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Pankreatik Nekroz ve Tedavisi

Year 2025, Volume: 20 Issue: 3, 241 - 248
https://doi.org/10.17517/ksutfd.1744167

Abstract

Akut pankreatit temel olarak pankreas dokusunun inflamasyonudur ve hafif interstisyel (ödematöz) pankreatitten, önemli lokal veya sistemik komplikasyonlarla beraber ciddi oranda morbidite ve mortalitesi olan şiddetli hastalığa kadar ilerleyebilir. Vakaların %80’i hafif olup ciddi morbidite olmaksızın 5-7 günde gerilerken %20’sinde başvuruda veya ilk 72 saat içinde yaygın pankreatik nekroz ve organ yetmezliği ile birlikte seyreden şiddetli veya fulminant akut pankreatit tablosu ortaya çıkmaktadır. Bu durumda %25-30 mortal seyretmektedir. Bu derlemede pankreatik nekroz ve tedavisine güncel bilgiler ışığında pratik bir yaklaşım sunmak amaçlanmıştır.

References

  • Frossard JL, Steer ML, Pastor CM. Acute pancreatitis. Lancet. 2008 Jan 12;371(9607):143-52.
  • Cappell MS. Acute pancreatitis: etiology, clinical presentation, diagnosis, and therapy. Med Clin North Am 2008; 92: 889-923.
  • Brown A, Young B, Morton J, Behrns K, Shaheen N. Are health-related outcomes in acute pancreatitis improving? An analysis of national trends in the U.S. from 1997 to 2003. JOP 2008;9(4):408-14.
  • Spanier BW, Dijkgraaf MG, Bruno MJ. Epidemiology, aetiology and outcome of acute and chronic pancreatitis: An update. Best Pract Res Clin Gastroenterol 2008;22(1):45-63.
  • Mofidi R, Duff MD, Wigmore SJ, Madhavan KK, Garden OJ, Parks RW. Association between early systemic inflammatory response, severity of multiorgan dysfunction and death in acute pancreatitis. Br J Surg. 2006;93(6):738.
  • Fagenholz PJ, Castillo CF, Harris NS, Pelletier AJ, Camargo CA Jr. Increasing United States hospital admissions for acute pancreatitis, 1988-2003. Ann Epidemiol. 2007;17(7):491.
  • Eland IA, Sturkenboom MJ, Wilson JH, Stricker BH. Incidence and mortality of acute pancreatitis between 1985 and 1995. Scand J Gastroenterol 2000;35(10):1110-6.
  • Frey CF, Zhou H, Harvey DJ, White RH. The incidence and case-fatality rates of acute biliary, alcoholic, and idiopathic pancreatitis in California, 1994–2001. Pancreas 2006; 33: 336–44.
  • Gloor B, Müller CA, Worni M, Martignoni ME, Uhl W, Büchler MW. Late mortality in patients with severe acute pancreatitis.Br J Surg. 2001;88(7):975.
  • Banks PA, Freeman ML. Practice guidelines in acute pancreatitis. Am J Gastroenterol 2006;101(10):2379-400.
  • Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, Tsiotos GG, Vege SS; Acute Pancreatitis Classification Working Group. Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus.Gut. 2013 Jan;62(1):102-11.
  • Balthazar EJ, Robinson DL, Megibow AJ, Ranson JH. Acute pancreatitis: value of CT in establishing prognosis. Radiology. 1990;174(2):331.
  • Simchuk EJ, Traverso LW, Nukui Y, Kozarek RA. Computed tomography severity index is a predictor of outcomes for severe pancreatitis. Am J Surg. 2000;179(5):352.
  • Bollen TL, Singh VK, Maurer R, Repas K, van Es HW, Banks PA, Mortele KJ. A comparative evaluation of radiologic and clinical scoring systems in the early prediction of severity in acute pancreatitis. Am J Gastroenterol. 2012;107(4):612.
  • Tenner S, Sica G, Hughes M, Noordhoek E, Feng S, Zinner M, Banks PA. Relationship of necrosis to organ failure in severe acute pancreatitis. Gastroenterology. 1997;113(3):899.
  • Heinrich S, Schäfer M, Rousson V, Clavien PA. Evidence-based treatment of acute pancreatitis a look at established paradigms. Ann Surg 2006;243:154–68.
  • Kim DH, Pickhardt PJ.Radiologic assessment of acute and chronic pancreatitis. Surg Clin North Am 2007;87(6):1341-58.
  • Lankisch PG, Mahlke R, Blum T, et al. Hemoconcentration: an early marker of severe and/or necrotizing pancreatitis? A critical appraisal. Am J Gastroenterol 2001;96:2081–85.
  • Matull WR, Pereira SP, O’Donohue JW. Biochemical markers of acute pancreatitis. J Clin Pathol 2006; 59: 340–44.
  • UK working Party on acute pancreatitis. UK guidelines for the management of acute pancreatitis. Gut 2005;54:1–9.
  • Garg PK, Madan K, Pande GK, Khanna S, Sathyanarayan G, Bohidar NP, Tandon RK. Association of extent and infection of pancreatic necrosis with organ failure and death in acute necrotizing pancreatitis. Clin Gastroenterol Hepatol. 2005 Feb;3(2):159-66.
  • Haydock MD, Mittal A, Wilms HR, et al. Fluid Therapy in Acute Pancreatitis: Anybody's Guess. Ann Surg 2013; 257:182.
  • Wu BU, Johannes RS, Sun X, et al. Early changes in blood urea nitrogen predict mortality in acute pancreatitis. Gastroenterology 2009;137:129.
