THE EVALUATION OF DEPRESSION AND SOCIAL ANXIETY AMONG CHILDREN WITH CELIAC DISEASE

Year 2021, Volume: 22 Issue: 4, 261 - 266, 01.07.2021

Ayşegül Bükülmez , Ayşe Tolunay Oflu , Erdem İçiğen Lütfi Molon , Tuğba Koca

https://doi.org/10.18229/kocatepetip.763911

Abstract

OBJECTIVE: Depression and anxiety levels adult patients with celiac disease (CD) have been investigated and conflicting results have been reported. However, there are limited studies on the association of CD with depression and anxiety in pediatric patients. The aim of this study was to investigate the presence of a tendency toward depression and social anxiety in children with CD.
MATERIAL AND METHODS: Patients aged between 8-14 years old and who had a gluten-free diet for at least one year and healthy controls within the same age group were included in this study. All participants were administered the Children Depression Inventory (CDI) and Social Anxiety Scale-Revised (SASC-R). 45 children with celiac disease and 45 healthy children were included in this study.
RESULTS: The mean age of the experimental group was 11.6 ± 2.4 years old and 76% were female. The mean age of the control group was 12,0±2.1 years old and 62% were female. No significant differences were found between children with CD and healthy controls in terms of CDI and SASC-R scores. Anxiety levels of the patients whose adherence to the diet was good were found to be higher.
CONCLUSIONS: This study showed that the incidences of depression and social anxiety were not different from healthy children as similar to previous studies in children with CD.

Keywords

depression,, celiac disease,, social anxiety,

ÇÖLYAK HASTALIĞI OLAN ÇOCUKLARDA DEPRESYON VE SOSYAL ANKSİYETENİN DEĞERLENDİRİLMESİ

Abstract

AMAÇ: Çölyak hastalığı (ÇH) olan erişkin hastalarda depresyon ve anksiyete düzeyi araştırılmış ve çelişkili sonuçlar bildirilmiştir. Öte yandan çocuk hastalarda ÇH ile depresyon ve anksiyete birlikteliği ile ilgili sınırlı sayıda çalışma bulunmaktadır. Bu çalışmanın amacı ÇH olan çocuklarda depresyon ve sosyal anksiyeteye eğilimin varlığını araştırmaktır.
GEREÇ VE YÖNTEM: Bu çalışmaya en az bir yıldır glutensiz diyet alan 8 - 14 yaş grubundaki hastalar ile aynı yaş grubundaki sağlıklı kontroller dahil edilmiştir. Tüm katılımcılara Çocuklar için Depresyon Ölçeği (ÇİDÖ) = CDI ve Sosyal Anksiyete Ölçeği (ÇSAÖ-Y) = SASC-R uygulandı. Bu çalışmaya 45 çölyak hastalığı olan çocuk ve 45 sağlıklı çocuk dahil edildi.
BULGULAR: Çalışma grubunun yaş ortalaması 11.6±2,4 yıl idi ve %76’sı kızdı. Kontrol grubunun yaş ortalaması 12,0±2,1 yıl idi ve %62’isi kızdı. ÇH olan çocuklarla sağlıklı kontroller arasında hem CDI hem SASC-R de skoru açısından anlamlı farklılık saptanmadı. Diyet uyumu iyi olan hastaların anksiyete düzeylerinin daha yüksek olduğu saptandı.
SONUÇ: Bu çalışma göstermiştir ki daha önce yapılan çalışmalara benzer şekilde ÇH olan çocuklarda depresyon ve sosyal anksiyete sıklığı sağlıklı çocuklardan farklı değildir.

