The Relationship between COVID-19 Suspected Patient’s Coagulation and Platelet Parameters and Polymerase Chain Reaction Results

Abstract

Objective: This study aims to investigate the relationship between prothrombin time (PT), activated partial thromboplastin time (aPTT), INR (International Normalized Ratio), and D-dimer levels, platelet (PLT) levels at hospital admission, and positivity or negativity of Polymerase Chain Reaction (PCR) test results in patients with suspected coronavirus disease-19 (COVID-19) followed at COVID-19 services. Method: This study was performed on 238 patients with the prediagnosis of COVID-19, all patients are hospitalised in Samsun city at our hospital between 11 March 2020-30 May 2020. According to COVID-19 PCR test results, PCR test negative 119 individua and PCR test positive 119 patients were included in the study. PT, aPTT, D-dimer, INR, and PLT levels were examined. Result: While PCR test negative individuals had a mean PT value of 11.46±0.86 sec, PCR test positive patients had a mean PT value of 12.97±3.65 sec (p<0.001). There was no significant difference in mean aPTT values of PCR test positive and negative patients. Whereas INR, D-dimer increased significantly in PCR test positive patients. PLT value decreased from a mean value of 266.75±71.36*109/L in PCR test negative patients to 241.18±96.64*109/L in PCR test positive patients (p=0.002). Conclusion: In our study, it was found that in patients who were admitted to hospital with COVID-19 suspicion and followed up in COVID-19 services, PT, D-dimer, INR, PLT values were important in detecting coagulopathy and thrombocytopenia in the group who were PCR positivity.

Keywords

• COVID-19
• PT
• aPTT
• D-dimer
• INR
• PCR test
• PLT

COVID-19 Şüphesi Taşıyan Hastaların Koagülasyon ve Trombosit Parametreleri ile Polimeraz Zincirleme Tepkimesi Sonuçları Arasındaki İlişki

Abstract

Amaç: COVID-19 şüphesi ile COVID-19 servislerinde takip edilen hastaların, hastaneye başvuru sırasında yapılan Protrombin Zamanı (PT), aktive Parsiyel Tromboplastin Zamanı (aPTT), INR (International Normalized Ratio), D-Dimer düzeyleri, Trombosit (PLT) düzeyleri ile Polimeraz Zincirleme Tepkimesi (PCR) sonucunun pozitif veya negatif durumu arasındaki ilişkiyi araştırmak amaçlanmaktadır. Gereç ve Yöntem: Bu çalışma 11 Mart 2020- 30 Mayıs 2020 tarihleri arasında, Samsun ilinde, hastanemizde COVID-19 şüphesi ile yatan 238 hasta ile yapılmıştır. COVID-19 sonuçlarına göre PCR testi negatif 119 kişi ve PCR testi pozitif 119 hasta çalışmaya dahil edilmiştir. PT, aPTT, D-dimer, INRve PLT düzeylerine bakılmıştır. Bulgular: PT; PCR testi negatif katılımcılarda ortalama 11,46±0,86 sn değeri bulunurken, PCR testi pozitif hastalarda 12,97±3,65 sn, (p<0,01), aPTT; PCR negatif katılımcılarda ortalama 24,38±3,40 sn, PCR pozitif hastalarda ise 24,18±4,83 sn,(p>0,05) olarak bulunmuştur. D-Dimer, PCR testi negatif katılımcılarda ortalama 0,23±0,12 μg/ML, PCR testi pozitif hastalarda ise 2,10±5,60 μg/ML, (p<0,01) olarak tespit edilmiştir. INR; PCR negative katılımcılarda 0,99±0,12 değeri, PCR pozitif hastalarda ise 1,14±0,35, (p<0,01) değeri bulunmuştur. PLT; PCR testi negative katılımcılarda 266,75±71,36 (109/L), PCR testi pozitif hastalarda ise 241,18±96,64 (109/L) olarak saptanmıştır (p=0,002). Sonuç: Çalışmamızda, hastaneye COVID-19 şüphesi ile başvuran, COVID-19 servislerinde takip edilen, PCR pozitif olan hastalarda, PT, D-Dimer, INR, PLT değerlerinin, koagülopati ve trombositopeni tespitinde önemli olduğu saptandı.

Keywords

• COVID-19
• PT
• aPTT
• D-Dimer
• INR
• PLT
• PCR Test

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