VÜCUT KİTLE İNDEKSİ, ADİPONEKTİN VE CRP'NİN PREMENOPOZAL KADINLARDA MİGREN SIKLIĞI VE ŞİDDETİNE ETKİSİ

Year 2025, Volume: 26 Issue: 4, 341 - 346, 13.10.2025

Elif Simin Issı , Şule Bilen , Sevilay Sezer

https://doi.org/10.18229/kocatepetip.1575737

Abstract

AMAÇ: Enflamasyon, migren için olası bir mekanizma olarak araştırılmaktadır. Obezite ve adipokinlerin enflamasyondaki rolü ve migrenle ilişkisi üzerine birçok çalışma yürütülmektedir. Bu çalışmada amacımız, premenopozal kadınlarda interiktal dönemde plazma adiponektin (ADP) düzeyleri, vücut kitle indeksi (VKİ) ve C-reaktif protein (CRP) ile migren ataklarının sıklığı ve şiddeti arasındaki ilişkiyi belirlemektir.
GEREÇ VE YÖNTEM: Çalışmaya 38 ayaktan tedavi gören premenopozal kadın ve yaş uyumlu 32 sağlıklı kontrol dahil edilmiştir. Hastalara Uluslararası Başağrısı Derneği kriterlerine göre migren tanısı konulmuştur. Hastaların baş ağrısız dönemdeki CRP, ADP düzeyleri, lökosit sayıları ve VKİ değerleri kontrol grubu ile karşılaştırılmıştır.
BULGULAR: VKİ ve CRP düzeylerinin hasta ve kontrol grubunda karşılaştırılmasında pozitif ve istatistiksel olarak anlamlı bir korelasyon gözlenmiştir (sırasıyla p=0.01, p=0.03). Her iki grupta da VKİ ve ADP düzeylerinin karşılaştırılmasında bir korelasyon saptanmamıştır (kontroller için p=0.053, hastalar için p=0.285). Migren atak sıklığının hastaların VKİ, CRP ve ADP düzeyleri ile karşılaştırılmasında istatistiksel olarak anlamlı bir ilişki bulunmamıştır (sırasıyla p=0.669, p=0.989, p=0.201). VKİ ile ağrı şiddeti arasında pozitif ve anlamlı bir ilişki saptanmıştır (p=0.017). CRP, ADP ve ağrı şiddeti arasında ise ilişki bulunamamıştır (sırasıyla p=0.827, p=0.359).
SONUÇ: Bir enflamasyon belirteci olan CRP, VKİ'nin artışı ile ilişkili olarak artmaktadır. Yüksek VKİ, şiddetli migren ataklarını destekleyebilir. Sonuç olarak, kilo alımını önlemek ve kilo vermeyi önermek, şiddetli baş ağrısı ataklarını yönetmede terapötik bir yol olabilir.

Keywords

Adiponektin , Vücut kitle indeksi , C-reaktif protein , Migren , Premenopozal periyot

THE IMPACT OF BODY MASS INDEX, ADIPONECTIN AND C-REACTIVE PROTEIN ON FREQUENCY AND SEVERITY OF MIGRAINE ATTACKS IN PREMENOPAUSAL WOMEN

Abstract

OBJECTIVE: Inflammation has been investigated as a possible mechanism for underlying migraine. Many studies continue to be conducted on the role of obesity and adipokines in inflammation and their relationship with migraine. Our objective was to determine the relationship between plasma adiponectin (ADP) levels, body mass index (BMI), and C-reactive protein (CRP), with the frequency and severity of migraine attacks in premenopausal women during the interictal period.
MATERIAL AND METHODS: The study included 38 premenopausal women receiving outpatient treatment for migraine and 32 age-matched healthy controls. The patients were diagnosed with migraine according to the International Headache Society criteria. The patients' CRP, ADP levels, leukocyte counts during the headache-free period, and BMI were compared with those of the control group.
RESULTS: A positive and statistically significant correlation was observed in the comparison of BMI and CRP levels in both the patient and control groups (p=0.01, p=0.03, respectively). No correlation could be established in terms of the comparison of BMI and ADP levels in either group (p=0.053 for controls, p=0.285 for patients). No statistically significant association was found in the comparison of the frequency of migraine attacks with the BMI, CRP, and ADP levels of the patients (p=0.669, p=0.989, p=0.201, respectively). A positive and significant relationship was determined between BMI and pain severity (p=0.017). However, no relationship between CRP, ADP levels, and pain severity was found (p=0.827, p=0.359, respectively).
CONCLUSIONS: CRP, as an established marker of inflammation, increases in relation to a rise in BMI. High BMI may contribute to the development of severe migraine attacks. In conclusion, preventing weight gain and advising weight loss may be a therapeutic strategy for managing severe headache attacks.

Keywords

Adiponectin , Body mass index , C-reactive protein , Migraine , Premenopausal period.

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