Üriner Sistem Semptomları Olan Multipl Sklerozlu Hastalarda Üriner Sinir Büyüme Faktörü Düzeyleri

Yıl 2021, Cilt: 16 Sayı: 2, 273 - 278, 07.07.2021

Muhammed Seyithanoğlu , Yılmaz İnanç , Songül Bavli

https://doi.org/10.17517/ksutfd.793595

Öz

Amaç: MS hastalarında idrar sinir büyüme faktörünün (NGF) duyarlılığını ve özgüllüğünü detrüsör aşırı aktivitesinin belirteçleri olarak tahmin etmek.
Materyal ve Metod: Multipl Skleroz tanısı ile takip edilen üriner sistem semptomları olan 20 gönüllü hasta ve Multipl Skleroz tanısı olan ancak üriner sistem semptomları olmayan 29 gönüllü hasta çalışmaya dahil edildi. Kişilerden kapsamlı bir anamnez ve spot idrar örnekleri alındı. Benzer yaş ve cinsiyet dağılımına sahip 27 sağlıklı gönüllü NGF düzeyleri açısından karşılaştırma yapmak üzere dahil edildi ve spot idrar örnekleri alındı.
Bulgular: İdrar NGF düzeyleri ve NGF/idrar Kreatinin oranları üriner semptomları bulunan MS hasta grubunda üriner semptomları bulunmayan hasta grubuna göre istatistiki olarak anlamlı olmayan şekilde daha düşüktü, üriner semptomları olmayan hasta grubunda da control grubuna göre istatistiki olarak anlamlılık içermeyen düşüklük gözlendi (p: 0,114 ve 0,833)
Sonuç: Multipl sklerozlu hastalarda idrar nörotrofinleri detrüsör aşırı aktivitesini teşhis etmek için kullanılabilir.

Anahtar Kelimeler

Multipl skleroz, sinir büyüme faktörü, idrar yolu disfonksiyonu

Urinary Nerve Growth Factor Levels In Multiple Sclerosis Patients With Urinary System Symptoms

Öz

Aim: To estimate the sensitivity and specificity of the serum and urinary nerve growth factor (NGF) in MS patients as markers of detrusor overactivity.
Materials and Methods: 20 volunteers who were diagnosed with MS and who had urinary tract symptoms and 29 volunteers who were diagnosed with MS however who did not have urinary tract symptoms were included in the study. A comprehensive anamnesis and spot urine samples were obtained from the subjects. Twenty seven healthy volunteers with similar age and gender distribution were included for making a comparison with regard to NGF levels and spot urine samples were obtained.
Results: Urinary NGF levels and NGF/urinary creatinine ratios were found lower in the group composed of MS patients who had urinary symptoms compared to the group composed of MS patients who did not have urinary symptoms but the difference was not statistically significant. These parameters were found lower in patient group who did not have urinary symptoms compared to control group however the difference was not statistically significant (p: 0,114 and 0,833)
Conclusions: urinary neurotrophins in patients with multiple sclerosis can be used to diagnose detrusor overactivity.

Anahtar Kelimeler

Multiple sclerosis, nerve growth factor, urinary tract dysfunction

Kaynakça

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