Effects of Green Tea in Ischemia-Reperfusion Injury Models of Experimental Animals

Yıl 2017, Cilt: 12 Sayı: 2, 4 - 13, 04.08.2017

Yusuf Ergün

https://doi.org/10.17517/ksutfd.310324

Öz

Ischemia-reperfusion injury appears in various types
of clinical conditions involving different tissues such as brain, skeletal
muscle, heart, gut, liver, kidney, retina, pancreas and testis. Although
oxidative stress has been shown to have a pivotal role in the aetiology of
ischemia-reperfusion injury, several mechanisms including inflammation,
leukocyte infiltration and apoptosis have been included as well. In an attempt
to reduce ischemia-reperfusion injury, various substances have been tested so
far. However, none of them have evolved as a medicinal product to be used in
these indications yet. In this context, green tea contents have been shown to
possess favourable effects in distinct forms of animal models relating to
ischemia-reperfusion injury. In this review, the effects of green tea contents
on ischemia-reperfusion injury models of animals have been discussed in a historical
and tissue-specific manner.

Anahtar Kelimeler

Epigallocatechin gallate; green tea; ischemia-reperfusion injury

Deney hayvanlarındaki iskemi-reperfüzyon hasarı modellerinde yeşil çayın etkileri

Öz

İskemi-reperfüzyon hasarı beyin, çizgili kas, kalp, bağırsak, karaciğer,
böbrekler, retina, pankreas ve testis gibi farklı dokuları kapsayan çeşitli
birçok klinik durumda ortaya çıkmaktadır. Her ne kadar oksidatif stresin
iskemi-reperfüzyon hasarının etiyolojisinde merkezi bir rol oynadığı
gösterişmiş olsa da, inflamasyon, lökosit infiltrasyonu ve apoptozis gibi
birçok mekanizma da dahil edilmiştir. İskemi-reperfüzyon hasarını azaltmak için
bugüne kadar çeşitli maddeler test edilmiştir. Ancak, hiçbiri bu endikasyonda
kullanılmak üzere medikal ürün olarak henüz evrilmemiştir. Bu bağlamda, yeşil
çay içeriklerinin farklı formdaki hayvan iskemi-reperfüzyon hasarı modellerinde
faydalı etkiler gösterdikleri bulunmuştur. Bu derlemede, yeşil çay
içeriklerinin hayvan iskemi-reperfüzyon hasarı modelleri üzerindeki etkileri tarihsel
ve dokuya spesifik bir şekilde tartışılmıştır.     

