Abstract
Kaposi sarkomu (KS) endotel kaynaklı anjiyo-proliferatif bir hastalıktır. Dört ana KS türü vardır; klasik, endemik, iyatrojenik (transplantasyonla ilişkili KS) ve HIV ile ilişkili. Hastalık daha çok mukokutanöz bölgelerde ortaya çıksa da; yüz, gövde, alt ekstremitelerin derisi ve genital bölge sıklıkla tutulur. KS ürogenital sistemde en çok peniste görülse de skrotal hastalık nadirdir. 68 yaşında erkek hasta, skrotumda mavi-mor lezyonlarla dermatoloji kliniğine başvurdu. Doku biyopsisi sonucu 'Klasik Kaposi Sarkomu' olarak sonuçlanınca tıbbi onkoloji kliniğimize sevk edildi. Serolojik testi HIV negatifti ancak merkezimizde Human Herpes Virus (HHV) 8 testi yoktu. Hasta on gün boyunca günlük 300 cGy küratif radyoterapi aldı. Komplikasyon olarak tedavi alanında lokalize dermatit ve minimal lenfosel gelişti. Bu lezyonlar lokal semptomatik tedavi ile birkaç gün içinde düzeldi. Tedaviyi tamamladıktan üç ay sonra rezidü KS yoktu. Hastanın takibi nükssüz olarak devam etmektedir. Epidemik ve HIV ile ilişkili KS sıklıkla ürogenital yolu tutsa da, klasik KS nadiren görülür. KS en çok peniste görülürken skrotum yerleşimi çok nadirdir. Literatürde HIV pozitif ve negatif hastalardan oluşan toplam 9 hasta bildirilmiştir. Bildiğimiz kadarıyla bizim olgumuz HIV negatif bir hastada tanımlanan 4. skrotal KS hastasıdır.
Keywords
References
- 1. Wang HW, Trotter MWB, Lagos D, et al. Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma. Nat Genet. 2004;36(7):687-93.
- 2. Feller L, Lemmer J, Wood NH, et al. HIV-associated oral Kaposi sarcoma and HHV-8: a review. J Int Acad Periodontol . 2007;9(4):129-36.
- 3. Lager I, Altini M, Coleman H, et al. Oral Kaposi’s sarcoma: A clinicopathologic study from South Africa. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;96(6):701-10.
- 4. Hansen A, Boshoff C, Lagos D. Kaposi sarcoma as a model of oncogenesis and cancer treatment. Expert Rev Anticancer Ther. 2007;7(2):211-20.
- 5. Mitsuyasu RT. Clinical variants and staging of Kaposi’s sarcoma. Semin Oncol. 1987;14(3):13-8.
- 6. Braun M. Classics in Oncology. Idiopathic multiple pigmented sarcoma of the skin by Kaposi. CA Cancer J Clin. 1982;32(6):340-7.
- 7. Ozmen H, Baba D, Kacagan C, et al. Case report: HIV negative isolated scrotal Kaposi’s sarcoma. Int J Surg Case Rep. 2014;5(12):1086-7.
- 8. Vyas S, Manabe T, Herman JR, et al. Kaposi’s sarcoma of scrotum. Urology. 1976;8(1):82-5.
- 9. Gümüşay Ö, Şen TA, Alıcı Ö, et al. HIV Negatif Olguda Skrotal Kaposi Sarkomu. Gaziosmanpaşa Üniversitesi Tıp Fakültesi Derg. 2015;(3):241-245.
- 10. Yenice MG, Varnalı E, Şeker KG, et al. Scrotal Kaposi’s Sarcoma in HIV-negative patient: A case report and review of the literature. Turkish J Urol. 2018;44(2):182-4
Abstract
Kaposi sarcoma (KS) is an endothelial originated angio-proliferative disease. There are four main types of KS; classic, endemic, iatrogenic (transplantation associated KS) and HIV-associated. Even if the disease mostly occurs in mucocutaneous sites; face, trunk, the skin of the lower extremities, and genitalia frequently involved. Even KS is mostly seen in the penis in the urogenital system, the scrotal disease is rare. A 68-year-old male was admitted to the dermatology clinic with blue-purple lesions on the scrotum. He was referred to our medical oncology clinic when tissue biopsy was resulted as ‘Classical Kaposi Sarcoma’. His serologic test was negative for HIV Human Herpes Virus but (HHV-8) test was not available at our center. The patient received curative radiotherapy daily 300 cGy for ten days. Localize dermatitis and minimal lymphocele developed on the treatment field as a complication. These lesions recovered in a few days with local symptomatic treatment. There was no residual KS after the three months completed the therapy. The patients’ follow-up continues as free of recurrence. Although epidemic and HIV-associated KS frequently involved urogenital tract, classic KS is rarely seen. The KS is mostly seen in the penis while scrotum localization is very rare. In the literature, a total number of 9 patients which are composed by HIV positive and negative patients is reported. To the best our knowledge, our case is 4th scrotal KS patient described in an HIV-negative patient.
Keywords
References
- 1. Wang HW, Trotter MWB, Lagos D, et al. Kaposi sarcoma herpesvirus-induced cellular reprogramming contributes to the lymphatic endothelial gene expression in Kaposi sarcoma. Nat Genet. 2004;36(7):687-93.
- 2. Feller L, Lemmer J, Wood NH, et al. HIV-associated oral Kaposi sarcoma and HHV-8: a review. J Int Acad Periodontol . 2007;9(4):129-36.
- 3. Lager I, Altini M, Coleman H, et al. Oral Kaposi’s sarcoma: A clinicopathologic study from South Africa. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003;96(6):701-10.
- 4. Hansen A, Boshoff C, Lagos D. Kaposi sarcoma as a model of oncogenesis and cancer treatment. Expert Rev Anticancer Ther. 2007;7(2):211-20.
- 5. Mitsuyasu RT. Clinical variants and staging of Kaposi’s sarcoma. Semin Oncol. 1987;14(3):13-8.
- 6. Braun M. Classics in Oncology. Idiopathic multiple pigmented sarcoma of the skin by Kaposi. CA Cancer J Clin. 1982;32(6):340-7.
- 7. Ozmen H, Baba D, Kacagan C, et al. Case report: HIV negative isolated scrotal Kaposi’s sarcoma. Int J Surg Case Rep. 2014;5(12):1086-7.
- 8. Vyas S, Manabe T, Herman JR, et al. Kaposi’s sarcoma of scrotum. Urology. 1976;8(1):82-5.
- 9. Gümüşay Ö, Şen TA, Alıcı Ö, et al. HIV Negatif Olguda Skrotal Kaposi Sarkomu. Gaziosmanpaşa Üniversitesi Tıp Fakültesi Derg. 2015;(3):241-245.
- 10. Yenice MG, Varnalı E, Şeker KG, et al. Scrotal Kaposi’s Sarcoma in HIV-negative patient: A case report and review of the literature. Turkish J Urol. 2018;44(2):182-4
Details
| Primary Language | English |
|---|---|
| Subjects | Clinical Sciences |
| Journal Section | Case Report |
| Authors | |
| Publication Date | July 16, 2025 |
| Acceptance Date | November 26, 2023 |
| Published in Issue | Year 2025 Volume: 26 Issue: 3 |
