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