Approach to Vitamin B12 Deficiency

Abstract

Vitamin B12 found in animal foods acts as cofactor in two enzyme systems in the human body. Vitamin B12 shows the majority of its physiological effects via to its contribution to the homocysteine methionine cycle. Vitamin B12 deficiency is mostly caused by disorders related to absorption mechanisms and is associated with many diseases primarily neurological and hematological diseases. Due to the large measurement uncertainty, serum vitamin B12 levels should be determined as well as homocysteine levels. Finally, parenteral treatment approaches is accepted as a more accurate method in vitamin B12 deficiency.

Keywords

• Vitamin B12 deficiency,Methionine,Succinyl CoenzymeA

Vitamin B12 Yetersizliğine Yaklaşım

Abstract

Hayvansal gıdalarda bulunan vitamin B12; insan vücudunda iki enzim sisteminde kofaktör olarak görev alır. Vitamin B12 fizyolojik etkilerinin çoğunluğunu homosistein metiyonin döngüsüne sağladığı katkı yoluyla gösterir. Vitamin B12 yetmezliği çoğunlukla emilim mekanizmaları ile ilişkili bozukluklardan kaynaklanır ve öncelikle nörolojik ve hematolojik hastalıklar olmak üzere pek çok hastalıkla ilişkilendirilir. Ölçüm belirsizliğinin geniş olması nedeniyle serum vitamin B12 seviyesinin tespit edilmesinin yanında homosistein seviyesine de bakılması gereklidir. Son olarak vitamin B12 yetersizliğinde paranteral tedavi yaklaşımı daha doğru bir yöntem olarak kabul görmektedir. 

Keywords

• Vitamin B12 yetmezliği,Metiyonin,Süksinil KoenzimA

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