Abstract
Özet :
Amaç: Önceden diyastolik kalp yetmezliği
sistolik kalp yetmezliğinin gibi değerlendirilirken günümüzde bunların
birbirinden ayrı patofizyolojik mekanizmalarla ilerlediği bilinmektedir. Biz bu
çalışmada serum Sistatin C konsantrasyonu ile kalbin diyastolik fonksiyonları
arasındaki ilişkiyi göstermeyi denedik.
Yöntem: Bu çalısmaya Mayıs 2010 ve Eylül
2010 tarihleri arasında Düzce Universitesi Tıp Fakültesi Hastanesi Kardiyoloji polikliniğine başvuran
bireyler dahil edildi. Deneklerin diyastolik parametreleri değerlendirildi ve
Sistatin C düzeyleri çalışıldı.Denekler diyastolik fonksiyonlarına göre normal
,grade 1, grade 2 olarak üç gruba ayrıldı ve serum sistain-c düzeyi ile bu
gruplar arasında ilişki araştırıldı.
Bulgular: Bu çalışmada, Grade I ve Grade II
diyastolik disfonksiyonu olan denekler ile diyastolik fonksiyonu olmayan
denekler serum Sistatin C seviyelerine göre karşılaştırıldı. Diyastolik
disfonksiyon olan gruplarda Sistatin C düzeyinde anlamlı düzeyde artmış olduğu
gösterildi (normal -grade 1:p<0,0001,Normal-grade 2: P<0,004). Sistatin C
değeri için cutof değerini 0,997 ng/ml olarak bulduk. Bu noktada sistatin C nin diyastolik disfonsiyonu
göstermede spesifitesi % 80,
sensitivitesi
% 78.95 bulundu .
Sonuç: Serum sistain C düzeyi diyastolik
disfonksiyonun erken tespitinde ve takibinde faydalı olabilir.
Abstract:
Aim: Formerly diastolic heart failure
eveluated as sistolic heart failure but nowadays we know their distinc
patophisyolojical mechanism.In this study we tried to Show the relations
between diastolic dysfunction and serum cyctatin C consantrations.
Methods : We included the individuals who admitted to cardiology clinic of Düzce
University Medical Faculty between May 2010 and September 2010. We evaluate the
serum cystatin C consantrations and
diastolic dysfunction among 88 person. we evoluated the diastolic parameters
with 2D echocardiography , TDI and PW doppler mesuraments.The 88 study
participants were categorized according to their diastolic parameters into
three groups normal ,grade 1 and grade 2. We made cystatistical analysis in
each groups and parameters.
Results: İn this study the participants
who has grade 1 and grade 2 diastolic disfunction were compaired with normal
participants (who has normal Diastolic function) according to their serum
cycstatin C consentrations.We shown the sytatisticly significant incrise of
serum cycstatin C levels in the group of diastolic disfunction Grade 1 and
Grade 2.(nomal-grade 1:p<0,0001,normal-grade 2:p<0,004). And we find that
the cut off ratio for Cystatin C was 0,997 ng/ml . On this point Cystatin c was
%80 specific and %78.95 sensitive for diastolic disfunction.
Conclusion: Serum Cystatin C levels may be
useful in the early detection and monitoring of diastolic dysfunction.