  • Wu BU, Hwang JQ, Gardner TH, et al. Lactated Ringer's solution reduces systemic inflammation compared with saline in patients with acute pancreatitis. Clin Gastroenterol Hepatol 2011; 9:710.
  • Kapoor K, Repas K, Singh VK, Conwell DL, Mortele KJ, Wu BU, Banks PA. Does the duration of abdominal pain prior to admission influence the severity of acute pancreatitis? JOP. 2013 Mar 10;14(2):171-5. .
  • Wereszczynska-Siemiatkowska U, Swidnicka-Siergiejko A, Siemiatkowski A, Dabrowski A. Early Enteral Nutrition Is Superior to Delayed Enteral Nutrition for the Prevention of Infected Necrosis and Mortality in Acute Pancreatitis. Pancreas. 2013 May;42(4):640-646.
  • Al-Omran M, Albalawi ZH, Tashkandi MF, Al-Ansary LA. Enteral versus parenteral nutrition for acute pancreatitis. Cochrane Database Syst Rev 2010; :CD002837.
  • Jiang K, Huang W, Yang XN, Xia Q. Present and future of prophylactic antibiotics for severe acute pancreatitis. World J Gastroenterol. 2012 Jan 21;18(3):279-84.
  • Yao L, Huang X, Li Y, Shi R, Zhang G. Prophylactic antibiotics reduce pancreatic necrosis in acute necrotizing pancreatitis: a meta-analysis of randomized trials. Dig Surg. 2010;27(6):442-9.
  • Mortelé KJ, Girshman J, Szejnfeld D, et al. CT-guided percutaneous catheter drainage of acute necrotizing pancreatitis: clinical experience and observations in patients with sterile and infected necrosis. AJR Am J Roentgenol 2009; 192:110.
  • Forsmark CE, Baillie J; AGA Institute Clinical Practice and Economics Committee; AGA Institute Governing Board. AGA Institute technical review on acute pancreatitis. Gastroenterology 2007;132(5):2022-44.
  • Beck WC, Bhutani MS, Raju GS, Nealon WH. Surgical management of late sequelae in survivors of an episode of acute necrotizing pancreatitis. J Am Coll Surg. 2012 Apr;214(4):682-8.
  • Perez A, Whang EE, Brooks DC, et al. Is severity of necrotizing pancreatitis increased in extended necrosis and infected necrosis? Pancreas 2002;25:229–33.
  • Gotzinger P, Wamser P, Exner R, et al. Surgical treatment of severe acute pancreatitis: Timing of operation is crucial for survival. Surg Infect (Larchmt) 2003;4:205–11.
  • Mier J, Leon EL, Castillo A, et al. Early versus late necrosectomy in severe necrotizing pancreatitis. Am J Surg 1997;173:71–5.
  • Connor S, Alexakis N, Raraty MG, et al. Early and late complications after pancreatic necrosectomy. Surgery 2005;137:499–505.
  • Van Brunschot S, Bakker OJ, Besselink MG, Bollen TL, Fockens P, Gooszen HG, van Santvoort HC; Dutch Pancreatitis Study Group. Treatment of necrotizing pancreatitis. Clin Gastroenterol Hepatol. 2012 Nov;10(11):1190-201.
  • Baron TH, Harewood GC, Morgan DE, et al. Outcome differences after endoscopic drainage of pancreatic necrosis, acute pancreatic pseudocysts, and chronic pancreatic pseudocysts. Gastrointest Endosc 2002;56:7–17.
  • Traverso LW, Kozarek RA. Pancreatic necrosectomy: Definitions and technique. J Gastrointest Surg 2005;9:436–9.
  • Sriram PV, Kaffes AJ, Rao GV, et al. Endoscopic ultrasound-guided drainage of pancreatic pseudocysts complicated by portal hypertension or by intervening vessels. Endoscopy 2005;37:231–5.
  • Werner J, Feuerbach S, Uhl W, et al. Management of acute pancreatitis: From surgery to interventional intensive care. Gut 2005;54:426–36.
  • Seewald S, Groth S, Omar S, et al. Aggressive endoscopic therapy for pancreatic necrosis and pancreatic abscess: A new safe and effective treatment algorithm. Gastrointest Endosc 2005;62:92–100.
  • Howard TJ, Rhodes GJ, Selzer DJ, et al. Roux-en-Y internal drainage is the best surgical option to treat patients with disconnected duct syndrome after severe acute pan- pancreatitis. Surgery 2001;130:714–9.
  • Mouli VP, Sreenivas V, Garg PK. Efficacy of Conservative Treatment, Without Necrosectomy, for Infected Pancreatic Necrosis: A Systematic Review and Meta-analysis. Gastroenterology. 2012 Oct 12. doi:pii: S0016-5085(12)01494-1.
  • Cirocchi R, Trastulli S, Desiderio J, Boselli C, Parisi A, Noya G, Falconi M. Minimally invasive necrosectomy versus conventional surgery in the treatment of infected pancreatic necrosis: a systematic review and a meta-analysis of comparative studies. Surg Laparosc Endosc Percutan Tech. 2013 Feb;23(1):8-20.
  • Angel García-Ureña M, López-Monclús J, Melero-Montes D, Blázquez-Hernando LA, Castellón-Pavón C, Calvo-Durán E, Gordo-Vidal F, Hoyo LF. Video-assisted Laparoscopic Débridement for Retroperitoneal Pancreatic Collections: A Reliable Step-up Approach. Am Surg. 2013 Apr;79(4):429-33.

