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A Detailed Look At Autonomic Involvement in Multiple Sclerosis: Clinical and Diagnostic Approach

Year 2025, Volume: 20 Issue: 3, 233 - 236
https://doi.org/10.17517/ksutfd.1530360

Abstract

Multiple sclerosis is an autoimmune disease of the central nervous system and one of the most common causes of disability in young people. It affects the autonomic nervous system, presenting a wide range of symptoms and signs similar to those of the somatic nervous system. Clinical signs of autonomic nervous system involvement were found in 85% of patients. Bladder and bowel problems, sexual dysfunction, cardiovascular dysfunction, thermoregulatory dysfunction, orthostatic hypotension, and fatigue are among the findings of autonomic nervous system involvement. Autonomic symptoms cause disability and decreased quality of life at least as much as motor symptoms. Patients should be questioned regarding autonomic symptoms, and treatment should be initiated if necessary.

References

  • Oh J, Vidal-Jordana A, Montalban X. Multiple sclerosis: clinical aspects. Curr Opin Neurol. 2018 Dec;31(6):752-759. doi: 10.1097/WCO.0000000000000622. PMID: 30300239.
  • Reich DS, Lucchinetti CF, Calabresi PA. Multiple Sclerosis. N Engl J Med. 2018 Jan 11;378(2):169-180. doi: 10.1056/NEJMra1401483. PMID: 29320652; PMCID: PMC6942519.
  • Sirbu CA, Mezei RM, Falup-Pecurariu C, Bratu OG, Sirbu AM, Ghinescu MC, et al. Autonomic dysfunctions in multiple sclerosis: Challenges of clinical practice (Review). Exp Ther Med. 2020 Dec;20(6):196. doi: 10.3892/etm.2020.9326. Epub 2020 Oct 14. PMID: 33123226; PMCID: PMC7588778.
  • de Seze J, Stojkovic T, Gauvrit JY, Devos D, Ayachi M, Cassim F, et al. Autonomic dysfunction in multiple sclerosis: cervical spinal cord atrophy correlates. J Neurol. 2001 Apr;248(4):297-303. doi: 10.1007/s004150170204. Erratum in: J Neurol 2001 Dec;248(12):1111. PMID: 11374094.
  • Racosta JM, Kimpinski K, Morrow SA, Kremenchutzky M. Autonomic dysfunction in multiple sclerosis. Auton Neurosci. 2015 Dec;193:1-6. doi: 10.1016/j.autneu.2015.06.001. Epub 2015 Jun 7. PMID: 26070809.
  • Nakipoglu GF, Kaya AZ, Orhan G, Tezen O, Tunc H, Ozgirgin N, et al. Urinary dysfunction in multiple sclerosis. J Clin Neurosci. 2009 Oct;16(10):1321-4. doi: 10.1016/j.jocn.2008.12.012. Epub 2009 Jun 27. PMID: 19560927.
  • Aharony SM, Lam O, Corcos J. Evaluation of lower urinary tract symptoms in multiple sclerosis patients: Review of the literature and current guidelines. Can Urol Assoc J. 2017 Jan-Feb;11(1-2):61-64. doi: 10.5489/cuaj.4058. PMID: 28443147; PMCID: PMC5403674.
  • Litwiller SE, Frohman EM, Zimmern PE. Multiple sclerosis and the urologist. J Urol 1999 Mar;161(3):743-57. Erratum in: J Urol 1999 Jul;162(1):172. PMID: 10022678.
  • Sörös P, Hachinski V. Cardiovascular and neurological causes of sudden death after ischaemic stroke. Lancet Neurol. 2012 Feb;11(2):179-88. doi: 10.1016/S1474-4422(11)70291-5. PMID: 22265213.
  • Lensch E, Jost WH. Autonomic disorders in multiple sclerosis. Autoimmune Dis. 2011;2011:803841. doi: 10.4061/2011/803841. Epub 2011 Apr 17. PMID: 21603189; PMCID: PMC3096149.
  • Zorzon M, Zivadinov R, Monti Bragadin L, Moretti R, De Masi R, Nasuelli D, et al. Sexual dysfunction in multiple sclerosis: a 2-year follow-up study. J Neurol Sci. 2001 Jun 15;187(1-2):1-5. doi: 10.1016/s0022-510x(01)00493-2. PMID: 11440738.
  • Barak Y, Achiron A, Elizur A, Gabbay U, Noy S, Sarova-Pinhas I. Sexual dysfunction in relapsing-remitting multiple sclerosis: magnetic resonance imaging, clinical, and psychological correlates. J Psychiatry Neurosci. 1996 Jul;21(4):255-8. PMID: 8754594; PMCID: PMC1188782.
  • Janardhan V, Bakshi R. Quality of life and its relationship to brain lesions and atrophy on magnetic resonance images in 60 patients with multiple sclerosis. Arch Neurol. 2000 Oct;57(10):1485-91. doi: 10.1001/archneur.57.10.1485. PMID: 11030802.
  • Zivadinov R, Zorzon M, Locatelli L, Stival B, Monti F, Nasuelli D, et al. Sexual dysfunction in multiple sclerosis: a MRI, neurophysiological and urodynamic study. J Neurol Sci. 2003 Jun 15;210(1-2):73-6. doi: 10.1016/s0022-510x(03)00025-x. PMID: 12736092.
  • Hanken K, Eling P, Hildebrandt H. The representation of inflammatory signals in the brain - a model for subjective fatigue in multiple sclerosis. Front Neurol. 2014 Dec 11;5:264. doi: 10.3389/fneur.2014.00264. PMID: 25566171; PMCID: PMC4263099.
  • Sander C, Hildebrandt H, Schlake HP, Eling P, Hanken K. Subjective Cognitive Fatigue and Autonomic Abnormalities in Multiple Sclerosis Patients. Front Neurol. 2017 Sep 13;8:475. doi: 10.3389/fneur.2017.00475. PMID: 28955298; PMCID: PMC5601401.
  • Kodounis A, Stamboulis E, Constantinidis TS, Liolios A. Measurement of autonomic dysregulation in multiple sclerosis. Acta Neurol Scand. 2005 Dec;112(6):403-8. doi: 10.1111/j.1600-0404.2005.00446.x. PMID: 16281924.
  • Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD. The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol. 1989 Oct;46(10):1121-3. doi: 10.1001/archneur.1989.00520460115022. PMID: 2803071.
  • Adamec I, Habek M. Autonomic dysfunction in multiple sclerosis. Clin Neurol Neurosurg. 2013 Dec;115 Suppl 1:S73-8. doi: 10.1016/j.clineuro.2013.09.026. PMID: 24321161.

