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Effects of Isotretinoin Treatment on Sleep and Quality of Life in Patients with Acne Vulgaris

Year 2018, , 65 - 73, 28.03.2018
https://doi.org/10.18521/ktd.378682

Abstract

Objective: We
aimed to investigate the effect of isotretinoin treatment on sleep and quality
of life in patients with AV.



Methods: Sixty-six
AV patients, who had attended the dermatology outpatient clinic and started
isotretinoin treatment, and forty-three healthy controls, were enrolled in the
study. Pittsburg Sleep Quality Index (PSQI), short form-36 (SF-36), and Global
Acne Grading System (GAGS) were administered to all patients twice; before and
two months after the treatment. The results were compared with the healthy
control group.



Results: The
pretreatment physical health scores of the patients were significantly higher
than the healthy controls. No
significant differences were observed between before-after isotretinoin
treatment regarding physical and mental health scores in AV patients. While
there were no significant differences between the pretreatment and healthy
control group in terms of total PSQI scores; the scores of sleep duration were
significantly lower in the pretreatment group. No significant differences were
observed between before-after isotretinoin treatment regarding total PSQI and subcomponent
scores in AV patients. There was a statistically significant negative
correlation between pre- and post-treatment total PSQI scores and physical,
mental health scores in patients with AV.



Conclusion:
Results of the present study suggest that
isotretinoin therapy does not affect the sleep quality in patients with AV. The
impairment of sleep quality negatively affects the quality of life in patients
with AV. More comprehensive studies assessing the effect of isotretinoin
treatment on sleep quality are needed.

References

  • 1- Erturan İ, Aktepe E, Kocaman O, ve ark. Akneli Ergenlerin yaşam kalitesi, yalnızlık ve yaşam doyumu düzeylerinin değerlendirilmesi. Türkderm. 2014; 48: 172-6.
  • 2- Karadag AS, Bilgili SG, Selvi Y, et al. Effects of isotretinoin treatment on general psychiatric symptoms, quality of life and social phobia in acne vulgaris patients. J Eur Acad Dermatol Venereol. 2013; 27:260-1.
  • 3- Schrom K,Nagy T,Mostow E. Depression screening using health questionnaires in patients receiving oral isotretinoin for acne vulgaris. J Am Acad Dermatol. 2016; 75: 237-9.
  • 4- Deveci E, Ozturk A, Kırpınar İ, et al. Akneli hastalarda izotretinoin kullanımı sırasında dikkat ve yürütücü işlevlerde düzelme. Türkderm. 2013; 47: 109-113.
  • 5- McGrath EJ, Lowell CR, Gillison CR, et al. A prospective trial of the effects of isotretinoin on quality of life and depressive symptoms. Br J Dermatol. 2010; 163: 1323-1329.
  • 6- Marron SE, Tomas-Aragones L, Boira S. Anxiety, depression, quality of life and patient satisfaction in acne patients treated with oral isotretinoin. Acta Derm Venereol. 2013; 93: 701-6.
  • 7- Biçici F, Berksoy Hayta S, Akyol M, et al. Psoriasisli hastalarda uyku kalitesinin değerlendirilmesi. Türkderm. 2015; 49: 208-12.
  • 8- Ismailogullari S, Ferahbas A, Aksu M, et al. Effects of isotretinoin treatment on sleep in patients with severe acne: a pilot study. J Eur Acad Dermatol Venereol. 2012; 26: 778-81.
  • 9- Hanna KJ, Agnieszka KP, Michal D, et al. Affective disorders as potential complication of anti-acne treatment with isotretinoin: A case series. J Affect Disord. 2016; 204: 154-8.
  • 10- Doshi A, Zaheer A, Stiller MJ. A comparison of current acne grading systems and proposal of a novel system. Int J Dermatol. 1997; 36: 416-8.
  • 11- Ware JE, Sherbourne CD. The MOS 36-item Short-Form Health Survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992; 30: 473-83.
  • 12- Agargün MY, Kara H, Anlar Ö. Pittsburgh Uyku kalitesi indeksinin geçerliliği ve güvenilirliği. Türk Psikiyatri Dergisi. 1996; 7: 107-15.
  • 13- Türel Ertmertcan A. Akne ve yaşam Kalitesi. Dermatoz. 2007; 2: 91-97.
  • 14- Cyrulnik AA, Viola KV, Gewirtzman AJ, et al. High-dose isotretinoin in acne vulgaris: improved treatment outcomes and quality of life. Int J Dermatol. 2012; 51: 1123-30.
  • 15- Öztürkcan S, Aydemir Ö, Inanır I. Akne vulgarisli hastalarda yaşam kalitesi. T Klin Dermatoloji 2002; 12: 131-134.
  • 16- Jones-Caballero M, Chren MM, Soler B, et al. Quality of life in mild to moderate acne: relationship to clinical severity and factors influencing change with treatment. J Eur Acad Dermatol Venereol 2007; 21: 219-226.
  • 17- Zisapel N. Sleep and sleep disturbances: Biological basis and clinical implications. Cell Mol Life Sci 2007; 64: 1174-86.
  • 18- Oyetakin-White P, Suggs A, Koo B, et al. Does poor sleep quality affect skin ageing? Clin Exp Dermatol. 2015; 40: 17-22.
  • 19- Bilgiç Ö, Bilgiç A, Altinyazar HC. Relationship between sleep quality and facial sebum levels in women with acne vulgaris. Indian J Dermatol Venereol Leprol. 2016; 82: 313-4.
  • 20- Smedje H, Schwan S, Hallberg E, et al. Onset of Kleine-Levin Syndrome in association with isotretinoin treatment. Acta Paediatr. 2010; 99: 946-8.
  • 21- Shehi GM, Bryson WJ. Hypersomnia associated with isotretinoin in a patient with recurrent major depressive disorder and acne vulgaris. Sleep. 2004; 27: 821.