References
- KAYNAKLAR:1. Margulies, İs depressed Myocyte Contractility Centrally involved in heart failure ? Ciculation Research.2003;92:350-3582. Hogg K, Swedberg K, McMurray J: Heart failure with preserved left vetricular systolic function:Epidomiology,clinical characteristics,and prognosis,J Am Call Cardiol 34.951,20023. Vasan RS,Lery D:Defining diastolic heart failure: A call for standerdized diagnostic criteria, Ciculation 101:2118,20004. Working Group Report. How to diagnose diastolic heart failure? European Study Group on Diastolic Heart Failure. Eur Heart J1998;19:990–1003.5. Newman DJ, Thakkar H, Edwards RG, Wilkie M, White T, Grubb AO, Price CP. Serum cystatin C measured by automated immunoassay: a more sensitive marker of changes in GFR than serum creatinine. Kidney Int 1995; 47(1):312-8. 47 6. Palsdottir A, Abrahamson M, Thorsteinsson L, Arnason A, Olafsson I, Grubb A, Jensson O. Mutation in cystatin C gene causes hereditary brain haemorrhage. Lanset, 1988; 2: 603-604.7. Cimerman N, Brguljan PM, Krasovec M, Suskovic S, Kos J. Serum cystatin C, a potent inhibitor of cysteine proteinases, is elevated in asthmatic patients. Clin Chim Acta, 2000; 300: 83-95.8. Coll E, Botey A, Alvarez L, Poch E, Quinto L, Saurina A, et al. Serum cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as a marker for early renal impairment. Am J Kidney Dis. 2000 Jul;36(1):29–34. 9. Fliser D, Ritz E. Serum cystatin C concentration as a marker of renal dysfunction in the elderly. Am J Kidney Dis. 2001 Jan;37(1):79–83. 10. Sarnak MJ, Katz R, Stehman-Breen CO, Fried LF, Jenny NS, Psaty BM, et al. Cystatin C concentration as a risk factor for heart failure in older adults. Ann Intern Med. 2005 Apr 5;142(7):497–505.11. Bibbins-Domingo K, Chertow GM, Fried LF, Odden MC, Newman AB, Kritchevsky SB, et al. Renal function and heart failure risk in older black and white individuals: the health, aging, and body composition study. Arch Intern Med. 2006 Jul 10;166(13):1396–1402. 12. Ix JH, Shlipak MG, Chertow GM, Ali S, Schiller NB, Whooley MA. Cystatin C, left ventricular hypertrophy, and diastolic dysfunction: data from the Heart and Soul Study. J Card Fail. 2006 Oct;12(8):601–607.13. Stewart GA, Gansevoort RT, Mark PB, Rooney E, McDonagh TA, Dargie HJ, et al. Electrocardiographic abnormalities and uremic cardiomyopathy. Kidney Int. 2005 Jan;67(1):217–226.14. Aurigemma GP, Gottdiener JS, Shemanski L, Gardin J, Kitzman D. Predictive value of systolic and diastolic function for incident congestive heart failure in the elderly: the cardiovascular health study. J Am Coll Cardiol 2001;37:1042–8. [PubMed: 11263606]15. Sarnak MJ, Katz R, Stehman-Breen CO, Fried LF, Jenny NS, Psaty BM, et al. Cystatin C concentration as a risk factor for heart failure in older adults. Ann Intern Med 2005;142:497–505. [PubMed: 15809461]
Abstract
Abstract:
Aim: Formerly diastolic heart failure
eveluated as sistolic heart failure but nowadays we know their distinc
patophisyolojical mechanism.In this study we tried to Show the relations
between diastolic dysfunction and serum cyctatin C consantrations.
Methods : We included the individuals who admitted to cardiology clinic of Düzce
University Medical Faculty between May 2010 and September 2010. We evaluate the
serum cystatin C consantrations and
diastolic dysfunction among 88 person. we evoluated the diastolic parameters
with 2D echocardiography , TDI and PW doppler mesuraments.The 88 study
participants were categorized according to their diastolic parameters into
three groups normal ,grade 1 and grade 2. We made cystatistical analysis in
each groups and parameters.
Results: İn this study the participants
who has grade 1 and grade 2 diastolic disfunction were compaired with normal
participants (who has normal Diastolic function) according to their serum
cycstatin C consentrations.We shown the sytatisticly significant incrise of
serum cycstatin C levels in the group of diastolic disfunction Grade 1 and
Grade 2.(nomal-grade 1:p<0,0001,normal-grade 2:p<0,004). And we find that
the cut off ratio for Cystatin C was 0,997 ng/ml . On this point Cystatin c was
%80 specific and %78.95 sensitive for diastolic disfunction.