Multipl Skleroziste Otonomik Tutuluma Detaylı Bir Bakış: Klinik ve Tanısal Yaklaşım

Year 2025, Volume: 20 Issue: 3, 233 - 236
https://doi.org/10.17517/ksutfd.1530360

Abstract

Multipl skleroz, merkezi sinir sisteminin otoimmün bir hastalığıdır ve gençlerde engelliliğin en yaygın nedenlerinden biridir. Somatik sinir sisteminde olduğu gibi otonom sinir sistemini de çok çeşitli semptom ve bulgularla etkiler. Hastaların %85'inde otonom sinir sistemi tutulumunun klinik bulguları saptanmıştır. Mesane ve bağırsak sorunları, cinsel, kardiyovasküler, termoregülatuar disfonksiyon, ortostatik hipotansiyon ve yorgunluk otonom sinir sistemi tutulumunun bulguları arasındadır. Otonomik semptomlar en az motor semptomlar kadar özürlülüğe ve yaşam kalitesinde azalmaya neden olur. Hastalar otonomik semptomlar açısından sorgulanmalı ve gerekirse tedavi başlanmalıdır.

References

  • Oh J, Vidal-Jordana A, Montalban X. Multiple sclerosis: clinical aspects. Curr Opin Neurol. 2018 Dec;31(6):752-759. doi: 10.1097/WCO.0000000000000622. PMID: 30300239.
  • Reich DS, Lucchinetti CF, Calabresi PA. Multiple Sclerosis. N Engl J Med. 2018 Jan 11;378(2):169-180. doi: 10.1056/NEJMra1401483. PMID: 29320652; PMCID: PMC6942519.
  • Sirbu CA, Mezei RM, Falup-Pecurariu C, Bratu OG, Sirbu AM, Ghinescu MC, et al. Autonomic dysfunctions in multiple sclerosis: Challenges of clinical practice (Review). Exp Ther Med. 2020 Dec;20(6):196. doi: 10.3892/etm.2020.9326. Epub 2020 Oct 14. PMID: 33123226; PMCID: PMC7588778.
  • de Seze J, Stojkovic T, Gauvrit JY, Devos D, Ayachi M, Cassim F, et al. Autonomic dysfunction in multiple sclerosis: cervical spinal cord atrophy correlates. J Neurol. 2001 Apr;248(4):297-303. doi: 10.1007/s004150170204. Erratum in: J Neurol 2001 Dec;248(12):1111. PMID: 11374094.
  • Racosta JM, Kimpinski K, Morrow SA, Kremenchutzky M. Autonomic dysfunction in multiple sclerosis. Auton Neurosci. 2015 Dec;193:1-6. doi: 10.1016/j.autneu.2015.06.001. Epub 2015 Jun 7. PMID: 26070809.
  • Nakipoglu GF, Kaya AZ, Orhan G, Tezen O, Tunc H, Ozgirgin N, et al. Urinary dysfunction in multiple sclerosis. J Clin Neurosci. 2009 Oct;16(10):1321-4. doi: 10.1016/j.jocn.2008.12.012. Epub 2009 Jun 27. PMID: 19560927.
  • Aharony SM, Lam O, Corcos J. Evaluation of lower urinary tract symptoms in multiple sclerosis patients: Review of the literature and current guidelines. Can Urol Assoc J. 2017 Jan-Feb;11(1-2):61-64. doi: 10.5489/cuaj.4058. PMID: 28443147; PMCID: PMC5403674.
  • Litwiller SE, Frohman EM, Zimmern PE. Multiple sclerosis and the urologist. J Urol 1999 Mar;161(3):743-57. Erratum in: J Urol 1999 Jul;162(1):172. PMID: 10022678.
  • Sörös P, Hachinski V. Cardiovascular and neurological causes of sudden death after ischaemic stroke. Lancet Neurol. 2012 Feb;11(2):179-88. doi: 10.1016/S1474-4422(11)70291-5. PMID: 22265213.
