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Gastrik kanserde tümör belirleyici düzeylerindeki değişiklikler ile lenf nodu disseksiyon seviyeleri arasında bir ilişki var mı?

Year 2017, Volume: 9 Issue: 2, 146 - 149, 06.07.2017
https://doi.org/10.18521/ktd.305030

Abstract

Amaç:
Retrospektif olarak lenf nodu diseksiyon düzeylerinin tümör markerları
üzerindeki etkilerini araştırmayı amaçladık.

Metod:
Ocak 2014 ile Aralık 2016 tarihleri arasında rezektabl mide kanseri nedeniyle
radikal gastrektomi uygulanan 52 hastayı çalışmaya aldık ve lenf nodu
diseksiyon düzeylerine göre 3 gruba ayırdık (D1, n=18; D1+, n=10; ve D2, n=24).
Toplam çıkarılan lenf nodu sayısı, metastatik lenf nodu sayısı, hastalığın
evresi ile preoperatif ve postoperatif CEA ve CA 19-9 düzeyleri kaydedildi. Tüm
evrelerde toplu olarak ve evrelerine göre ayrı ayrı, preoperatif tümör
markerlerının postoperatif düzeylerine olan oranları gruplara arasında Kruskal
Wallis testi kullanılarak karşılaştırıldı.





Bulgular:
Toplam
çıkarılan lenf nodu sayısı D2 grubunda D1’e kıyasla daha fazlaydı ancak
metastatik lenf nodları, tümör evreleri  ve
preoperatif ve postoperatif tümör markerları açısından gruplar arasında fark
yoktu. Tüm gruplarda CEA düzeylerindeki değişiklikler evrelerin hepsinde
benzerdi. Öte yandan CA 19-9 düzelerinde D1 grubunda D1+ ve D2 grubuna kıyasla
azalma oranları daha azdı (preoperatif düzeylerin postoperatif düzeylere
oranlarının medyan değerleri sırasıyla; 1.09; 0.67; 0.51; D1 ile D1+
kıyaslandığında p=0.040; D1 ve D2 kıyaslandığında p<0,001). Tartışma: Tümör markerları lenf nodu
diseksiyonunun genişliğinden etkilenebilmektedir. Bu araştırmada, lenf nodu
diseksiyon düzeyi arttıkça, CA19-9 düzeylerindeki azalmanın daha fazla olduğu
gözlendi. 

References

  • 1- Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 2010;17:1471–4.
  • 2- Reiter W, Stieber P, Reuter C, et al. Prognostic value of preoperative serum levels of CEA, CA 19-9 and CA 72-4 in gastric carcinoma. Anticancer Res. 1997;17:2903–6.
  • 3- Takahashi Y, Takeuchi T, Sakamoto J, et al. The usefulness of CEA and/or CA19-9 in monitoring for recurrence in gastric cancer patients: a prospective clinical study. Gastric Cancer. 2003;6:142–5.
  • 4- Marrelli D, Roviello F, De Stefano A, et al. Prognostic significance of CEA, CA 19-9 and CA 72-4 preoperative serum levels in gastric carcinoma. Oncology. 1999;57:55–62.
  • 5- Nam DH, Lee YK, Park JC, et al. Prognostic Value of Early Postoperative Tumor Marker Response in Gastric Cancer. Ann Surg Oncol. 2013;20:3905–11.
  • 6- Songun I, Putter H, Kranenbarg EM, et al Surgical treatment of gastric cancer: 15-year follow-up results of the randomised nationwide Dutch D1D2 trial.. Lancet Oncol. 2010;11(5):439-49.
  • 7- Fan B, Xiong B. Investigation of serum tumor markers in the diagnosis of gastric cancer. Hepatogastroenterology. 2011;58: 239–45.
  • 8- Dilege E, Mihmanli M, Demir U, et al. Prognostic value of preoperative CEA and CA 19-9 levels in resectable gastric cancer. Hepatogastroenterology. 2010;57:674–7.
  • 9- Song YX, Huang XZ, Gao P, et al. Clinicopathologic and Prognostic Value of Serum Carbohydrate Antigen 19-9 in Gastric Cancer: A Meta-Analysis. Dis Markers. 2015;2015:549843.
  • 10- Kim DH, Oh SJ, Oh CA, et al. The relationships between perioperative CEA, CA 19-9, and CA 72-4 and recurrence in gastric cancer patients after curative radical gastrectomy. J Surg Oncol. 2011;104:585–91.

Is there a relation between the changes in tumor marker levels and lymph node dissection levels in gastric cancer?

Year 2017, Volume: 9 Issue: 2, 146 - 149, 06.07.2017
https://doi.org/10.18521/ktd.305030

Abstract

Objective: We
aimed to investigate the effects of the levels of lymph node dissection on the
changes in the tumor markers including CEA and CA19-9, retrospectively. Methods: Between January 2014 and
December 2016, we enrolled 52 patients who had received radical gastrectomy as
an initial treatment due to resectable gastric cancer and divided into 3 groups
according to the levels of lymph node dissections (D1, n=18; D1+, n=10; and D2,
n=24). The total number of the harvested lymph nodes and metastatic lymph
nodes, the stages of the disease and preoperative and postoperative CEA and
CA19-9 levels were recorded. Results: The
number of the harvested lymph nodes were greater in group D2 compared to D1,
however no difference was found in the number of the metastatic lymph nodes,
the tumor stages  nor in the preoperative
and postoperative tumor marker levels between groups. The changes in CEA levels
were similar in all groups in all stages, either. On the other hand, the reduction
rates in CA19-9 levels in group D1 were less than in group D1+ and D2 (median
values of ratios of preoperative levels to postoperative levels respectively; 1,09;
0,67; 0,51; p=0,040 for D1 vs D1+; p<0,001 for D1 vs D2) whereas there were
no difference between groups D1+ and D2 (p>0,05). Discussion: The tumor markers may be affected by the extent of the
lymph node dissection. The greater the level of dissection, the greater the
reduction in CA19-9 levels was observed in the present study. 

