METABOLİK SENDROM VE EREKTİL DİSFONKSİYON İLİŞKİSİ

Yıl 2020, , 58 - 63, 26.03.2020

Murat Şahin

https://doi.org/10.17517/ksutfd.623628

Öz

Metabolik sendrom insülin direnci, hiperinsülinemi, hipertansiyon, obezite
ve dislipidemi ile karakterize bir metabolik bozukluktur. Erektil disfonksiyon başarılı
bir cinsel ilişki sağlamak için ereksiyonun başlatılamaması yada
sürdürülememesi olarak tanımlanmaktadır. Hem erektil disfonksiyon hem metabolik
sendrom endotelyal disfonksiyon ve ateroskleroza yol açan ortak risk
faktörlerine sahiptirler.  

Anahtar Kelimeler

metabolik sendrom, erektil disfonksiyon

ASSOCIATION BETWEEN METABOLIC SYNDROME AND ERECTILE DYSFUNCTION

Öz

Metabolic syndrome is a metabolic dysregulation characterized by insülin
resistance, hyperinsulinemia, hypertension, obesity, and dyslipidemia. Erectile
dysfunction is defined as the persistent inability to achieve and maintain
erection to perform successful sexual intercourse. Both erectile dysfunction
and metabolic syndrome share common risk factors that cause endothelial
dysfunction and atherosclerosis. 