Pancreatic Necrosis and Treatment

Year 2025, Volume: 20 Issue: 3, 241 - 248
https://doi.org/10.17517/ksutfd.1744167

Abstract

Acute pancreatitis is essentially inflammation of pancreatic tissue and can progress from mild interstitial (edematous) pancreatitis to severe disease with significant local or systemic complications and significant morbidity and mortality. While 80% of cases are mild and resolve in 5-7 days without serious morbidity, 20% present with severe or fulminant acute pancreatitis with widespread pancreatic necrosis and organ failure on presentation or within the first 72 hours. In this case, 25-30% have a mortal course. In this review, we aimed to present a practical approach to pancreatic necrosis and its treatment in the light of current knowledge.

References

  • Frossard JL, Steer ML, Pastor CM. Acute pancreatitis. Lancet. 2008 Jan 12;371(9607):143-52.
  • Cappell MS. Acute pancreatitis: etiology, clinical presentation, diagnosis, and therapy. Med Clin North Am 2008; 92: 889-923.
  • Brown A, Young B, Morton J, Behrns K, Shaheen N. Are health-related outcomes in acute pancreatitis improving? An analysis of national trends in the U.S. from 1997 to 2003. JOP 2008;9(4):408-14.
  • Spanier BW, Dijkgraaf MG, Bruno MJ. Epidemiology, aetiology and outcome of acute and chronic pancreatitis: An update. Best Pract Res Clin Gastroenterol 2008;22(1):45-63.
  • Mofidi R, Duff MD, Wigmore SJ, Madhavan KK, Garden OJ, Parks RW. Association between early systemic inflammatory response, severity of multiorgan dysfunction and death in acute pancreatitis. Br J Surg. 2006;93(6):738.
  • Fagenholz PJ, Castillo CF, Harris NS, Pelletier AJ, Camargo CA Jr. Increasing United States hospital admissions for acute pancreatitis, 1988-2003. Ann Epidemiol. 2007;17(7):491.
  • Eland IA, Sturkenboom MJ, Wilson JH, Stricker BH. Incidence and mortality of acute pancreatitis between 1985 and 1995. Scand J Gastroenterol 2000;35(10):1110-6.
  • Frey CF, Zhou H, Harvey DJ, White RH. The incidence and case-fatality rates of acute biliary, alcoholic, and idiopathic pancreatitis in California, 1994–2001. Pancreas 2006; 33: 336–44.
  • Gloor B, Müller CA, Worni M, Martignoni ME, Uhl W, Büchler MW. Late mortality in patients with severe acute pancreatitis.Br J Surg. 2001;88(7):975.
  • Banks PA, Freeman ML. Practice guidelines in acute pancreatitis. Am J Gastroenterol 2006;101(10):2379-400.
  • Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, Tsiotos GG, Vege SS; Acute Pancreatitis Classification Working Group. Classification of acute pancreatitis--2012: revision of the Atlanta classification and definitions by international consensus.Gut. 2013 Jan;62(1):102-11.
  • Balthazar EJ, Robinson DL, Megibow AJ, Ranson JH. Acute pancreatitis: value of CT in establishing prognosis. Radiology. 1990;174(2):331.
  • Simchuk EJ, Traverso LW, Nukui Y, Kozarek RA. Computed tomography severity index is a predictor of outcomes for severe pancreatitis. Am J Surg. 2000;179(5):352.
  • Bollen TL, Singh VK, Maurer R, Repas K, van Es HW, Banks PA, Mortele KJ. A comparative evaluation of radiologic and clinical scoring systems in the early prediction of severity in acute pancreatitis. Am J Gastroenterol. 2012;107(4):612.