References

  • 1- Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 2010;17:1471–4.
  • 2- Reiter W, Stieber P, Reuter C, et al. Prognostic value of preoperative serum levels of CEA, CA 19-9 and CA 72-4 in gastric carcinoma. Anticancer Res. 1997;17:2903–6.
  • 3- Takahashi Y, Takeuchi T, Sakamoto J, et al. The usefulness of CEA and/or CA19-9 in monitoring for recurrence in gastric cancer patients: a prospective clinical study. Gastric Cancer. 2003;6:142–5.
  • 4- Marrelli D, Roviello F, De Stefano A, et al. Prognostic significance of CEA, CA 19-9 and CA 72-4 preoperative serum levels in gastric carcinoma. Oncology. 1999;57:55–62.
  • 5- Nam DH, Lee YK, Park JC, et al. Prognostic Value of Early Postoperative Tumor Marker Response in Gastric Cancer. Ann Surg Oncol. 2013;20:3905–11.
  • 6- Songun I, Putter H, Kranenbarg EM, et al Surgical treatment of gastric cancer: 15-year follow-up results of the randomised nationwide Dutch D1D2 trial.. Lancet Oncol. 2010;11(5):439-49.
  • 7- Fan B, Xiong B. Investigation of serum tumor markers in the diagnosis of gastric cancer. Hepatogastroenterology. 2011;58: 239–45.
  • 8- Dilege E, Mihmanli M, Demir U, et al. Prognostic value of preoperative CEA and CA 19-9 levels in resectable gastric cancer. Hepatogastroenterology. 2010;57:674–7.
  • 9- Song YX, Huang XZ, Gao P, et al. Clinicopathologic and Prognostic Value of Serum Carbohydrate Antigen 19-9 in Gastric Cancer: A Meta-Analysis. Dis Markers. 2015;2015:549843.
  • 10- Kim DH, Oh SJ, Oh CA, et al. The relationships between perioperative CEA, CA 19-9, and CA 72-4 and recurrence in gastric cancer patients after curative radical gastrectomy. J Surg Oncol. 2011;104:585–91.
There are 10 citations in total.

Details

Subjects Health Care Administration
Journal Section Articles
Authors

Fatih Yaşar

Bartu Badak

Setenay Öner

Ersin Ateş

Adnan Şahin

Uğur Bilge

Tarık Çağa This is me

Publication Date July 6, 2017
Acceptance Date June 19, 2017
Published in Issue Year 2017 Volume: 9 Issue: 2

Cite

APA Yaşar, F., Badak, B., Öner, S., Ateş, E., et al. (2017). Is there a relation between the changes in tumor marker levels and lymph node dissection levels in gastric cancer?. Konuralp Medical Journal, 9(2), 146-149. https://doi.org/10.18521/ktd.305030
AMA Yaşar F, Badak B, Öner S, Ateş E, Şahin A, Bilge U, Çağa T. Is there a relation between the changes in tumor marker levels and lymph node dissection levels in gastric cancer?. Konuralp Medical Journal. July 2017;9(2):146-149. doi:10.18521/ktd.305030
Chicago Yaşar, Fatih, Bartu Badak, Setenay Öner, Ersin Ateş, Adnan Şahin, Uğur Bilge, and Tarık Çağa. “Is There a Relation Between the Changes in Tumor Marker Levels and Lymph Node Dissection Levels in Gastric Cancer?”. Konuralp Medical Journal 9, no. 2 (July 2017): 146-49. https://doi.org/10.18521/ktd.305030.
EndNote Yaşar F, Badak B, Öner S, Ateş E, Şahin A, Bilge U, Çağa T (July 1, 2017) Is there a relation between the changes in tumor marker levels and lymph node dissection levels in gastric cancer?. Konuralp Medical Journal 9 2 146–149.
IEEE F. Yaşar, “Is there a relation between the changes in tumor marker levels and lymph node dissection levels in gastric cancer?”, Konuralp Medical Journal, vol. 9, no. 2, pp. 146–149, 2017, doi: 10.18521/ktd.305030.
ISNAD Yaşar, Fatih et al. “Is There a Relation Between the Changes in Tumor Marker Levels and Lymph Node Dissection Levels in Gastric Cancer?”. Konuralp Medical Journal 9/2 (July 2017), 146-149. https://doi.org/10.18521/ktd.305030.
JAMA Yaşar F, Badak B, Öner S, Ateş E, Şahin A, Bilge U, Çağa T. Is there a relation between the changes in tumor marker levels and lymph node dissection levels in gastric cancer?. Konuralp Medical Journal. 2017;9:146–149.
MLA Yaşar, Fatih et al. “Is There a Relation Between the Changes in Tumor Marker Levels and Lymph Node Dissection Levels in Gastric Cancer?”. Konuralp Medical Journal, vol. 9, no. 2, 2017, pp. 146-9, doi:10.18521/ktd.305030.
Vancouver Yaşar F, Badak B, Öner S, Ateş E, Şahin A, Bilge U, Çağa T. Is there a relation between the changes in tumor marker levels and lymph node dissection levels in gastric cancer?. Konuralp Medical Journal. 2017;9(2):146-9.