Anahtar Kelimeler

metabolic syndrome, erectile dysfunction

Kaynakça

• 1. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: Findings from the Third National Health and Nutrition Examination Survey. J Am Med Assoc. 2002;287(3):356–9. 2. Ford ES, Giles WH, Mokdad AH. Increasing prevalence of the metabolic syndrome among U.S. adults. Diabetes Care. 2004;27(10):2444–9. 3. Abacı A, Kılıçkap M, Göksülük H, Karaaslan D, Barçın C, Kayıkçıoğlu M, et al. Data on prevalence of metabolic syndrome in Turkey: Systematic review, meta-analysis and meta-regression of epidemiological studies on cardiovascular risk factors. Turk Kardiyol Dern Arsivi-Archives Turkish Soc Cardiol [Internet]. 2018 [cited 2019 Jun 20];46(7):591–601. Available from: http://www.ncbi.nlm.nih.gov/pubmed/303919884. Engin A. The Pathogenesis of Obesity-Associated Adipose Tissue Inflammation. In: Advances in experimental medicine and biology [Internet]. 2017 [cited 2019 Jun 20]. p. 221–45. Available from: http://www.ncbi.nlm.nih.gov/pubmed/285852015. Swaroop JJ, Rajarajeswari D, Naidu JN. Association of TNF-α with insulin resistance in type 2 diabetes mellitus. Indian J Med Res. 2012;135(1):127–30. 6. Li Y, Zhong X, Cheng G, Zhao C, Zhang L, Hong Y, et al. Hs-CRP and all-cause, cardiovascular, and cancer mortality risk: A meta-analysis. Atherosclerosis [Internet]. 2017 Apr [cited 2019 Jun 20];259:75–82. Available from: http://www.ncbi.nlm.nih.gov/pubmed/283274517. Rehman K, Akash MSH, Liaqat A, Kamal S, Qadir MI, Rasul A. Role of Interleukin-6 in Development of Insulin Resistance and Type 2 Diabetes Mellitus. Crit Rev Eukaryot Gene Expr [Internet]. 2017 [cited 2019 Jun 20];27(3):229–36. Available from: http://www.ncbi.nlm.nih.gov/pubmed/291996088. Del Giudice M, Gangestad SW. Rethinking IL-6 and CRP: Why they are more than inflammatory biomarkers, and why it matters. Brain Behav Immun [Internet]. 2018 May [cited 2019 Jun 20];70:61–75. Available from: http://www.ncbi.nlm.nih.gov/pubmed/294993029. Jung RG, Motazedian P, Ramirez FD, Simard T, Di Santo P, Visintini S, et al. Association between plasminogen activator inhibitor-1 and cardiovascular events: a systematic review and meta-analysis. Thromb J [Internet]. 2018 [cited 2019 Jun 20];16:12. Available from: http://www.ncbi.nlm.nih.gov/pubmed/2999192610. Gruzdeva O, Borodkina D, Uchasova E, Dyleva Y, Barbarash O. Leptin resistance: underlying mechanisms and diagnosis. Diabetes Metab Syndr Obes [Internet]. 2019 [cited 2019 Jun 20];12:191–8. Available from: http://www.ncbi.nlm.nih.gov/pubmed/3077440411. Rachek LI. Free fatty acids and skeletal muscle insulin resistance. Prog Mol Biol Transl Sci [Internet]. 2014 Jan 1 [cited 2019 Jun 20];121:267–92. Available from: https://www.sciencedirect.com/science/article/pii/B9780128001011000089?via%3Dihub12. Boden G, Lebed B, Schatz M, Homko C, Lemieux S. Effects of Acute Changes of Plasma Free Fatty Acids on Intramyocellular Fat Content and Insulin Resistance in Healthy Subjects. Diabetes [Internet]. 2001 Jul 1 [cited 2019 Jun 19];50(7):1612–7. Available from: http://diabetes.diabetesjournals.org/cgi/doi/10.2337/diabetes.50.7.161213. Kaur J. A comprehensive review on metabolic syndrome. Cardiol Res Pract [Internet]. 2014 [cited 2019 Jun 19];2014:943162. Available from: http://www.ncbi.nlm.nih.gov/pubmed/24711954%0Ahttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC396633114. Ormazabal V, Nair S, Elfeky O, Aguayo C, Salomon C, Zuñiga FA. Association between insulin resistance and the development of cardiovascular disease. Cardiovasc Diabetol [Internet]. 2018 [cited 2019 Jun 24];17(1):122. Available from: http://www.ncbi.nlm.nih.gov/pubmed/3017059815. Sánchez A, Contreras C, Martínez P, Muñoz M, Martínez AC, García-Sacristán A, et al. Endothelin A (ET(A)) receptors are involved in augmented adrenergic vasoconstriction and blunted nitric oxide-mediated relaxation of penile arteries from insulin-resistant obese zucker rats. J Sex Med [Internet]. 2014 Jun [cited 2019 Jul 30];11(6):1463–74. Available from: http://www.ncbi.nlm.nih.gov/pubmed/2469790816. Sansbury BE, Hill BG. Regulation of obesity and insulin resistance by nitric oxide. Free Radic Biol Med [Internet]. 2014 Aug [cited 2019 Jun 19];73:383–99. Available from: https://linkinghub.elsevier.com/retrieve/pii/S089158491400232917. Phé V, Rouprêt M. Erectile dysfunction and diabetes: A review of the current evidence-based medicine and a synthesis of the main available therapies. Diabetes Metab [Internet]. 2012 Feb [cited 2019 Jun 19];38(1):1–13. Available from: https://linkinghub.elsevier.com/retrieve/pii/S126236361100163718. Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: Results of the Massachusetts Male Aging Study. J Urol. 1994;151(1):54–61. 19. O. Apostolov E, Ok E, Burns S, Nawaz S, Savenka A, V. Shah S, et al. Carbamylated-Oxidized LDL: Proatherosclerotic Effects on Endothelial Cells and Macrophages. J Atheroscler Thromb. 2013;20(12):878–92. 20. Ahn TY, Gömez-Coronado D, Martínez V, Cuevas P, Goldstein I, Sâenz De Tejada I. Enhanced contractility of rabbit corpus cavernosum smooth muscle by oxidized low density lipoproteins. Int J Impot Res. 1999;11(1):9–14. 21. Lewis T V., Dart AM, Chin-Dusting JPF. Endothelium-dependent relaxation by acetylcholine is impaired in hypertriglyceridemic humans with normal levels of plasma LDL cholesterol. J Am Coll Cardiol. 1999;33(3):805–12. 22. Zheng H, Liu X, Patel KP. Centrally mediated erectile dysfunction in rats with type 1 diabetes: Role of angiotensin II and superoxide. J Sex Med. 2013;10(9):2165–76. 23. Fraga-Silva RA, Montecucco F, Mach F, Santos RAS, Stergiopulos N. Pathophysiological role of the renin-angiotensin system on erectile dysfunction. Vol. 43, European Journal of Clinical Investigation. 2013. p. 978–85. 24. Jin L, Lagoda G, Leite R, Webb RC, Burnett AL. NADPH oxidase activation: A mechanism of hypertension-associated erectile dysfunction. J Sex Med. 2008;5(3):544–51. 25. Gonçalves FZ, Lizarte Neto FS, Novais PC, Gattas D, Lourenço LG, de Carvalho CAM, et al. Expression profile of endothelin receptors (ETA and ETB) and microRNAs-155 and -199 in the corpus cavernosum of rats submitted to chronic alcoholism and diabetes mellitus. Brazilian J Med Biol Res = Rev Bras Pesqui medicas e Biol [Internet]. 2018 Mar 1 [cited 2019 Jul 31];51(3):e6329. Available from: http://www.ncbi.nlm.nih.gov/pubmed/2951387926. Wang X, Huang W, Zhang Y. Relation between hypertension and erectile dysfunction: a meta-analysisof cross-section studies. Int J Impot Res [Internet]. 2018 Jun 22 [cited 2019 Jul 31];30(3):141–6. Available from: http://www.nature.com/articles/s41443-018-0020-z