Distinguishing Venous Outflow Insufficiency from Ischemia–Reperfusion Injury Using a Hydro-Manometer: A Case Series
Abstract
Aim: Venous insufficiency is a cause of failure in microsurgical replantation and free flap surgery and may be difficult to distinguish intraoperatively from ischemia–reperfusion injury. This study aims to introduce a simple, low-cost, and quantitative intraoperative method—the Hydro-Manometer technique—for assessing venous drainage capacity under physiological pressure conditions.
Material and Methods: This retrospective case series included seven patients treated between 2024 and 2025 who demonstrated clinically relevant venous drainage pathology. The Hydro-Manometer technique was applied intraoperatively in cases showing compromised tissue perfusion despite technically patent arterial and venous anastomoses. Venous drainage capacity was evaluated using a hydrostatic saline column corresponding to physiological venular pressure (20 cmH₂O).
Results: In all cases, arterial and venous anastomoses were confirmed to be patent intraoperatively. Venous thrombosis was identified and treated with thrombectomy in six patients. In one patient, the Hydro-Manometer revealed insufficient venous drainage capacity due to proximal venous pathology, which was successfully managed with venous grafting. All free flaps and replanted tissues survived, with no cases of postoperative venous thrombosis or tissue necrosis during follow-up.
Conclusion: The Hydro-Manometer provides an objective, quantitative, and easily applicable intraoperative assessment of venous drainage capacity in microsurgical procedures. By facilitating differentiation between venous outflow insufficiency and ischemia–reperfusion injury, this method may improve intraoperative decision-making and help prevent avoidable tissue loss.
Keywords
Supporting Institution
Ethical Statement
Thanks
References
- 1. Muntean MV, Muntean V, Ardelean F, Georgescu A. Dynamic perfusion assessment during perforator flap surgery: an up-to-date. Clujul Medical. 2015;88(3):293-7. doi:10.15386/cjmed-484.
- 2. Boissiere F, Gandolfi S, Riot S, Kerfant N, Jenzeri A, Hendriks S, et al. Flap venous congestion and salvage techniques: a systematic literature review. Plast Reconstr Surg Glob Open. 2021;9(1):e3327. doi:10.1097/GOX.0000000000003327.
- 3. Smit JM, Negenborn VL, Jansen SM, Jaspers ME, de Vries R, Heymans MW, et al. Intraoperative evaluation of perfusion in free flap surgery: a systematic review and meta‐analysis. Microsurgery. 2018;38(7):804–18. doi:10.1002/micr.30320.
- 4. Ko E, Song YJ, Choe K, Park Y, Yang S, Lim CH. The effects of intravenous fluid viscosity on the accuracy of intravenous infusion flow regulators. J Korean Med Sci. 2022;37(9):e71. doi:10.3346/jkms.2022.37.e71.
- 5. Levick JR, Michel CC. Microvascular fluid exchange and the revised Starling principle. Cardiovasc Res. 2010;87(2):198–210. doi:10.1093/cvr/cvq062.
- 6. Barrett KE, Barman SM, Brooks HL, Yuan J. Blood as a circulatory fluid & the dynamics of blood & lymph flow. In: Barrett KE, Barman SM, Brooks HL, Yuan J, editors. Ganong's review of medical physiology. 26th ed., New York: McGraw-Hill Education; 2019. p. 557-88.
- 7. Hall JE, Hall ME. Overview of the circulation: pressure, flow, and resistance. In: Hall JE, Hall ME, editors. Guyton and hall textbook of medical physiology. 14th ed., Philadelphia: Elsevier; 2021. p. 171-81.
- 8. Vaienti L, Gazzola R, Benanti E, Leone F, Marchesi A, Parodi PC, et al. Failure by congestion of pedicled and free flaps for reconstruction of lower limbs after trauma: the role of negative-pressure wound therapy. J Orthop Traumatol. 2013;14(3):213–7. doi:10.1007/s10195-013-0236-0.
Details
Primary Language
English
Subjects
Health Care Administration
Journal Section
Research Article
Publication Date
March 24, 2026
Submission Date
January 25, 2026
Acceptance Date
March 3, 2026
Published in Issue
Year 2026 Volume: 18 Number: 1


