İnflamatuar Bağırsak Hastalıklarında Sigara İçme Durumu, Karbon Monoksit Düzeyleri ile Yaşam Kalitesi ve Hastalık Özellikleri Arasındaki İlişki

Abstract

Amaç: Bu çalışmada inflamatuar barsak hastalığı olan hastalarda sigara içme durumu ile ekshale edilen karbon monoksit (E-CO) düzeyleri, yaşam kalitesi ve hastalık özellikleri arasındaki ilişkiyi incelenmiştir. Yöntemler: Hastanemize 01.12.2020-01.03.2021 tarihleri arasında başvuran inflamatuar bağırsak hastalığı (İBH) olan 121 hastanın demografik, hastalık özellikleri ve sigara içme durumları araştırıldı. İlk takipten sonra bu katılımcıların (E-CO) seviyeleri birbirini izleyen dört haftada bir ölçüldü. Bu E-CO okumalarının ortalaması, ana E-CO değeri olarak kabul edildi. İlk uygulamadan bir ay sonra SF-36 Yaşam Kalitesi Ölçeği uygulanarak değişkenler arasındaki ilişki araştırıldı. Bulgular: Katılımcıların yaş ortalaması 42,06±14,9 yıl olup, %36,3'ü aktif olarak sigara içiyordu. Crohn hastalığı (CH) olan hastalar daha yüksek sigara içme oranı sergilerken, ülseratif kolitli (ÜK) sigara içenlerde anlamlı olarak daha yüksek ortalama CO ppm değerleri bulunmuştur (p<0,05). Sigara içen ÜK hastalarının genel sağlık bileşenleri içmeyenlere göre daha yüksekti (p<0,05). ÜK grubunda günlük içilen ortalama sigara sayısı, ortalama CO ppm, Fagerström Nikotin Bağımlılık Testi (FNBT), paket yılı ile SF-36'nın fiziksel ve mental bileşenleri arasında zayıf korelasyon saptandı (p<0,05). CH grubunda mental bileşenler ile ortalama E-CO arasında zayıf negatif korelasyon vardı (p=0,027). Sigara içmeyen grupta pasif içiciliğe maruz kalan katılımcılar ile böyle bir maruziyeti olmayanlar arasında fark gözlenmedi (p>0,05). Sonuç: Sonuçlarımız, sigara içmenin ÜK tanılı hastalarda sağlık kalitesi üzerinde zayıf bir pozitif etkiye sahip olduğunu, ancak Crohn hastalarında herhangi bir etkisinin olmadığını ortaya koydu.

Keywords

• Crohn hastalığı
• inflamatuar barsak hastalığı
• karbon monoksit
• sigara
• ülseratif kolit

The Relationship between Smoking Status, Carbon Monoxide Levels and Quality of Life, Disease Characteristics in Inflammatory Bowel Diseases

Abstract

Objective: The aim of the study was to analyze the relationship between smoking status and exhaled carbon monoxide (E-CO) levels, quality of life, and disease characteristics in patients with inflammatory bowel disease. Methods: The demographic and disease characteristics and smoking status of 121 patients with inflammatory bowel disease who presented our hospital between 01.12.2020 and 01.03.2021 were investigated. After the first follow-up, the E-CO levels of these participants were measured every four consecutive weeks. The mean of these E-CO readings was accepted as the main E-CO value. After one month after their first application SF-36 Quality of Life Scale was applied. The relationship between these variables was investigated. Results: The mean age of the participants was 42.06±14.9 years, and 36.3% were active smokers. While patients with Crohn’s disease (CD) exhibited a higher smoking rate, smokers with ulcerative colitis (UC) registered significantly higher mean CO ppm readings (p<0.05). The general health components of smoker UC patients were higher than those of non-smokers (p<0.05). A weak correlation was determined between mean number of cigarettes smoked per day, mean CO ppm, Fagerström Nicotine Dependency Test (FNDT), package year, and the physical and mental components of SF-36 in the UC group (p<0.05). There was a weak negative correlation between mental components and mean E-CO in the CD group (p=0.027). No difference was observed in the non-smoker group between participants exposed to second-hand smoke and those with no such exposure (p>0.05). Conclusion: Our results revealed that smoking has a weak positive effect on the quality of health in patients with UC, but no effect on patients with CD.

Keywords

• Carbon monoxide
• Crohn
• inflammatory bowel disease
• SF-36
• smoking
• ulcerative colitis

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