Kronik Spontan Ürtikerli Hastalarda Kronik Yaygın Ağrı Sıklığı ve Yaşam Kalitesi Üzerine Etkisi

Year 2019, , 101 - 105, 25.03.2019

Ragıp Ertaş Kemal Erol

https://doi.org/10.18521/ktd.520277

Cited By: 3

Abstract

Amaç:

Kronik
spontan ürtiker (KSÜ), düşük yaşam kalitesi ile seyreden,
kronik, yaygın ve zorlayıcı bir hastalıktır. Bu çalışmanın
temel amacı, KSÜ hastalarında, Kronik Yaygın Ağrının (KYA)
varlığını araştırmak ve KYA ile KSÜ arasında klinik
özellikler, laboratuvar belirteçler, hastalık aktivite skorları
ile dermatoloji yaşam kalitesi indeksi (DYKİ) arasındaki olası
bağlantıyı ortaya koymaktır.

Yöntem:

KSÜ'
lü 91 hasta, KYA varlığı açısından üçüncü basamak
polikliniğinde değerlendirildi. KSÜ’lü hastalarda, KYA (en az
üç ay boyunca dört kadran ve aksiyel olmak üzere beş vücut
bölgesinden dördünde veya daha fazlasında ağrı) varlığı
romatoloji polikliniğinde değerlendirildi. Ayrıca, hastaların
anti-nükleer antikor (ANA), eritrosit sedimantasyon hızı, CRP
(C-reaktif protein), B12, total IgE ve anti-TPO test sonuçları da
analiz edildi. Hastalar hastalığın başlangıcı ve süresi, eşlik
eden morbiditeleri, anjioödem varlığı, atopi öyküsü ve uykudan
uyandıran gece kaşıntısı yönüyle değerlendirildi. Hastaların
hastalık aktivitesini ortaya koymak için ürtiker kontrol testi
(UKT), ürtiker aktivite skoru (UAS) ve hekim ve hastaların genel
sağlık durumunu ayrı ayrı değerlendirdiği görsel analog skala
kullanıldı. Ayrıca, hastaların yaşam kalitesi dermatolojik
hastalık yaşam kalite indeksi (DYKİ) ile değerlendirildi.

Sonuç:

KSÜ’lü
91 hastadan 23'ünde (25.3%) KYA mevcuttu. KYA +, KSÜ' lü
hastalarda anlamlı yüksek Doktor Global değerlendirme skoru
(p=0.003), Hasta global değerlendirme skoru (p=0.005), UAS
(p=0.046), DYKİ (p<0.001) ve düşük UCT skorları bulundu.
KYA’lı 23 hastanın dokuzunda, eşlik eden hastalık olarak astım
(39.1%) bulundu (p=0.005).

Tartışma

Ürtiker
hastalarında KYA'nın varlığı, hastaların yaşam kalitesini ve
hastalık skorlarını olumsuz yönde etkileyebilir.

Keywords

Kronik Spontan Ürtiker, Kronik Yaygın Ağrı, Ürtiker kontrol testi, Ürtiker aktivite skoru

The Frequency of Chronic Widespread Pain and Its Impact on Quality of Life in Patients with Chronic Spontaneous Urticaria

Abstract

Background
and aims

Chronic
spontaneous urticaria (CSU)
is a chronic, common and debilitating disease
and
associated with severely impaired quality of life (QoL). The
main aims of this study are to explore the presence of Chronic
Widespread Pain (CWP) in patients with CSU
and to reveal the possible associations between CWP and CSU on the
clinical features, laboratory markers and urticaria activity scores
with QoL.

Methods

We assessed
the 91
patients with CSU for CWP
in a tertiary outpatient clinic.
CWP
(pain in four or more out of five bodily regions, i.e. the four
quadrants and axially at least for three months)
was assessed in
a rheumatology outpatient clinic in patients with CSU.
We also analyzed the test results of anti-nuclear antibody (ANA),
blood sedimentation
rate, CRP (C-reactive protein), B12, total IgE, and anti-TPO.
Patients were
assessed for their onset and duration of disease, comorbidities,
occurrence of angioedema and history of atopy, and nocturnal pruritus
with disturbed sleep. Patients disease activity were assessed by the
urticaria control test (UCT), urticaria activity score (UAS) and
visual analog scale of physician and patient’s global assessment.
Furthermore,
patients completed a questionnaire to assess the quality of life
(QoL) for dermatologic diseases.

Results

Of
the 91 patients with CSU assessed for CWP, 23 (25.3%) were positive.
CWP +ve patients with CSU had significantly higher physician global
assessment score (p=0.003), Patients global assessment score
(p=0.005), UAS (p=0.046), dermatologic QoL (p<0.001) and lower UCT
(p=0.005) scores. Nine of 23 CWP +ve patients had asthma (39.1%) as a
comorbidity (p=0.008).

Conclusions

The
presence of CWP in patients with urticaria may have a negative impact
on the quality of life of the patients and disease scores.

Keywords

Chronic Spontaneous Urticaria, Chronic Widespread Pain, Urticaria control test urticaria activity score

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