Are the conventional risk factors still valid for acute myeloid leukemia patients?

Abstract

Objective: The aim of this study was to investigate the survival data of patients with acute myeloid leukemia (AML) and to determine the risk factors that can be easily evaluated.

Method: A retrospective analysis  was made of the AML patients admitted to our center between 2009-2018. Demographic data and disease data were analyzed and response rates, overall survival (OS) and progression-free survival (PFS) rates were calculated. Factors affecting survival were determined using Cox-regression analysis.

Results: A total of 119 patients were included in the study during the 9-year study period. Of these, 21 patients had secondary AML and 11 had acute promyelocytic leukemia (APL). The mean follow-up period was 12.43 ± 15.63 months. OS of all patients was 9.20 months and PFS was 7.23 months. Age and leukocyte count at the time of diagnosis were found to have a significant impact on both OS and PFS (p <0.05).

Conclusion: In addition to genetic and molecular features, which are expensive and not easily available, the age and leukocyte count of AML patients remain important as prognostic factors.

Keywords

• leukemia,survival,age

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