Radiotherapy and Temozolomide Non-Rresponsive Adult Spinal Cord Astrocytoma with a Good Response to Bevacizumab: A Case Report and Literature Review

Year 2021, Volume: 16 Issue: 1, 117 - 121, 08.02.2021

Ayşegül Üçüncü Kefeli Süleyman Halil

https://doi.org/10.17517/ksutfd.767351

Abstract

The incidence of spinal cord astrocytomas (SCAs) is very low and therefore, management of these tumors are challenging due to this paucity. In this report, a patient with a recurrent SCA was successfully treated with bevacizumab after failing to previous therapies including radiotherapy (RT) and temozolomide (TMZ). Bevacizumab is an angiogenesis inhibitor that is widely used in high grade gliomas and shows promise for SCAs spinal cord astrocytomas but there is limited data about the usage of bevacizumab in SCAs. We herein add an important contribution to the literature by reporting a nearly total response to bevacizumab in a patient with low grade SCA.

Keywords

bevacizumab, temozolomide, spinal cord astrocytoma

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Thanks

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Bevasizumab’a İyi Cevap Veren, Radyoterapi ve Temozolomid Tedavisine Yanıtsız Bir Erişkin Spinal Kord Astrositomu; Olgu Sunumu ve Literatür Derlemesi

Abstract

Spinal kord astrositomlarının (SKA) görülme sıklığı çok düşüktür ve bu insidans azlığı nedeniyle bu tümörlerin yönetimi zordur. Bu vakada, rekürren SKA'lı bir hastada, radyoterapi (RT) ve temozolomid (TMZ) dahil olmak üzere önceki tedavilerden fayda görmeyen bir hastada bevasizumab ile görülen iyi yanıtı bildirmekteyiz. Bevasizumab, yüksek dereceli gliomlarda yaygın olarak kullanılan ve spinal kord astrositomları için umut vaat eden bir anjiyojenez inhibitörüdür, ancak SKA'larda bevasizumab kullanımı hakkında sınırlı veri bulunmaktadır. Bu yazıda, düşük dereceli SKA'lı bir vakada bevasizumab ile tama yakın cevap bildirerek literatüre önemli bir katkı eklemekteyiz.

Keywords

bevasizumab,, temozolomid, spinal kord astrositomu

Project Number

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