Keywords

cölyak hastalığı,, depresyon,, sosyal anksiyete,

References

• 1. Rubio-Tapia A, Hill ID, Kelly CP, et al. ACG Clinical Guidelines: Diagnosis and Management of Celiac Disease. American Journal of Gastroenterology 2013;108(5):656.
• 2. Smith LB, Lynch KF, Kurppa K, et al. Psychological Manifestations of Celiac Disease Autoimmunity in Young Children. Pediatrics 2017;139(3):e20162848.
• 3. Husby S, Koletzko S, Korponay-Szabó IR, et al. European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac Disease: Journal of Pediatric Gastroenterology and Nutrition 2012;54(1):136–160.
• 4. Campagna G, Pesce M, Tatangelo R, et al. The progression of coeliac disease: its neurological and psychiatric implications. Nutr Res Rev 2017;30(1):25–35.
• 5. Jafari SMA, Talebi S, Mostafavi N, et al. Quality Of Life in Children with Celiac Disease: A Cross-sectional Study. International Journal of Pediatrics 2017; 5(7):5339-5349.
• 6. Kovacs M. Rating scales to assess depression in school-aged children. Acta Paedopsychiatr 1981;46(5–6):305–315.
• 7. Oy B. Cocukluk depresyonu derecelendirme olceği: Sağlıklı ve çocuk ruh sağlığı kliniğine başvuran çocuklarda uygulanması. Turk Psikiyatri Derg 1991;2(2):137-140.
• 8. Greca AML, Dandes SK, Wick P, et al. Development of the Social Anxiety Scale for Children: Reliability and Concurrent Validity. Journal of Clinical Child Psychology 1988;17(1):84–91.
• 9. Greca AML, Stone WL. Social Anxiety Scale for Children-Revised: Factor Structure and Concurrent Validity. Journal of Clinical Child Psychology 1993;22(1):17–27.
• 10. Demir T, Eralp-Demir D, Türksoy N, et al. Çocuklar İçin Sosyal Anksiyete Ölçeğinin geçerlilik ve güvenilirliği. Düşünen Adam 2000; 13(1):42-48.
• 11. Fidan T, Ertekin V, Karabağ K. Depression-anxiety levels and the quality of life among children and adolescents with coeliac disease. Dusunen Adam 2013;26(3):232–238.
• 12. Esenyel S, Unal F, Vural P. Depression and anxiety in child and adolescents with follow-up celiac disease and in their families. Turk J Gastroenterol 2014;25(4):381–385.
• 13. Simsek S, Baysoy G, Gencoglan S, et al. Effects of Gluten-Free Diet on Quality of Life and Depression in Children With Celiac Disease. Journal of Pediatric Gastroenterology and Nutrition 2015;61(3):303.
• 14. Ruggieri M, Incorpora G, Polizzi A, et al. Prevalence of Neurologic and Psychiatric Manifestations in Children with Gluten Sensitivity. The Journal of Pediatrics 2008;152(2):244-249.
• 15. Mazzone L, Reale L, Spina M, et al. Compliant gluten-free children with celiac disease: an evaluation of psychological distress. BMC Pediatr 2011;11(1):46.
• 16. Pynnönen PA, Isometsä ET, Aronen ET, et al. Mental disorders in adolescents with celiac disease. Psychosomatics 2004;45(4):325–335.
• 17. Pynnönen PA, Isometsä ET, Verkasalo MA, et al. Gluten-free diet may alleviate depressive and behavioural symptoms in adolescents with coeliac disease: a prospective follow-up case-series study. BMC Psychiatry 2005;5(1):14.
• 18. Smith DF, Gerdes LU. Meta-analysis on anxiety and depression in adult celiac disease. Acta Psychiatr Scand 2012;125(3):189–193.
• 19. Addolorato G, Mirijello A, D’Angelo C, et al. State and trait anxiety and depression in patients affected by gastrointestinal diseases: psychometric evaluation of 1641 patients referred to an internal medicine outpatient setting. Int J Clin Pract 2008;62(7):1063–1069.
• 20. Ciacci C, Iovino P, Amoruso D, et al. Grown-up coeliac children: the effects of only a few years on a gluten-free diet in childhood. Aliment Pharmacol Ther 2005;21(4):421–429.
• 21. Ciacci C, Iavarone A, Mazzacca G, et al. Depressive symptoms in adult coeliac disease. Scand J Gastroenterol 1998;33(3):247–250.
• 22. Häuser W, Janke K-H, Klump B, et al. Anxiety and depression in adult patients with celiac disease on a gluten-free diet. World J Gastroenterol 2010;16(22):2780–2787.
• 23. Ludvigsson JF, Lebwohl B, Chen Q, et al. Anxiety after coeliac disease diagnosis predicts mucosal healing: a population-based study. Aliment Pharmacol Ther 2018;48(10):1091–1098.