Epilepsi Oluşum Mekanizmaları

Abstract

Epilepsi yaygýn görülen ciddi nörolojik hastalýklardan biridir. Epileptik nöbetler aºýrý senkron ve devamlý boºalým yapan bir grup nörondan kaynaklanmaktadýr. Epileptik nöbet; beyindeki anormal aºýrý veya senkron nöronal aktiviteden dolayý oluºan geçici semptomlara verilen addýr. Epilepsi ise; epileptik nöbet oluºturmaya kalýcý bir yatkýnlýk ile karakterize olan beyin hastalýðýdýr. Epileptogenez; spontan nöbetlerin oluºmasýna neden olan moleküler ve hücresel deðiºikliklerinin kaskadýnýn tetiklenmesi ile sonuçlanan beyin hasarý sürecini ifade etmektedir. Nöbet oluºumuna yol açan yaygýn faktörler; hipoglisemi, hiponatremi, hipokalsemi gibi metabolik anormallikler, akut nörolojik hasara neden olan menenjit, inme, kafa travmasý gibi durumlar, nöbet eºiðini düºüren ilaçlar, alkol yoksunluðu ve çocuklarda yüksek ateºtir

Keywords

• Epilepsi, nöbet, epileptogenez

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