Do Complete Blood Count Parameters Show the Functional Level in Stroke Patients?

Yıl 2019, Cilt: 14 Sayı: 1, 1 - 5, 15.03.2019

Tuba Tülay Koca , Aydın Arslan

https://doi.org/10.17517/ksutfd.455246

Öz

Objective: Inflammation has a crucial role in the pathogenesis of stroke, and in recent years, complete blood parameters and their derivatives have led to poor prognosis in the course of various diseases. We aimed to elucidate the relation of various whole blood parameters and derivatives with the functional levels of stroke patients.

Matherial
and Methods: Patients diagnosed with
stroke in our clinic between 2016 and 2017 years were retrospectively analyzed.
All patients were recorded for age, gender, etiology, involved side, spasticity,
functional ambulatory scale (FAS), upper and lower extremity Brunnstrom grades.
Acute phase reactants, erythrocyte sedimentation rate (ESR), C-reactive protein
(RBC), and complete blood count and sub-parameters of all patients at the time
of admission, white blood cell (WBC), erythrocyte distribution width (RDW),
platelet distribution width (PDW), mean platelet volume reactive protein (CRP) were
recorded.

Results: Fifty-five (55) male (63.2%) and 30 female (34.5%)
were included in the study at the age range of 32-85 years. Sixty-four percent
(64%) of the patients were diagnosed with stroke for less than 1 year, 86.2%
was ischemic, and 50.6% was right-sided. There was no spasticity in 25.3% of
the patients. Ashworth grade 1 spasticity was the most frequently observed in
23% of the cases with spasticity. Functional levels were most frequently with a
ratio of 20.7% FAS 3, upper extremity with a ratio of 32.2% was Brunnstrom grade
3, at lower extremity was Brunstrom grade 5 with a ratio of 28.7%.

Conclusion: Inflammatory parameters provide information about the functional level in stroke patients. Systemic inflammation that triggers an inflammatory reaction or inhibition of neuronal pathways is a potential future therapeutic target in stroke patients.therapeutic target in stroke patients.

Anahtar Kelimeler

stroke, neuroinflammation, functional level

İnme Hastalarında Tam Kan Sayımı Parametreleri Fonksiyonel Seviyeyi Gösterir mi?

Öz

Amaç: İnflamasyon, inme patogenezinde çok önemli bir role
sahiptir, son yıllarda tam kan parametre ve türevleri çeşitli
hastalıkların seyrinde kötü prognoz kriteri olarak yol gösterici bulunmaktadır. Burada çeşitli tam kan parametre ve
türevlerinin inmeli hastaların fonksiyonel seviyeleriyle ilişkisini ortaya
koymayı amaçladık.

Gereç ve Yöntem:
Kliniğimize 2016-2017 yılları arasında yatarak tedavi gören inme tanılı
hastalar retrospektif olarak analiz edildi. Tüm hastaların yaş, cinsiyet,
etiyoloji, tutulan taraf, spastisite varlığı, fonksiyonel ambulasyon seviyeleri
(FAS), üst ve alt ekstremite Brunnstrom evreleri kayıt edildi. Tüm hastaların
yatış sırasındaki tam kan sayısı ve alt parametreleri, beyaz küre (WBC),
eritrosit dağılım genişliği (RDW), platelet dağılım genişliği (PDW), ortalama
platelet volüm (MPV) ile akut faz reaktanları, eritrosit sedimentasyon hızı
(ESR), C-reaktif protein (CRP) kayıt edildi.

Bulgular: Çalışmamıza 32-85 yaş aralığında 55 erkek (%
63.2), 30 kadın (% 34.5) hasta dahil edildi. 
Hastaların % 64’ü 1 yıldan kısa süre inme tanılı, % 86.2’si iskemik, % 50.6’sı
sağ taraf tutulumlu idi.  Hastaların % 25.3’ünde
spastisite yoktu. Spastisite gözlenenler içinde en sık % 23 oranı ile Ashworth
evre 1 spastisite gözlendi. Fonsiyonel düzeyleri en sık % 20.7 oranı ile FAS
3,  üst ekstremite % 32.2 oranı ile Brunnstrom
evre 3, alt ekstremitede % 28.7 oranı ile Brunstrom evre 5 seviyede idi.

Sonuç:
İnflamasyon parametreleri inmeli hastalarda
fonksiyonel seviye hakkında bilgi vermektedir. İnflamatuar reaksiyonu
tetikleyen sistemik inflamasyonu veya nöronal yolların inhibisyonu inme
hastalarında gelecekteki potansiyel tedavi hedefleridir.

Anahtar Kelimeler

inme, nöroinflamasyon, fonksiyonel seviye

Kaynakça

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