Akne Vulgarisli Hastalarda İzotretinoin Tedavisinin Uyku ve Yaşam Kalitesine Etkisi

Year 2018, , 65 - 73, 28.03.2018
https://doi.org/10.18521/ktd.378682

Abstract

References

  • 1- Erturan İ, Aktepe E, Kocaman O, ve ark. Akneli Ergenlerin yaşam kalitesi, yalnızlık ve yaşam doyumu düzeylerinin değerlendirilmesi. Türkderm. 2014; 48: 172-6.
  • 2- Karadag AS, Bilgili SG, Selvi Y, et al. Effects of isotretinoin treatment on general psychiatric symptoms, quality of life and social phobia in acne vulgaris patients. J Eur Acad Dermatol Venereol. 2013; 27:260-1.
  • 3- Schrom K,Nagy T,Mostow E. Depression screening using health questionnaires in patients receiving oral isotretinoin for acne vulgaris. J Am Acad Dermatol. 2016; 75: 237-9.
  • 4- Deveci E, Ozturk A, Kırpınar İ, et al. Akneli hastalarda izotretinoin kullanımı sırasında dikkat ve yürütücü işlevlerde düzelme. Türkderm. 2013; 47: 109-113.
  • 5- McGrath EJ, Lowell CR, Gillison CR, et al. A prospective trial of the effects of isotretinoin on quality of life and depressive symptoms. Br J Dermatol. 2010; 163: 1323-1329.
  • 6- Marron SE, Tomas-Aragones L, Boira S. Anxiety, depression, quality of life and patient satisfaction in acne patients treated with oral isotretinoin. Acta Derm Venereol. 2013; 93: 701-6.
  • 7- Biçici F, Berksoy Hayta S, Akyol M, et al. Psoriasisli hastalarda uyku kalitesinin değerlendirilmesi. Türkderm. 2015; 49: 208-12.
  • 8- Ismailogullari S, Ferahbas A, Aksu M, et al. Effects of isotretinoin treatment on sleep in patients with severe acne: a pilot study. J Eur Acad Dermatol Venereol. 2012; 26: 778-81.
  • 9- Hanna KJ, Agnieszka KP, Michal D, et al. Affective disorders as potential complication of anti-acne treatment with isotretinoin: A case series. J Affect Disord. 2016; 204: 154-8.
  • 10- Doshi A, Zaheer A, Stiller MJ. A comparison of current acne grading systems and proposal of a novel system. Int J Dermatol. 1997; 36: 416-8.
  • 11- Ware JE, Sherbourne CD. The MOS 36-item Short-Form Health Survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992; 30: 473-83.
  • 12- Agargün MY, Kara H, Anlar Ö. Pittsburgh Uyku kalitesi indeksinin geçerliliği ve güvenilirliği. Türk Psikiyatri Dergisi. 1996; 7: 107-15.
  • 13- Türel Ertmertcan A. Akne ve yaşam Kalitesi. Dermatoz. 2007; 2: 91-97.
  • 14- Cyrulnik AA, Viola KV, Gewirtzman AJ, et al. High-dose isotretinoin in acne vulgaris: improved treatment outcomes and quality of life. Int J Dermatol. 2012; 51: 1123-30.
  • 15- Öztürkcan S, Aydemir Ö, Inanır I. Akne vulgarisli hastalarda yaşam kalitesi. T Klin Dermatoloji 2002; 12: 131-134.
  • 16- Jones-Caballero M, Chren MM, Soler B, et al. Quality of life in mild to moderate acne: relationship to clinical severity and factors influencing change with treatment. J Eur Acad Dermatol Venereol 2007; 21: 219-226.
  • 17- Zisapel N. Sleep and sleep disturbances: Biological basis and clinical implications. Cell Mol Life Sci 2007; 64: 1174-86.
  • 18- Oyetakin-White P, Suggs A, Koo B, et al. Does poor sleep quality affect skin ageing? Clin Exp Dermatol. 2015; 40: 17-22.
  • 19- Bilgiç Ö, Bilgiç A, Altinyazar HC. Relationship between sleep quality and facial sebum levels in women with acne vulgaris. Indian J Dermatol Venereol Leprol. 2016; 82: 313-4.
  • 20- Smedje H, Schwan S, Hallberg E, et al. Onset of Kleine-Levin Syndrome in association with isotretinoin treatment. Acta Paediatr. 2010; 99: 946-8.
  • 21- Shehi GM, Bryson WJ. Hypersomnia associated with isotretinoin in a patient with recurrent major depressive disorder and acne vulgaris. Sleep. 2004; 27: 821.
There are 21 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Articles
Authors

