-

Abstract

Introduction: During and after adjuvant therapy of breast cancer organ toxicity could exist. Lung toxicity was the one of these frequent treatment complications. In our study the impact of the tumor localization to the lung toxicity after adjuvant therapy of breast cancer was investigated. Material and Method: A total of 78 subjects from Kayseri Education and Research Hospital and Mersin State Hospital were included in the study. For each breast the total number of patients was 39 (right and left breast). All of the patients were in remission and treatments of the patients had finished 6 months before inclusion. All patients were examined with respiratory function test. Results: There was no statistically significant between FEV1, FEC, FEV1/FVC values in the patient groups for the right and left breast cancer. Discussion: Despite the small number of patients included, our study showed that tumor localization does not affect the lung toxicity due to the chemoradiotherapy

Keywords

• -

Adjuvan Kemoradyoterapi Alan Meme Kanserli Hastalarda Tümör Lokalizasyonunun Akciğer Toksisitesine Etkisi

Abstract

Giriş: Meme kanseri adjuvan tedavisi sırasında ve sonrasında organ toksisiteleri oluşabilmektedir. Bunlar içinde akciğer toksisitesi sık görülen tedavi komplikasyonlarındandır. Çalışmamızda meme kanseri adjuvan tedavisi sonrası oluşabilen akciğer toksisitesine kanserin lokalize olduğu meme bölgesinin etkisi olup olmadığı araştırılmıştır. Materyal ve Metod: Kayseri Eğitim ve Araştırma Hastanesi ile Mersin Devlet Hastanesinden toplam 78 meme kanserli hasta alındı. Her iki meme lokalizasyonu için (sağ ve sol meme) hasta sayısı 39 idi. Hastalar remisyonda idi ve tedavileri 6 ay önce bitmişti. Tüm hastalara solunum fonksiyon testi uygulandı. Sonuçlar. Yapılan istatistiksel test sonucunda hastaların solunum fonksiyon testleri açısından sağ ve sol meme karsinomlu hasta grupları için FEV1, FVC ve FEV1/FVC değerleri arasında anlamlı fark yoktu. Tartışma. Hasta sayıları az olsa da çalışmamız, meme lokalizasyonunun meme kanserli hastalarda, kemoradyoterapiye bağlı akciğer toksisitesini etkilemediğini göstermektedir

Keywords

• Meme Kanseri, Kemoradyoterapi, Solunum

References

1. Jacobs C, Slade M, Lavery B. Doxorubicin and BOOP. A possible near fatal association. Clin Oncol (R Coll Radiol) 2002; 14(3):262.
2. Read, WL, Mortimer, JE, Picus, J. Severe interstitial pneumonitis associated with docetaxel administration. Cancer 2002; 94(3):847.
3. Khan A, McNally D, Tutschka PJ, Bilgrami S. Paclitaxel-induced acute bilateral pneumonitis. Ann Pharmacother 1997; 31(12):1471.
4. Joerger M, Gunz A, Speich R, Pestalozzi BC. Gemcitabine-related pulmonary toxicity. Swiss Med Wkly 2002; 132(1-2):17.
5. Segura A, Yuste A, Cercos A, et al. Pulmonary fibrosis induced by cyclophosphamide. Ann Pharmacother 2001; 35(7-8):894-7.
6. Lind P. Clinical relevance of pulmonary toxicity in adjuvant breast cancer irradiation. Acta Oncol 2006; 45(1):13-5.
7. Davis SD, Yankelevitz DF, Henschke CI. Radiation effects on the lung: Clinical features, pathology, and imaging findings. AJR Am J Roentgenol 1992; 159(6):1157-64.
8. Lingos TI, Recht A, Vicini F, Abner A, Silver B, Harris JR. Radiation pneumonitis in breast cancer patients treated with conservative surgery and radiation therapy. Int J Radiat Oncol Biol Phys 1991; 21(2):355-60.

9. Abratt RP, Morgan GW, Silvestri G, Willcox P. Pulmonary complications of radiation therapy. Clin Chest Med 2004; 25(1):167-77.
10. Hardman PD, Tweeddale PM, Kerr GR, Anderson ED, Rodger A. The effect of pulmonary function of local and loco-regional irradiation for breast cancer, Radiother Oncol 1994; 30(1):33-42.
11. Vahid B, Marik PE. Pulmonary complications of novel antineoplastic agents for solid tumors. Chest 2008; 133(2):528-38.
12. Cleverley JR, Screaton NJ, Hiorns MP, Flint JD, Müller NL. Drug-induced lung disease: high-resolution CT and histological findings. Clin Radiol 2002; 57(4):292-9.
13. Lind PA, Rosfors S, Wennberg B, Glas U, Bevegard S, Fornander T. Pulmonary function following adjuvant chemotherapy and radiotherapy for breast cancer and the issue of three-dimensional treatment planning. Radiother Oncol 1998; 49(3):245-54.
14. Hernberg M, Virkkunen P, Maasilta P, et al. Pulmonary toxicity after radiotherapy in primary breast cancer patients: results from a randomized chemotherapy study. Int J Radiat Oncol Biol Phys 2002; 52(1):128-36.