Urinary Nerve Growth Factor Levels In Multiple Sclerosis Patients With Urinary System Symptoms

Muhammed Seyithanoğlu; Yılmaz İnanç; Songül Bavli

doi:10.17517/ksutfd.793595

TR EN

Üriner Sistem Semptomları Olan Multipl Sklerozlu Hastalarda Üriner Sinir Büyüme Faktörü Düzeyleri

Öz

Amaç: MS hastalarında idrar sinir büyüme faktörünün (NGF) duyarlılığını ve özgüllüğünü detrüsör aşırı aktivitesinin belirteçleri olarak tahmin etmek. Materyal ve Metod: Multipl Skleroz tanısı ile takip edilen üriner sistem semptomları olan 20 gönüllü hasta ve Multipl Skleroz tanısı olan ancak üriner sistem semptomları olmayan 29 gönüllü hasta çalışmaya dahil edildi. Kişilerden kapsamlı bir anamnez ve spot idrar örnekleri alındı. Benzer yaş ve cinsiyet dağılımına sahip 27 sağlıklı gönüllü NGF düzeyleri açısından karşılaştırma yapmak üzere dahil edildi ve spot idrar örnekleri alındı. Bulgular: İdrar NGF düzeyleri ve NGF/idrar Kreatinin oranları üriner semptomları bulunan MS hasta grubunda üriner semptomları bulunmayan hasta grubuna göre istatistiki olarak anlamlı olmayan şekilde daha düşüktü, üriner semptomları olmayan hasta grubunda da control grubuna göre istatistiki olarak anlamlılık içermeyen düşüklük gözlendi (p: 0,114 ve 0,833) Sonuç: Multipl sklerozlu hastalarda idrar nörotrofinleri detrüsör aşırı aktivitesini teşhis etmek için kullanılabilir.

Anahtar Kelimeler

Multipl skleroz , sinir büyüme faktörü , idrar yolu disfonksiyonu

Urinary Nerve Growth Factor Levels In Multiple Sclerosis Patients With Urinary System Symptoms

Abstract

Aim: To estimate the sensitivity and specificity of the serum and urinary nerve growth factor (NGF) in MS patients as markers of detrusor overactivity. Materials and Methods: 20 volunteers who were diagnosed with MS and who had urinary tract symptoms and 29 volunteers who were diagnosed with MS however who did not have urinary tract symptoms were included in the study. A comprehensive anamnesis and spot urine samples were obtained from the subjects. Twenty seven healthy volunteers with similar age and gender distribution were included for making a comparison with regard to NGF levels and spot urine samples were obtained. Results: Urinary NGF levels and NGF/urinary creatinine ratios were found lower in the group composed of MS patients who had urinary symptoms compared to the group composed of MS patients who did not have urinary symptoms but the difference was not statistically significant. These parameters were found lower in patient group who did not have urinary symptoms compared to control group however the difference was not statistically significant (p: 0,114 and 0,833) Conclusions: urinary neurotrophins in patients with multiple sclerosis can be used to diagnose detrusor overactivity.

Keywords

Multiple sclerosis , nerve growth factor , urinary tract dysfunction

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Muhammed Seyithanoğlu ^*
0000-0002-8027-7549
Türkiye

Yılmaz İnanç
0000-0002-0423-0941
Türkiye

Songül Bavli
0000-0002-1688-7828
Türkiye

Publication Date

July 7, 2021

Submission Date

September 11, 2020

Acceptance Date

September 15, 2020

Published in Issue

Year 2021 Volume: 16 Number: 2

DOI

https://doi.org/10.17517/ksutfd.793595

IZ

https://izlik.org/JA42KD45BR

AMA

1.Seyithanoğlu M, İnanç Y, Bavli S. Urinary Nerve Growth Factor Levels In Multiple Sclerosis Patients With Urinary System Symptoms. KSU Medical Journal. 2021;16(2):273-278. doi:10.17517/ksutfd.793595

Üriner Sistem Semptomları Olan Multipl Sklerozlu Hastalarda Üriner Sinir Büyüme Faktörü Düzeyleri

Öz

Anahtar Kelimeler

Urinary Nerve Growth Factor Levels In Multiple Sclerosis Patients With Urinary System Symptoms

Abstract

Keywords

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

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