Vitamin A, Vitamin D, Zinc and Iron Levels in Children Undergoing Adenoidectomy and Placement of Tympanostomy Tubes

Abstract

Objectives: Adenoidectomy and the placement of tympanostomy tubes are among the most commonly performed surgical procedures in ear nose and throat clinics. Systemic and local causes have been implicated in the pathophysiology leading to these procedures. The aim of this study was to investigate a possible association between levels of vitamin A, vitamin D, iron, and zinc need to undergoing adenoidectomy and placement of tympanostomy tubes. Material and Methods: Demographic and disease-specific data were obtained from 31 Turkish children undergoing adenoidectomy and the placement of tympanostomy tubes, and 14 controls. Blood samples were taken for measurement of vitamin A, zinc, iron, and 25-hydroxy vitamin D (25[OH]D). All measurements were done in the same laboratory by the same researcher. Results: The study group comprised 13 (41.9%) girls and 18 (58.1%) boys, and the control group 7 (50%) girls and 7 (50%) boys. There were no statistically significant differences between study and control groups in plasma 25(OH)D, iron, zinc, or vitamin A levels (p>0.05). Conclusions: This pilot study did not show an association between serum vitamin D, iron, zinc, and vitamin A and the need to have an adenoidectomy and placement of tympanostomy tubes

Keywords

• Adenoidectomy
• Tympanostomy Tube
• Vitamin D
• Vitamin A
• Zinc
• Iron

Adenoidektomi ve kulaklara ventilasyon Tüpü Takılan Çocuklarda Vitamin A, Vitamin D, Çinko ve Demir Düzeyleri

Abstract

Amaç: Adenoidektomi ve kulağa ventilasyon tüpu takılması islemleri kulak burun boğaz kliniklerinde en sık uygulanan cerrahi işlemler arasında yer almaktadır. Bu işlemlere yol açan patofizyolojik mekanizmadan birçok sistemik ve lokal faktör sorumlu tutulmaktadır. Bu çalışmamızda adenoidektomi ve kulaklara ventilasyon tüpleri takılması ameliyatları yapılan çocuklarda, A vitamini, D vitamini, demir ve çinko düzeyleri arasında olası bir ilişkinin araştırılması amaçlanmıştır. Materyal ve Metod: Adenoidektomi ve kulaklara ventilasyon tüpü takılması islemi yapılan 31 hasta ve 14 sağlıklı çocuğun demografik yapıları ve hastalığa özgü verileri araştırıldı. A vitamini, çinko, demir ve 25-hidroksi vitamin D (25 [OH] D) ölçümü için kan örnekleri alındı. Tüm ölçümler aynı araştırmacı tarafından aynı laboratuvarda yapıldı. Bulgular: Çalışmaya toplam 45 çocuk dahil edildi. Çalışma grubu 13 (%41.9) kız ve 18 (%58.1) erkek, kontrol grubunda 7 (%50) kız ve 7 erkek (% 50) oluşmaktadır. Plazma 25(OH)vitamin D, demir, çinko ve A vitamini düzeyleri açısından çalışma ve kontrol grupları arasında istatistiksel olarak anlamlı fark, görülmedi (p<0.05). Sonuç: Çalışmamızda, serum vitamin A, vitamin D, demir ve çinko düzeyleri ile adenoidektomi ve kulağa ventilasyon tüpü takılması ihtiyacı arasında anlamlı bir ilişki görülmemiştir

Keywords

• Adenoidektomi
• Timpanostomi Tüpü
• D Vitamini
• A

References

1. Saylam G, Tatar EC, Tatar I, Ozdek A, Korkmaz H. Association of adenoid surface biofilm formation and chronic otitis media with effusion. Arch Otolaryngol Head Neck Surg. 2010;136(6):550-5.
2. Moro JR, Iwata M, von Andriano UH. Vitamin effects on the immune system: vitamins A and D take centre stage. Nat Rev Immunol. 2008;8(9):685-98.
3. Sigmundsdottir H, Pan J, Debes GF, et al. DCs metabolize sunlight-induced vitamin D3 to ‘program’ T cell attraction to the epidermal chemokine CCL27. Nat Immunol. 2007;8(3):285-93.
4. Pinto JM, Schneider J, Perez R, DeTineo M, Baroody FM, Naclerio RM. Serum 25 hydroxyvitamin D levels are lower in urban African American subjects with chronic rhinosinusitis. Allergy Clin Immunol. 2008;122(2):415-7.
5. Lasisi AO. The role of retinol in the etiology and outcome of suppurative otitis media. Eur Arch Otorhinolaryngol. 2009;266(5):647-52.
6. Long KZ, Montoya Y, Hertzmark E, Santos IJ, Rosado JL. A double-blind, randomized, clinical trial of the effect of vitamin A and zinc supplementation on diarrheal disease and respiratory tract infections in children in Mexico City, Mexico. Am J Clin Nutr. 2006;83(3):693-700.
7. Guven M, Aladag I, Eyibilen A, Filiz NO, Ozyurt H, Yelken K. Experimentally induced acute sinusitis and efficacy of vitamin A. Acta Otolaryngol. 2007;127(8):855-60.
8. Semba RD, Bloem MW. The anemia of vitamin A deficiency: epidemiology and pathogenesis. Eur J Clin Nutr. 2002; 56(4):271-81.

9. Coles CL, Rahmathullah L, Kanungo R, et al. Vitamin A supplementation at birth delays pneumococcal colonization in south Indian infants. J Nutr. 2001; 131(2):255-61.
10. Jimenez C, Leets I, Puche R, et al. A single dose of vitamin A improves haemoglobin concentration, retinol status and phagocytic function of neutrophils in preschool children. Br J Nutr. 2010;103(6):798-802.
11. Mejia LA, Chew F. Hematological effect of supplementing anemic children with vitamin A alone and in combination with Fe. Am J Clin Nutr. 1988;48(3):595-600.
12. Lassi ZS, Haider BA, Bhutta ZA. Zinc supplementation for the prevention of pneumonia in children aged 2 months to 59 months. Cochrane Database Syst Rev. 2010;12:5978.
13. Van den Aardweg MT, Schilder AG, Herkert E, Boonacker CW, Rovers MM. Adenoidectomy for otitis media in children. Cochrane Database Syst Rev. 2010;20:7810.
14. Holick MR. Vitamin D deficiency. N Engl J Med. 2007; 357(3):266-81.
15. Esteitie R, Naclerio RM, Baroody FM. Vitamin D levels in children undergoing adenotonsillectomies. Int J Pediatr Otorhinolaryngol. 2010;74(9):1075-7.
16. Craft NE, Haitema T, Brindle LK, Yamini S, Humphrey JH, West KP. Retinol analysis in dried blood spots by HPLC. J Nutr. 2000; 130(4):882-5.
17. Shankar AH, Prasad AS. Zinc and immune function: the biological basis of altered resistance to infection. Am J Clin Nutr. 1998;68(2 Suppl):447S-63S.
18. Bahl R, Bhandari N, Hambidge KM, Bhan MK. Plasma zinc as a predictor of diarrheal and respiratory morbidity in children in urban slum setting. Am J Clin Nutr. 1998;68(S2):S414-7.
19. Busuttil A, Kerr AIG, Logan RW. Iron deficiency in children undergoing tonsillectomy. J Laryngol Otol. 1979;93(1):49-58.
20. Onerci M, Kus S. Trace elements in children with chronic and recurrent tonsillitis. Int J Pediatr Otorhinolaryngol. 1997;41(1):47-51.