  • Lensch E, Jost WH. Autonomic disorders in multiple sclerosis. Autoimmune Dis. 2011;2011:803841. doi: 10.4061/2011/803841. Epub 2011 Apr 17. PMID: 21603189; PMCID: PMC3096149.
  • Zorzon M, Zivadinov R, Monti Bragadin L, Moretti R, De Masi R, Nasuelli D, et al. Sexual dysfunction in multiple sclerosis: a 2-year follow-up study. J Neurol Sci. 2001 Jun 15;187(1-2):1-5. doi: 10.1016/s0022-510x(01)00493-2. PMID: 11440738.
  • Barak Y, Achiron A, Elizur A, Gabbay U, Noy S, Sarova-Pinhas I. Sexual dysfunction in relapsing-remitting multiple sclerosis: magnetic resonance imaging, clinical, and psychological correlates. J Psychiatry Neurosci. 1996 Jul;21(4):255-8. PMID: 8754594; PMCID: PMC1188782.
  • Janardhan V, Bakshi R. Quality of life and its relationship to brain lesions and atrophy on magnetic resonance images in 60 patients with multiple sclerosis. Arch Neurol. 2000 Oct;57(10):1485-91. doi: 10.1001/archneur.57.10.1485. PMID: 11030802.
  • Zivadinov R, Zorzon M, Locatelli L, Stival B, Monti F, Nasuelli D, et al. Sexual dysfunction in multiple sclerosis: a MRI, neurophysiological and urodynamic study. J Neurol Sci. 2003 Jun 15;210(1-2):73-6. doi: 10.1016/s0022-510x(03)00025-x. PMID: 12736092.
  • Hanken K, Eling P, Hildebrandt H. The representation of inflammatory signals in the brain - a model for subjective fatigue in multiple sclerosis. Front Neurol. 2014 Dec 11;5:264. doi: 10.3389/fneur.2014.00264. PMID: 25566171; PMCID: PMC4263099.
  • Sander C, Hildebrandt H, Schlake HP, Eling P, Hanken K. Subjective Cognitive Fatigue and Autonomic Abnormalities in Multiple Sclerosis Patients. Front Neurol. 2017 Sep 13;8:475. doi: 10.3389/fneur.2017.00475. PMID: 28955298; PMCID: PMC5601401.
  • Kodounis A, Stamboulis E, Constantinidis TS, Liolios A. Measurement of autonomic dysregulation in multiple sclerosis. Acta Neurol Scand. 2005 Dec;112(6):403-8. doi: 10.1111/j.1600-0404.2005.00446.x. PMID: 16281924.
  • Krupp LB, LaRocca NG, Muir-Nash J, Steinberg AD. The fatigue severity scale. Application to patients with multiple sclerosis and systemic lupus erythematosus. Arch Neurol. 1989 Oct;46(10):1121-3. doi: 10.1001/archneur.1989.00520460115022. PMID: 2803071.
  • Adamec I, Habek M. Autonomic dysfunction in multiple sclerosis. Clin Neurol Neurosurg. 2013 Dec;115 Suppl 1:S73-8. doi: 10.1016/j.clineuro.2013.09.026. PMID: 24321161.
There are 19 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Derlemeler
Authors

Buket Tugan Yıldız 0000-0001-6783-2336

Early Pub Date November 22, 2025
Publication Date November 24, 2025
Submission Date August 12, 2024
Acceptance Date October 16, 2024
Published in Issue Year 2025 Volume: 20 Issue: 3

Cite

AMA Tugan Yıldız B. A Detailed Look At Autonomic Involvement in Multiple Sclerosis: Clinical and Diagnostic Approach. KSU Medical Journal. November 2025;20(3):233-236. doi:10.17517/ksutfd.1530360