The Role of the MAPH Score in Predicting Thrombus Burden in Unstable Angina Pectoris

İsmail Ataş; Mümin Murat Yazıcı; Ahmet Nurhak Çakır; Oğulcan Adak; Özlem Bilir

doi:10.18521/ktd.1871763

The Role of the MAPH Score in Predicting Thrombus Burden in Unstable Angina Pectoris

Abstract

Aim: Hemorheologic and viscosity-related parameters, including the Mean Platelet Volume–Age–Protein–Hematocrit (MAPH) score, have shown promising performance in predicting angiographic thrombus burden in ST segment elevation myocardial infarction (STEMI) and non-ST segment elevation myocardial infarction (NSTEMI). However, their diagnostic value in unstable angina pectoris (UAP) remains unclear. This study aimed to evaluate the predictive performance of the MAPH score compared with low-shear rate (LSR) and high-shear rate (HSR) blood viscosity parameters for estimating coronary thrombus burden in UAP.
Material and Methods: In this single-center retrospective observational study, 320 adult patients diagnosed with UAP who underwent coronary angiography were included. Thrombus burden was graded using the TIMI thrombus classification. Two cut-offs (TIMI ≥4 and ≥3) were analyzed separately. MAPH, LSR, and, HSR were calculated from admission laboratory values. Diagnostic performance was assessed using receiver operating characteristic (ROC) analysis.
Results: High thrombus burden was observed in 10.9% (TIMI ≥4) and 17.2% (TIMI ≥3) of patients. Age, diabetes mellitus, history of coronary artery disease, and troponin levels were higher in the high-thrombus-burden groups, but MAPH, LSR, and HSR values did not differ significantly between the groups. ROC analysis demonstrated limited discrimination for all parameters. For TIMI ≥4, AUC values were 0.552 for MAPH, 0.491 for HSR, and 0.500 for LSR. For TIMI ≥3, AUCs were 0.547, 0.516, and 0.519, respectively.
Conclusion: In patients with UAP, MAPH, HSR, and LSR the ability to predict angiographic thrombus burden was limited.

Keywords

Ethical Statement

The study protocol was approved by the Clinical Research Ethics Committee of Recep Tayyip Erdoğan University on January 8, 2026 (Approval No: 2026/11).

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

İsmail Ataş ^*
0000-0001-6723-8564
Türkiye

Mümin Murat Yazıcı
0000-0003-1957-7283
Türkiye

Ahmet Nurhak Çakır
0009-0006-9945-0395
Türkiye

Oğulcan Adak
0000-0003-1107-6329
Türkiye

Özlem Bilir
0000-0001-9016-1665
Türkiye

Publication Date

March 24, 2026

Submission Date

January 26, 2026

Acceptance Date

March 4, 2026

Published in Issue

Year 2026 Volume: 18 Number: 1

DOI

https://doi.org/10.18521/ktd.1871763

IZ

https://izlik.org/JA57BU85BW

Cite

RIS / Bibtex

APA

Ataş, İ., Yazıcı, M. M., Çakır, A. N., Adak, O., & Bilir, Ö. (2026). The Role of the MAPH Score in Predicting Thrombus Burden in Unstable Angina Pectoris. Konuralp Medical Journal, 18(1), 35-42. https://doi.org/10.18521/ktd.1871763

AMA

1.Ataş İ, Yazıcı MM, Çakır AN, Adak O, Bilir Ö. The Role of the MAPH Score in Predicting Thrombus Burden in Unstable Angina Pectoris. Konuralp Medical Journal. 2026;18(1):35-42. doi:10.18521/ktd.1871763

Chicago

Ataş, İsmail, Mümin Murat Yazıcı, Ahmet Nurhak Çakır, Oğulcan Adak, and Özlem Bilir. 2026. “The Role of the MAPH Score in Predicting Thrombus Burden in Unstable Angina Pectoris”. Konuralp Medical Journal 18 (1): 35-42. https://doi.org/10.18521/ktd.1871763.

EndNote

Ataş İ, Yazıcı MM, Çakır AN, Adak O, Bilir Ö (March 1, 2026) The Role of the MAPH Score in Predicting Thrombus Burden in Unstable Angina Pectoris. Konuralp Medical Journal 18 1 35–42.

IEEE

[1]İ. Ataş, M. M. Yazıcı, A. N. Çakır, O. Adak, and Ö. Bilir, “The Role of the MAPH Score in Predicting Thrombus Burden in Unstable Angina Pectoris”, Konuralp Medical Journal, vol. 18, no. 1, pp. 35–42, Mar. 2026, doi: 10.18521/ktd.1871763.

ISNAD

Ataş, İsmail - Yazıcı, Mümin Murat - Çakır, Ahmet Nurhak - Adak, Oğulcan - Bilir, Özlem. “The Role of the MAPH Score in Predicting Thrombus Burden in Unstable Angina Pectoris”. Konuralp Medical Journal 18/1 (March 1, 2026): 35-42. https://doi.org/10.18521/ktd.1871763.

JAMA

1.Ataş İ, Yazıcı MM, Çakır AN, Adak O, Bilir Ö. The Role of the MAPH Score in Predicting Thrombus Burden in Unstable Angina Pectoris. Konuralp Medical Journal. 2026;18:35–42.

MLA

Ataş, İsmail, et al. “The Role of the MAPH Score in Predicting Thrombus Burden in Unstable Angina Pectoris”. Konuralp Medical Journal, vol. 18, no. 1, Mar. 2026, pp. 35-42, doi:10.18521/ktd.1871763.

Vancouver

1.İsmail Ataş, Mümin Murat Yazıcı, Ahmet Nurhak Çakır, Oğulcan Adak, Özlem Bilir. The Role of the MAPH Score in Predicting Thrombus Burden in Unstable Angina Pectoris. Konuralp Medical Journal. 2026 Mar. 1;18(1):35-42. doi:10.18521/ktd.1871763