Tiroid Hastalıkları ve Erektil Disfonksiyon

Ayten Oğuz

doi:10.17517/ksutfd.579134

Tiroid Hastalıkları ve Erektil Disfonksiyon

Abstract

Erektil disfonksiyon (ED) hasta ve partnerinin yaşam kalitesini önemli derecede etkileyen, seksüel ve üreme fonksiyonunu bozan çok yönlü bir hastalıktır. ED birçok hastalıkla ilişkilidir. ED ve tiroid hormonları arasındaki ilişki ile ilgili veriler sınırlı olmakla birlikte, ED tiroid disfonksiyonlu erkeklerde yaygın olarak görülür. Ötiroidizmin sağlanması ile düzelir. Bu nedenle ED’li erkeklerde tiroid fonksiyonları taranmalı ve ötiroidizm sağlanmadan spesifik tedavi yapılmamalıdır. Bu derlemede literatür ışığında tiroid hastalıklarında ED yönetimi sunulmuştur.

Keywords

Erektil disfonksiyon,üreme,tiroid hormonu

References

1- Lizza EF, Rosen RC. Definition and classification of erectile dysfunction:report of the Nomenclature Committee of the International Society of Impotence Research. Int J Impot Res 1999;11:141–143
2- Habibi HR, Nelson ER, Allan ER. New insights into thyroid hormone function and modulation of reproduction in goldfish. Gen Comp Endocrinol. 2012;175(1):19-26
3- Doufas AG, Mastorakos G. The hypothalamic-pituitary-thyroid axis and the female reproductive system. Ann N Y Acad Sci. 2000;900:65-76
4- Wagner MS, Wajner SM, Maia AL. The role of thyroid hormone in testicular development and function. J Endocrinol. 2008;199(3):351-365
5- Wagner MS, Wajner SM, Maia AL. Is there a role for thyroid hormone on spermatogenesis? Microsc Res Tech. 2009;72(11):796-808
6- Flood DE, Fernandino JI, Langlois VS. Thyroid hormones in male reproductive development: evidence for direct crosstalk between the androgen and thyroid hormone axes. Gen Comp Endocrinol. 2013;192:2-14
7- Manna PR, Kero J, Tena-Sempere M, Pakarinen P, Stocco DM, Huhtaniemi IT. Assessment of mechanisms of thyroid hormone action in mouse Leydig cells: regulation of the steroidogenic acute regulatory protein, steroidogenesis, and luteinizing hormone receptor function. Endocrinology 2001;142:319–331.
8- Manna PR, Roy P, Clark BJ, Stocco DM, Huhtaniemi IT. Interaction of thyroid hormone and steroidogenic acute regulatory (StAR) protein in the regulation of murine Leydig cell steroidogenesis. J. Steroid Biochem. Mol. Biol. 2001;76:167–177
9- Antony FF, Aruldhas MM, Udhayakumar RCR, Maran RRM, Govindarajulu P. Inhibition of Leydig-cell activity in-vivo and in-vitro in hypothyroid rats. J. Endocrinol. 1995;144:293–300
10- Nagendra Prasad RJ, Datta M, Bhattacharya S. Differential regulation of Leydig cell 3beta-hydroxysteroid dehydrogenase/delta5-delta4-isomerase activity by gonadotropin and thyroid hormone in a freshwater perch,Anabas testudineus. Comp. Biochem. Physiology. 1999;Part C 124:165–173