Anahtar Kelimeler

Epigallokateşin gallat; yeşil çay; iskemi-reperfüzyon hasarı

Kaynakça

• Referans 1. Guo Q, Zhao B, Li M, Shen S, Xin W. Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes. Biochim Biophys Acta 1996;1304:210-222.
• Referans 2. Lin AM, Chyi BY, Wu LY, Hwang LS, Ho LT. The antioxidative property of green tea against iron-induced oxidative stress in rat brain. Chin J Physiol 1998;41:189-194.
• Referans 3. Lee S, Suh S, Kim S. Protective effects of the green tea polyphenol ()-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils. Neurosci Lett 2000;287:191-194.
• Referans 4. Hong JT, Ryu SR, Kim HJ, Lee JK, Lee SH, Kim DB, et al. Neuroprotective effect of green tea extract in experimental ischemia-reperfusion brain injury. Brain Res Bull 2000;53:743-749.
• Referans 5. Hong JT, Ryu SR, Kim HJ, Lee JK, Lee SH, Yun YP, et al. Protective effect of green tea extract on ischemia/reperfusion-induced brain injury in Mongolian gerbils. Brain Res 2001;888:11-18.
• Referans 6. Fang F, Han YJ, Cui ZQ. The protective effects of tea catechins on the injury of cerebral ischemia and reperfusion in rats. Zhongguo Zhong Yao Za Zhi 2001;26:777-780.
• Referans 7. Choi YB, Kim YI, Lee KS, Kim BS, Kim DJ. Protective effect of epigallocatechin gallate on brain damage after transient middle cerebral artery occlusion in rats. Brain Res 2004;1019.47-54.
• Referans 8. Park JW, Jang YH, Kim JM, Lee H, Park WK, Lim MB, et al. Green tea polyphenol ()-epigallocatechin gallate reduces neuronal cell damage and up-regulation of MMP-9 activity in hippocampal CA1 and CA2 areas following transient global cerebral ischemia. J Neurosci Res 2009;87:567-575.
• Referans 9. Lo EH, Wang X, Cuzner ML. Extracellular proteolysis in brain injury and inflammation: role for plasminogen activators and matrix metalloproteinases. J Neurosci Res 2002;69:1–9.
• Referans 10. Lv J, Xue R, Zhao J, Wei X, Gao H, Fu R, et al. An optimal dose of tea polyphenols protects against global cerebral ischemia/reperfusion injury. Neural Regen Res 2013;8:783-791.
• Referans 11. Schimidt HL, Vieira A, Altermann C, Martins A, Sosa P, Santos FW, et l. Memory deficits and oxidative stress in cerebral ischemia-reperfusion: neuroprotective role of physical exercise and green tea supplementation. Neurobiol Learn Mem 2014;114:242-250.
• Referans 12. Büttemeyer R, Philipp AW, Schlenzka L, Mall JW, Beissenhirtz M, Lisdat F. Epigallocatechin gallate can significantly decrease free oxygen radicals in the reperfusion injury in vivo. Transplant Proc 2003;35:3116-3120.
• Referans 13. Stoffels F, Lohöfener F, Beisenhirtz M, Lisdat F, Büttemeyer R. Concentration decrease of nitric oxide in the postischemic muscle is not only caused by the generation of O2-. Microsurgery 2007;27:565-568.
• Referans 14. Aneja R, Hake PW, Burroughs TJ, Denenberg AG, Wong HR, Zingarelli B. Epigallocatechin, a green tea polyphenol, attenuates myocardial ischemia reperfusion injury in rats. Mol Med 2004;10:55-62.
• Referans 15. Townsend PA, Scarabelli TM, Pasini E, Gitti G, Menegazzi M, Suzuki H, et al. Epigallocatechin-3-gallate inhibits STAT-1 activation and protects cardiac myocytes from ischemia/reperfusion-induced apoptosis. FASEB J 2004;18:1621-1623.
• Referans 16. Darra E, Shoji K, Mariotto S, Suzuki H. Protective effect of epigallocatechin-3-gallate on ischemia/reperfusion-induced injuries in the heart: STAT1 silencing flavonoid. Genes Nutr 2007;2:307-310.
• Referans 17. Hirai M, Hotta Y, Ishikawa N, Wakida Y, Fukuzawa Y, Isobe F, et al. Protective effects of EGCg or GCg, a green tea catechin epimer, against postischemic myocardial dysfunction in guinea-pig hearts. Life Sci 2007;80:1020-1032.
• Referans 18. Pagnotta E, Calonghi N, Hrelia S, Masotti L, Biagi P, Angeloni C. Green tea protects cytoskeleton from oxidative injury in cardiomyocytes. J Agric Food Chem 2006;54: 10159-10163.
• Referans 19. Akhlaghi M, Bandy B. Dietary green tea extract increases phase 2 enzyme activities in protecting against myocardial ischemia-reperfusion. Nutr Res 2010;30:32-39.
• Referans 20. Piao CS, Kim DS, Ha KC, Kim HR, Chae HJ, Chae SW. The Protective Effect of Epigallocatechin-3 Gallate on Ischemia/Reperfusion Injury in Isolated Rat Hearts: An ex vivo Approach. Korean J Physiol Pharmacol 2011;15:259-266.
• Referans 21. Yanagi S, Matsumura K, Marui A, Morishima M, Hyon SH, Ikeda T, et al. Oral pretreatment with a green tea polyphenol for cardioprotection against ischemia-reperfusion injury in an isolated rat heart model. J Thorac Cardiovasc Surg 2011;141(2):511-7.
• Referans 22. Kim SJ, Li M, Jeong CW, Bae HB, Kwak SH, Lee SH, et al. Epigallocatechin-3-gallate, a green tea catechin, protects the heart against regional ischemia-reperfusion injuries through activation of RISK survival pathways in rats. Arch Pharm Res 2014;37(8):1079-85.
• Referans 23. Potenza MA, Marasciulo FL, Tarquinio M, Tiravanti E, Colantuono G, Federici A, et al. EGCG, a green tea polyphenol, improves endothelial function and insulin sensitivity, reduces blood pressure, and protects against myocardial I/R injury in SHR. Am J Physiol Endocrinol Metab 2007;292(5):E1378-87.
