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Kronik Spontan Ürtikerli Hastalarda Kronik Yaygın Ağrı Sıklığı ve Yaşam Kalitesi Üzerine Etkisi

Year 2019, Volume: 11 Issue: 1, 101 - 105, 25.03.2019
https://doi.org/10.18521/ktd.520277

Abstract









Amaç:



Kronik
spontan ürtiker (KSÜ), düşük yaşam kalitesi ile seyreden,
kronik, yaygın ve zorlayıcı bir hastalıktır. Bu çalışmanın
temel amacı, KSÜ hastalarında, Kronik Yaygın Ağrının (KYA)
varlığını araştırmak ve KYA ile KSÜ arasında klinik
özellikler, laboratuvar belirteçler, hastalık aktivite skorları
ile dermatoloji yaşam kalitesi indeksi (DYKİ) arasındaki olası
bağlantıyı ortaya koymaktır.



Yöntem:



KSÜ'
lü 91 hasta, KYA varlığı açısından üçüncü basamak
polikliniğinde değerlendirildi. KSÜ’lü hastalarda, KYA (en az
üç ay boyunca dört kadran ve aksiyel olmak üzere beş vücut
bölgesinden dördünde veya daha fazlasında ağrı) varlığı
romatoloji polikliniğinde değerlendirildi. Ayrıca, hastaların
anti-nükleer antikor (ANA), eritrosit sedimantasyon hızı, CRP
(C-reaktif protein), B12, total IgE ve anti-TPO test sonuçları da
analiz edildi. Hastalar hastalığın başlangıcı ve süresi, eşlik
eden morbiditeleri, anjioödem varlığı, atopi öyküsü ve uykudan
uyandıran gece kaşıntısı yönüyle değerlendirildi. Hastaların
hastalık aktivitesini ortaya koymak için ürtiker kontrol testi
(UKT), ürtiker aktivite skoru (UAS) ve hekim ve hastaların genel
sağlık durumunu ayrı ayrı değerlendirdiği görsel analog skala
kullanıldı. Ayrıca, hastaların yaşam kalitesi dermatolojik
hastalık yaşam kalite indeksi (DYKİ) ile değerlendirildi.



Sonuç:



KSÜ’lü
91 hastadan 23'ünde (25.3%) KYA mevcuttu. KYA +, KSÜ' lü
hastalarda anlamlı yüksek Doktor Global değerlendirme skoru
(p=0.003), Hasta global değerlendirme skoru (p=0.005), UAS
(p=0.046), DYKİ (p<0.001) ve düşük UCT skorları bulundu.
KYA’lı 23 hastanın dokuzunda, eşlik eden hastalık olarak astım
(39.1%) bulundu (p=0.005).



Tartışma



Ürtiker
hastalarında KYA'nın varlığı, hastaların yaşam kalitesini ve
hastalık skorlarını olumsuz yönde etkileyebilir.