11- Biswas NM, Ghosh PK, Biswas R, Ghosh D. Effect of thyroidectomy, and thyroxine and alpha(2u)-globulin replacement therapy on testicular steroidogenic and gametogenic activities in rats. J. Endocrinol. 1994;140:343–347
12- Ram PA, Waxman DJ. Pretranslational control by thyroid hormone of rat liver steroid 5 alpha-reductase and comparison to the thyroid dependence of two growth hormone-regulated CYP2C mRNAs. J. Biol. Chem. 1990;265:19223–19229
13- Kala N, Ravisankar B, Govindarajulu P, Aruldhas MM. Impact of foetal onset hypothyroidism on the epididymis of mature rats. Int. J. Androl. 2002;25:139-148
14- Carosa E, Di Sante S, Rossi S, Castri A, D'Adamo F, Gravina GL, et al. Ontogenetic profile of the expression of thyroid hormone receptors in rat and human corpora cavernosa of the penis. J Sex Med. 2010;7(4 Pt 1):1381-1390
15- Ozdemirci S, Yildiz F, Utkan T, Ulak G, Cetinaslan B, Erden F et al. Impaired neurogenic and endothelium-dependent relaxant responses of corpus cavernosum smooth muscle from hyperthyroid rabbits. Eur J Pharmacol. 2001;428(1):105-111
16- Krassas GE. The male and female reproductive system in thyrotoxicosis. In: Braverman LE, Utiger RD, eds. Werner and Ingbar’s the thyroid-a fundamental and clinical text. 9th ed. Philadelphia: Lippincott Williams &Wilkins;2005:621–628
17- Johnson CA. Thyroid issues in reproduction. Clin Tech Small Anim Pract 2002;17:129-132
18- Sharpe RM, McKinnell C, Kivlin C, Fisher JS. Proliferation and functional maturation of Sertoli cells, and their relevance to disorders of testis function in childhood. Reproduction 2003;125:769-784
19- Buzzard JJ, Wreford NG, Morrison JR. Thyroid hormone, retinoic acid, and testosterone suppress proliferation and induce markers of differentiation in cultured rat Sertoli cells. Endocrinology 2003;144:3722-3731
20- Jana NR, Bhattacharya S. Binding of thyroid hormone to goat testicular cell induces generation of a proteinaceous factor which stimulates androgen release. J Endocrinol 1994;143:549-556
21- Hardy MP, Kirby JD, Hess RA, Cooke PS. Leydig cell increase their numbers but decline in steroidogenic function in the adult after neonatal hypothyroidism. Endocrinology 1993;132:2417-2420
22- Maran RR, Arunakaran J, Aruldhas MM. T3 Directly stimulates basal and modulates LH induced testosterone and estradiol production by rat Leydig cells in vitro. Endocrine J 2000;47:417-428
23- Manna PR, Tena-Sempere M, Huhtaniemi IT. Molecular mechanisms of thyroid hormone-stimulated steroidogenesis in mouse leydig tumor cells. J Biol Chem 1999;274:5909-5918
24- Chandrasekhar Y, Holland MK, D’Occhio MJ, Setchell BP. Spermatogenesis, seminal characteristics and reproductive hormone levels in mature rams with induced hypothyroidism and hyperthyroidism. J Endocrinol 1985;105:39–46
25- Krassas GE. Thyroid disease and female reproduction (modern trends). Fertil Steril 2000;74:1063–1070
26- McDermott MT. Thyroid disease and reproductive health. Thyroid 2004;14(Suppl 1):1–3
27- Ruder H, Corvol P, Mahoudeau JA, Ross GT, Lipsett MB. Effects of induced hyperthyroidism on steroid metabolism in man. J Clin Endocrinol Metab 1971;33:382–387
28- Krassas GE, Poppe K, Glinoer D. Thyroid function and human reproductive health. Endocr Rev. 2010;31(5):702-755
29- Abalovich M, Levalle O, Hermes R, Scaglia H, Aranda C, Zylbersztein C, et al. Hypothalamic-pituitary-testicular axis and seminal parameters in hyperthyroid males. Thyroid 1999;9:857-863
30- Krassas GE, Pontikides N. Male reproductive function in thyroid alterations. Best Pract Res Clin Endocrinol Metab 2004;18:183–195
31- Clyde HR, Walsh PC, English RW. Elevated plasma testosterone and gonadotropin levels in infertile males with hyperthyroidism. Fertil Steril 1976;27:662–666
32- Kidd GS, Glass AR, Vigersky RA. The hypothalamicpituitary-testicular axis in thyrotoxicosis. J Clin Endocrinol Metab 1979;48:798–802
33- Hudson RW, Edwards AL. Testicular function in hyperthyroidism. J Androl 1992;13:117–124
34- Meikle AW. The interrelationships between thyroid dysfunction and hypogonadism in men and boys. Thyroid 2004;14 (Suppl 1):17–25
35- Carani C, Isidori AM, Granata A, Carosa E, Maggi M, Lenzi A, et al. Multicenter Study on the Prevalence of Sexual Symptoms in Male Hypo- and Hyperthyroid Patients. J Clin Endocrinol Metab 2005;90:6472–6479
36- Veronelli A, Masu A, Ranieri R, Rognoni C, Laneri M, Pontiroli AE. Prevalence of erectile dysfunction in thyroid disorders: comparison with control subjects and with obese and diabetic patients. Int J Impot Res 2006;18:111–114
37- Chopra IJ, Tulchinsky D. Status of estrogen-androgen balance in hyperthyroid men with Graves’ Disease. J Clin Endocrinol Metab 1974;38:269–277
38- Corona G, Petrone L, Mannucci E, Jannini EA, Mansani R, Magini A, et al. Psycho-biological correlates of rapid ejaculation in patients attending an andrologic unit for sexual dysfunctions. Eur Urol 2004;46:615–622
39- Hayek A, Chapman EM, Crawford JD. Long-term results of treatment of thyrotoxicosis in children and adolescents with radioactive iodine. N Engl J Med 1970;283:949–953
40- Mazzaferri EL, Jhiang SM. Long-term impact of initial surgical and medical therapy on papillary and follicular thyroid cancer. Am J Med 1994;97:418–428
41- Krassas GE, Pontikides N. Gonadal effect of radiation from 131I in male patients with thyroid carcinoma. Arch Androl 2005;51:171-175
42- Gabrielson AT, Sartor RA, Hellstrom WJG. The Impact of Thyroid Disease onSexual Dysfunction in Men and Women. Sex Med Rev. 2019;7(1):57-70
43- Vela´zquez EM, Bellabarba Arata G. Effects of thyroid status on pituitary gonadotropin and testicular reserve in men. Arch Androl 1997;38:85–92
44- Gordon GG, Southren AL, Tochimoto S, Rand JJ, Olivo J. Effect of hyperthyroidism and hypothyroidism on the metabolism of testosterone and androstenedione in man. J Clin Endocrinol Metab 1969;29:164–170
45- Tagawa N, Takano T, Fukata S, Kuma K, Tada H, Izumi Y, et al. Serum concentration of androstenediol and androstenediol sulfate in patients with hyperthyroidism and hypothyroidism. Endocr J 2001;48:345–354
46- Krassas GE, Papadopoulou F, Tziomalos K, Zeginiadou T, Pontikides N. Hypothyroidism has an adverse effect on human spermatogenesis: a prospective, controlled study. Thyroid 2008;18:1255–1259
47- Nikoobakht MR, Aloosh M, Nikoobakht N, Mehrsay AR, Biniaz F, Karjalian MA. The role of hypothyroidism in male infertility and erectile dysfunction. Urol J 2012;9(1):405–409
48- Krassas GE, Tziomalos K, Papadopoulou F, Pontikides N, Perros P. Erectile dysfunction in patients with hyper- and hypothyroidism: how common and should we treat? J Clin Endocrinol Metab 2008;93:1815-1819
49- Poppe K, Glinoer D, Tournaye H, Maniewski U, Haentjens P, Velkeniers B. Is systematic screening for thyroid disorders indicated in subfertile men? Eur J Endocrinol 2006;154(3):363–366
50- Corona G, Wu FC, Forti G, Lee DM, O'Connor DB, O'Neill TW, et al; EMAS Study Group. Thyroid hormones and male sexual function. Int J Androl. 2012;35(5):668-679

