Abstract
Aim: In this study, it was aimed to investigate of the clinical efficacy of melatonin treatment on neuropsychiatric symptoms in elderly patients with hypothyroidism. Method: The study was conducted on 51 patients with hypothyroidism. The patients’ anxiety, depressive symptoms and sleep disturbance were recorded with the Hospital Anxiety and Depression Scale (HADS). The Patients were randomized into two groups. The first group of patients (25 patients) received standard replacement therapy with L-thyroxine and symptomatic therapy for 1 month. The second group of patients (26) received melatonin at a dose of 15 mg per night for 1 month (combination therapy) along with L-thyroxine. Results: There was a significant decrease in TSH levels after therapy in both groups. The decrease was more in the group who received combination therapy (82,2 ± 1,5% versus 66,1 ± 2,4%, respectively). Depressive state was significantly reduced only in the combination therapy group (10,9 ± 0,9 points versus 6,9 ± 0,5 points). Furthermore, in patients receiving melatonin there was a significant reduction in subclinical depression (13,2 ± 3,4% versus 7,7 ± 1,1%, p<0,05). Conclusion: Addition of melatonin to the standard therapy is effective in controlling depressive symptoms in patients with hypothyroidism living in Kazakhstan
Keywords
References
- Berbel P, Guadano-Ferraz A, Angulo A. Role of thyroid hormones in the maturation of interhemispheric connection in rats. Behav Brain Res.1994;64(1-2):9-14.
- Pal'tsev MA, Kvetnoĭ IM, Poliakova VO, Kvetnaia TV, Trofimov AV. [Neuroimmunoendocrine mechanisms of aging]. Adv Gerontol. 2009;22(1):24-36. Review. [Russian].
- Kvetnoy IM, Hernández-Yago J, Hernández JM, Kvetnaia TV, Reiter RJ, Khavinson VK. Diffuse neuroendocrine system and mitochondrial diseases: molecular and cellular bases of pathogenesis, new approaches to diagnosis and therapy. Neuro Endocrinol Lett. 2000;21(2):83-99.
- Anisimov VN, Bondarenko LA, Khavinson VKh.Effect of pineal peptide preparation (epithalamin) on life span and pineal and serum melatonin level in old rats. Ann N Y Acad Sci. 1992 Dec 26;673:53-7.
- Bondarenko LA, Gevorkyan AR. The Influence Of A Course Injection Of Melatonin On The Hormonal Activity Of The Hypophyseal-Thyroid System In Old Rats With Age-Related Hypothyroidism. Буковинський медичний вісник. Buk. Med. Herald. 2009;13(4): 38-40.
- Vriend J, Wasserman RA. Effects of Afternoon Injections of Melatonin in Hypothyroid Male Syrian Hamsters. Neuroendocrinology 1986;42(6):498-503.
Melatonin Tedavisinin Yaşlı Hipotiroidili Hastaların Nöro-Psikiyatrik Semptomları Üzerindeki Etkinliği
Abstract
Amaç: Bu çalışmanın amacı melatonin tedavisinin yaşlı hipotiroidili hastaların araştırmaktır. Metot: Hipotiroidili 51 hasta çalışmaya alındı. Hastaların depresyon ve anksiyete skorları ve uyku bozukluğu derecesi “Hastane Anksiyete Depresyon Skalası” (HADS) skalası ile değerlendirildi. Hastalar bir ay süreyle L-tiroksin ve melatonin+ L-tiroksin tedavilerine randomize edildiler. Bulgular: Tedavi sonrası kombinasyon tedavisi alan gurupta daha fazla olmak üzere her 2 grupta TSH seviyeleri geriledi (%82,2±1,5’ ye karşılık %66,1±2,4). Depressif durum kombinasyon tedavisi alan gurupta anlamlı olarak azaldı (10,9±0,9 puana karşılık 6,9±0,5 puan). Ayrıca kombinasyon tedavisi alan grupta subklinik depresyon oranı azaldı (%13,2±3,4’ ye karşılık %7,7±1,1) Sonuç: Kazakistan’da yaşayan hipotiroidili hastalarda standart tedaviye melatonin eklenmesi hastaların depressif semptomlarını kontrol altına almada etkilidir
Keywords
References
- Berbel P, Guadano-Ferraz A, Angulo A. Role of thyroid hormones in the maturation of interhemispheric connection in rats. Behav Brain Res.1994;64(1-2):9-14.
- Pal'tsev MA, Kvetnoĭ IM, Poliakova VO, Kvetnaia TV, Trofimov AV. [Neuroimmunoendocrine mechanisms of aging]. Adv Gerontol. 2009;22(1):24-36. Review. [Russian].
- Kvetnoy IM, Hernández-Yago J, Hernández JM, Kvetnaia TV, Reiter RJ, Khavinson VK. Diffuse neuroendocrine system and mitochondrial diseases: molecular and cellular bases of pathogenesis, new approaches to diagnosis and therapy. Neuro Endocrinol Lett. 2000;21(2):83-99.
- Anisimov VN, Bondarenko LA, Khavinson VKh.Effect of pineal peptide preparation (epithalamin) on life span and pineal and serum melatonin level in old rats. Ann N Y Acad Sci. 1992 Dec 26;673:53-7.
- Bondarenko LA, Gevorkyan AR. The Influence Of A Course Injection Of Melatonin On The Hormonal Activity Of The Hypophyseal-Thyroid System In Old Rats With Age-Related Hypothyroidism. Буковинський медичний вісник. Buk. Med. Herald. 2009;13(4): 38-40.
- Vriend J, Wasserman RA. Effects of Afternoon Injections of Melatonin in Hypothyroid Male Syrian Hamsters. Neuroendocrinology 1986;42(6):498-503.
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Articles |
| Authors | |
| Publication Date | April 1, 2013 |
| Published in Issue | Year 2013 Volume: 5 Issue: 1 |