References

  • 1. O’Donnel BF, Lawlor F, Simpson J, et al. The impact of chronic urticaria on the quality of life. Br J Dermatol [Internet]. 1997 Feb 1;136(2):197–201. Available from: https://doi.org/10.1046/j.1365-2133.1997.d01-1168.x
  • 2. Zuberbier T, Aberer W, Asero R, et al. The EAACI/GA2LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Allergy [Internet]. 2018 Jul 1;73(7):1393–414. Available from: https://doi.org/10.1111/all.13397
  • 3. Ertaş R, Özyurt K, Yıldız S, et al. Adverse reaction to omalizumab in patients with chronic urticaria: flare up or ineffectiveness? Iran J Allergy, Asthma Immunol. 2016;15(1):82–6.
  • 4. Ertaş R, Özyurt K, Karakükçü Ç, et al. Evaluation of platelet parameters and neutrophil/lymphocyte ratio during omalizumab treatment in patients with severe chronic spontaneous urticaria. Turkish J Med Sci. 2018;48(6):1255–62.
  • 5. Ertas R, Ozyurt K, Atasoy M, et al. The clinical response to omalizumab in chronic spontaneous urticaria patients is linked to and predicted by IgE levels and their change. Allergy Eur J Allergy Clin Immunol. 2018;73(3):705–12.
  • 6. Ertas R, Ozyurt K, Ozlu E, et al. Increased IgE levels are linked to faster relapse in patients with omalizumab-discontinued chronic spontaneous urticaria. J Allergy Clin Immunol [Internet]. 2017;140(6). Available from: http://linkinghub.elsevier.com/retrieve/pii/S0091674917313519
  • 7. Häuser W, Perrot S, Sommer C, et al. Diagnostic confounders of chronic widespread pain: not always fibromyalgia. Pain reports [Internet]. 2017 Apr 30;2(3):e598–e598. Available from: https://www.ncbi.nlm.nih.gov/pubmed/29392213
  • 8. Croft P, Rigby AS, Boswell R, et al. The prevalence of chronic widespread pain in the general population. J Rheumatol [Internet]. 1993 Apr;20(4):710—713. Available from: http://europepmc.org/abstract/MED/8496870
  • 9. Andrews P, Steultjens M, Riskowski J. Chronic widespread pain prevalence in the general population: A systematic review. Eur J Pain [Internet]. 2018 Jan;22(1):5—18. Available from: https://doi.org/10.1002/ejp.1090
  • 10. Ozlu E , Ertaş R , Özyurt K , et al . "Effects of Isotretinoin Treatment on Sleep and Quality of Life in Patients with Acne Vulgaris". Konuralp Tıp Dergisi 10 (2018): 65-73
  • 11. Özel A , Tütün Yümin E, Tuğ T, et al. "Effects of Quadriceps Muscle Strength and Kinesiophobia on Health Related Quality of Life in Elderly Women and Men with Chronic Obstructive Pulmonary Disease". Konuralp Tıp Dergisi 10 (2018): 333-340
  • 12. Hapa A, Özdemir O, Ersoy Evans S, et al. Kronik ürtikerli hastalarda fibromiyalji sendromu sıklığının değerlendirilmesi. Turkderm [Internet]. 2012 Dec 15;46(4):202–5. Available from: http://www.journalagent.com/z4/download_fulltext.asp?pdir=turkderm&plng=tur&un=TURKDERM-81489
  • 13. Yener M, Erturan I, Ceyhan AM, et al. The evaluation of prevalence of fibromyalgia in patients with chronic urticaria. Med Sci Monit [Internet]. 2013 Sep 11;19:757–61. Available from: https://www.ncbi.nlm.nih.gov/pubmed/24022252
  • 14. Torresani C, Bellafiore S, et al. Chronic urticaria is usually associated with fibromyalgia syndrome. Acta Derm Venereol. 2009;89(4):389–92.
  • 15. Kato K, Sullivan PF, Evengård B, et al. Chronic Widespread Pain and Its Comorbidities: A Population-Based Study. Arch Intern Med [Internet]. 2006 Aug 14;166(15):1649–54. Available from: https://dx.doi.org/10.1001/archinte.166.15.1649

The Frequency of Chronic Widespread Pain and Its Impact on Quality of Life in Patients with Chronic Spontaneous Urticaria

Year 2019, Volume: 11 Issue: 1, 101 - 105, 25.03.2019
https://doi.org/10.18521/ktd.520277

Abstract









Background
and aims



Chronic
spontaneous urticaria (CSU)

is a chronic, common and debilitating disease

and
associated with severely impaired quality of life (QoL).
The
main aims of this study are to explore the presence of Chronic
Widespread Pain (CWP) in patients with
CSU
and to reveal the possible associations between CWP and CSU on the
clinical features, laboratory markers and urticaria activity scores
with QoL.



Methods




We assessed
the
91
patients with CSU for CWP

in a tertiary outpatient clinic
.
CWP
(pain in four or more out of five bodily regions, i.e. the four
quadrants and axially at least for three months)

was assessed
in
a rheumatology outpatient clinic in patients with CSU.