Details

Primary Language

Turkish

Subjects

Health Care Administration

Journal Section

Review

Authors

Ayten Oğuz ^*
0000-0002-9518-8610
Türkiye

Publication Date

July 8, 2020

Submission Date

June 18, 2019

Acceptance Date

October 2, 2019

Published in Issue

Year 2020 Volume: 15 Number: 2

DOI

https://doi.org/10.17517/ksutfd.579134

IZ

https://izlik.org/JA47FR78YF

APA

Oğuz, A. (2020). Tiroid Hastalıkları ve Erektil Disfonksiyon. Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi, 15(2), 83-87. https://doi.org/10.17517/ksutfd.579134

AMA

1.Oğuz A. Tiroid Hastalıkları ve Erektil Disfonksiyon. KSU Medical Journal. 2020;15(2):83-87. doi:10.17517/ksutfd.579134

Chicago

Oğuz, Ayten. 2020. “Tiroid Hastalıkları Ve Erektil Disfonksiyon”. Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi 15 (2): 83-87. https://doi.org/10.17517/ksutfd.579134.

EndNote

Oğuz A (July 1, 2020) Tiroid Hastalıkları ve Erektil Disfonksiyon. Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi 15 2 83–87.

IEEE

[1]A. Oğuz, “Tiroid Hastalıkları ve Erektil Disfonksiyon”, KSU Medical Journal, vol. 15, no. 2, pp. 83–87, July 2020, doi: 10.17517/ksutfd.579134.

ISNAD

Oğuz, Ayten. “Tiroid Hastalıkları Ve Erektil Disfonksiyon”. Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi 15/2 (July 1, 2020): 83-87. https://doi.org/10.17517/ksutfd.579134.

JAMA

1.Oğuz A. Tiroid Hastalıkları ve Erektil Disfonksiyon. KSU Medical Journal. 2020;15:83–87.

MLA

Oğuz, Ayten. “Tiroid Hastalıkları Ve Erektil Disfonksiyon”. Kahramanmaraş Sütçü İmam Üniversitesi Tıp Fakültesi Dergisi, vol. 15, no. 2, July 2020, pp. 83-87, doi:10.17517/ksutfd.579134.

Vancouver

1.Ayten Oğuz. Tiroid Hastalıkları ve Erektil Disfonksiyon. KSU Medical Journal. 2020 Jul. 1;15(2):83-7. doi:10.17517/ksutfd.579134

Cited By

Erkek köpeklerde kastrasyonun serum TSH düzeyi ile ilişkisi

Kocatepe Veterinary Journal

https://doi.org/10.30607/kvj.1141999

Evaluation of Depression, Anxiety, Body Perception and Sexual Functions in Patients Diagnosed With Acromegaly

Uludağ Üniversitesi Tıp Fakültesi Dergisi

https://doi.org/10.32708/uutfd.1786076