Conclusion: Serum Cystatin C levels may be
useful in the early detection and monitoring of diastolic dysfunction.
Key Words: Diastolic heart failure, Cystatin C,
Echocardiography
References
- KAYNAKLAR:1. Margulies, İs depressed Myocyte Contractility Centrally involved in heart failure ? Ciculation Research.2003;92:350-3582. Hogg K, Swedberg K, McMurray J: Heart failure with preserved left vetricular systolic function:Epidomiology,clinical characteristics,and prognosis,J Am Call Cardiol 34.951,20023. Vasan RS,Lery D:Defining diastolic heart failure: A call for standerdized diagnostic criteria, Ciculation 101:2118,20004. Working Group Report. How to diagnose diastolic heart failure? European Study Group on Diastolic Heart Failure. Eur Heart J1998;19:990–1003.5. Newman DJ, Thakkar H, Edwards RG, Wilkie M, White T, Grubb AO, Price CP. Serum cystatin C measured by automated immunoassay: a more sensitive marker of changes in GFR than serum creatinine. Kidney Int 1995; 47(1):312-8. 47 6. Palsdottir A, Abrahamson M, Thorsteinsson L, Arnason A, Olafsson I, Grubb A, Jensson O. Mutation in cystatin C gene causes hereditary brain haemorrhage. Lanset, 1988; 2: 603-604.7. Cimerman N, Brguljan PM, Krasovec M, Suskovic S, Kos J. Serum cystatin C, a potent inhibitor of cysteine proteinases, is elevated in asthmatic patients. Clin Chim Acta, 2000; 300: 83-95.8. Coll E, Botey A, Alvarez L, Poch E, Quinto L, Saurina A, et al. Serum cystatin C as a new marker for noninvasive estimation of glomerular filtration rate and as a marker for early renal impairment. Am J Kidney Dis. 2000 Jul;36(1):29–34. 9. Fliser D, Ritz E. Serum cystatin C concentration as a marker of renal dysfunction in the elderly. Am J Kidney Dis. 2001 Jan;37(1):79–83. 10. Sarnak MJ, Katz R, Stehman-Breen CO, Fried LF, Jenny NS, Psaty BM, et al. Cystatin C concentration as a risk factor for heart failure in older adults. Ann Intern Med. 2005 Apr 5;142(7):497–505.11. Bibbins-Domingo K, Chertow GM, Fried LF, Odden MC, Newman AB, Kritchevsky SB, et al. Renal function and heart failure risk in older black and white individuals: the health, aging, and body composition study. Arch Intern Med. 2006 Jul 10;166(13):1396–1402. 12. Ix JH, Shlipak MG, Chertow GM, Ali S, Schiller NB, Whooley MA. Cystatin C, left ventricular hypertrophy, and diastolic dysfunction: data from the Heart and Soul Study. J Card Fail. 2006 Oct;12(8):601–607.13. Stewart GA, Gansevoort RT, Mark PB, Rooney E, McDonagh TA, Dargie HJ, et al. Electrocardiographic abnormalities and uremic cardiomyopathy. Kidney Int. 2005 Jan;67(1):217–226.14. Aurigemma GP, Gottdiener JS, Shemanski L, Gardin J, Kitzman D. Predictive value of systolic and diastolic function for incident congestive heart failure in the elderly: the cardiovascular health study. J Am Coll Cardiol 2001;37:1042–8. [PubMed: 11263606]15. Sarnak MJ, Katz R, Stehman-Breen CO, Fried LF, Jenny NS, Psaty BM, et al. Cystatin C concentration as a risk factor for heart failure in older adults. Ann Intern Med 2005;142:497–505. [PubMed: 15809461]
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Health Care Administration |
| Journal Section | Articles |
| Authors | |
| Publication Date | August 15, 2018 |
| Acceptance Date | June 12, 2018 |
| Published in Issue | Year 2018 |