BLOOD LIPID PROFILE IN PRIMARY OPEN-ANGLE GLAUCOMA: A BIOCHEMICAL ANALYSIS STUDY

Year 2021, Volume: 22 Issue: 6, 439 - 444, 18.10.2021

Leyla Eryiğit Eroğul Murat Kaşıkcı Özgür Eroğul Hamidu Gobeka

https://doi.org/10.18229/kocatepetip.772149

Abstract

ABSTRACT
OBJECTIVE: Investigation of blood lipid profile in primary open-angle glaucoma (POAG).
MATERIAL AND METHODS: In this study, there were 100 participants, of whom 50 were patients with POAG and 50 were non-POAG patients consulted in the ophthalmology clinic. Levels of blood lipids including total cholesterol, low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglyceride (TG) were investigated. Data were compared with t-test, Mann Whitney U, Fischer correlation and Chi-square test. p<0.05 was considered statistically significant.
RESULTS: While the mean age of the POAG patients was 65.7±11.09 years, the mean age of the non-POAG patients was 66.2±10.44 years. The normal reference ranges for laboratory tests in this study were 0-200 mg/dl for total cholesterol, 0-130 mg/dl for LDL, 35-70 mg/dl for HDL, and 35-160 mg/dl for TGs. The blood lipid levels in POAG and non-POAG patients were as following: total cholesterol 199±47 mg/dl and 202±46 mg/dl (p>0.05), LDL 114±37 mg/dl and 112±43 37 mg/dl (p>0.05), HDL 51±14 mg/dl and 54±19mg/dl (p>0.05), and TG 170±69 mg/dl and 146±102 mg/dl (p<0.05), respectively.
CONCLUSIONS: In this study, no statistically significant difference was found between POAG and non-POAG patients regarding total cholesterol, LDL, and HDL levels. Yet, changes in the blood lipid profile may be associated with not only the patients' age but also prevalent systemic diseases. The present study demonstrated a remarkable finding that the level of TG was hig

Keywords

Blood lipid profile, Primary open-angle glaucoma, Triglyceride

Supporting Institution

The study did not receive any financial support.

PRİMER AÇIK AÇILI GLOKOMDA KAN LİPİD PROFİLİ: BİR BİYOKİMYASAL ANALİZ ÇALIŞMASI

Abstract

AMAÇ: Primer açık açılı glokomda (POAG) kan lipit profilinin araştırılması.
GEREÇ VE YÖNTEM: Bu çalışmada, 50'si POAG hastası ve 50'si POAG olmayan hasta olmak üzere oftalmoloji kliniğine başvuran 100 katılımcı vardı. Total kolesterol, düşük yoğunluklu lipoprotein (LDL), yüksek yoğunluklu lipoprotein (HDL) ve trigliserit (TG) dahil olmak üzere kan lipit seviyeleri araştırıldı. Veriler t testi, Mann Whitney U, Fischer korelasyonu ve Ki-kare testi ile karşılaştırıldı. p <0,05 istatistiksel olarak anlamlı kabul edildi.
BULGULAR: POAG hastalarının yaş ortalaması 65.7 ± 11.09 iken POAG olmayan hastaların yaş ortalaması 66.2 ± 10.44 idi. Çalışmada kullanılan laboratuvar testlerinin normal sınırları total kolesterol için 0-200 mg / dl, LDL için 0-130 mg / dl, HDL için 35-70 mg / dl ve TG'ler için 35-160 mg / dl idi. POAG ve POAG dışı hastalarda sırası ile kan lipit düzeyleri; total kolesterol: 199 ± 47 mg / dl ve 202 ± 46 mg / dl (p> 0.05), LDL: 114 ± 37 mg / dl ve 112 ± 43 37 mg / dl (p> 0.05), HDL: 51 ± 14 mg / dl ve 54 ± 19mg / dl (p> 0.05) ve TG: 170 ± 69 mg / dl ve 146 ± 102 mg / dl (p <0.05) idi.
SONUÇ: Bu çalışmada POAG ve POAG olmayan hastalar arasında total kolesterol, LDL ve HDL düzeyleri açısından fark bulunmadı. Bununla birlikte, kan lipit profilindeki değişiklikler sadece hastaların yaşı ile değil, aynı zamanda yaygın sistemik hastalıklarla da ilişkili olabilir. Bu çalışma POAG hastalarında TG düzeyinin genel popülasyona göre daha yüksek olduğunu dikkat çekici bir bulgu olarak göstermiştir.

Keywords

Kan lipit profili, Primer açık açılı glokom, Trigliserit

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