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Abstract

Aim: Pemphigus vulgaris (PV) is an autoimmune blistering skin disease. The aim of this study is to determine the relationship between the neutrophil-to-lymphocyte ratio (NLR) and PV. Methods: A total of 49 newly diagnosed patients with PV and 48 healthy controls were included in the study. The patients were grouped into mild, moderate and severe types according to the dose of administered corticosteroids. All data was obtained using inpatient records. Disease severity, findings on physical examination, complete blood count (CBC), C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) parameters were noted. Lymphocyte and neutrophil numbers were noted from CBC findings. The NLR was compared between the patients and controls and among the patient groups. Analysis of data was done using SPSS 15.0. Results: Neutrophil count, NLR, ESR and CRP levels of the patients with PV were higher than the controls (p<0.001, p=0.002, p<0.001, p<0.001, respectively). NLR, CRP and ESR were not correlated with disease activity. Conclusion: NLR has been shown to be a useful indicator of disease severity and prognosis in many diseases. This study demonstrates that it is a parameter distinguishing patients with PV from healthy controls

Keywords

• Neutrophil-to-Lymphocyte Ratio, Pemphigus Vulgaris, İnflammation

Nötrofil/lenfosit Oranının Pemfigus Vulgaris ile İlişkisi

Abstract

Amaç: Pemfigus vulgaris (PV), otoimmün kökenli, bül oluşumuyla seyreden bir deri hastalığıdır. Bu çalışmanın amacı, PV hastalarındaki inflamasyon ile nötrofil-lenfosit oranı (NLO) arasındaki ilişkiyi belirlemektir. Yöntem: Çalışmaya 49 yeni tanı konan pemfigus vulgaris hastası ile 48 sağlıklı birey dahil edildi. Hastalar, hastalığın şiddetine bağlı olarak başlanan steroid dozuna göre; hafif, orta ve şiddetli hastalık olarak üç alt grupta sınıflandırıldı. Tüm veriler yatan hasta kayıtlarının incelenmesiyle elde edildi. Tüm hastalarda hastalık şiddet indeksi, muayene bulguları, tam kan sayımı (TKS), C reaktif protein (CRP) ve eritrosit sedimentasyon hızı (ESH) incelendi. Lenfosit ve nötrofil sayısı TKS verilerinden not edildi. Nötrofil-lenfosit oranı (NLO), hastalık alt grupları arasında ve kontroller ile SPSS 15,0 programı kullanılarak karşılaştırıldı. Bulgular: Çalışmamızda nötrofil sayısı, NLO, ESH ve CRP düzeyleri pemfiguslu hastalarda kontrollerden yüksekti (sırasıyla, p<0,001, p=0,002, p<0,001, p<0,001). NLO, CRP ve ESH düzeyleri hastalık şiddet skoruyla korele değildi. Sonuç: NLO’nun birçok hastalıkta şiddet ve prognoz belirteci olarak kullanışlı ve yararlı bir parametre olduğu saptanmıştır. Kolayca hesaplanan bu ölçeğin, PV’li hastalarda da kontrollerden ayırt edici bir gösterge olduğu saptandı

Keywords

• Nötrofil-Lenfosit Oranı, Pemfigus Vulgaris, İnflamasyon

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