We also analyzed the test results of anti-nuclear antibody (ANA),
blood sedimentation
rate, CRP (C-reactive protein), B12, total IgE, and anti-TPO
.
Patients were
assessed for their onset and duration of disease, comorbidities,
occurrence of angioedema and history of atopy, and nocturnal pruritus
with disturbed sleep. Patients disease activity were assessed by the
urticaria control test (UCT), urticaria activity score (UAS) and
visual analog scale of physician and patient’s global assessment.
Furthermore,
patients completed a questionnaire to assess the quality of life
(QoL) for dermatologic diseases.



Results



Of
the 91 patients with CSU assessed for CWP, 23 (25.3%) were positive.
CWP +ve patients with CSU had significantly higher physician global
assessment score (p=0.003), Patients global assessment score
(p=0.005), UAS (p=0.046), dermatologic QoL (p<0.001) and lower UCT
(p=0.005) scores. Nine of 23 CWP +ve patients had asthma (39.1%) as a
comorbidity (p=0.008).



Conclusions



The
presence of CWP in patients with urticaria may have a negative impact
on the quality of life of the patients and disease scores.




References

  • 1. O’Donnel BF, Lawlor F, Simpson J, et al. The impact of chronic urticaria on the quality of life. Br J Dermatol [Internet]. 1997 Feb 1;136(2):197–201. Available from: https://doi.org/10.1046/j.1365-2133.1997.d01-1168.x
  • 2. Zuberbier T, Aberer W, Asero R, et al. The EAACI/GA2LEN/EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria. Allergy [Internet]. 2018 Jul 1;73(7):1393–414. Available from: https://doi.org/10.1111/all.13397
  • 3. Ertaş R, Özyurt K, Yıldız S, et al. Adverse reaction to omalizumab in patients with chronic urticaria: flare up or ineffectiveness? Iran J Allergy, Asthma Immunol. 2016;15(1):82–6.
  • 4. Ertaş R, Özyurt K, Karakükçü Ç, et al. Evaluation of platelet parameters and neutrophil/lymphocyte ratio during omalizumab treatment in patients with severe chronic spontaneous urticaria. Turkish J Med Sci. 2018;48(6):1255–62.
  • 5. Ertas R, Ozyurt K, Atasoy M, et al. The clinical response to omalizumab in chronic spontaneous urticaria patients is linked to and predicted by IgE levels and their change. Allergy Eur J Allergy Clin Immunol. 2018;73(3):705–12.
  • 6. Ertas R, Ozyurt K, Ozlu E, et al. Increased IgE levels are linked to faster relapse in patients with omalizumab-discontinued chronic spontaneous urticaria. J Allergy Clin Immunol [Internet]. 2017;140(6). Available from: http://linkinghub.elsevier.com/retrieve/pii/S0091674917313519
  • 7. Häuser W, Perrot S, Sommer C, et al. Diagnostic confounders of chronic widespread pain: not always fibromyalgia. Pain reports [Internet]. 2017 Apr 30;2(3):e598–e598. Available from: https://www.ncbi.nlm.nih.gov/pubmed/29392213
  • 8. Croft P, Rigby AS, Boswell R, et al. The prevalence of chronic widespread pain in the general population. J Rheumatol [Internet]. 1993 Apr;20(4):710—713. Available from: http://europepmc.org/abstract/MED/8496870
  • 9. Andrews P, Steultjens M, Riskowski J. Chronic widespread pain prevalence in the general population: A systematic review. Eur J Pain [Internet]. 2018 Jan;22(1):5—18. Available from: https://doi.org/10.1002/ejp.1090
  • 10. Ozlu E , Ertaş R , Özyurt K , et al . "Effects of Isotretinoin Treatment on Sleep and Quality of Life in Patients with Acne Vulgaris". Konuralp Tıp Dergisi 10 (2018): 65-73
  • 11. Özel A , Tütün Yümin E, Tuğ T, et al. "Effects of Quadriceps Muscle Strength and Kinesiophobia on Health Related Quality of Life in Elderly Women and Men with Chronic Obstructive Pulmonary Disease". Konuralp Tıp Dergisi 10 (2018): 333-340
  • 12. Hapa A, Özdemir O, Ersoy Evans S, et al. Kronik ürtikerli hastalarda fibromiyalji sendromu sıklığının değerlendirilmesi. Turkderm [Internet]. 2012 Dec 15;46(4):202–5. Available from: http://www.journalagent.com/z4/download_fulltext.asp?pdir=turkderm&plng=tur&un=TURKDERM-81489
  • 13. Yener M, Erturan I, Ceyhan AM, et al. The evaluation of prevalence of fibromyalgia in patients with chronic urticaria. Med Sci Monit [Internet]. 2013 Sep 11;19:757–61. Available from: https://www.ncbi.nlm.nih.gov/pubmed/24022252
  • 14. Torresani C, Bellafiore S, et al. Chronic urticaria is usually associated with fibromyalgia syndrome. Acta Derm Venereol. 2009;89(4):389–92.
  • 15. Kato K, Sullivan PF, Evengård B, et al. Chronic Widespread Pain and Its Comorbidities: A Population-Based Study. Arch Intern Med [Internet]. 2006 Aug 14;166(15):1649–54. Available from: https://dx.doi.org/10.1001/archinte.166.15.1649
There are 15 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Articles
Authors