• Referans 24. Kim CJ, Kim JM, Lee SR, Jang YH, Kim JH, Chun KJ. Polyphenol (-)-epigallocatechin gallate targeting myocardial reperfusion limits infarct size and improves cardiac function. Korean J Anesthesiol 2010;58(2):169-75.
• Referans 25. Song DK, Jang Y, Kim JH, Chun KJ, Lee D, Xu Z. Polyphenol (-)-epigallocatechin gallate during ischemia limits infarct size via mitochondrial K(ATP) channel activation in isolated rat hearts. J Korean Med Sci 2010;25(3):380-6.
• Referans 26. Lee SK, Kim JH, Kim JS, Jang Y, Kim J, Park YH, et al. Polyphenol (-)-epigallocatechin gallate-induced cardioprotection may attenuate ischemia-reperfusion injury through adenosine receptor activation: a preliminary study. Korean J Anesthesiol 2012;63(4):340-5.
• Referans 27. Liou YM, Hsieh SR, Wu TJ, Chen JY. Green tea extract given before regional myocardial ischemia-reperfusion in rats improves myocardial contractility by attenuating calcium overload. Pflugers Arch 2010;460(6):1003-14. Referans 28. Muià C, Mazzon E, Di Paola R, Genovese T, Menegazzi M, Caputi AP, eet al. Green tea polyphenol extract attenuates ischemia/reperfusion injury of the gut. Naunyn Schmiedebergs Arch Pharmacol 2005;371(5):364-74.
• Referans 29. Zhong Z, Froh M, Connor HD, Li X, Conzelmann LO, Mason RP, et al. Prevention of hepatic ischemia-reperfusion injury by green tea extract. Am J Physiol Gastrointest Liver Physiol 2002;283(4):G957-64.
• Referans 30. Fiorini RN, Donovan JL, Rodwell D, Evans Z, Cheng G, May HD, et al. Short-term administration of (-)-epigallocatechin gallate reduces hepatic steatosis and protects against warm hepatic ischemia/reperfusion injury in steatotic mice. Liver Transpl 2005;11(3):298-308.
• Referans 31. Giakoustidis DE, Giakoustidis AE, Iliadis S, Koliakou K, Antoniadis N, Kontos N, et al. Attenuation of liver ischemia/reperfusion induced apoptosis by epigallocatechin-3-gallate via down-regulation of NF-kappaB and c-Jun expression. J Surg Res 2010;159(2):720-8.
• Referans 32. Liang R, Nickkholgh A, Kern M, Schneider H, Benzing S, Zorn M, et al. Green tea extract ameliorates reperfusion injury to rat livers after warm ischemia in a dose-dependent manner. Mol Nutr Food Res 2011;55(6):855-63.
• Referans 33. Jang YH, Lee YC, Park NH, Shin HY, Mun KC, Choi MS, et al. Polyphenol (-)-epigallocatechin gallate protection from ischemia/reperfusion-induced renal injury in normotensive and hypertensive rats. Transplant Proc 2006;38(7):2190-4.
• Referans 34. Rah DK, Han DW, Baek HS, Hyon SH, Park BY, Park JC. Protection of rabbit kidney from ischemia/reperfusion injury by green tea polyphenol pretreatment. Arch Pharm Res 2007;30(11):1447-54.
• Referans 35. Kakuta Y, Okumi M, Isaka Y, Tsutahara K, Abe T, Yazawa K, et al. Epigallocatechin-3-gallate protects kidneys from ischemia reperfusion injury by HO-1 upregulation and inhibition of macrophage infiltration. Transpl Int 2011;24(5):514-22.
• Referans 36. Twal M, Kiefer P, Salameh A, Schnabel J, Ossmann S, von Salisch S, et al. Reno-protective effects of epigallocatechingallate in a small piglet model of extracorporeal circulation. Pharmacol Res 2013;67(1):68-78.
• Referans 37. Li YW, Zhang Y, Zhang L, Li X, Yu JB, Zhang HT, et al. Protective effect of tea polyphenols on renal ischemia/reperfusion injury via suppressing the activation of TLR4/NF-κB p65 signal pathway. Gene 2014;542(1):46-51.
• Referans 38. Lv J, Feng M, Zhang L, Wan X, Zeng YC, Liang PF, et al. Protective effect of epigallocatechin gallate, a major constituent of green tea, against renal ischemia-reperfusion injury in rats. Int Urol Nephrol 2015;47(8):1429-35.
• Referans 39. Zhang B, Safa R, Rusciano D, Osborne NN. Epigallocatechin gallate, an active ingredient from green tea, attenuates damaging influences to the retina caused by ischemia/reperfusion. Brain Res 2007;1159:40-53.
• Referans 40. Zhang B, Rusciano D, Osborne NN. Orally administered epigallocatechin gallate attenuates retinal neuronal death in vivo and light-induced apoptosis in vitro. Brain Res 2008;1198:141-52.
• Referans 41. Peng PH, Ko ML, Chen CF. Epigallocatechin-3-gallate reduces retinal ischemia/reperfusion injury by attenuating neuronal nitric oxide synthase expression and activity. Exp Eye Res 2008;86(4):637-46.
• Referans 42. Hara Y, Fujino M, Takeuchi M, Li XK. Green-tea polyphenol (-)-epigallocatechin-3-gallate provides resistance to apoptosis in isolated islets. J Hepatobiliary Pancreat Surg 2007;14(5):493-7.
• Referans 43. Zhang T, Yang D, Fan Y, Xie P, Li H. Epigallocatechin-3-gallate enhances ischemia/reperfusion-induced apoptosis in human umbilical vein endothelial cells via AKT and MAPK pathways. Apoptosis 2009;14(10):1245-54.
• Referans 44. Sugiyama A, Chiba M, Nakagami T, Kawano S, Sanada Y, Tajiri T, et al. Beneficial effects of (-)-epigallocatechin gallate on ischemia-reperfusion testicular injury in rats. J Pediatr Surg 2012;47(7):1427-32.
• Referans 45. Al-Maghrebi M, Renno WM, Al-Ajmi N. Epigallocatechin-3-gallate inhibits apoptosis and protects testicular seminiferous tubules from ischemia/reperfusion-induced inflammation. Biochem Biophys Res Commun 2012;420(2):434-9.