Gebelikte Folik Asit, B12 Vitamini, D Vitamini ve İyot Destekleri Kullanmak Gerekli Midir? Olası Riskler

Hilal Şimşek; Yasemin Karaağaç; Esra Tunçer; Hülya Yardımcı

doi:10.17517/ksutfd.832401

EN TR

Is It Necessary Folic Acid, Vitamin B12, Vitamin D and Iodine Supplementation in Pregnancy?: Posssible Risks

Abstract

Due to the increasing nutritional requirements in the pregnancy, taking certain micronutrients as dietary supplements and thus minimizing the risks associated with deficiency is of great importance in the protection of maternal and fetal health. In pregnancy, dietary supplements are vital in severe or moderate deficiency of nutrients, also bring various risks in conditions of mild deficiency or adequate maternal nutrient storage. The effect of folic acid supplementation on prevent congenital anomalies, has been proven. In maternal period, excessive intake of folic acid may cause carcinogenicity, negatively affect the absorption of zinc, lead to delays in the diagnosis and treatment of vitamin B12 deficiency, and may be associated with the risk of childhood asthma and allergy. Vitamin B12 is another vitamin whose deficiency is associated with fetal anomalies. Although the toxic effect of vitamin B12 is not reported, a case report showing allergic reactions was found in the literature review in case of excessive intake. Vitamin D, which is beneficial in the prevention of neonatal hypocalcemia and rickets, excessive intake of the supplement may be a teratogenic effect. Iodine supplement is effective in preventing diseases such as cretinism associated with iodine insufficiency. However, it has been stated that excessive intake of iodine supplement may lead to an increase in the prevalence of thyroid dysfunction of the pregnant woman, subclinical and overt hypothyroidism during pregnancy and negatively affect the psychomotor development of the baby. The use of nutritional supplements at the recommended doses during pregnancy is appropriate, but attention should also be paid to excessive intake as well as prevention of insufficiency. In this review, the risks of excessive intake of folic acid, vitamin B12, vitamin D, and iodine supplements used in pregnancy are discussed

Keywords

Pregnancy , Dietary Supplements , Folic Acid , Vitamin B12 , Vitamin D , Iodine

Gebelikte Folik Asit, B12 Vitamini, D Vitamini ve İyot Destekleri Kullanmak Gerekli Midir? Olası Riskler

Öz

Gebelik sürecinde artan gereksinimler dolayısıyla; özellikle bazı mikro besin ögelerinin besin desteği olarak alınması ve böylece yetersizlik ile ilişkili risklerinin en aza indirilmesi, maternal ve fetal sağlığın korunmasında büyük öneme sahiptir. Gebelikte, besin ögelerinin ciddi veya orta düzeyde yetersizliğinde, hayat kurtarıcı nitelikte olan destekler; hafif yetersizlik veya maternal depoların yeterli olduğu koşullarda, çeşitli riskleri de beraberinde getirmektedir. Doğumsal anomalilerin önlenmesinde etkisi kanıtlanmış olan folik asitin maternal dönemde fazla alımı durumunda kanserojeniteyi tetikleyebileceği, çinko emilimini olumsuz etkileyebileceği, B12 vitamini eksikliğinin tanısında ve tedavisinde gecikmelere yol açabileceği, çocukluk çağı astım, alerji riski ile ilişkili olabileceği görülmüştür. Eksikliği fetal anomaliler ile ilişkilendirilen bir diğer vitamin olan B12’nin toksik etkisi bildirilmemekle birlikte literatür taramasında fazla alımı durumunda alerjik reaksiyonlar gösteren bir vaka raporuna rastlanmıştır. Yenidoğan hipokalsemisi ve raşitizmin önlenmesinde etkili D vitamini desteğinin fazla alımı teratojen etki gösterebilir. İyot yetersizliği ile ilişkili kretenizm gibi hastalıkların önlenmesinde etkili olan iyot desteğinin fazla alımının gebenin tiroid disfonksiyonuna, gebelikteki subklinik ve aşikâr hipotiroidizm prevalansında artışa yol açabileceği ve bebeğin psikomotor gelişimini olumsuz etkileyebileceği belirtilmiştir. Gebelikte önerilen dozlarda besin desteklerinin kullanımı uygundur ancak yetersizliğin önlenmesi kadar fazla alım konusunda da dikkatli olunmalıdır. Bu derlemede; gebelikte yaygın olarak kullanılan folik asit, B12 vitamini, D vitamini ve iyot besin desteklerinin fazla alımına ilişkin riskler tartışılmıştır.

Anahtar Kelimeler

Gebelik , Besin Desteği , Folik Asit , B12 vitamini , D vitamini , İyot

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Details

Primary Language

Turkish

Subjects

Health Care Administration

Journal Section

Review

Authors

Hilal Şimşek ^*
0000-0002-2744-1610
Türkiye

Yasemin Karaağaç
0000-0002-2757-2485
Türkiye

Esra Tunçer
0000-0001-7151-842X
Türkiye

Hülya Yardımcı
0000-0002-2664-4176
Türkiye

Publication Date

November 1, 2021

Submission Date

November 28, 2020

Acceptance Date

January 30, 2021

Published in Issue

Year 2021 Volume: 16 Number: 3

DOI

https://doi.org/10.17517/ksutfd.832401

IZ

https://izlik.org/JA37YS87US

AMA

1.Şimşek H, Karaağaç Y, Tunçer E, Yardımcı H. Gebelikte Folik Asit, B12 Vitamini, D Vitamini ve İyot Destekleri Kullanmak Gerekli Midir? Olası Riskler. KSU Medical Journal. 2021;16(3):439-447. doi:10.17517/ksutfd.832401

Gebelikte Folik Asit, B12 Vitamini, D Vitamini ve İyot Destekleri Kullanmak Gerekli Midir? Olası Riskler

Is It Necessary Folic Acid, Vitamin B12, Vitamin D and Iodine Supplementation in Pregnancy?: Posssible Risks

Abstract

Keywords

Gebelikte Folik Asit, B12 Vitamini, D Vitamini ve İyot Destekleri Kullanmak Gerekli Midir? Olası Riskler

Öz

Anahtar Kelimeler

References

Details

Primary Language

Subjects

Journal Section

Authors

Publication Date

Submission Date

Acceptance Date

Published in Issue

DOI

IZ

Cite

Cited By

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GEBELERİN PREKONSEPSİYONEL DÖNEMDE FOLİK ASİT BİLGİSİ, KULLANIM PREVALANSI VE İLİŞKİLİ FAKTÖRLER

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