Ragıp Ertaş This is me 0000-0002-9269-2619

Kemal Erol 0000-0003-0673-3961

Publication Date March 25, 2019
Acceptance Date March 10, 2019
Published in Issue Year 2019 Volume: 11 Issue: 1

Cite

APA Ertaş, R., & Erol, K. (2019). Kronik Spontan Ürtikerli Hastalarda Kronik Yaygın Ağrı Sıklığı ve Yaşam Kalitesi Üzerine Etkisi. Konuralp Medical Journal, 11(1), 101-105. https://doi.org/10.18521/ktd.520277
AMA Ertaş R, Erol K. Kronik Spontan Ürtikerli Hastalarda Kronik Yaygın Ağrı Sıklığı ve Yaşam Kalitesi Üzerine Etkisi. Konuralp Medical Journal. March 2019;11(1):101-105. doi:10.18521/ktd.520277
Chicago Ertaş, Ragıp, and Kemal Erol. “Kronik Spontan Ürtikerli Hastalarda Kronik Yaygın Ağrı Sıklığı Ve Yaşam Kalitesi Üzerine Etkisi”. Konuralp Medical Journal 11, no. 1 (March 2019): 101-5. https://doi.org/10.18521/ktd.520277.
EndNote Ertaş R, Erol K (March 1, 2019) Kronik Spontan Ürtikerli Hastalarda Kronik Yaygın Ağrı Sıklığı ve Yaşam Kalitesi Üzerine Etkisi. Konuralp Medical Journal 11 1 101–105.
IEEE R. Ertaş and K. Erol, “Kronik Spontan Ürtikerli Hastalarda Kronik Yaygın Ağrı Sıklığı ve Yaşam Kalitesi Üzerine Etkisi”, Konuralp Medical Journal, vol. 11, no. 1, pp. 101–105, 2019, doi: 10.18521/ktd.520277.
ISNAD Ertaş, Ragıp - Erol, Kemal. “Kronik Spontan Ürtikerli Hastalarda Kronik Yaygın Ağrı Sıklığı Ve Yaşam Kalitesi Üzerine Etkisi”. Konuralp Medical Journal 11/1 (March 2019), 101-105. https://doi.org/10.18521/ktd.520277.
JAMA Ertaş R, Erol K. Kronik Spontan Ürtikerli Hastalarda Kronik Yaygın Ağrı Sıklığı ve Yaşam Kalitesi Üzerine Etkisi. Konuralp Medical Journal. 2019;11:101–105.
MLA Ertaş, Ragıp and Kemal Erol. “Kronik Spontan Ürtikerli Hastalarda Kronik Yaygın Ağrı Sıklığı Ve Yaşam Kalitesi Üzerine Etkisi”. Konuralp Medical Journal, vol. 11, no. 1, 2019, pp. 101-5, doi:10.18521/ktd.520277.
Vancouver Ertaş R, Erol K. Kronik Spontan Ürtikerli Hastalarda Kronik Yaygın Ağrı Sıklığı ve Yaşam Kalitesi Üzerine Etkisi. Konuralp Medical Journal. 2019;11(1):101-5.