  • Tenner S, Sica G, Hughes M, Noordhoek E, Feng S, Zinner M, Banks PA. Relationship of necrosis to organ failure in severe acute pancreatitis. Gastroenterology. 1997;113(3):899.
  • Heinrich S, Schäfer M, Rousson V, Clavien PA. Evidence-based treatment of acute pancreatitis a look at established paradigms. Ann Surg 2006;243:154–68.
  • Kim DH, Pickhardt PJ.Radiologic assessment of acute and chronic pancreatitis. Surg Clin North Am 2007;87(6):1341-58.
  • Lankisch PG, Mahlke R, Blum T, et al. Hemoconcentration: an early marker of severe and/or necrotizing pancreatitis? A critical appraisal. Am J Gastroenterol 2001;96:2081–85.
  • Matull WR, Pereira SP, O’Donohue JW. Biochemical markers of acute pancreatitis. J Clin Pathol 2006; 59: 340–44.
  • UK working Party on acute pancreatitis. UK guidelines for the management of acute pancreatitis. Gut 2005;54:1–9.
  • Garg PK, Madan K, Pande GK, Khanna S, Sathyanarayan G, Bohidar NP, Tandon RK. Association of extent and infection of pancreatic necrosis with organ failure and death in acute necrotizing pancreatitis. Clin Gastroenterol Hepatol. 2005 Feb;3(2):159-66.
  • Haydock MD, Mittal A, Wilms HR, et al. Fluid Therapy in Acute Pancreatitis: Anybody's Guess. Ann Surg 2013; 257:182.
  • Wu BU, Johannes RS, Sun X, et al. Early changes in blood urea nitrogen predict mortality in acute pancreatitis. Gastroenterology 2009;137:129.
  • Wu BU, Hwang JQ, Gardner TH, et al. Lactated Ringer's solution reduces systemic inflammation compared with saline in patients with acute pancreatitis. Clin Gastroenterol Hepatol 2011; 9:710.
  • Kapoor K, Repas K, Singh VK, Conwell DL, Mortele KJ, Wu BU, Banks PA. Does the duration of abdominal pain prior to admission influence the severity of acute pancreatitis? JOP. 2013 Mar 10;14(2):171-5. .
  • Wereszczynska-Siemiatkowska U, Swidnicka-Siergiejko A, Siemiatkowski A, Dabrowski A. Early Enteral Nutrition Is Superior to Delayed Enteral Nutrition for the Prevention of Infected Necrosis and Mortality in Acute Pancreatitis. Pancreas. 2013 May;42(4):640-646.
  • Al-Omran M, Albalawi ZH, Tashkandi MF, Al-Ansary LA. Enteral versus parenteral nutrition for acute pancreatitis. Cochrane Database Syst Rev 2010; :CD002837.
  • Jiang K, Huang W, Yang XN, Xia Q. Present and future of prophylactic antibiotics for severe acute pancreatitis. World J Gastroenterol. 2012 Jan 21;18(3):279-84.
  • Yao L, Huang X, Li Y, Shi R, Zhang G. Prophylactic antibiotics reduce pancreatic necrosis in acute necrotizing pancreatitis: a meta-analysis of randomized trials. Dig Surg. 2010;27(6):442-9.
  • Mortelé KJ, Girshman J, Szejnfeld D, et al. CT-guided percutaneous catheter drainage of acute necrotizing pancreatitis: clinical experience and observations in patients with sterile and infected necrosis. AJR Am J Roentgenol 2009; 192:110.
  • Forsmark CE, Baillie J; AGA Institute Clinical Practice and Economics Committee; AGA Institute Governing Board. AGA Institute technical review on acute pancreatitis. Gastroenterology 2007;132(5):2022-44.
  • Beck WC, Bhutani MS, Raju GS, Nealon WH. Surgical management of late sequelae in survivors of an episode of acute necrotizing pancreatitis. J Am Coll Surg. 2012 Apr;214(4):682-8.
