SİSTEMİK İMMÜN-İNFLAMASYON İNDEKSİNİN TUBAL EKTOPİK GEBELİKTEKİ ROLÜ

Year 2024, Volume: 25 Issue: 1 - OCAK 2024 SAYISI, 70 - 75, 17.01.2024

Özlem Erten , Cenk Soysal

https://doi.org/10.18229/kocatepetip.1207403

Abstract

AMAÇ: Çalışmamızda, ektopik gebelik tanısı konan gebeler ile sağlıklı gebeler arasında hematolojik inflamasyon parametrelerinden sistemik immün inflamasyon indeksinin (SII) karşılaştırılması amaçlanmıştır.
GEREÇ VE YÖNTEM: Bu retrospektif vaka kontrol çalışması Temmuz 2021 – Ekim 2022 tarihleri arasında üçüncü basamak Eğitim Araştırma Hastanesi’nde yapıldı. 55 tubal toplam ektopik gebeliği olan gebeler ve 106 sağlıklı gebe olmak üzere 161 hasta dahil edildi. Hastaların demografik bilgileri ve laboratuar parametreleri kaydedildi. Hastalar tubal ektopik gebelik ve kontrol grubu olmak üzere iki gruba ayrılıp SII, monosit lenfosit oranı (MLR), nötrofil lenfosit oranı (NLR) ve platelet lenfosit oranı (PLR) inflamasyon markerları açısından karşılaştırıldı. SII değeri şu şekilde hesaplandı: trombosit sayısı x (nötrofil/lenfosit).
BULGULAR: Sağlıklı gebelerle karşılaştırıldığında SII, NLR, PLR ve MLR açısıdan ektopik gebelik grubunda anlamlı bir fark bulunmadı (p=0.308, p=0.216, p=0.124 ve p=0.071). Tubal ektopik gebelik grubu incelendiğinde rüptüre ektopik gebeliklerde rüptüre olmayan tubal ektopik gebeliklere göre SII, NLR ve PLR’de anlamlı değişim olmaz iken (p=0.706, 0.354, 0.071) ve MLR düzeyinde azalma bulundu (p=0.018).
SONUÇ: Ektopik gebelikteki inflamatuar süreç literatürde sınırlı sayıda çalışma ile halen tartışılmakla birlikte çalışmamızın sonucu olarak tubal ektopik gebelikte SII, NLR, PLR düzeyleri sağlıklı gebelikere göre değişmezken rüptüre ektopik gebeliklerde MLR düzeyinin azaldığını ortaya koyduk.

Keywords

Ektopik gebelik, Tam kan sayımı, İnflamasyon

THE ROLE OF THE SYSTEMIC IMMUNE-INFLAMMATION INDEX IN TUBAL ECTOPIC PREGNANCY

Abstract

OBJECTIVE: In our study, it was aimed to compare the systemic immune-inflammation index (SII), one of the inflammation parameters, between pregnant women diagnosed with ectopic pregnancy and healthy pregnant women.
MATERIAL AND METHODS: This retrospective case-control study was conducted at a tertiary education and research hospital between July 2021 and October 2022. A total of 161 patients, which 55 pregnant women with tubal ectopic pregnancies and 106 healthy pregnant women were included. Demographic information and laboratory parameters of the patients were recorded. The patients were divided into two groups as tubal ectopic pregnancy and control group and compared in terms of SII, monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) inflammation markers. The SII value was calculated as: platelet count x (neutrophil/lymphocyte).
RESULTS: No significant difference was found in the ectopic pregnancy group in terms of SII, NLR, PLR and MLR when compared with healthy pregnant women (p=0.308, p=0.216, p=0.124 and p=0.071). When the tubal ectopic pregnancy group was examined, there was no significant change in SII, NLR and PLR in ruptured ectopic pregnancies compared to non-ruptured tubal ectopic pregnancies (p=0.706, 0.354, 0.071) and a decrease in MLR levels was found (p=0.018).
CONCLUSIONS: Although the inflammatory process in ectopic pregnancy is still being discussed with a limited number of studies in the literature, as a result of our study, we revealed that SII, NLR, PLR levels did not change in tubal ectopic pregnancy compared to healthy pregnancies, while MLR levels decreased in ruptured ectopic pregnancies.

Keywords

Ectopic pregnancy, Complete blood count, Inflammation

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