Emin Özlü 0000-0001-9600-0248

Ragıp Ertaş This is me 0000-0002-9269-2619

Kemal Özyurt 0000-0002-6913-8310

İsmail Karaatlı 0000-0003-2014-9307

Ayşe Serap Karadağ 0000-0003-4333-8274

Publication Date March 28, 2018
Acceptance Date February 13, 2018
Published in Issue Year 2018

Cite

APA Özlü, E., Ertaş, R., Özyurt, K., Karaatlı, İ., et al. (2018). Akne Vulgarisli Hastalarda İzotretinoin Tedavisinin Uyku ve Yaşam Kalitesine Etkisi. Konuralp Medical Journal, 10(1), 65-73. https://doi.org/10.18521/ktd.378682
AMA Özlü E, Ertaş R, Özyurt K, Karaatlı İ, Karadağ AS. Akne Vulgarisli Hastalarda İzotretinoin Tedavisinin Uyku ve Yaşam Kalitesine Etkisi. Konuralp Medical Journal. March 2018;10(1):65-73. doi:10.18521/ktd.378682
Chicago Özlü, Emin, Ragıp Ertaş, Kemal Özyurt, İsmail Karaatlı, and Ayşe Serap Karadağ. “Akne Vulgarisli Hastalarda İzotretinoin Tedavisinin Uyku Ve Yaşam Kalitesine Etkisi”. Konuralp Medical Journal 10, no. 1 (March 2018): 65-73. https://doi.org/10.18521/ktd.378682.
EndNote Özlü E, Ertaş R, Özyurt K, Karaatlı İ, Karadağ AS (March 1, 2018) Akne Vulgarisli Hastalarda İzotretinoin Tedavisinin Uyku ve Yaşam Kalitesine Etkisi. Konuralp Medical Journal 10 1 65–73.
IEEE E. Özlü, R. Ertaş, K. Özyurt, İ. Karaatlı, and A. S. Karadağ, “Akne Vulgarisli Hastalarda İzotretinoin Tedavisinin Uyku ve Yaşam Kalitesine Etkisi”, Konuralp Medical Journal, vol. 10, no. 1, pp. 65–73, 2018, doi: 10.18521/ktd.378682.
ISNAD Özlü, Emin et al. “Akne Vulgarisli Hastalarda İzotretinoin Tedavisinin Uyku Ve Yaşam Kalitesine Etkisi”. Konuralp Medical Journal 10/1 (March 2018), 65-73. https://doi.org/10.18521/ktd.378682.
JAMA Özlü E, Ertaş R, Özyurt K, Karaatlı İ, Karadağ AS. Akne Vulgarisli Hastalarda İzotretinoin Tedavisinin Uyku ve Yaşam Kalitesine Etkisi. Konuralp Medical Journal. 2018;10:65–73.
MLA Özlü, Emin et al. “Akne Vulgarisli Hastalarda İzotretinoin Tedavisinin Uyku Ve Yaşam Kalitesine Etkisi”. Konuralp Medical Journal, vol. 10, no. 1, 2018, pp. 65-73, doi:10.18521/ktd.378682.
Vancouver Özlü E, Ertaş R, Özyurt K, Karaatlı İ, Karadağ AS. Akne Vulgarisli Hastalarda İzotretinoin Tedavisinin Uyku ve Yaşam Kalitesine Etkisi. Konuralp Medical Journal. 2018;10(1):65-73.