  • Perez A, Whang EE, Brooks DC, et al. Is severity of necrotizing pancreatitis increased in extended necrosis and infected necrosis? Pancreas 2002;25:229–33.
  • Gotzinger P, Wamser P, Exner R, et al. Surgical treatment of severe acute pancreatitis: Timing of operation is crucial for survival. Surg Infect (Larchmt) 2003;4:205–11.
  • Mier J, Leon EL, Castillo A, et al. Early versus late necrosectomy in severe necrotizing pancreatitis. Am J Surg 1997;173:71–5.
  • Connor S, Alexakis N, Raraty MG, et al. Early and late complications after pancreatic necrosectomy. Surgery 2005;137:499–505.
  • Van Brunschot S, Bakker OJ, Besselink MG, Bollen TL, Fockens P, Gooszen HG, van Santvoort HC; Dutch Pancreatitis Study Group. Treatment of necrotizing pancreatitis. Clin Gastroenterol Hepatol. 2012 Nov;10(11):1190-201.
  • Baron TH, Harewood GC, Morgan DE, et al. Outcome differences after endoscopic drainage of pancreatic necrosis, acute pancreatic pseudocysts, and chronic pancreatic pseudocysts. Gastrointest Endosc 2002;56:7–17.
  • Traverso LW, Kozarek RA. Pancreatic necrosectomy: Definitions and technique. J Gastrointest Surg 2005;9:436–9.
  • Sriram PV, Kaffes AJ, Rao GV, et al. Endoscopic ultrasound-guided drainage of pancreatic pseudocysts complicated by portal hypertension or by intervening vessels. Endoscopy 2005;37:231–5.
  • Werner J, Feuerbach S, Uhl W, et al. Management of acute pancreatitis: From surgery to interventional intensive care. Gut 2005;54:426–36.
  • Seewald S, Groth S, Omar S, et al. Aggressive endoscopic therapy for pancreatic necrosis and pancreatic abscess: A new safe and effective treatment algorithm. Gastrointest Endosc 2005;62:92–100.
  • Howard TJ, Rhodes GJ, Selzer DJ, et al. Roux-en-Y internal drainage is the best surgical option to treat patients with disconnected duct syndrome after severe acute pan- pancreatitis. Surgery 2001;130:714–9.
  • Mouli VP, Sreenivas V, Garg PK. Efficacy of Conservative Treatment, Without Necrosectomy, for Infected Pancreatic Necrosis: A Systematic Review and Meta-analysis. Gastroenterology. 2012 Oct 12. doi:pii: S0016-5085(12)01494-1.
  • Cirocchi R, Trastulli S, Desiderio J, Boselli C, Parisi A, Noya G, Falconi M. Minimally invasive necrosectomy versus conventional surgery in the treatment of infected pancreatic necrosis: a systematic review and a meta-analysis of comparative studies. Surg Laparosc Endosc Percutan Tech. 2013 Feb;23(1):8-20.
  • Angel García-Ureña M, López-Monclús J, Melero-Montes D, Blázquez-Hernando LA, Castellón-Pavón C, Calvo-Durán E, Gordo-Vidal F, Hoyo LF. Video-assisted Laparoscopic Débridement for Retroperitoneal Pancreatic Collections: A Reliable Step-up Approach. Am Surg. 2013 Apr;79(4):429-33.
There are 46 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Derlemeler
Authors

Mesut Kuş 0009-0009-0709-7275

Serhat Akpınar 0009-0002-3851-937X

Bülent Kantarçeken 0000-0003-4214-817X

Kadir Gişi 0000-0003-4082-4832

Early Pub Date November 22, 2025
Publication Date November 26, 2025
Submission Date July 16, 2025
Acceptance Date August 1, 2025
Published in Issue Year 2025 Volume: 20 Issue: 3

Cite

AMA Kuş M, Akpınar S, Kantarçeken B, Gişi K. Pankreatik Nekroz ve Tedavisi. KSU Medical Journal. November 2025;20(3):241-248. doi:10.17517/ksutfd.1744167